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The map label for this gene is adhE

Identifier: 41409694

GI number: 41409694

Start: 3993354

End: 3994445

Strand: Reverse

Name: adhE

Synonym: MAP3596c

Alternate gene names: 41409694

Gene position: 3994445-3993354 (Counterclockwise)

Preceding gene: 41409697

Following gene: 41409684

Centisome position: 82.7

GC content: 74.54

Gene sequence:

>1092_bases
GTGCTGCAGCGCATCGGGGCGCCCCGGCCCTATGCGCGCTCGCGACCGATCACCATCACCGACGTGGAGTTGGCGCCCCC
GGGGCGCGACGAGGTCTTGGTCCGCATCGAGGCGGCCGGCATCTGCCATTCCGACCTGTCGGTGGTCGACGGCAACCGGG
TGCGCCCGGTGCCGATGCTGCTCGGTCACGAGGCGGCCGGGATCGTCGAGCGGGTCGGTCCCGGGGTCGCCGACCTGGCC
GTGGGCGCCCGGGTGGTGCTGGTGTTCCTGCCGCGCTGCGGCCGGTGCGCGGCGTGCGCGACCGAGGGCCTGACGCCGTG
TGAACCGGGCAGCGCGGCCAACGGGGCCGGCACGCTGCTGGGCGGCGATATTCGGCTCAGCCGGGCCGGCCGGCCGGTGT
ATCACCACCTCGGGGTCTCGGGGTTCGCCACGCACGCGGTGGTCAATCGGGCCAGCGCGGTCGAGGTGCCGCCCGACGTG
CCGGCCGAGGTTGCCGCGCTGCTCGGCTGCGCGGTGCTGACCGGCGGCGGCGCGGTGTTCAACGTGGGCCGCCCCGCGCC
GGGCCAGACGGTCGCCGTCGTCGGGCTGGGCGGCGTCGGGATGGCGGCGCTTCTGACCGCGCTCACCTACGACGGCGTTC
CGGTGGTCGCCGTCGACCAGCTGCCGGAGAAGCTGGCCGCGGCCCGGCGGTTGGGCGCGCACCAGGCGTACACGCCGCAG
CAGGCCGTCGAGGCGCGGGTGAAGGCGGCGGTGGTGATCGAAGCCGTCGGCCATCCCGCCGCGCTGCAGACTGCGATCGA
CCTGACGGCCCCCGGCGGGCGCACCATCACCGTCGGCCTGCCGCCGCCGGACGCGCGGATCACGTTGTCGCCGTTGGGTT
TTGTGGCCGAGGGCCGGTCGCTGATCGGCAGCTACCTCGGTTCGGCGGTGCCGAGCCGGGACATCCCCCGGTTCGTCGAG
CTGTGGCGCGCGGGCCGGCTGCCGGTGGAATCGCTGGTGTCGTCCACGATCCGGCTGGAAGACATCAACGAGGCGATGGA
TCATCTGGCCGACGGCACCGCGGTGCGCCAGCTGATCCGGTTCGACGCCTAA

Upstream 100 bases:

>100_bases
GCACCGGGAAGTCGTTGCTGGTCAACCCCTCCGGGGCGGGGGGAACTACGGGAGCCGACGCCATGGTTGTATTCCAGCAT
GTCCGGAATTCGGGGGGGCG

Downstream 100 bases:

>100_bases
TCGCGGTGCAACGCCGCCGACAGCACCTCGCCCTGCAGCGCGAACAATCGCTGCGAGCCCGGCCAGTCCGGCAGCAGCGA
GTCGAAGCCGTGGCAGGCAC

Product: AdhE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MLQRIGAPRPYARSRPITITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLA
VGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDV
PAEVAALLGCAVLTGGGAVFNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQ
QAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITLSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVE
LWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA

Sequences:

>Translated_363_residues
MLQRIGAPRPYARSRPITITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLA
VGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDV
PAEVAALLGCAVLTGGGAVFNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQ
QAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITLSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVE
LWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA
>Mature_363_residues
MLQRIGAPRPYARSRPITITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLA
VGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDV
PAEVAALLGCAVLTGGGAVFNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQ
QAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITLSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVE
LWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=33.5180055401662, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=32.6869806094183, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=32.1329639889197, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=30.2197802197802, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=30.2197802197802, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=30.327868852459, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI156523966, Length=355, Percent_Identity=30.9859154929577, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI71565154, Length=361, Percent_Identity=28.808864265928, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=31.3218390804598, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=31.404958677686, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=25.8258258258258, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=24.8554913294798, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081918, Length=307, Percent_Identity=30.2931596091205, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=24.9299719887955, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082125, Length=365, Percent_Identity=24.1095890410959, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=24.7252747252747, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=359, Percent_Identity=24.7910863509749, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=24.8554913294798, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786825, Length=269, Percent_Identity=30.8550185873606, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082401, Length=354, Percent_Identity=26.5536723163842, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790718, Length=334, Percent_Identity=25.1497005988024, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=368, Percent_Identity=30.1630434782609, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71997431, Length=370, Percent_Identity=29.7297297297297, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=29.8550724637681, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71988145, Length=346, Percent_Identity=26.3005780346821, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=356, Percent_Identity=25.2808988764045, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=28.0653950953678, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=27.7258566978193, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=324, Percent_Identity=27.1604938271605, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=26.625386996904, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=324, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=356, Percent_Identity=25, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=359, Percent_Identity=25.6267409470752, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=358, Percent_Identity=25.4189944134078, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=30.7692307692308, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37297; Mature: 37297

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQRIGAPRPYARSRPITITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPML
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCHHH
LGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLL
HCCHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCEEE
GGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVF
ECCEEEECCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
NVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQ
ECCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHH
QAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITLSPLGFVAEGRS
HHHHHHHHHEEEEEECCCCHHHHHEEEEECCCCCEEEEECCCCCCEEEECCCCHHHHHHH
LIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIR
HHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FDA
CCC
>Mature Secondary Structure
MLQRIGAPRPYARSRPITITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPML
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCHHH
LGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLL
HCCHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCEEE
GGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVF
ECCEEEECCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
NVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQ
ECCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHH
QAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITLSPLGFVAEGRS
HHHHHHHHHEEEEEECCCCHHHHHEEEEECCCCCEEEEECCCCCCEEEECCCCHHHHHHH
LIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIR
HHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FDA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]