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The map label for this gene is gppA [H]

Identifier: 42521708

GI number: 42521708

Start: 55889

End: 56803

Strand: Direct

Name: gppA [H]

Synonym: Bd0061

Alternate gene names: 42521708

Gene position: 55889-56803 (Clockwise)

Preceding gene: 42521707

Following gene: 42521709

Centisome position: 1.48

GC content: 51.37

Gene sequence:

>915_bases
ATGAAAAAAGTTGCAGCACTTGATCTTGGAACCAACACCTTCCTGTGCCTGATTGTTTCTGGTGACAAAGATGGAATCAA
AAAGGTGCATCGTGATCTGATGCAGGTGGTGCGTTTGGGTCAAGGTGTTGGGCAGACCGGAGAGTTTCATCCGGATGCTT
TGGCCAGAGCCCGTCAGTGTCTGACGGAATTCAAAAAAGAAATCGATTCTGAACACGTCGATCAGATTCTGGCAATGGCG
ACCTCCGCCGCGCGTGACGCCCGCAACGGTCAGGAGCTTTTCCGTATCGGTGAAGAGCTGGGCATTCCCATTGAAATTAT
TCCCGGCGAGGACGAAGCGCGAATCACGTATCTTGGAGGAACAGCGGGAAGTGCCAGCCCAAATCTGACTTCGTTGGTGG
TGGATGTCGGTGGTGGCTCCACAGAACTGATCGTCGGCAAAGGGTCAGAAATTTTGTATGGCCACAGTCTGGATATCGGT
GGTGTGCGGTTAACAGAAAAATTTGTCACGACTCAACCCGTGATCGAAAAAGATCGCATACCCCTGGAAGCTTATATTCA
GGAACAACTGGCGACGATCCTGCCGGAGATTCAAAAACACAAGATTGATCAGATCGTGGCAGTGGCCGGAACACCCACCG
CCCTGGTGGCAATTGAAGTTGGTGGCTTTGATGAAAAGAAGGTCGATGGTTACTTCCTGAAGAAAGACCGTCTGGCCCAC
TGGGTGGAGGAATTTGCCCGTACCACAGTCGAAGAAAAAAAGACCAAGTATCAACTGGGCGGCCGAGCGGATATCATTTT
TGCAGGAGCTTCGATCCTGCTGGCAGTGGTGGAAGCTTTGAAACTGGAAGGCATGGTCGTCACGACCAAAGGGGTTCGTT
ATGGGGTTGCGCTGGAAATGCTCCACGTTCGCTAA

Upstream 100 bases:

>100_bases
CTTTGTCGGTGCCGTGATGAAGGCCTCCAAGGGGCAGGCCAATCCGGACCTTGTGAACAAGATTCTTCTAGAGAAACTGA
AATAGAACAGGATATTTGAA

Downstream 100 bases:

>100_bases
ATTTGTGATGTTCGCAGGACTGTCCCTGGTCCTGTCTCCGCAGGCTTTTGCGGCCAAGGAATTTTCAAAAAAGAAAGTCA
CTCTGGGCTCCAAGACTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKKVAALDLGTNTFLCLIVSGDKDGIKKVHRDLMQVVRLGQGVGQTGEFHPDALARARQCLTEFKKEIDSEHVDQILAMA
TSAARDARNGQELFRIGEELGIPIEIIPGEDEARITYLGGTAGSASPNLTSLVVDVGGGSTELIVGKGSEILYGHSLDIG
GVRLTEKFVTTQPVIEKDRIPLEAYIQEQLATILPEIQKHKIDQIVAVAGTPTALVAIEVGGFDEKKVDGYFLKKDRLAH
WVEEFARTTVEEKKTKYQLGGRADIIFAGASILLAVVEALKLEGMVVTTKGVRYGVALEMLHVR

Sequences:

>Translated_304_residues
MKKVAALDLGTNTFLCLIVSGDKDGIKKVHRDLMQVVRLGQGVGQTGEFHPDALARARQCLTEFKKEIDSEHVDQILAMA
TSAARDARNGQELFRIGEELGIPIEIIPGEDEARITYLGGTAGSASPNLTSLVVDVGGGSTELIVGKGSEILYGHSLDIG
GVRLTEKFVTTQPVIEKDRIPLEAYIQEQLATILPEIQKHKIDQIVAVAGTPTALVAIEVGGFDEKKVDGYFLKKDRLAH
WVEEFARTTVEEKKTKYQLGGRADIIFAGASILLAVVEALKLEGMVVTTKGVRYGVALEMLHVR
>Mature_304_residues
MKKVAALDLGTNTFLCLIVSGDKDGIKKVHRDLMQVVRLGQGVGQTGEFHPDALARARQCLTEFKKEIDSEHVDQILAMA
TSAARDARNGQELFRIGEELGIPIEIIPGEDEARITYLGGTAGSASPNLTSLVVDVGGGSTELIVGKGSEILYGHSLDIG
GVRLTEKFVTTQPVIEKDRIPLEAYIQEQLATILPEIQKHKIDQIVAVAGTPTALVAIEVGGFDEKKVDGYFLKKDRLAH
WVEEFARTTVEEKKTKYQLGGRADIIFAGASILLAVVEALKLEGMVVTTKGVRYGVALEMLHVR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=304, Percent_Identity=30.2631578947368, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788848, Length=312, Percent_Identity=26.6025641025641, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 32973; Mature: 32973

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVAALDLGTNTFLCLIVSGDKDGIKKVHRDLMQVVRLGQGVGQTGEFHPDALARARQC
CCCEEEEECCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LTEFKKEIDSEHVDQILAMATSAARDARNGQELFRIGEELGIPIEIIPGEDEARITYLGG
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEC
TAGSASPNLTSLVVDVGGGSTELIVGKGSEILYGHSLDIGGVRLTEKFVTTQPVIEKDRI
CCCCCCCCCEEEEEECCCCCEEEEEECCCEEEEECCCCCCCEEEHHHHHCCCCCHHCCCC
PLEAYIQEQLATILPEIQKHKIDQIVAVAGTPTALVAIEVGGFDEKKVDGYFLKKDRLAH
CHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCCCCCCEEECHHHHHH
WVEEFARTTVEEKKTKYQLGGRADIIFAGASILLAVVEALKLEGMVVTTKGVRYGVALEM
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCEEEEECCCEECCEEEE
LHVR
EECC
>Mature Secondary Structure
MKKVAALDLGTNTFLCLIVSGDKDGIKKVHRDLMQVVRLGQGVGQTGEFHPDALARARQC
CCCEEEEECCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LTEFKKEIDSEHVDQILAMATSAARDARNGQELFRIGEELGIPIEIIPGEDEARITYLGG
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEC
TAGSASPNLTSLVVDVGGGSTELIVGKGSEILYGHSLDIGGVRLTEKFVTTQPVIEKDRI
CCCCCCCCCEEEEEECCCCCEEEEEECCCEEEEECCCCCCCEEEHHHHHCCCCCHHCCCC
PLEAYIQEQLATILPEIQKHKIDQIVAVAGTPTALVAIEVGGFDEKKVDGYFLKKDRLAH
CHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCCCCCCEEECHHHHHH
WVEEFARTTVEEKKTKYQLGGRADIIFAGASILLAVVEALKLEGMVVTTKGVRYGVALEM
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCEEEEECCCEECCEEEE
LHVR
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA