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The map label for this gene is pnp

Identifier: 41410128

GI number: 41410128

Start: 4491216

End: 4491998

Strand: Direct

Name: pnp

Synonym: MAP4030

Alternate gene names: 41410128

Gene position: 4491216-4491998 (Clockwise)

Preceding gene: 41410125

Following gene: 41410129

Centisome position: 92.99

GC content: 69.86

Gene sequence:

>783_bases
ATGCACCACAATGGTCGGATGCTCGGAGTCATCGGCGGCAGCGGCTTCTACACCTTCTTCGGATCCGACGCCGACGACGT
CACCGTGGATACCCCGTACGGGCCGCCCAGCGCCCCGGTCACCGTCGGCGCCGTCGGCGGGCACCGGGTGGCCTTCCTGC
CCCGGCACGAATTCTCCGCGCACACCGTGCCGTACCGGGCCAACCTGTGGGCGCTGCGCAAACTCGGTGTGCGCCGGGTG
CTGGCGCCGTGCGCGGTCGGCAGCCTGGTGCCCGAGCTCGGCCCGGGCGCCGTCGTGGTGCCCGACCAGCTGGTCGACCG
CACCCGCGGGCGCGCCGACACCTATTTCGACTCCGGGGCCGTGCACGTCGACTTCGCCGACCCGTACTGCCCGGCGCTGC
GCGAGGCGGTGACCGGGCTGCCGGGGGTGGTCGATGGCGGCACCATGGTGGTGATCCAGGGGCCGCGGTTTTCCACCCGC
GCCGAGAGCCGGTGGTTCGCCTCGGCCGGGTTCTCGCTGGTGAACATGACCGGCTACCCGGAGGCGGTGCTCGCCCGGGA
GCTTGAAATATGTTATGCGGCAATCGCTTTGGTCACAGATCTGGATGCCGGTGTGAGCGCCGGTGAGGGAGTGAAGGCGG
TTGAGGTGTTCGCCGAGTTCGAGAAGAACATCGAGCCGTTCAAGAAGCTGGTGCGCGACGCCATCGGCCGGGTCGCCGCC
GAGCGCAGCTGTACGCAGTGCTCACCGCACACCGGGGTGAGCCTGCCGATCGAGCTGCCATGA

Upstream 100 bases:

>100_bases
GCAACGTGCGCGGCCGCGCACCGGAGATCCACTGCCCGAGATTGGCCACACCGACATCCTGCCAGGATGCGCGGCCGGGC
CCTGCGATCAGCCCGCGCTC

Downstream 100 bases:

>100_bases
GGGTGCTGGTGACGGGGGCGGCCGGGTTCATCGGCTCGCGGGTGGCCGCCGCGCTGCGGGCGGCGGGCCACGACGTCGTC
GCCGTCGACGCGTTACTGGC

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MHHNGRMLGVIGGSGFYTFFGSDADDVTVDTPYGPPSAPVTVGAVGGHRVAFLPRHEFSAHTVPYRANLWALRKLGVRRV
LAPCAVGSLVPELGPGAVVVPDQLVDRTRGRADTYFDSGAVHVDFADPYCPALREAVTGLPGVVDGGTMVVIQGPRFSTR
AESRWFASAGFSLVNMTGYPEAVLARELEICYAAIALVTDLDAGVSAGEGVKAVEVFAEFEKNIEPFKKLVRDAIGRVAA
ERSCTQCSPHTGVSLPIELP

Sequences:

>Translated_260_residues
MHHNGRMLGVIGGSGFYTFFGSDADDVTVDTPYGPPSAPVTVGAVGGHRVAFLPRHEFSAHTVPYRANLWALRKLGVRRV
LAPCAVGSLVPELGPGAVVVPDQLVDRTRGRADTYFDSGAVHVDFADPYCPALREAVTGLPGVVDGGTMVVIQGPRFSTR
AESRWFASAGFSLVNMTGYPEAVLARELEICYAAIALVTDLDAGVSAGEGVKAVEVFAEFEKNIEPFKKLVRDAIGRVAA
ERSCTQCSPHTGVSLPIELP
>Mature_260_residues
MHHNGRMLGVIGGSGFYTFFGSDADDVTVDTPYGPPSAPVTVGAVGGHRVAFLPRHEFSAHTVPYRANLWALRKLGVRRV
LAPCAVGSLVPELGPGAVVVPDQLVDRTRGRADTYFDSGAVHVDFADPYCPALREAVTGLPGVVDGGTMVVIQGPRFSTR
AESRWFASAGFSLVNMTGYPEAVLARELEICYAAIALVTDLDAGVSAGEGVKAVEVFAEFEKNIEPFKKLVRDAIGRVAA
ERSCTQCSPHTGVSLPIELP

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=249, Percent_Identity=35.7429718875502, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71980569, Length=247, Percent_Identity=40.4858299595142, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323045, Length=261, Percent_Identity=35.632183908046, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20130079, Length=254, Percent_Identity=36.2204724409449, Blast_Score=154, Evalue=4e-38,
Organism=Drosophila melanogaster, GI221459247, Length=251, Percent_Identity=32.2709163346614, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 27582; Mature: 27582

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHNGRMLGVIGGSGFYTFFGSDADDVTVDTPYGPPSAPVTVGAVGGHRVAFLPRHEFSA
CCCCCEEEEEEECCCEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCEEEEEECCCCCC
HTVPYRANLWALRKLGVRRVLAPCAVGSLVPELGPGAVVVPDQLVDRTRGRADTYFDSGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCCCCEECCCE
VHVDFADPYCPALREAVTGLPGVVDGGTMVVIQGPRFSTRAESRWFASAGFSLVNMTGYP
EEEECCCCCCHHHHHHHHCCCCEECCCEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCC
EAVLARELEICYAAIALVTDLDAGVSAGEGVKAVEVFAEFEKNIEPFKKLVRDAIGRVAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ERSCTQCSPHTGVSLPIELP
HCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MHHNGRMLGVIGGSGFYTFFGSDADDVTVDTPYGPPSAPVTVGAVGGHRVAFLPRHEFSA
CCCCCEEEEEEECCCEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCEEEEEECCCCCC
HTVPYRANLWALRKLGVRRVLAPCAVGSLVPELGPGAVVVPDQLVDRTRGRADTYFDSGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCCCCEECCCE
VHVDFADPYCPALREAVTGLPGVVDGGTMVVIQGPRFSTRAESRWFASAGFSLVNMTGYP
EEEECCCCCCHHHHHHHHCCCCEECCCEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCC
EAVLARELEICYAAIALVTDLDAGVSAGEGVKAVEVFAEFEKNIEPFKKLVRDAIGRVAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ERSCTQCSPHTGVSLPIELP
HCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]