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The map label for this gene is trxC

Identifier: 41410438

GI number: 41410438

Start: 4820942

End: 4821295

Strand: Direct

Name: trxC

Synonym: MAP4340

Alternate gene names: 41410438

Gene position: 4820942-4821295 (Clockwise)

Preceding gene: 41410437

Following gene: 41410439

Centisome position: 99.82

GC content: 61.86

Gene sequence:

>354_bases
ATGACCGACGCCGAAAAGGCCAGCGCCACAATAGAAGTCTCCGACGCATCGTTTTCCACCGATGTGTTGGCCAGCAATAA
GCCTGTGCTGGTTGACTTTTGGGCGACATGGTGTGGTCCCTGCAAGATGGTTGCGCCGGTGCTCGAGGAAATCGCCAGCG
AGCGCGGCGATCACCTCACCGTCGCCAAGCTCGACGTCGACGCCAACCCGGAAACCGCCCAAAACTTCCAGGTGGTCTCC
ATTCCCACCCTGATCCTGTTCAAGGACGGCCAGCCCGTGAAGCGGATCGTCGGCGCCAAGGGCAAGGCGGCGCTGCTGCG
TGAGCTTTCCGACGCGGTTCCCAACCTCGGCTGA

Upstream 100 bases:

>100_bases
CCGAACGCTGGCTCGCCGAACATGCCGAGTCCAGTGCGGCCGCGCAAGGCGATGCCACCGAATTCCCGGGCAGTACCGAC
ACATTGATTGGAGCACCGCA

Downstream 100 bases:

>100_bases
TCTTCTTTTCATTTCGTCGCACCACGCCCCGCGGATGGCCTGGGGTTTTCCCGAATTCACGAAGCGTCTGCGACAATACG
GTTAGCTGTTGCCGCTATGC

Product: TrxC

Products: NA

Alternate protein names: Trx; MPT46 [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MTDAEKASATIEVSDASFSTDVLASNKPVLVDFWATWCGPCKMVAPVLEEIASERGDHLTVAKLDVDANPETAQNFQVVS
IPTLILFKDGQPVKRIVGAKGKAALLRELSDAVPNLG

Sequences:

>Translated_117_residues
MTDAEKASATIEVSDASFSTDVLASNKPVLVDFWATWCGPCKMVAPVLEEIASERGDHLTVAKLDVDANPETAQNFQVVS
IPTLILFKDGQPVKRIVGAKGKAALLRELSDAVPNLG
>Mature_116_residues
TDAEKASATIEVSDASFSTDVLASNKPVLVDFWATWCGPCKMVAPVLEEIASERGDHLTVAKLDVDANPETAQNFQVVSI
PTLILFKDGQPVKRIVGAKGKAALLRELSDAVPNLG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI50592994, Length=76, Percent_Identity=42.1052631578947, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=53.921568627451, Blast_Score=114, Evalue=2e-27,
Organism=Escherichia coli, GI1788936, Length=113, Percent_Identity=37.1681415929204, Blast_Score=85, Evalue=1e-18,
Organism=Escherichia coli, GI87081747, Length=86, Percent_Identity=38.3720930232558, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=38.2716049382716, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=87, Percent_Identity=39.0804597701149, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=79, Percent_Identity=34.1772151898734, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=81, Percent_Identity=40.7407407407407, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=75, Percent_Identity=38.6666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=75, Percent_Identity=38.6666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=70, Percent_Identity=42.8571428571429, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=75, Percent_Identity=38.6666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=92, Percent_Identity=32.6086956521739, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=46.5116279069767, Blast_Score=86, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=50.6493506493506, Blast_Score=84, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=40.5063291139241, Blast_Score=75, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=39.7959183673469, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=43.0379746835443, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=43.0379746835443, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=88, Percent_Identity=40.9090909090909, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=43.421052631579, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=40.7407407407407, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639068, Length=81, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12451; Mature: 12320

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAEKASATIEVSDASFSTDVLASNKPVLVDFWATWCGPCKMVAPVLEEIASERGDHLT
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCEEE
VAKLDVDANPETAQNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDAVPNLG
EEEEECCCCCCCCCCEEEEEECEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDAEKASATIEVSDASFSTDVLASNKPVLVDFWATWCGPCKMVAPVLEEIASERGDHLT
CCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCEEE
VAKLDVDANPETAQNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDAVPNLG
EEEEECCCCCCCCCCEEEEEECEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]