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Identifier: 41410230

GI number: 41410230

Start: 4610876

End: 4611631

Strand: Direct

Name: end

Synonym: MAP4132

Alternate gene names: 41410230

Gene position: 4610876-4611631 (Clockwise)

Preceding gene: 41410229

Following gene: 41410231

Centisome position: 95.47

GC content: 68.52

Gene sequence:

>756_bases
GTGCTCATCGGTTCACACGTCCGCAACGACGACCCGCTGGCCGCCGCGCAGGCGGACGGCGCAGACGCGGTGCAGTTCTT
CCTCTCCAACCCGCAGAGCTGGAAGAAACCCAAACCCCGCGACGACGCCGAGGCGCTCAAGGCGTCGAGCGTGCCGCTGT
ACGTGCACGCGCCGTATCTCATCAACGTCGCCTCGGCGAACAACCGCGTGCGCATCCCGTCGCGCAAGATCCTGCAGGAC
ACCTGCGACGCCGCCGCGGAGATCAACGCCACGGCGGTCATCGTGCACGGCGGCCACGCCGACGACAACGACATGGAGGC
CGGTTTCGAACGCTGGGTGAAGGCGCTCGACTACCTGGAAACCGACGTGCAGGTGTATCTGGAGAACACCGCCGGCGGCG
ACCACGCGATGGCCCGCCACTTCGACACCATCGGCCGGCTGTGGGATCGCATCGGCGACAAGGGGATTGGCTTCTGCCTG
GACACCTGCCACGCCTGGGCCGCGGGTGAGGCGCTGATCGACGCCGTGGACCGGATCAAGGCGCTGACCGGGCGCATCGA
TTTGGTGCACTGCAACGACTCCCGGGACGCGGCGGGCTCGGGGGCCGACCGGCACGCCAACTTCGGCACCGGCCAGATCG
ACCCCGACCTGCTCGTCACCGTTGTCAAGGCCGCCGCCGCGCCGGTGATCTGCGAAACCGCCGACGAGGGCCGCAAGGAC
GACATCGCCTTCCTGCGGGAGCACACCAAGAGCTGA

Upstream 100 bases:

>100_bases
GAAACTACCGTCACGCTCGGCGGGCGTCGCCGAGCTCGCGGGCGTCGCCGTGCACGCTCGGCGTCGCCGGGCGTCGGGGC
ATCTCACTAGACTGGCCGAC

Downstream 100 bases:

>100_bases
GCACCGCGGCGCGCTGTTACACCTCTTGTGCAACTGTCGGAAAAATGTAACATTGGTGGCATGTCGGACACGCATGTCGT
CACCAACTAGGTGCCACCCC

Product: endonuclease IV

Products: NA

Alternate protein names: Endodeoxyribonuclease IV; Endonuclease IV [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLIGSHVRNDDPLAAAQADGADAVQFFLSNPQSWKKPKPRDDAEALKASSVPLYVHAPYLINVASANNRVRIPSRKILQD
TCDAAAEINATAVIVHGGHADDNDMEAGFERWVKALDYLETDVQVYLENTAGGDHAMARHFDTIGRLWDRIGDKGIGFCL
DTCHAWAAGEALIDAVDRIKALTGRIDLVHCNDSRDAAGSGADRHANFGTGQIDPDLLVTVVKAAAAPVICETADEGRKD
DIAFLREHTKS

Sequences:

>Translated_251_residues
MLIGSHVRNDDPLAAAQADGADAVQFFLSNPQSWKKPKPRDDAEALKASSVPLYVHAPYLINVASANNRVRIPSRKILQD
TCDAAAEINATAVIVHGGHADDNDMEAGFERWVKALDYLETDVQVYLENTAGGDHAMARHFDTIGRLWDRIGDKGIGFCL
DTCHAWAAGEALIDAVDRIKALTGRIDLVHCNDSRDAAGSGADRHANFGTGQIDPDLLVTVVKAAAAPVICETADEGRKD
DIAFLREHTKS
>Mature_251_residues
MLIGSHVRNDDPLAAAQADGADAVQFFLSNPQSWKKPKPRDDAEALKASSVPLYVHAPYLINVASANNRVRIPSRKILQD
TCDAAAEINATAVIVHGGHADDNDMEAGFERWVKALDYLETDVQVYLENTAGGDHAMARHFDTIGRLWDRIGDKGIGFCL
DTCHAWAAGEALIDAVDRIKALTGRIDLVHCNDSRDAAGSGADRHANFGTGQIDPDLLVTVVKAAAAPVICETADEGRKD
DIAFLREHTKS

Specific function: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by ble

COG id: COG0648

COG function: function code L; Endonuclease IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AP endonuclease 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788483, Length=274, Percent_Identity=26.2773722627737, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531193, Length=262, Percent_Identity=24.8091603053435, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322735, Length=253, Percent_Identity=24.1106719367589, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018246
- InterPro:   IPR001719
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =3.1.21.2 [H]

Molecular weight: Translated: 27093; Mature: 27093

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00729 AP_NUCLEASE_F2_1 ; PS00730 AP_NUCLEASE_F2_2 ; PS00731 AP_NUCLEASE_F2_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGSHVRNDDPLAAAQADGADAVQFFLSNPQSWKKPKPRDDAEALKASSVPLYVHAPYL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCCCCHHHHHHHCCCCEEEECCEE
INVASANNRVRIPSRKILQDTCDAAAEINATAVIVHGGHADDNDMEAGFERWVKALDYLE
EEEECCCCEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TDVQVYLENTAGGDHAMARHFDTIGRLWDRIGDKGIGFCLDTCHAWAAGEALIDAVDRIK
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALTGRIDLVHCNDSRDAAGSGADRHANFGTGQIDPDLLVTVVKAAAAPVICETADEGRKD
HHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHH
DIAFLREHTKS
HHHHHHHHCCC
>Mature Secondary Structure
MLIGSHVRNDDPLAAAQADGADAVQFFLSNPQSWKKPKPRDDAEALKASSVPLYVHAPYL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCCCCHHHHHHHCCCCEEEECCEE
INVASANNRVRIPSRKILQDTCDAAAEINATAVIVHGGHADDNDMEAGFERWVKALDYLE
EEEECCCCEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TDVQVYLENTAGGDHAMARHFDTIGRLWDRIGDKGIGFCLDTCHAWAAGEALIDAVDRIK
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALTGRIDLVHCNDSRDAAGSGADRHANFGTGQIDPDLLVTVVKAAAAPVICETADEGRKD
HHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHH
DIAFLREHTKS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]