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The map label for this gene is trmH [C]

Identifier: 41409957

GI number: 41409957

Start: 4321276

End: 4321935

Strand: Direct

Name: trmH [C]

Synonym: MAP3859

Alternate gene names: 41409957

Gene position: 4321276-4321935 (Clockwise)

Preceding gene: 41409956

Following gene: 41409958

Centisome position: 89.47

GC content: 71.52

Gene sequence:

>660_bases
GTGGACGCAGCGATGAGCGAACCGGGGCCCACCGAATGGTCCGCGACGCCGTCCGCCGGCGTCGGGCCGTGGCGCGGCGA
GCTTCCCGACGACCCGCGCTATGACCCAATCCTGTTGCGCGACGGCGACACTCGCAACGTCGTCGACGCCTACCGGTACT
GGAGCCGCGAGGCGATCATCGCCGACATCGACCGGCGCCGCCATCCGCTGCACGTGGCGATCGAGAACTTCGGCCACGAC
GCCAACATCGGCTCGGTGGTGCGCACCGCGAACGCCTTCGCCGTGCACACCGTGCACATCGTGGGGCGGCGGCGGTGGAA
TCGCCGCGGCGCCATGGTGACCGACCGCTATCAGCGGCTGTGCCACCACGACAGCACCGCCGAGCTGCTCGACTTCGCGG
CCGCCGCGGGGTTGACCGTCGTCGCCGTCGACAACGTCCCGGGCGCGGCGCGGCTGGAAGAGACCACGCTGCCGCGGGAG
TGCCTGCTGGTGTTCGGTCAGGAGGGCCCGGGCATCACCGACGACACCCGCACCGGCGCCACGCTGACGGTGTCGATCGC
CCAGTTCGGCTCGACGCGCAGCATCAACGCCGGCGTGGCCGCCGGCATCGCGATGCACGCCTGGATCCAGCAGCACGCCG
ATTTGTCGCAGGCCTGGTGA

Upstream 100 bases:

>100_bases
TGGACGCGGTGCACGTGAACGCGTCGCTGTGCACGCAGGGCGAGATCAACGACGCGCTGCTGTATGCGACGCTGGCCATC
GACGGCACCCACGCCGGGGT

Downstream 100 bases:

>100_bases
AGCCGGCGCACCCGTCGAGTGTGTACTCACGGCGGCCCCGGCCGGCGTGTCGTCGCCAACGATGCACACTCGACGCCGCT
GGGCGGCCGGGCGTGAGGCA

Product: hypothetical protein

Products: S-adenosyl-L-homocysteine; tRNATyr Containing 2'-O-methylguanosine [C]

Alternate protein names: RNA Methyltransferase; rRNA Methylase; TRNA/RRNA MethyltransferaU; RNA Methyltransferase TrmH Family; TrmH Family RNA Methyltransferase; 23S RRNA Methyltransferase; RNA Methylase Family Protein; Spou RRNA Methylase Family Protein; SPOU RRNA Methylase Family Protein; Methyltransferase; TRNA/RRNA Methyltransferase Family Protein

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MDAAMSEPGPTEWSATPSAGVGPWRGELPDDPRYDPILLRDGDTRNVVDAYRYWSREAIIADIDRRRHPLHVAIENFGHD
ANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTAELLDFAAAAGLTVVAVDNVPGAARLEETTLPRE
CLLVFGQEGPGITDDTRTGATLTVSIAQFGSTRSINAGVAAGIAMHAWIQQHADLSQAW

Sequences:

>Translated_219_residues
MDAAMSEPGPTEWSATPSAGVGPWRGELPDDPRYDPILLRDGDTRNVVDAYRYWSREAIIADIDRRRHPLHVAIENFGHD
ANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTAELLDFAAAAGLTVVAVDNVPGAARLEETTLPRE
CLLVFGQEGPGITDDTRTGATLTVSIAQFGSTRSINAGVAAGIAMHAWIQQHADLSQAW
>Mature_219_residues
MDAAMSEPGPTEWSATPSAGVGPWRGELPDDPRYDPILLRDGDTRNVVDAYRYWSREAIIADIDRRRHPLHVAIENFGHD
ANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTAELLDFAAAAGLTVVAVDNVPGAARLEETTLPRE
CLLVFGQEGPGITDDTRTGATLTVSIAQFGSTRSINAGVAAGIAMHAWIQQHADLSQAW

Specific function: Specifically Methylates Guanosine-18 In Various tRNAs. [C]

COG id: COG0566

COG function: function code J; rRNA methylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.34 [C]

Molecular weight: Translated: 23928; Mature: 23928

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAAMSEPGPTEWSATPSAGVGPWRGELPDDPRYDPILLRDGDTRNVVDAYRYWSREAII
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHE
ADIDRRRHPLHVAIENFGHDANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRL
EHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEEEHHHHHCCCCCCHHHHHHHH
CHHDSTAELLDFAAAAGLTVVAVDNVPGAARLEETTLPRECLLVFGQEGPGITDDTRTGA
HCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHHCCCHHHEEEECCCCCCCCCCCCCCC
TLTVSIAQFGSTRSINAGVAAGIAMHAWIQQHADLSQAW
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDAAMSEPGPTEWSATPSAGVGPWRGELPDDPRYDPILLRDGDTRNVVDAYRYWSREAII
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHE
ADIDRRRHPLHVAIENFGHDANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRL
EHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEEEHHHHHCCCCCCHHHHHHHH
CHHDSTAELLDFAAAAGLTVVAVDNVPGAARLEETTLPRECLLVFGQEGPGITDDTRTGA
HCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHHCCCHHHEEEECCCCCCCCCCCCCCC
TLTVSIAQFGSTRSINAGVAAGIAMHAWIQQHADLSQAW
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; tRNATyr [C]

Specific reaction: S-Adenosyl-L-methionine + tRNATyr = S-adenosyl-L-homocysteine + tRNATyr Containing 2'-O-methylguanosine [C]

General reaction: Methyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA