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The map label for this gene is lldD1

Identifier: 41410252

GI number: 41410252

Start: 4631848

End: 4633032

Strand: Direct

Name: lldD1

Synonym: MAP4154

Alternate gene names: 41410252

Gene position: 4631848-4633032 (Clockwise)

Preceding gene: 41410251

Following gene: 41410253

Centisome position: 95.9

GC content: 70.72

Gene sequence:

>1185_bases
GTGGCCGACGAATGGTTTGAAACCGTCGCCATCGCTCAGCAACGGGCCAAGCGGCGGTTGCCGAAATCCGTTTATGCGGC
CCTGATCGCGGCCAGCGAAAAGGGAATCACGGTCTCCGACAACGTCGAAGCGTTCGGCGAACTCGGTTTCGCCCCGCATG
TCGTCGGCGCCCCGGCCAAGCGTGAGCTGACGACAACCGTTATGGGACAAGAGATCTCGATGCCGGTGCTGATCTCGCCG
ACCGGTGTGCAGGCCGTCGACCCGGACGGCGAGGTCGCTGTCGCGCGCGCCGCCGCGGCCCGCGGCACCGCTATGGGCCT
GTCCTCCTTCGCCAGCAAGCCGATCGAGGAAGTCATCGCGGTGAACCCCAAGGTGTTCTTCCAGGTGTACTGGCTGGGTG
GGCGCGACGCGATCGCCGAGCGGGTGGAGCGGGCCCGGCAGGCCGGCGCGGTCGGGCTGATCGTCACCACCGACTGGTCG
TTCTCGCACGGGCGGGACTGGGGCAGCCCCAAGATCCCCGAGGAGATGAACCTGCGCACCATCCTGCGGTTGTCCCCGGA
GGCGGTGTTCAAGCCCCGCTGGCTGTGGAAGTTCGGCAAGACGCTGCGGCCGCCGGAGTTGCGGGTGCCCAACCAGGGCC
GCCGCGGCGAGCCCGGCCCGCCGTTCTTCGCCGCCTACGGCGAGTGGATGGGCACGCCCCCGCCGACCTGGGAGGACATC
GCCTGGCTGCGTGAGCTGTGGGGCGGGCCGTTCATGCTCAAGGGCGTGATGCGCGTGGACGACGCCAAAAGGGCGGTGGA
TGCCGGGGTTTCGGCCATCTCGGTGTCCAACCACGGCGGCAACAACCTGGACGGCACGCCGGCGTCGATTCGCGCCCTGC
CCGCGATCGCCGAGGCGGTCGGCGACCAGATCGAGGTGTTGCTGGACGGCGGTGTCCGGCGCGGCAGCGACGTCGTCAAG
GCGGTGGCGCTGGGGGCGCGCGCGGTGATGATCGGCCGGGCCTACCTGTGGGGCCTGGCCGCCGCCGGCCAGGCCGGGGT
GGAGAACGTCCTCGACATCCTGCGCGGGGGCATCGACTCGGCGCTGATGGGTCTGGGGCATTCCTCGGTGCACGATCTCG
GGCCGAGCGACATCCTGGTGCCGCCCGGGTTCACCCGGGCGCTGGGCGTGCCGCCGGCCGGCTGA

Upstream 100 bases:

>100_bases
GCATCCGCCAACCCGTGCCGCTCACCCTCTCGGTGCGGCCGCCGGTCCTGACCCCCGCCGCGCCGCCGGCCCGGTTGTGC
AACGAAAGCCCGGTCTGACC

Downstream 100 bases:

>100_bases
GCAAAGCCGGGCCATCCGGGGCGGCTTGGCCGGGATTATTTGACGGCCGCGGTAATCCTGGTACGGGCGGGGTAACCGTG
ACGAACGAGCCCACCGTTCG

Product: LldD1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MADEWFETVAIAQQRAKRRLPKSVYAALIAASEKGITVSDNVEAFGELGFAPHVVGAPAKRELTTTVMGQEISMPVLISP
TGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIAVNPKVFFQVYWLGGRDAIAERVERARQAGAVGLIVTTDWS
FSHGRDWGSPKIPEEMNLRTILRLSPEAVFKPRWLWKFGKTLRPPELRVPNQGRRGEPGPPFFAAYGEWMGTPPPTWEDI
AWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAIAEAVGDQIEVLLDGGVRRGSDVVK
AVALGARAVMIGRAYLWGLAAAGQAGVENVLDILRGGIDSALMGLGHSSVHDLGPSDILVPPGFTRALGVPPAG

Sequences:

>Translated_394_residues
MADEWFETVAIAQQRAKRRLPKSVYAALIAASEKGITVSDNVEAFGELGFAPHVVGAPAKRELTTTVMGQEISMPVLISP
TGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIAVNPKVFFQVYWLGGRDAIAERVERARQAGAVGLIVTTDWS
FSHGRDWGSPKIPEEMNLRTILRLSPEAVFKPRWLWKFGKTLRPPELRVPNQGRRGEPGPPFFAAYGEWMGTPPPTWEDI
AWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAIAEAVGDQIEVLLDGGVRRGSDVVK
AVALGARAVMIGRAYLWGLAAAGQAGVENVLDILRGGIDSALMGLGHSSVHDLGPSDILVPPGFTRALGVPPAG
>Mature_393_residues
ADEWFETVAIAQQRAKRRLPKSVYAALIAASEKGITVSDNVEAFGELGFAPHVVGAPAKRELTTTVMGQEISMPVLISPT
GVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIAVNPKVFFQVYWLGGRDAIAERVERARQAGAVGLIVTTDWSF
SHGRDWGSPKIPEEMNLRTILRLSPEAVFKPRWLWKFGKTLRPPELRVPNQGRRGEPGPPFFAAYGEWMGTPPPTWEDIA
WLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAIAEAVGDQIEVLLDGGVRRGSDVVKA
VALGARAVMIGRAYLWGLAAAGQAGVENVLDILRGGIDSALMGLGHSSVHDLGPSDILVPPGFTRALGVPPAG

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=370, Percent_Identity=37.027027027027, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI54234014, Length=368, Percent_Identity=33.4239130434783, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI7705393, Length=368, Percent_Identity=33.4239130434783, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1790033, Length=365, Percent_Identity=36.1643835616438, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193208036, Length=361, Percent_Identity=33.2409972299169, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI32566217, Length=278, Percent_Identity=28.0575539568345, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323587, Length=389, Percent_Identity=28.2776349614396, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281363140, Length=372, Percent_Identity=32.5268817204301, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI78707190, Length=372, Percent_Identity=32.5268817204301, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI78707188, Length=385, Percent_Identity=31.4285714285714, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41855; Mature: 41724

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADEWFETVAIAQQRAKRRLPKSVYAALIAASEKGITVSDNVEAFGELGFAPHVVGAPAK
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCCCCCCCH
RELTTTVMGQEISMPVLISPTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIA
HHHHHHHHCCCCCCCEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCHHHHHHH
VNPKVFFQVYWLGGRDAIAERVERARQAGAVGLIVTTDWSFSHGRDWGSPKIPEEMNLRT
CCCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
ILRLSPEAVFKPRWLWKFGKTLRPPELRVPNQGRRGEPGPPFFAAYGEWMGTPPPTWEDI
HEEECCHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHH
AWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAIAEAV
HHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHC
GDQIEVLLDGGVRRGSDVVKAVALGARAVMIGRAYLWGLAAAGQAGVENVLDILRGGIDS
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
ALMGLGHSSVHDLGPSDILVPPGFTRALGVPPAG
HHHHCCCCHHHCCCCCCEEECCCCHHHCCCCCCC
>Mature Secondary Structure 
ADEWFETVAIAQQRAKRRLPKSVYAALIAASEKGITVSDNVEAFGELGFAPHVVGAPAK
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCCCCCCCH
RELTTTVMGQEISMPVLISPTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIA
HHHHHHHHCCCCCCCEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCHHHHHHH
VNPKVFFQVYWLGGRDAIAERVERARQAGAVGLIVTTDWSFSHGRDWGSPKIPEEMNLRT
CCCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
ILRLSPEAVFKPRWLWKFGKTLRPPELRVPNQGRRGEPGPPFFAAYGEWMGTPPPTWEDI
HEEECCHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHH
AWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAIAEAV
HHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHC
GDQIEVLLDGGVRRGSDVVKAVALGARAVMIGRAYLWGLAAAGQAGVENVLDILRGGIDS
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
ALMGLGHSSVHDLGPSDILVPPGFTRALGVPPAG
HHHHCCCCHHHCCCCCCEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]