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The map label for this gene is ctpA

Identifier: 41410382

GI number: 41410382

Start: 4750199

End: 4752427

Strand: Direct

Name: ctpA

Synonym: MAP4284

Alternate gene names: 41410382

Gene position: 4750199-4752427 (Clockwise)

Preceding gene: 41410381

Following gene: 41410383

Centisome position: 98.35

GC content: 74.2

Gene sequence:

>2229_bases
ATGAGCACACCGCCACGGCACGTCGACGAGGGGACCTTCCCCGACCACACCGCCTCAACCGCTCGCATCGAGCTGGAGAT
CACCGGGATGACCTGCGCCTCATGCGCGGCCCGGATCGAAAAGAAGCTGAACAAGCTGGACGGCGTCACAGCGACCGTCA
ACTACGCCACCGAGAAGGCCGCGGTCAGCGCGCCCGCGAGTTACGACCCGCAAACGCTGATCACCGAGATCGAAAACGCC
GGGTACGCCGCCGCCGTGGCGAAGCCGTCGCCGCCGCGGGACGACCCGGAGCTCGCCTCGCTGCGCAGGCGCCTGGTCAC
CGCCACAGCCCTGGCCGGGCCGGTGATCGCCGTGGCGATGATTCCCGCGCTGCAATTCCAGCACTGGCACTGGGCGGCGC
TGGCCCTGACCGCGCCGGTGGTCGGGTGGTGCGGGCGCCCCTTCCACGCTGCCGCGTGGGCCAACCTCAAACATGGCGTC
GCCACCATGGACACCCTGATCTCGATCGGCACGCTGGCGGCCTTCCTGTGGTCGCTGTACGCCCTGGTTCTCGGGGCGGC
CGACCGGCCCGGCATGCGGCACGACTTCGAGCTGACCGTCGGGCACGGCGCCCACGTCTCCCACGTCGCGGCCCCGTGCC
ACGTCTACTTCGAGGTGGCGGCCGGGGTGACGCTGTTCGTGCTGGCCGGCCGGTACTTCGAGCGGCGGTCCAAGCGGACG
GCCGGCGCCGCGCTGCGGGCGCTGCTGGCGCTGGGCGCCAAGGACGTCGCGGTGCTGCGGGCGGGCGCCGAAACCCGCAT
CCCGATCGAGCGGTTGGCCGTCGGCGACGAGTTCGTGGTGCGTCCCGGGGAACGGATCGCCACCGACGGGATCGTCGTCG
CGGGCTCCTCGGCGGTGGACGCCGCCATGCTGACCGGTGAGTCCGTCCCGGTCGAGGTCGGCGTGGGCGACGGCGTGACC
GGCGGCACCGTCAACGCCGGCGGCCGGCTGGTGGTGCGCGCCACCGGGATCGGCGACGACACCCAACTGGCCCGGATGGC
CCAACTGGTCGAACGGGCCCAGTCCGGCAAGGCCGACGCGCAGCGGCTCGCCGACCGCGTCTCGGGGGTGTTCGTCCCCG
TCGTGCTGCTGCTCGCGGTGGCAACCCTGGCCGGCTGGCTGACGGCGGGCGGCACCCTGGCCACCGCCCTGACCGCGGCC
GTCGCGGTGCTCATCATCGCCTGCCCGTGCGCGCTGGGACTGGCCACCCCGACCGCCCTGCTGGTCGGCACCGGCCGGGC
CGCCCAGCTTGGAGTCCTGATCAAGGGGCCCGAAGTGCTCGAGACCACCCGCGCCGTCGACACCGTCGTGCTCGACAAGA
CCGGGACCGTCACCACCGGCGCCATGACCGTGCTCGACGTGGTCGCCGCCGACGGCACCGACCGCGCCACGCTGTTGCGC
TACGCCGGGGCGCTGGAGGCCGCCTCCGAACACCCCATCGCGCACGCCATCGCCCGGGACGCCAAGGCGGAACTCGGCCC
GCTGCCCACCCCCACCGGCTTCCGCGCGGTCGGCGGCGGCGGCGTGCACGGCAGGGTGGACGGCCACGCCGTCGCGGTCG
GGCGGCCGAGGTGGCTGGCCGAGCGCGGCCTGCGCCCGGACGCCGCCCTGGCGGCGGCCGCCGCGCGCGCCGAGCACGAC
GGCAAAACGGTGGTCGCCGTCGGCTGGGACGGCCGGGCGCGCGGCATCCTGGCGCTGGCCGACACCGTCAAACCCTGCAG
CGCCGCGGCGGTGCGGCAGTTCACCCGGCTGGGCCTGACGCCGATCCTGTTGACCGGCGACAACCACACCGTCGCCCGCC
GCATCGCCGGCGAGCTCGGGATCGGCGAGGTCATCTCCGGCGCGCTGCCCGCCGACAAGGTCGAGGCCGTCAAGCGCCTG
CAATCCGCGGGCCGGGTGGTGGCCATGGGCACCGGCACCGACGTCGCGATCGAGGCCGCCGACGTCACCGTGGTCCGCGG
CGACCTGCGCGCGGCCGTCGACGCGATCCGGCTCTCCCGGCGCACGCTGGCCACCATCAAGACCAACCTGGTGTGGGCCT
TCGGCTACAACCTGGCCGCGATTCCCCTGGCGGCGCTCGGCATGCTCAACCCGATGCTGGCCGGCGCCGCCATGGCGCTG
TCCAGCGTGCTCGTCGTCGGCAACAGCCTGCGGCTGCGCTCGTTCGCCAGCATCATCCCCGGCGCGTGA

Upstream 100 bases:

>100_bases
CGGACACCGGCCGGCTCGTCGTCACCAGCGCGGTGCCCATCGACACCGACGCCGTCCTCGGCGCGGTCGACGAAGCCGGC
TTCCAGGCCGTCTTGGTCGC

Downstream 100 bases:

>100_bases
GCCGCGCAGCATCGGCCGGCCGGCGGCGCCGGTATGGGATAGTTGGTCGGGCCGCCGCTTTCGGTCATCCCGGCCGACCG
GTCGACCGCCACCTCCCCCT

Product: CtpA

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MSTPPRHVDEGTFPDHTASTARIELEITGMTCASCAARIEKKLNKLDGVTATVNYATEKAAVSAPASYDPQTLITEIENA
GYAAAVAKPSPPRDDPELASLRRRLVTATALAGPVIAVAMIPALQFQHWHWAALALTAPVVGWCGRPFHAAAWANLKHGV
ATMDTLISIGTLAAFLWSLYALVLGAADRPGMRHDFELTVGHGAHVSHVAAPCHVYFEVAAGVTLFVLAGRYFERRSKRT
AGAALRALLALGAKDVAVLRAGAETRIPIERLAVGDEFVVRPGERIATDGIVVAGSSAVDAAMLTGESVPVEVGVGDGVT
GGTVNAGGRLVVRATGIGDDTQLARMAQLVERAQSGKADAQRLADRVSGVFVPVVLLLAVATLAGWLTAGGTLATALTAA
VAVLIIACPCALGLATPTALLVGTGRAAQLGVLIKGPEVLETTRAVDTVVLDKTGTVTTGAMTVLDVVAADGTDRATLLR
YAGALEAASEHPIAHAIARDAKAELGPLPTPTGFRAVGGGGVHGRVDGHAVAVGRPRWLAERGLRPDAALAAAAARAEHD
GKTVVAVGWDGRARGILALADTVKPCSAAAVRQFTRLGLTPILLTGDNHTVARRIAGELGIGEVISGALPADKVEAVKRL
QSAGRVVAMGTGTDVAIEAADVTVVRGDLRAAVDAIRLSRRTLATIKTNLVWAFGYNLAAIPLAALGMLNPMLAGAAMAL
SSVLVVGNSLRLRSFASIIPGA

Sequences:

>Translated_742_residues
MSTPPRHVDEGTFPDHTASTARIELEITGMTCASCAARIEKKLNKLDGVTATVNYATEKAAVSAPASYDPQTLITEIENA
GYAAAVAKPSPPRDDPELASLRRRLVTATALAGPVIAVAMIPALQFQHWHWAALALTAPVVGWCGRPFHAAAWANLKHGV
ATMDTLISIGTLAAFLWSLYALVLGAADRPGMRHDFELTVGHGAHVSHVAAPCHVYFEVAAGVTLFVLAGRYFERRSKRT
AGAALRALLALGAKDVAVLRAGAETRIPIERLAVGDEFVVRPGERIATDGIVVAGSSAVDAAMLTGESVPVEVGVGDGVT
GGTVNAGGRLVVRATGIGDDTQLARMAQLVERAQSGKADAQRLADRVSGVFVPVVLLLAVATLAGWLTAGGTLATALTAA
VAVLIIACPCALGLATPTALLVGTGRAAQLGVLIKGPEVLETTRAVDTVVLDKTGTVTTGAMTVLDVVAADGTDRATLLR
YAGALEAASEHPIAHAIARDAKAELGPLPTPTGFRAVGGGGVHGRVDGHAVAVGRPRWLAERGLRPDAALAAAAARAEHD
GKTVVAVGWDGRARGILALADTVKPCSAAAVRQFTRLGLTPILLTGDNHTVARRIAGELGIGEVISGALPADKVEAVKRL
QSAGRVVAMGTGTDVAIEAADVTVVRGDLRAAVDAIRLSRRTLATIKTNLVWAFGYNLAAIPLAALGMLNPMLAGAAMAL
SSVLVVGNSLRLRSFASIIPGA
>Mature_741_residues
STPPRHVDEGTFPDHTASTARIELEITGMTCASCAARIEKKLNKLDGVTATVNYATEKAAVSAPASYDPQTLITEIENAG
YAAAVAKPSPPRDDPELASLRRRLVTATALAGPVIAVAMIPALQFQHWHWAALALTAPVVGWCGRPFHAAAWANLKHGVA
TMDTLISIGTLAAFLWSLYALVLGAADRPGMRHDFELTVGHGAHVSHVAAPCHVYFEVAAGVTLFVLAGRYFERRSKRTA
GAALRALLALGAKDVAVLRAGAETRIPIERLAVGDEFVVRPGERIATDGIVVAGSSAVDAAMLTGESVPVEVGVGDGVTG
GTVNAGGRLVVRATGIGDDTQLARMAQLVERAQSGKADAQRLADRVSGVFVPVVLLLAVATLAGWLTAGGTLATALTAAV
AVLIIACPCALGLATPTALLVGTGRAAQLGVLIKGPEVLETTRAVDTVVLDKTGTVTTGAMTVLDVVAADGTDRATLLRY
AGALEAASEHPIAHAIARDAKAELGPLPTPTGFRAVGGGGVHGRVDGHAVAVGRPRWLAERGLRPDAALAAAAARAEHDG
KTVVAVGWDGRARGILALADTVKPCSAAAVRQFTRLGLTPILLTGDNHTVARRIAGELGIGEVISGALPADKVEAVKRLQ
SAGRVVAMGTGTDVAIEAADVTVVRGDLRAAVDAIRLSRRTLATIKTNLVWAFGYNLAAIPLAALGMLNPMLAGAAMALS
SVLVVGNSLRLRSFASIIPGA

Specific function: Involved In Copper Efflux. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=813, Percent_Identity=34.1943419434194, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI115529486, Length=837, Percent_Identity=32.0191158900836, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI55743073, Length=537, Percent_Identity=36.1266294227188, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI118498343, Length=253, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI22748667, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI153946397, Length=311, Percent_Identity=25.4019292604502, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786691, Length=754, Percent_Identity=37.7984084880637, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1789879, Length=754, Percent_Identity=30.106100795756, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1786914, Length=421, Percent_Identity=29.9287410926366, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI2367363, Length=613, Percent_Identity=24.1435562805873, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=818, Percent_Identity=30.5623471882641, Blast_Score=314, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6320475, Length=645, Percent_Identity=33.7984496124031, Blast_Score=322, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6319772, Length=725, Percent_Identity=28.1379310344828, Blast_Score=243, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6321430, Length=553, Percent_Identity=24.4122965641953, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325221, Length=551, Percent_Identity=22.6860254083485, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221329854, Length=590, Percent_Identity=33.2203389830508, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000579
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 76196; Mature: 76065

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPPRHVDEGTFPDHTASTARIELEITGMTCASCAARIEKKLNKLDGVTATVNYATEKA
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECHHHH
AVSAPASYDPQTLITEIENAGYAAAVAKPSPPRDDPELASLRRRLVTATALAGPVIAVAM
HHCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IPALQFQHWHWAALALTAPVVGWCGRPFHAAAWANLKHGVATMDTLISIGTLAAFLWSLY
HHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ALVLGAADRPGMRHDFELTVGHGAHVSHVAAPCHVYFEVAAGVTLFVLAGRYFERRSKRT
HHHHCCCCCCCCCCCEEEEECCCCCHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGAALRALLALGAKDVAVLRAGAETRIPIERLAVGDEFVVRPGERIATDGIVVAGSSAVD
HHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCCCCEEECCCCEECCCCEEEECCCHHH
AAMLTGESVPVEVGVGDGVTGGTVNAGGRLVVRATGIGDDTQLARMAQLVERAQSGKADA
HHHCCCCCCEEEEECCCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHH
QRLADRVSGVFVPVVLLLAVATLAGWLTAGGTLATALTAAVAVLIIACPCALGLATPTAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LVGTGRAAQLGVLIKGPEVLETTRAVDTVVLDKTGTVTTGAMTVLDVVAADGTDRATLLR
EEECCCCCEEEEEEECCHHHHHHHHHHEEEECCCCCEEHHHHHHHHHHHCCCCCHHHHHH
YAGALEAASEHPIAHAIARDAKAELGPLPTPTGFRAVGGGGVHGRVDGHAVAVGRPRWLA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCEEEEECCCHHHH
ERGLRPDAALAAAAARAEHDGKTVVAVGWDGRARGILALADTVKPCSAAAVRQFTRLGLT
HCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC
PILLTGDNHTVARRIAGELGIGEVISGALPADKVEAVKRLQSAGRVVAMGTGTDVAIEAA
EEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEEEC
DVTVVRGDLRAAVDAIRLSRRTLATIKTNLVWAFGYNLAAIPLAALGMLNPMLAGAAMAL
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SSVLVVGNSLRLRSFASIIPGA
HHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
STPPRHVDEGTFPDHTASTARIELEITGMTCASCAARIEKKLNKLDGVTATVNYATEKA
CCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECHHHH
AVSAPASYDPQTLITEIENAGYAAAVAKPSPPRDDPELASLRRRLVTATALAGPVIAVAM
HHCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IPALQFQHWHWAALALTAPVVGWCGRPFHAAAWANLKHGVATMDTLISIGTLAAFLWSLY
HHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ALVLGAADRPGMRHDFELTVGHGAHVSHVAAPCHVYFEVAAGVTLFVLAGRYFERRSKRT
HHHHCCCCCCCCCCCEEEEECCCCCHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGAALRALLALGAKDVAVLRAGAETRIPIERLAVGDEFVVRPGERIATDGIVVAGSSAVD
HHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCCCCEEECCCCEECCCCEEEECCCHHH
AAMLTGESVPVEVGVGDGVTGGTVNAGGRLVVRATGIGDDTQLARMAQLVERAQSGKADA
HHHCCCCCCEEEEECCCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHH
QRLADRVSGVFVPVVLLLAVATLAGWLTAGGTLATALTAAVAVLIIACPCALGLATPTAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LVGTGRAAQLGVLIKGPEVLETTRAVDTVVLDKTGTVTTGAMTVLDVVAADGTDRATLLR
EEECCCCCEEEEEEECCHHHHHHHHHHEEEECCCCCEEHHHHHHHHHHHCCCCCHHHHHH
YAGALEAASEHPIAHAIARDAKAELGPLPTPTGFRAVGGGGVHGRVDGHAVAVGRPRWLA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCEEEEECCCHHHH
ERGLRPDAALAAAAARAEHDGKTVVAVGWDGRARGILALADTVKPCSAAAVRQFTRLGLT
HCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC
PILLTGDNHTVARRIAGELGIGEVISGALPADKVEAVKRLQSAGRVVAMGTGTDVAIEAA
EEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEEEC
DVTVVRGDLRAAVDAIRLSRRTLATIKTNLVWAFGYNLAAIPLAALGMLNPMLAGAAMAL
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SSVLVVGNSLRLRSFASIIPGA
HHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]