Click here to switch to the map view.

The map label for this gene is fadE8

Identifier: 41410231

GI number: 41410231

Start: 4611722

End: 4613320

Strand: Direct

Name: fadE8

Synonym: MAP4133

Alternate gene names: 41410231

Gene position: 4611722-4613320 (Clockwise)

Preceding gene: 41410230

Following gene: 41410232

Centisome position: 95.49

GC content: 71.17

Gene sequence:

>1599_bases
GTGCCACCCCTGGACAACTACAACCCCGCCGGCTCCCCGGTGCTCGTCGAGGCCCTGATCCGCGAGGGTGGGCAGTGGGG
CCTGGACGAGGTCAACGAGGTGGGGGCGTTGTCGGCCAGCCGTCAGGCGCAGCGCTGGGGCGAGCTCGCCGACCGCAACC
GGCCCATCCTGCACACCCACGACCGCAACGGCTACCGCGTCGACGAGGTCGAGTACGACCCGGCCTACCACGAGCTGATG
CGTACCGCGATCGCCCACGGCCTGCACGCCGCGCCGTGGGCCGACGACCGGCCGGGGGCGCACGTCGTCCGCGCCGCCAA
GACCTCGGTGTGGACGGTCGAGCCGGGACACGTCTGCCCGATCTCGATGACCTATGCCGTGGTGCCCGCGCTGCGCTTCA
ACCCCGAGCTGGCCAAGGTGTACGAGCCGCTGCTGACCAGCCGCGAATACGACCCGGAACTCAGGGTGGCCACCACCAAA
CCCGGGATCACCGCGGGCATGTCGATGACCGAGAAGCAGGGCGGCTCCGACGTGCGTGCCGGCACCACCCAGGCCGTCCC
GAACGGCGACGGCTCCTACCGCCTGACCGGCCACAAGTGGTTCACCTCGGCGCCGATGTGCGACATCTTCCTGGTGCTGG
CCCAGGCACCCGGCGGGCTGTCTTGCTTCCTGCTGCCGCGGGTGCTGCCCGACGGCACCCGCAACCGGATGTTCCTGCAG
CGTCTCAAGGACAAGCTGGGCAACCACGCCAACGCGTCCAGCGAGGTCGAATACGACGGCGCCGTCGCCTGGCTGGTCGG
CGAGGAGGGCCGCGGCGTGCCGACCATCATCGAGATGGTGAACCTGACCCGGCTGGACTGCACGCTGGGCAGCGCCACCA
GTATGCGCACCGGCCTGACCCGCGCGATCTACCACGCCCAGCACCGAAAGGCGTTCGGCGCCTACCTGATTGACCAGCCG
TTGATGCGCAACGTGCTGGCCGATCTGGCCGTCGAGGCCGAGGCCGCGACCATGGTCGCGATGCGGATGGCCGGCGCCAC
CGACAAGGCGGTGCGCGGCGATCAGCGCGAGGCCCTGCTGCGCCGCATCGGCCTGGCAGCCAGCAAGTACTGGGTGTGCA
AGCGTTCCACCCCGCACGCCGCCGAGGCGCTGGAATGCCTGGGCGGCAACGGCTACGTCGAGGACTCGGGCATGCCGCGG
CTGTACCGGGAGGCGCCGCTGATGGGCATCTGGGAGGGCTCGGGCAATGTCAGCGCGCTGGACACGTTGCGCGCCATGGC
AACTCGCCCGGAATGCGTCGAGGTGCTGTTCGACGAACTCGCCGAGGCCGCCGGTCAGGATCCGCGCCTGGGCGGCCACG
TCGACCGGCTGCGGGCCGACCTGGCCGAGTTGGACACCATCCAGTACCGGGCCCGCAAGGTGGCCGAGGACATCTGCCTG
GCCCTGCAGGGCTCGCTGCTGGTGCGCCACGGCCATCCGGCCGTCGCCGAGGCGTTCCTGACCACCCGGCTGGACCGCCG
GTGGGGAGGCGCCTTCGGCACCATGCCCGACGGGCTGGAGCTGGCGCCCATCCTCGAGCGGGCCCTGGTCAAGGGCTGA

Upstream 100 bases:

>100_bases
CAAGAGCTGAGCACCGCGGCGCGCTGTTACACCTCTTGTGCAACTGTCGGAAAAATGTAACATTGGTGGCATGTCGGACA
CGCATGTCGTCACCAACTAG

Downstream 100 bases:

>100_bases
ACCACAACATGACTTGCGCCGGCGACGATGCAGAGCACGGCGATGGGGAGGAGCGGCGCCGATGACCCACGCGATCAGGC
CGGTCGACTTCGACAACCTG

Product: FadE8

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MPPLDNYNPAGSPVLVEALIREGGQWGLDEVNEVGALSASRQAQRWGELADRNRPILHTHDRNGYRVDEVEYDPAYHELM
RTAIAHGLHAAPWADDRPGAHVVRAAKTSVWTVEPGHVCPISMTYAVVPALRFNPELAKVYEPLLTSREYDPELRVATTK
PGITAGMSMTEKQGGSDVRAGTTQAVPNGDGSYRLTGHKWFTSAPMCDIFLVLAQAPGGLSCFLLPRVLPDGTRNRMFLQ
RLKDKLGNHANASSEVEYDGAVAWLVGEEGRGVPTIIEMVNLTRLDCTLGSATSMRTGLTRAIYHAQHRKAFGAYLIDQP
LMRNVLADLAVEAEAATMVAMRMAGATDKAVRGDQREALLRRIGLAASKYWVCKRSTPHAAEALECLGGNGYVEDSGMPR
LYREAPLMGIWEGSGNVSALDTLRAMATRPECVEVLFDELAEAAGQDPRLGGHVDRLRADLAELDTIQYRARKVAEDICL
ALQGSLLVRHGHPAVAEAFLTTRLDRRWGGAFGTMPDGLELAPILERALVKG

Sequences:

>Translated_532_residues
MPPLDNYNPAGSPVLVEALIREGGQWGLDEVNEVGALSASRQAQRWGELADRNRPILHTHDRNGYRVDEVEYDPAYHELM
RTAIAHGLHAAPWADDRPGAHVVRAAKTSVWTVEPGHVCPISMTYAVVPALRFNPELAKVYEPLLTSREYDPELRVATTK
PGITAGMSMTEKQGGSDVRAGTTQAVPNGDGSYRLTGHKWFTSAPMCDIFLVLAQAPGGLSCFLLPRVLPDGTRNRMFLQ
RLKDKLGNHANASSEVEYDGAVAWLVGEEGRGVPTIIEMVNLTRLDCTLGSATSMRTGLTRAIYHAQHRKAFGAYLIDQP
LMRNVLADLAVEAEAATMVAMRMAGATDKAVRGDQREALLRRIGLAASKYWVCKRSTPHAAEALECLGGNGYVEDSGMPR
LYREAPLMGIWEGSGNVSALDTLRAMATRPECVEVLFDELAEAAGQDPRLGGHVDRLRADLAELDTIQYRARKVAEDICL
ALQGSLLVRHGHPAVAEAFLTTRLDRRWGGAFGTMPDGLELAPILERALVKG
>Mature_531_residues
PPLDNYNPAGSPVLVEALIREGGQWGLDEVNEVGALSASRQAQRWGELADRNRPILHTHDRNGYRVDEVEYDPAYHELMR
TAIAHGLHAAPWADDRPGAHVVRAAKTSVWTVEPGHVCPISMTYAVVPALRFNPELAKVYEPLLTSREYDPELRVATTKP
GITAGMSMTEKQGGSDVRAGTTQAVPNGDGSYRLTGHKWFTSAPMCDIFLVLAQAPGGLSCFLLPRVLPDGTRNRMFLQR
LKDKLGNHANASSEVEYDGAVAWLVGEEGRGVPTIIEMVNLTRLDCTLGSATSMRTGLTRAIYHAQHRKAFGAYLIDQPL
MRNVLADLAVEAEAATMVAMRMAGATDKAVRGDQREALLRRIGLAASKYWVCKRSTPHAAEALECLGGNGYVEDSGMPRL
YREAPLMGIWEGSGNVSALDTLRAMATRPECVEVLFDELAEAAGQDPRLGGHVDRLRADLAELDTIQYRARKVAEDICLA
LQGSLLVRHGHPAVAEAFLTTRLDRRWGGAFGTMPDGLELAPILERALVKG

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=297, Percent_Identity=26.5993265993266, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI226958414, Length=297, Percent_Identity=26.5993265993266, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4557233, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4557235, Length=306, Percent_Identity=26.797385620915, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI76496475, Length=306, Percent_Identity=26.797385620915, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4501859, Length=294, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI7656849, Length=273, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082384, Length=511, Percent_Identity=43.8356164383562, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI86563383, Length=487, Percent_Identity=29.5687885010267, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI86563381, Length=487, Percent_Identity=29.5687885010267, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17538396, Length=323, Percent_Identity=27.8637770897833, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=266, Percent_Identity=26.3157894736842, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=268, Percent_Identity=27.2388059701493, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=285, Percent_Identity=24.9122807017544, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=276, Percent_Identity=23.9130434782609, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71985192, Length=224, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281363737, Length=376, Percent_Identity=25.531914893617, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356377, Length=263, Percent_Identity=25.0950570342205, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666513, Length=283, Percent_Identity=25.0883392226148, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355753, Length=294, Percent_Identity=24.4897959183673, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646207, Length=259, Percent_Identity=23.5521235521236, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 57999; Mature: 57868

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLDNYNPAGSPVLVEALIREGGQWGLDEVNEVGALSASRQAQRWGELADRNRPILHTH
CCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
DRNGYRVDEVEYDPAYHELMRTAIAHGLHAAPWADDRPGAHVVRAAKTSVWTVEPGHVCP
CCCCEECCCEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCC
ISMTYAVVPALRFNPELAKVYEPLLTSREYDPELRVATTKPGITAGMSMTEKQGGSDVRA
EEHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHCCCHHHHCCCCCCCC
GTTQAVPNGDGSYRLTGHKWFTSAPMCDIFLVLAQAPGGLSCFLLPRVLPDGTRNRMFLQ
CCCCCCCCCCCCEEEECCEEECCCCHHHHHHHHHCCCCCCEEEEEHHHCCCCCCHHHHHH
RLKDKLGNHANASSEVEYDGAVAWLVGEEGRGVPTIIEMVNLTRLDCTLGSATSMRTGLT
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHH
RAIYHAQHRKAFGAYLIDQPLMRNVLADLAVEAEAATMVAMRMAGATDKAVRGDQREALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHH
RRIGLAASKYWVCKRSTPHAAEALECLGGNGYVEDSGMPRLYREAPLMGIWEGSGNVSAL
HHHCCHHHCEEEEECCCCCHHHHHHHHCCCCEECCCCCCHHHHHCCCEEEEECCCCHHHH
DTLRAMATRPECVEVLFDELAEAAGQDPRLGGHVDRLRADLAELDTIQYRARKVAEDICL
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALQGSLLVRHGHPAVAEAFLTTRLDRRWGGAFGTMPDGLELAPILERALVKG
HHCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PPLDNYNPAGSPVLVEALIREGGQWGLDEVNEVGALSASRQAQRWGELADRNRPILHTH
CCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
DRNGYRVDEVEYDPAYHELMRTAIAHGLHAAPWADDRPGAHVVRAAKTSVWTVEPGHVCP
CCCCEECCCEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCC
ISMTYAVVPALRFNPELAKVYEPLLTSREYDPELRVATTKPGITAGMSMTEKQGGSDVRA
EEHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHCCCHHHHCCCCCCCC
GTTQAVPNGDGSYRLTGHKWFTSAPMCDIFLVLAQAPGGLSCFLLPRVLPDGTRNRMFLQ
CCCCCCCCCCCCEEEECCEEECCCCHHHHHHHHHCCCCCCEEEEEHHHCCCCCCHHHHHH
RLKDKLGNHANASSEVEYDGAVAWLVGEEGRGVPTIIEMVNLTRLDCTLGSATSMRTGLT
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHH
RAIYHAQHRKAFGAYLIDQPLMRNVLADLAVEAEAATMVAMRMAGATDKAVRGDQREALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHH
RRIGLAASKYWVCKRSTPHAAEALECLGGNGYVEDSGMPRLYREAPLMGIWEGSGNVSAL
HHHCCHHHCEEEEECCCCCHHHHHHHHCCCCEECCCCCCHHHHHCCCEEEEECCCCHHHH
DTLRAMATRPECVEVLFDELAEAAGQDPRLGGHVDRLRADLAELDTIQYRARKVAEDICL
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALQGSLLVRHGHPAVAEAFLTTRLDRRWGGAFGTMPDGLELAPILERALVKG
HHCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]