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The map label for this gene is gyrA [H]

Identifier: 42521655

GI number: 42521655

Start: 6410

End: 8893

Strand: Direct

Name: gyrA [H]

Synonym: Bd0005

Alternate gene names: 42521655

Gene position: 6410-8893 (Clockwise)

Preceding gene: 42521654

Following gene: 42521656

Centisome position: 0.17

GC content: 50.72

Gene sequence:

>2484_bases
ATGGAAAATAATCAAGAAGAAAAAGGCGTCACGTTAGTTGATATCAGCAAGGAGATGCGCGGAGCCTATCTGCAGTACTC
CATGTCTGTGATCGTGGGCCGTGCCCTGCCGGATGTTCGTGACGGTTTGAAACCGGTTCACCGCCGTGTCTTGTTTGCTC
AAAGTGAAATGAACAACCGCCACAACAGACCGTACTTGAAGTCGGCCCGTGTGGTCGGCGACGTGATCGGTAAATATCAC
CCGCACGGTGATGCTTCCGTTTACGATACCATGGTTCGTATGGCCCAGGACTTCTCCCTGCGCTACCCGCTTGAGGATGG
TCAGGGGAACTTCGGTTCCATCGACGGTGACTCTCCGGCAGCTATGCGTTACACCGAGATCCGTTTGACCGCTTTGGCAG
AAGAACTGCTTAATGATCTGGAAAAAGAAACTGTTTCTTTCGGTCCGAACTACGATGACTCTTTGTTGATCCCGACGGTT
CTTCCATCCAAGTTCCCGAACTTGCTGGTGAACGGTTCTGCGGGTATCGCGGTTGGTATGGCGACGAACATTCCTCCGCA
CAATCTGGGCGAGGTTATCGACGGATGTATCCATCTGATCGGAAACCCTGACTGTCAGATCGAAGATCTCATGCAACACA
TCAAGGGTCCGGACTTCCCGACTTGCGGTGTGATCGCCGGCCGTGAAGGCATCTTGCAGGCCTACAAAAAAGGCCGTGGC
ATCGTCACTATCAAGGCGGTGGCGGAAATCGTTCAGGTCAAAGACCGTGAAGAGATCATCATCACCGAGATCCCGTACCA
GGTGAACAAAGCCAAGCTGATTGAAAGCATGGCGGACCTTGTTCGTGACAAACAAATCGAAGGCATCTCTGACATCCGTG
ATGAGTCTTCCCGAGAAGGCATGCGTATCGTTGTTGTTCTGAAACGCGGTGAAAATGCCAGCGTGATCCTGAACAGACTT
TACAAGTACACGCAGATGCAGACGAGCTTCGGTATCATCATGCTGGCGCTGGATGCGAAAAACCAGCCAGTGACTTTCGA
TCTGAAAGGCATGCTGGAAGCGTTCGTGGATCACCGCCGTGACGTGGTTACGAAACGTTGTATCTTCGAACTGAAAAAAG
CCCAGGAGCGCGCGCACATCCTGGAAGGTCTGAAAAAAGCCCTGGATCACATCGAAGAAGTGATCAAAACCATCCGTGCT
TCCAAAGAGGCTAACGCCGCACGTGAAGCATTGATGTCGAAATTTGAATTCTCTGAAAGACAAGCTGTTGCAATCCTGGA
AATGCGTTTGCAGCGTTTGACCGGTCTAGAACGTGACAAGATCGTTGCGGAACTGGCTGAGTTGATGAAACAAATCGACT
GGTTGAAGTTCGTTCTTTCTGACGTTCGCGAGATTTACAAAATCATCGTGAGCGAACTGGAAGACGTGAAAAAACGGTAC
GCCGATCCACGACGCACTCAAATCACGGGTGATCTGAGTGATCTGGAAGACGAAGACCTGATTGCTGATGAACAGATGGT
TGTGACTGTGACCAACACAGGCTTGATCAAACGTATCCCGGTAGAAGAATACCGCGTGCAAAAACGTGGCGGTAAAGGCC
TGAAGGGTATGGAGACCAAGGAAGAGGACTACGTCACGGACATCTTCTCTGCGAGCACAAAAACCATGCTGTTGGTCTTC
ACCGACAAAGGTAAGGTTTACTGGTGTAAAGTTCACCGTCTGCCTTTGGGCACAAGAACTTCCAAAGGGAAATCTTTGGC
GAACGTGGTTCAGCTTTCCAATGGTGAAAGCGTTCGTGCGATTTTGCCGGTGAATGAATTCAGTGAAAACAAATACGCCG
TGATGCTGACTGAAAAAGGCGTTATCAAGAAGACATCTTTGGATGCCTTTGCGAACCCTCGTACCGCAGGTATCATCGCA
TTGACCACCGATCTTGATGACGGTGTGATCGATGTGAAGATCTCTGATGGTCAGAGCGATATCTTCATTGCAACCAAAGA
AGGTATGTCCATCCGCTTCAACGAAGCAGATGTGCGCGAGATGGGCCGTACCGCCCGCGGCGTGAAAGCAATCACTTTGG
CAAAAGACGATGTCGTGGTGGCGATGGAAGTTCTTGAGAAGAACACCAAAGACACCATCTTGATGGTGACCTCCAAAGGT
TACGGTAAACGTTCAGAAACGGGCGAATACCGCATCCAGTCCCGTGGTGGTGTGGGTATCATCACTCAAAAGACCACGGA
CAAGGTCGGTCTGGTCATCGGCACCAAAAAAGTCGCTGACAATATGGAACTTATTCTTTCCACCGACAAAGGGCAGGTTA
TCCGCATGAAAGTGACGGACATCTCTGTTCTGGGTCGTAACACCCAAGGTGTGCGTCTGATCAATATCGACGAGAAAGAC
GAGACTGTGACGGGCGTGGCGGTTGTGGCTGAAGACGAAACGGCGACGGAGGAAACTCCAGCACCGGAAGGCGCACCACA
CTAA

Upstream 100 bases:

>100_bases
TGATGGGTGAAATGGTTGAGCCTCGTCGTCAATTCATCCACGACAACGCATTGTTGGCACGAAGCCTGGACGTTTAATTT
TTTAAGGGATTTGAAATTTT

Downstream 100 bases:

>100_bases
TATGATCAGAGCCTTGCTGGTCGTCCTAGTCTTGGCTCTGTCCGCCTGCTCTTCGCAGGAAGAGGCGGACTTTAAACAAG
CTCAAAAATCCATATCCCAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MENNQEEKGVTLVDISKEMRGAYLQYSMSVIVGRALPDVRDGLKPVHRRVLFAQSEMNNRHNRPYLKSARVVGDVIGKYH
PHGDASVYDTMVRMAQDFSLRYPLEDGQGNFGSIDGDSPAAMRYTEIRLTALAEELLNDLEKETVSFGPNYDDSLLIPTV
LPSKFPNLLVNGSAGIAVGMATNIPPHNLGEVIDGCIHLIGNPDCQIEDLMQHIKGPDFPTCGVIAGREGILQAYKKGRG
IVTIKAVAEIVQVKDREEIIITEIPYQVNKAKLIESMADLVRDKQIEGISDIRDESSREGMRIVVVLKRGENASVILNRL
YKYTQMQTSFGIIMLALDAKNQPVTFDLKGMLEAFVDHRRDVVTKRCIFELKKAQERAHILEGLKKALDHIEEVIKTIRA
SKEANAAREALMSKFEFSERQAVAILEMRLQRLTGLERDKIVAELAELMKQIDWLKFVLSDVREIYKIIVSELEDVKKRY
ADPRRTQITGDLSDLEDEDLIADEQMVVTVTNTGLIKRIPVEEYRVQKRGGKGLKGMETKEEDYVTDIFSASTKTMLLVF
TDKGKVYWCKVHRLPLGTRTSKGKSLANVVQLSNGESVRAILPVNEFSENKYAVMLTEKGVIKKTSLDAFANPRTAGIIA
LTTDLDDGVIDVKISDGQSDIFIATKEGMSIRFNEADVREMGRTARGVKAITLAKDDVVVAMEVLEKNTKDTILMVTSKG
YGKRSETGEYRIQSRGGVGIITQKTTDKVGLVIGTKKVADNMELILSTDKGQVIRMKVTDISVLGRNTQGVRLINIDEKD
ETVTGVAVVAEDETATEETPAPEGAPH

Sequences:

>Translated_827_residues
MENNQEEKGVTLVDISKEMRGAYLQYSMSVIVGRALPDVRDGLKPVHRRVLFAQSEMNNRHNRPYLKSARVVGDVIGKYH
PHGDASVYDTMVRMAQDFSLRYPLEDGQGNFGSIDGDSPAAMRYTEIRLTALAEELLNDLEKETVSFGPNYDDSLLIPTV
LPSKFPNLLVNGSAGIAVGMATNIPPHNLGEVIDGCIHLIGNPDCQIEDLMQHIKGPDFPTCGVIAGREGILQAYKKGRG
IVTIKAVAEIVQVKDREEIIITEIPYQVNKAKLIESMADLVRDKQIEGISDIRDESSREGMRIVVVLKRGENASVILNRL
YKYTQMQTSFGIIMLALDAKNQPVTFDLKGMLEAFVDHRRDVVTKRCIFELKKAQERAHILEGLKKALDHIEEVIKTIRA
SKEANAAREALMSKFEFSERQAVAILEMRLQRLTGLERDKIVAELAELMKQIDWLKFVLSDVREIYKIIVSELEDVKKRY
ADPRRTQITGDLSDLEDEDLIADEQMVVTVTNTGLIKRIPVEEYRVQKRGGKGLKGMETKEEDYVTDIFSASTKTMLLVF
TDKGKVYWCKVHRLPLGTRTSKGKSLANVVQLSNGESVRAILPVNEFSENKYAVMLTEKGVIKKTSLDAFANPRTAGIIA
LTTDLDDGVIDVKISDGQSDIFIATKEGMSIRFNEADVREMGRTARGVKAITLAKDDVVVAMEVLEKNTKDTILMVTSKG
YGKRSETGEYRIQSRGGVGIITQKTTDKVGLVIGTKKVADNMELILSTDKGQVIRMKVTDISVLGRNTQGVRLINIDEKD
ETVTGVAVVAEDETATEETPAPEGAPH
>Mature_827_residues
MENNQEEKGVTLVDISKEMRGAYLQYSMSVIVGRALPDVRDGLKPVHRRVLFAQSEMNNRHNRPYLKSARVVGDVIGKYH
PHGDASVYDTMVRMAQDFSLRYPLEDGQGNFGSIDGDSPAAMRYTEIRLTALAEELLNDLEKETVSFGPNYDDSLLIPTV
LPSKFPNLLVNGSAGIAVGMATNIPPHNLGEVIDGCIHLIGNPDCQIEDLMQHIKGPDFPTCGVIAGREGILQAYKKGRG
IVTIKAVAEIVQVKDREEIIITEIPYQVNKAKLIESMADLVRDKQIEGISDIRDESSREGMRIVVVLKRGENASVILNRL
YKYTQMQTSFGIIMLALDAKNQPVTFDLKGMLEAFVDHRRDVVTKRCIFELKKAQERAHILEGLKKALDHIEEVIKTIRA
SKEANAAREALMSKFEFSERQAVAILEMRLQRLTGLERDKIVAELAELMKQIDWLKFVLSDVREIYKIIVSELEDVKKRY
ADPRRTQITGDLSDLEDEDLIADEQMVVTVTNTGLIKRIPVEEYRVQKRGGKGLKGMETKEEDYVTDIFSASTKTMLLVF
TDKGKVYWCKVHRLPLGTRTSKGKSLANVVQLSNGESVRAILPVNEFSENKYAVMLTEKGVIKKTSLDAFANPRTAGIIA
LTTDLDDGVIDVKISDGQSDIFIATKEGMSIRFNEADVREMGRTARGVKAITLAKDDVVVAMEVLEKNTKDTILMVTSKG
YGKRSETGEYRIQSRGGVGIITQKTTDKVGLVIGTKKVADNMELILSTDKGQVIRMKVTDISVLGRNTQGVRLINIDEKD
ETVTGVAVVAEDETATEETPAPEGAPH

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=425, Percent_Identity=24.9411764705882, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=357, Percent_Identity=26.6106442577031, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=838, Percent_Identity=49.7613365155131, Blast_Score=787, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=687, Percent_Identity=35.5167394468704, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=391, Percent_Identity=25.8312020460358, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=299, Percent_Identity=29.0969899665552, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=29.9465240641711, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91945; Mature: 91945

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNQEEKGVTLVDISKEMRGAYLQYSMSVIVGRALPDVRDGLKPVHRRVLFAQSEMNNR
CCCCCCCCCEEEEEECHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
HNRPYLKSARVVGDVIGKYHPHGDASVYDTMVRMAQDFSLRYPLEDGQGNFGSIDGDSPA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCC
AMRYTEIRLTALAEELLNDLEKETVSFGPNYDDSLLIPTVLPSKFPNLLVNGSAGIAVGM
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEE
ATNIPPHNLGEVIDGCIHLIGNPDCQIEDLMQHIKGPDFPTCGVIAGREGILQAYKKGRG
ECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEECCCHHHHHHHHCCCC
IVTIKAVAEIVQVKDREEIIITEIPYQVNKAKLIESMADLVRDKQIEGISDIRDESSREG
EEEHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
MRIVVVLKRGENASVILNRLYKYTQMQTSFGIIMLALDAKNQPVTFDLKGMLEAFVDHRR
CEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHH
DVVTKRCIFELKKAQERAHILEGLKKALDHIEEVIKTIRASKEANAAREALMSKFEFSER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
QAVAILEMRLQRLTGLERDKIVAELAELMKQIDWLKFVLSDVREIYKIIVSELEDVKKRY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADPRRTQITGDLSDLEDEDLIADEQMVVTVTNTGLIKRIPVEEYRVQKRGGKGLKGMETK
CCCCCEEEECCHHCCCCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHCCCCCCCCCCCC
EEDYVTDIFSASTKTMLLVFTDKGKVYWCKVHRLPLGTRTSKGKSLANVVQLSNGESVRA
CHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCHHHHHHEECCCCCEEE
ILPVNEFSENKYAVMLTEKGVIKKTSLDAFANPRTAGIIALTTDLDDGVIDVKISDGQSD
EECCCCCCCCCEEEEEECCCCEEECCCHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCE
IFIATKEGMSIRFNEADVREMGRTARGVKAITLAKDDVVVAMEVLEKNTKDTILMVTSKG
EEEEECCCCEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECCC
YGKRSETGEYRIQSRGGVGIITQKTTDKVGLVIGTKKVADNMELILSTDKGQVIRMKVTD
CCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEECHHHHCCEEEEEECCCCCEEEEEEEE
ISVLGRNTQGVRLINIDEKDETVTGVAVVAEDETATEETPAPEGAPH
EEEECCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MENNQEEKGVTLVDISKEMRGAYLQYSMSVIVGRALPDVRDGLKPVHRRVLFAQSEMNNR
CCCCCCCCCEEEEEECHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
HNRPYLKSARVVGDVIGKYHPHGDASVYDTMVRMAQDFSLRYPLEDGQGNFGSIDGDSPA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCC
AMRYTEIRLTALAEELLNDLEKETVSFGPNYDDSLLIPTVLPSKFPNLLVNGSAGIAVGM
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEE
ATNIPPHNLGEVIDGCIHLIGNPDCQIEDLMQHIKGPDFPTCGVIAGREGILQAYKKGRG
ECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEECCCHHHHHHHHCCCC
IVTIKAVAEIVQVKDREEIIITEIPYQVNKAKLIESMADLVRDKQIEGISDIRDESSREG
EEEHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
MRIVVVLKRGENASVILNRLYKYTQMQTSFGIIMLALDAKNQPVTFDLKGMLEAFVDHRR
CEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHH
DVVTKRCIFELKKAQERAHILEGLKKALDHIEEVIKTIRASKEANAAREALMSKFEFSER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
QAVAILEMRLQRLTGLERDKIVAELAELMKQIDWLKFVLSDVREIYKIIVSELEDVKKRY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADPRRTQITGDLSDLEDEDLIADEQMVVTVTNTGLIKRIPVEEYRVQKRGGKGLKGMETK
CCCCCEEEECCHHCCCCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHCCCCCCCCCCCC
EEDYVTDIFSASTKTMLLVFTDKGKVYWCKVHRLPLGTRTSKGKSLANVVQLSNGESVRA
CHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCHHHHHHEECCCCCEEE
ILPVNEFSENKYAVMLTEKGVIKKTSLDAFANPRTAGIIALTTDLDDGVIDVKISDGQSD
EECCCCCCCCCEEEEEECCCCEEECCCHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCE
IFIATKEGMSIRFNEADVREMGRTARGVKAITLAKDDVVVAMEVLEKNTKDTILMVTSKG
EEEEECCCCEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECCC
YGKRSETGEYRIQSRGGVGIITQKTTDKVGLVIGTKKVADNMELILSTDKGQVIRMKVTD
CCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEECHHHHCCEEEEEECCCCCEEEEEEEE
ISVLGRNTQGVRLINIDEKDETVTGVAVVAEDETATEETPAPEGAPH
EEEECCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]