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The map label for this gene is dapA

Identifier: 42521694

GI number: 42521694

Start: 41100

End: 41981

Strand: Direct

Name: dapA

Synonym: Bd0046

Alternate gene names: 42521694

Gene position: 41100-41981 (Clockwise)

Preceding gene: 42521693

Following gene: 42521695

Centisome position: 1.09

GC content: 50.45

Gene sequence:

>882_bases
ATGAAAAATTTCAAAGGCACGTTCACCGCACTGGTAACGCCATTTAAAAACGGAAAGATCGACTTCGCTTCGCTGGATAA
GCTTCTGAAGCAACAACTGGCTGGCGGCGTGGATGGTTTTGTCGTCAACGGCACGACGGGTGAAAGTCCTGTATTGACCT
CCTCAGAGAAGGCCGAGCTTTTCAAACACATCCGCAATGTCTGCGGAGACAAAGTTGTTTTGATCATGGGAACCGGTTCC
AACAACACGGCCCAAACCATTGAAGATTCCCGCAAGGCGGAAGAAATGGGTGCGGATGCGATTTTGGTTGTGGTTCCCTA
CTACAACAAACCACCACAGCGTGGACTGTATGAACACTTTAAAGCCGTGGCGTCTTCTGTGAAGATTCCAACCATTCTTT
ACAATGTTCCGGGTCGCACCATCACCTCGCTTGAAACTGGCACCATCCGTGATCTTGCCAAAGTCAAAGGTGTGGTTGGC
ATCAAAGAAGCCACCGGCAAAATTGATCTGGCCAGTGAAATCATCAAAGCCTGCGGCAGCGAATTTGTGATGCTGTCCGG
GGATGACGGCACTTACGTTGAATTCCTGGGCGTTGGTGGCCATGGGGTGATTTCAGTTGCGTCACATGTGATTCCGGCAC
AAATGGTGCAGTGGAAAAAATGGGTGTCTGAAGGCGCGCTGGATAAAGCCCGCGCGGATATCGCAAAATACAACGACCTG
ATCAATCTTCTTTTCGTTGAAGCCAATCCGATCCCGGTGAAAAAGGCGTTGCAGTTGATGGGCATTCTGGAGTCCGCAGA
ACTGCGTCTGCCATTGGTGGAGCTGGGTGCTGAAAACACCGCAAAACTTCAGGCCGAGATGAAAAAAGTGGGTGTGCTGT
GA

Upstream 100 bases:

>100_bases
GTTCAATGCAAGTGACATTCGTCAGTGGTGATCCCCACCCGCTGATGGAAGGGGACGCGGTTTTTGTCGGGGACTTTAAA
TACAATCTTGAGGTGGTAGG

Downstream 100 bases:

>100_bases
AGAAAATCAAAATCGGCCTGATGGGTTCTGCCGGCCGTATGGGTCAAGAGATCGCCGGGGTGATTGAAGCCAACCCCCGC
TGCGAACTGGTGTATGCTCC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKNFKGTFTALVTPFKNGKIDFASLDKLLKQQLAGGVDGFVVNGTTGESPVLTSSEKAELFKHIRNVCGDKVVLIMGTGS
NNTAQTIEDSRKAEEMGADAILVVVPYYNKPPQRGLYEHFKAVASSVKIPTILYNVPGRTITSLETGTIRDLAKVKGVVG
IKEATGKIDLASEIIKACGSEFVMLSGDDGTYVEFLGVGGHGVISVASHVIPAQMVQWKKWVSEGALDKARADIAKYNDL
INLLFVEANPIPVKKALQLMGILESAELRLPLVELGAENTAKLQAEMKKVGVL

Sequences:

>Translated_293_residues
MKNFKGTFTALVTPFKNGKIDFASLDKLLKQQLAGGVDGFVVNGTTGESPVLTSSEKAELFKHIRNVCGDKVVLIMGTGS
NNTAQTIEDSRKAEEMGADAILVVVPYYNKPPQRGLYEHFKAVASSVKIPTILYNVPGRTITSLETGTIRDLAKVKGVVG
IKEATGKIDLASEIIKACGSEFVMLSGDDGTYVEFLGVGGHGVISVASHVIPAQMVQWKKWVSEGALDKARADIAKYNDL
INLLFVEANPIPVKKALQLMGILESAELRLPLVELGAENTAKLQAEMKKVGVL
>Mature_293_residues
MKNFKGTFTALVTPFKNGKIDFASLDKLLKQQLAGGVDGFVVNGTTGESPVLTSSEKAELFKHIRNVCGDKVVLIMGTGS
NNTAQTIEDSRKAEEMGADAILVVVPYYNKPPQRGLYEHFKAVASSVKIPTILYNVPGRTITSLETGTIRDLAKVKGVVG
IKEATGKIDLASEIIKACGSEFVMLSGDDGTYVEFLGVGGHGVISVASHVIPAQMVQWKKWVSEGALDKARADIAKYNDL
INLLFVEANPIPVKKALQLMGILESAELRLPLVELGAENTAKLQAEMKKVGVL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=299, Percent_Identity=27.4247491638796, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13540533, Length=214, Percent_Identity=28.0373831775701, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=40.893470790378, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1786463, Length=232, Percent_Identity=31.0344827586207, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87082415, Length=302, Percent_Identity=26.4900662251656, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789620, Length=272, Percent_Identity=26.4705882352941, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_BDEBA (Q6MRM9)

Other databases:

- EMBL:   BX842646
- RefSeq:   NP_967074.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q6MRM9
- SMR:   Q6MRM9
- GeneID:   2733553
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0046
- NMPDR:   fig|264462.1.peg.44
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q6MRM9
- BioCyc:   BBAC264462:BD0046-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31444; Mature: 31444

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFKGTFTALVTPFKNGKIDFASLDKLLKQQLAGGVDGFVVNGTTGESPVLTSSEKAEL
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHH
FKHIRNVCGDKVVLIMGTGSNNTAQTIEDSRKAEEMGADAILVVVPYYNKPPQRGLYEHF
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
KAVASSVKIPTILYNVPGRTITSLETGTIRDLAKVKGVVGIKEATGKIDLASEIIKACGS
HHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHEEEHHCCCCCHHHHHHHHHCCC
EFVMLSGDDGTYVEFLGVGGHGVISVASHVIPAQMVQWKKWVSEGALDKARADIAKYNDL
CEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
INLLFVEANPIPVKKALQLMGILESAELRLPLVELGAENTAKLQAEMKKVGVL
EEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNFKGTFTALVTPFKNGKIDFASLDKLLKQQLAGGVDGFVVNGTTGESPVLTSSEKAEL
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHH
FKHIRNVCGDKVVLIMGTGSNNTAQTIEDSRKAEEMGADAILVVVPYYNKPPQRGLYEHF
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
KAVASSVKIPTILYNVPGRTITSLETGTIRDLAKVKGVVGIKEATGKIDLASEIIKACGS
HHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHEEEHHCCCCCHHHHHHHHHCCC
EFVMLSGDDGTYVEFLGVGGHGVISVASHVIPAQMVQWKKWVSEGALDKARADIAKYNDL
CEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
INLLFVEANPIPVKKALQLMGILESAELRLPLVELGAENTAKLQAEMKKVGVL
EEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA