Click here to switch to the map view.

The map label for this gene is mutT3

Identifier: 41409994

GI number: 41409994

Start: 4361622

End: 4362263

Strand: Direct

Name: mutT3

Synonym: MAP3896

Alternate gene names: 41409994

Gene position: 4361622-4362263 (Clockwise)

Preceding gene: 41409990

Following gene: 41409996

Centisome position: 90.31

GC content: 74.92

Gene sequence:

>642_bases
GTGCACGGCGACGGTGACGGGTGGGTGATCTCCGAGCGCGGCGCCCACTACTGGGGTCGGTACGGCGCCGCCGGTTTGCT
GCTGCGCGCCCCGCAACCCGACGGTACGCCCGCCGTGCTGCTGCAGCACCGCGCGGTGTGGAGCCATCAGGGCGGCACCT
GGGGACTGCCCGGCGGCGCCCGGGACAGCCACGAGACACCCGAGGAGACCGCGGTCCGCGAAGCGAACGAGGAGGCCGGC
CTGCTGGTCGACCGGCTCGCCGTGCGCGCCAGCGTGGTGACGGCCGAGGTCGCCGGGGTGGGCGGCACCCGGTGGAGCTA
CACCACCGTGATCGCGGACGCCGACGAACTGCTGCACACCGTGCCCAACCGGGAAAGCGCCGAGATGCGCTGGGTCGCCG
AGGACGAGGTGGCCGACCTGCCGCTGCACCCCGGCTTCGCGGCCAGCTGGCACCGGCTGCGCACCGAGCCCGCCCGGCTG
CCGCTGAGCCACGGCGACGAACGCCGGCAGTACCTGCCCCGCACCATCGAGCTGGAGGACGGCGTCTTCGTCTGGTGCAT
GCCCGGCGACCCGGCCGACACCGACGAGGCGTCCGCGCAGCTGTGCCGCCGGATCAGCGCGCTGCTGCCAGCGCCGAGCT
GA

Upstream 100 bases:

>100_bases
TATAAGCGAAGTCTAAGAGCATGTTCGGGTGGATGGGTGGAGGCGAAGCAATTGACGACGTGCCAGGGAACAAAGAACTA
AGTCTGCCTATCCTGAACTC

Downstream 100 bases:

>100_bases
GCCGCCGGGCCGCCGCGGCGGGGTCGTCCGCCGCGGTGATCGCCCGCACCACCACGACCCGGCGGGCCCCGGCGTCGAGC
ACCTCGGGCAGCCGCTGCGC

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MHGDGDGWVISERGAHYWGRYGAAGLLLRAPQPDGTPAVLLQHRAVWSHQGGTWGLPGGARDSHETPEETAVREANEEAG
LLVDRLAVRASVVTAEVAGVGGTRWSYTTVIADADELLHTVPNRESAEMRWVAEDEVADLPLHPGFAASWHRLRTEPARL
PLSHGDERRQYLPRTIELEDGVFVWCMPGDPADTDEASAQLCRRISALLPAPS

Sequences:

>Translated_213_residues
MHGDGDGWVISERGAHYWGRYGAAGLLLRAPQPDGTPAVLLQHRAVWSHQGGTWGLPGGARDSHETPEETAVREANEEAG
LLVDRLAVRASVVTAEVAGVGGTRWSYTTVIADADELLHTVPNRESAEMRWVAEDEVADLPLHPGFAASWHRLRTEPARL
PLSHGDERRQYLPRTIELEDGVFVWCMPGDPADTDEASAQLCRRISALLPAPS
>Mature_213_residues
MHGDGDGWVISERGAHYWGRYGAAGLLLRAPQPDGTPAVLLQHRAVWSHQGGTWGLPGGARDSHETPEETAVREANEEAG
LLVDRLAVRASVVTAEVAGVGGTRWSYTTVIADADELLHTVPNRESAEMRWVAEDEVADLPLHPGFAASWHRLRTEPARL
PLSHGDERRQYLPRTIELEDGVFVWCMPGDPADTDEASAQLCRRISALLPAPS

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 23221; Mature: 23221

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGDGDGWVISERGAHYWGRYGAAGLLLRAPQPDGTPAVLLQHRAVWSHQGGTWGLPGGA
CCCCCCCEEEECCCCCHHHCCCCCEEEEECCCCCCCHHEEEEHHHHHCCCCCCCCCCCCC
RDSHETPEETAVREANEEAGLLVDRLAVRASVVTAEVAGVGGTRWSYTTVIADADELLHT
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHH
VPNRESAEMRWVAEDEVADLPLHPGFAASWHRLRTEPARLPLSHGDERRQYLPRTIELED
CCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEEECC
GVFVWCMPGDPADTDEASAQLCRRISALLPAPS
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHGDGDGWVISERGAHYWGRYGAAGLLLRAPQPDGTPAVLLQHRAVWSHQGGTWGLPGGA
CCCCCCCEEEECCCCCHHHCCCCCEEEEECCCCCCCHHEEEEHHHHHCCCCCCCCCCCCC
RDSHETPEETAVREANEEAGLLVDRLAVRASVVTAEVAGVGGTRWSYTTVIADADELLHT
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHH
VPNRESAEMRWVAEDEVADLPLHPGFAASWHRLRTEPARLPLSHGDERRQYLPRTIELED
CCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEEECC
GVFVWCMPGDPADTDEASAQLCRRISALLPAPS
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]