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The map label for this gene is msrA

Identifier: 41409652

GI number: 41409652

Start: 3955372

End: 3955887

Strand: Reverse

Name: msrA

Synonym: MAP3554c

Alternate gene names: 41409652

Gene position: 3955887-3955372 (Counterclockwise)

Preceding gene: 41409656

Following gene: 41409650

Centisome position: 81.91

GC content: 65.5

Gene sequence:

>516_bases
ATGACGAACACGCAGAAAGCGATTCTGGCCGGCGGGTGCTTCTGGGGCATGCAAGAACTCATCCGCAAGCAACCCGGCGT
GGTGTCCACCCGGGTCGGCTACACCGGCGGTGACGTCCCCAACGCGACCTACCGCAACCACGGCACCCACGCCGAGGCCG
TCGAGATCATCTACGACCCGGCGGTCACCGACTACCGGCAGATCCTGGAGTTCTTCTTCCAGATCCACGATCCGACAACG
AAAGACCGGCAGGGCAACGACCGCGGACCCAGCTACCGCTCGGCGATCTTCTACACCGACGACGAGCAGAAGCGGATCGC
GCTGGACACCATCGCCGATGTGGAGGCCTCCGGTTTATGGCCCGGCAAGGTGGTGACCGAGGTCAGCCCGGCCGGCGACT
TCTGGGAAGCCGAGCCCGAGCACCAGGATTACCTGCAGCGCTACCCCAACGGGTACACCTGCCACTACATCCGCCCGGGC
TGGAAACTGCCGCGCCGGGCCACCTCCGGTAGCTGA

Upstream 100 bases:

>100_bases
TTTGTCGAGAGCTTTGCCTCGCGGGTGTATTCGATGGCGAACGTCAGGATAATCGGAGGGGGACTGCGGCCATTCGGCGA
GAGCGAAACGAGGCGATGAC

Downstream 100 bases:

>100_bases
ACCGCGCCCGGCTCAGCGCCGGTGCACCACGATCCGCCCGCCGTGTTTGGGGGTGAAGGCCACGCCGCGGCAGTGCCAGG
GCTCGTCCGGTGCGTCGGTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTNTQKAILAGGCFWGMQELIRKQPGVVSTRVGYTGGDVPNATYRNHGTHAEAVEIIYDPAVTDYRQILEFFFQIHDPTT
KDRQGNDRGPSYRSAIFYTDDEQKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHYIRPG
WKLPRRATSGS

Sequences:

>Translated_171_residues
MTNTQKAILAGGCFWGMQELIRKQPGVVSTRVGYTGGDVPNATYRNHGTHAEAVEIIYDPAVTDYRQILEFFFQIHDPTT
KDRQGNDRGPSYRSAIFYTDDEQKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHYIRPG
WKLPRRATSGS
>Mature_170_residues
TNTQKAILAGGCFWGMQELIRKQPGVVSTRVGYTGGDVPNATYRNHGTHAEAVEIIYDPAVTDYRQILEFFFQIHDPTTK
DRQGNDRGPSYRSAIFYTDDEQKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHYIRPGW
KLPRRATSGS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=38.7096774193548, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=38.7096774193548, Blast_Score=109, Evalue=9e-25,
Organism=Homo sapiens, GI208609993, Length=105, Percent_Identity=39.0476190476191, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1790665, Length=160, Percent_Identity=44.375, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=37.4149659863946, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=38.1818181818182, Blast_Score=107, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=36.8794326241135, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=37.5, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_MYCPA (Q73U14)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962488.1
- HSSP:   P0A5L0
- ProteinModelPortal:   Q73U14
- SMR:   Q73U14
- EnsemblBacteria:   EBMYCT00000036693
- GeneID:   2718952
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3554c
- NMPDR:   fig|262316.1.peg.3554
- GeneTree:   EBGT00050000017224
- HOGENOM:   HBG748152
- OMA:   VPNATYR
- ProtClustDB:   PRK14054
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19317; Mature: 19185

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: ACT_SITE 13-13

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTQKAILAGGCFWGMQELIRKQPGVVSTRVGYTGGDVPNATYRNHGTHAEAVEIIYDP
CCCCCCCEEECHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
AVTDYRQILEFFFQIHDPTTKDRQGNDRGPSYRSAIFYTDDEQKRIALDTIADVEASGLW
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEHHHHHCCCCCCCC
PGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHYIRPGWKLPRRATSGS
CCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TNTQKAILAGGCFWGMQELIRKQPGVVSTRVGYTGGDVPNATYRNHGTHAEAVEIIYDP
CCCCCCEEECHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
AVTDYRQILEFFFQIHDPTTKDRQGNDRGPSYRSAIFYTDDEQKRIALDTIADVEASGLW
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEHHHHHCCCCCCCC
PGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHYIRPGWKLPRRATSGS
CCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA