Click here to switch to the map view.

The map label for this gene is idsA

Identifier: 41409944

GI number: 41409944

Start: 4305038

End: 4306222

Strand: Direct

Name: idsA

Synonym: MAP3846

Alternate gene names: 41409944

Gene position: 4305038-4306222 (Clockwise)

Preceding gene: 41409943

Following gene: 41409945

Centisome position: 89.14

GC content: 70.04

Gene sequence:

>1185_bases
ATGACGTCGACCCTGCCTGACGCGCGGCCCGCCGTTGCCGCGCTGAACCCGCTCGAGGACTACCTCGCCGCGTGCAAACA
AGCCTGCGACCGGGAGATCGTCCGGCTGTACGGTTCGGGTGAGCGCGGGTCGAACGGGCTGTACCAGCTCATCCTCGACT
ACCCGCTGCGCGGCGGGAAGGCGCTCCGGCCGGCGCTGAGCATCGCCACCTGCCTCGGGCTCGGCGGCCACCTCGAGGCG
ATACTGCCGACCGCCGCAACGCTCGAGCTCTACCACAACGCGTTTCTCATCCACGACGACATCGAGGACGAATCATGGTG
GCGGCGAGGCAAACCCACGCTGCACATCGACTACGGCGTGCCGGTCGCGGTCAACGTCGGCGACGCCATGCTGTCGCTTT
CGCTGCAACCCCTGCTCGACAACGTCGAGCGGGTGGGGCTGGGGCCCGCGCTGCGCATCCTGCGTGCCGTGGCCACGATG
ACCCGCAAGACCGTCGACGGCCAGGCGCTCGAGCTGGACTGGGTGCACTCCAACACCTGGCGGCTCGATGACGCCGACTA
CCTCGAGATGGTGGAACTCAAGACCAGCTGGTACTCCTTCATCACGCCGTTGCAGGCCGGCACCGTCGCGGCCGGGGCAA
CACCCGACCGGATGGCCCCGTTGGAGTCGCTCGGGCGGCATCTCGGGGCGGCCTTCCAGATCACCGACGACCTGCTCAAC
CTGCGCGCCGACCCGCAGGAGTACGGCAAGGAGATCGGCGGCGACCTGTGGGAGGGCAAGCGCACCCTGATGCTGCTGCA
CACCCTGCGGCATGCCGAACCCGGCGACCAGCAGCGCGCGGTGCAGATCCTGTCCCGGCGCCGCCCGAGCCCCGACGCCG
AGTTCGACCTGACCGAGCTGCTGGACCGGCTCACCGCCGGCGGGCAACTGTCCGTCTCGGGCCGCACCGAGATCGACGCC
CGGCTGCGGCGGCACCACCACTCGGAAGTCAAGAGCCTCAACGACATTCGCTGGCTCTACGAATTGATGCACCGGGTGGG
CTCGCTCAACCACGCCCGCGACGTCGCCGTCCGGCAGGCCCGCCAGGCCGCCGCCGTGCTCGCCGGCCTGGACTGGTTTC
CCCGCAGCCGGCACCGCGACATGCTGGCCGCCCTGGTCGATTACGTGCACGGGCGGGCGCGATGA

Upstream 100 bases:

>100_bases
TCGTCGGCGACACATCCAACAACGCCATCAAGCTCGACGTCCGCCTCAGCTACGCCCTCAGGATCAAGGACGAAGCCGGG
CTCGTCGTCTTCCGCGCGTG

Downstream 100 bases:

>100_bases
ACCCCGAGGCACTGATCGGCATGCTGGCCGAACTCGAGCGGATCCGCGAGCTCACCCTCGACCTCGTCGAGCGGCAGGCC
CCCGGGTTGAACCCCGCCCC

Product: IdsA

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGSGERGSNGLYQLILDYPLRGGKALRPALSIATCLGLGGHLEA
ILPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDYGVPVAVNVGDAMLSLSLQPLLDNVERVGLGPALRILRAVATM
TRKTVDGQALELDWVHSNTWRLDDADYLEMVELKTSWYSFITPLQAGTVAAGATPDRMAPLESLGRHLGAAFQITDDLLN
LRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRAVQILSRRRPSPDAEFDLTELLDRLTAGGQLSVSGRTEIDA
RLRRHHHSEVKSLNDIRWLYELMHRVGSLNHARDVAVRQARQAAAVLAGLDWFPRSRHRDMLAALVDYVHGRAR

Sequences:

>Translated_394_residues
MTSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGSGERGSNGLYQLILDYPLRGGKALRPALSIATCLGLGGHLEA
ILPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDYGVPVAVNVGDAMLSLSLQPLLDNVERVGLGPALRILRAVATM
TRKTVDGQALELDWVHSNTWRLDDADYLEMVELKTSWYSFITPLQAGTVAAGATPDRMAPLESLGRHLGAAFQITDDLLN
LRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRAVQILSRRRPSPDAEFDLTELLDRLTAGGQLSVSGRTEIDA
RLRRHHHSEVKSLNDIRWLYELMHRVGSLNHARDVAVRQARQAAAVLAGLDWFPRSRHRDMLAALVDYVHGRAR
>Mature_393_residues
TSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGSGERGSNGLYQLILDYPLRGGKALRPALSIATCLGLGGHLEAI
LPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDYGVPVAVNVGDAMLSLSLQPLLDNVERVGLGPALRILRAVATMT
RKTVDGQALELDWVHSNTWRLDDADYLEMVELKTSWYSFITPLQAGTVAAGATPDRMAPLESLGRHLGAAFQITDDLLNL
RADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRAVQILSRRRPSPDAEFDLTELLDRLTAGGQLSVSGRTEIDAR
LRRHHHSEVKSLNDIRWLYELMHRVGSLNHARDVAVRQARQAAAVLAGLDWFPRSRHRDMLAALVDYVHGRAR

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=225, Percent_Identity=30.6666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI83700220, Length=225, Percent_Identity=30.6666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789578, Length=221, Percent_Identity=34.841628959276, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786623, Length=261, Percent_Identity=28.3524904214559, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508563, Length=301, Percent_Identity=27.5747508305648, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=273, Percent_Identity=26.007326007326, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325188, Length=262, Percent_Identity=25.1908396946565, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24651612, Length=258, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI281365769, Length=309, Percent_Identity=27.1844660194175, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24660002, Length=309, Percent_Identity=27.1844660194175, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 43822; Mature: 43690

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGSGERGSNGLYQLILDYPLRGGK
CCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCC
ALRPALSIATCLGLGGHLEAILPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDYGV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHCCCCEEEEECCC
PVAVNVGDAMLSLSLQPLLDNVERVGLGPALRILRAVATMTRKTVDGQALELDWVHSNTW
EEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
RLDDADYLEMVELKTSWYSFITPLQAGTVAAGATPDRMAPLESLGRHLGAAFQITDDLLN
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHCCHHHHHHHHHCCHHEEHHHHHH
LRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRAVQILSRRRPSPDAEFDLTEL
CCCCHHHHHHHHCCHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
LDRLTAGGQLSVSGRTEIDARLRRHHHSEVKSLNDIRWLYELMHRVGSLNHARDVAVRQA
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RQAAAVLAGLDWFPRSRHRDMLAALVDYVHGRAR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGSGERGSNGLYQLILDYPLRGGK
CCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCC
ALRPALSIATCLGLGGHLEAILPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDYGV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHCCCCEEEEECCC
PVAVNVGDAMLSLSLQPLLDNVERVGLGPALRILRAVATMTRKTVDGQALELDWVHSNTW
EEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
RLDDADYLEMVELKTSWYSFITPLQAGTVAAGATPDRMAPLESLGRHLGAAFQITDDLLN
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHCCHHHHHHHHHCCHHEEHHHHHH
LRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRAVQILSRRRPSPDAEFDLTEL
CCCCHHHHHHHHCCHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
LDRLTAGGQLSVSGRTEIDARLRRHHHSEVKSLNDIRWLYELMHRVGSLNHARDVAVRQA
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RQAAAVLAGLDWFPRSRHRDMLAALVDYVHGRAR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7979381 [H]