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The map label for this gene is pntAA

Identifier: 41409670

GI number: 41409670

Start: 3970777

End: 3971874

Strand: Direct

Name: pntAA

Synonym: MAP3572

Alternate gene names: 41409670

Gene position: 3970777-3971874 (Clockwise)

Preceding gene: 41409669

Following gene: 41409671

Centisome position: 82.21

GC content: 72.13

Gene sequence:

>1098_bases
ATGACAAATGCGCAGGCCAACGCGGTCAAGGTAGGGGTGGTCGCCGAATCCGGGGCCGACGAGCGGCGGGTCGCGCTGGT
GCCCAAGGCGGTGGCGTCGCTGGTGGGCAGCGGCCTGGCGGTGGTGGTCGAGTCCGGCGCGGGCGAGCGGGCCCTGCTGC
CCGACGCGCTCTACACCGAGGCCGGCGCCGACATCGGGGACGCGTGGGCCGCCGACATCGTGGTCAAGGTCGCGCCGCCG
ACGGCCGACGAGGTCGCCAAGCTGCACAGCGGGCAGACGCTGATCGGCTTCCTGGCGCCGCGCAACGCCGACAACTCGAT
CGGCGCTTTGAAGCAGGCGGGCGTGCAGGCCTTCGCGCTGGAGGCCATTCCGCGGATCTCGCGGGCCCAGGCGATGGACG
CGCTGTCGTCGCAGGGCAACGTGGCCGGCTACAAGGCGGTGCTGCTGGCCGCCTCGGAGTCGACCCGGTTCTTCCCGATG
CTGACGACGGCGGCGGGCACGGTGAAACCGGCCAGCGTGCTGGTGCTCGGCGTCGGGGTGGCCGGGTTGCAGGCGCTGGC
GACGGCCAAGCGGCTGGGCGCGCGCACGTCGGGCTACGACGTGCGTCCCGAGGTCGCCGACCAGGTGCGCTCGGTGGGCG
CGCAGTGGCTCGACCTGGGCATCGATGCGGCCGGTGAGGGCGGATACGCCCGCGAGCTCACCGAGGAAGAGCGGGCCCAG
CAGCAGAAGGCCCTGGAGGAGGCCATCGCCGGGTTCGACGTGGTGATCACCACGGCGTTGGTGCCCGGCCGCCCGGCGCC
GCGACTGGTGACCGCCGCGGCGGTCGAGTCGATGAAGCCGGGCAGCGTGGTGGTGGACCTGGCCGGCGAGACCGGCGGCA
ACTGCGAGCTGACCGAGCCGGGCAAGACGGTGGTCAAGCACGACGTCACCATCGCCGCCCCGCTGAACCTGCCGGCGACC
ATGCCCGAGCACGCCAGCGAGCTCTACAGCAAGAACATCACCGCGCTGCTGGACCTGCTGATCAAAGACGGCAAGCTGGC
CCCCGACTTCGACGACGAAGTCGTGGCGGCGGCGTGTGTGACACGGGAGAGTGCATAG

Upstream 100 bases:

>100_bases
GGCGCGGCGCGGCGACCGGGTTAGGGTGTTCACGCCAACGGGGTCGCCGATGAGTTGCCGGTAGGCAAGGAAATCAGCAA
GGAAAGTAGATGTACGCGCC

Downstream 100 bases:

>100_bases
ATGTACGACGAACTGTTGGCCAACCTGGCGATCCTGGTGCTGTCCGGGTTCGTCGGGTTCGCGGTCATCTCCAAGGTGCC
CAACACGCTGCACACGCCGC

Product: PntAA

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGERALLPDALYTEAGADIGDAWAADIVVKVAPP
TADEVAKLHSGQTLIGFLAPRNADNSIGALKQAGVQAFALEAIPRISRAQAMDALSSQGNVAGYKAVLLAASESTRFFPM
LTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTSGYDVRPEVADQVRSVGAQWLDLGIDAAGEGGYARELTEEERAQ
QQKALEEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGGNCELTEPGKTVVKHDVTIAAPLNLPAT
MPEHASELYSKNITALLDLLIKDGKLAPDFDDEVVAAACVTRESA

Sequences:

>Translated_365_residues
MTNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGERALLPDALYTEAGADIGDAWAADIVVKVAPP
TADEVAKLHSGQTLIGFLAPRNADNSIGALKQAGVQAFALEAIPRISRAQAMDALSSQGNVAGYKAVLLAASESTRFFPM
LTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTSGYDVRPEVADQVRSVGAQWLDLGIDAAGEGGYARELTEEERAQ
QQKALEEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGGNCELTEPGKTVVKHDVTIAAPLNLPAT
MPEHASELYSKNITALLDLLIKDGKLAPDFDDEVVAAACVTRESA
>Mature_364_residues
TNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGERALLPDALYTEAGADIGDAWAADIVVKVAPPT
ADEVAKLHSGQTLIGFLAPRNADNSIGALKQAGVQAFALEAIPRISRAQAMDALSSQGNVAGYKAVLLAASESTRFFPML
TTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTSGYDVRPEVADQVRSVGAQWLDLGIDAAGEGGYARELTEEERAQQ
QKALEEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGGNCELTEPGKTVVKHDVTIAAPLNLPATM
PEHASELYSKNITALLDLLIKDGKLAPDFDDEVVAAACVTRESA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=355, Percent_Identity=42.2535211267606, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI122939153, Length=355, Percent_Identity=42.2535211267606, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1787887, Length=362, Percent_Identity=42.8176795580111, Blast_Score=285, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17550456, Length=364, Percent_Identity=44.5054945054945, Blast_Score=294, Evalue=6e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 37303; Mature: 37172

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGERALLPDALYTE
CCCCCCCEEEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHH
AGADIGDAWAADIVVKVAPPTADEVAKLHSGQTLIGFLAPRNADNSIGALKQAGVQAFAL
CCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCHHHHHH
EAIPRISRAQAMDALSSQGNVAGYKAVLLAASESTRFFPMLTTAAGTVKPASVLVLGVGV
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCH
AGLQALATAKRLGARTSGYDVRPEVADQVRSVGAQWLDLGIDAAGEGGYARELTEEERAQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHH
QQKALEEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGGNCELTEP
HHHHHHHHHCCHHEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCC
GKTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLLIKDGKLAPDFDDEVVAAACV
CCEEEEECEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TRESA
HCCCC
>Mature Secondary Structure 
TNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGERALLPDALYTE
CCCCCCEEEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHH
AGADIGDAWAADIVVKVAPPTADEVAKLHSGQTLIGFLAPRNADNSIGALKQAGVQAFAL
CCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCHHHHHH
EAIPRISRAQAMDALSSQGNVAGYKAVLLAASESTRFFPMLTTAAGTVKPASVLVLGVGV
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCH
AGLQALATAKRLGARTSGYDVRPEVADQVRSVGAQWLDLGIDAAGEGGYARELTEEERAQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHH
QQKALEEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGGNCELTEP
HHHHHHHHHCCHHEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCC
GKTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLLIKDGKLAPDFDDEVVAAACV
CCEEEEECEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TRESA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]