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The map label for this gene is adhD

Identifier: 41409600

GI number: 41409600

Start: 3897853

End: 3899013

Strand: Direct

Name: adhD

Synonym: MAP3502

Alternate gene names: 41409600

Gene position: 3897853-3899013 (Clockwise)

Preceding gene: 41409599

Following gene: 41409605

Centisome position: 80.7

GC content: 69.42

Gene sequence:

>1161_bases
ATGAAGTGTCGTGCCGCCGTGATCCGCGGGGTCGGCCGGGACTGGGAGATCGCCGAGATCGAGCTCGACCCGCCGCGCAG
CGGTGAGGTGCTGGTGCGGATGGCCGTCGCCGGGATCTGCCACTCCGACGACCATCTGTTCACCGGTGACGTGGTGCCGA
CGCCCGAGGTGGTCGCCGCGAGCGGTCAGCCCGCGCCGGACTGGTTCCCGCTGCTCGGCGGTCACGAGGGCGCCGGTGTC
GTCGCGGAAGTCGGGCCGAACGTGACGTCGGTGCGCCCGGGCGACCACGTGGCGCTGTCGTTCATCCCGGCGTGCGGCAG
CTGCCGGTTCTGCGTGAACGGCCAGAGCTACATCTGCGACATCGGCGCCAGCCTGTTTCAGCGCGAGATGCCCACCGACG
GGACCTGCCGCCGCCATCTCGGTGCGGAAAACCTGTTGGCCTACGGGCAACTCGGCACCTTCGCCGAGTACGCGGTGCTC
TCCGAACGGTCCGTCATCAAGATCGACGAGGCGATTCCGTTCCATGCCGCCTCCCTGGTGTCGTGCGGAGTCAGCACCGG
ATGGGGCTCGGCGACGGTGTCGGCGGGCACCGAACCGGGCGACACCGTGGTGGTGATCGGCGCCGGCGGTGTCGGGATGA
ACGCGTTGCAGGGCGCCCGCGCGGTGGGCGCGAAGTACGTCGTCGCGGTCGATCCCGTTGCGGCCAAACGGGATTCGGCC
AAGATCTTCGGCGCCACGCACACCGCCGCGTCCGCGCGGGACGCCATACCGCTGGTCAGGGAGATCACCGCCGGCCTGAT
GGCCGACCGGGTGGTGGTCTGTCCCGGCGTGGTGCACGTGGACTTGATCCCGTTGGCGCTGGCGCTGCTGCGCAAGGGCG
GGGTCTGCGTGCTGACCGGCATCACCCCGTTCACCGAGCCCCCGGTTCCGCTGGTGCTGCAGGAGATGACGCTGTCGGCC
AAACAACTGCGGGGCGCCCTCTACGGCGGGATGAATCCGCGCACCAGCGTGCCGATGCTGTTGTCCCTGTATCAGGCGGG
CGATTTGAAACTCGACGAGTTGGTCACCCGCCACTACCGGCTCGACGAGATCAACGAGGCATTCGCCGACCTGCGCGAGG
GCCGCAACATCCGCGGCGTCATCGACTTCGCCAGCCGGTAG

Upstream 100 bases:

>100_bases
CGGAGCCACTTCGCGAATCCGGTTGAGCGGTAGCGCAAGATGGATTCGTGCCACGCCCCGGCGTGGCCCGGGGGACGCCA
CCAGAGAGCAAGGAGCCGCA

Downstream 100 bases:

>100_bases
CCGCTAACTCACGGCGCGATCCACTCCGAGGTCAGCGCGTACTCCGACAGATACTTCGTCGAACTCCATCCGCCGTCGAC
CACGATCGTCTGGCCGTTGA

Product: AdhD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKCRAAVIRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFTGDVVPTPEVVAASGQPAPDWFPLLGGHEGAGV
VAEVGPNVTSVRPGDHVALSFIPACGSCRFCVNGQSYICDIGASLFQREMPTDGTCRRHLGAENLLAYGQLGTFAEYAVL
SERSVIKIDEAIPFHAASLVSCGVSTGWGSATVSAGTEPGDTVVVIGAGGVGMNALQGARAVGAKYVVAVDPVAAKRDSA
KIFGATHTAASARDAIPLVREITAGLMADRVVVCPGVVHVDLIPLALALLRKGGVCVLTGITPFTEPPVPLVLQEMTLSA
KQLRGALYGGMNPRTSVPMLLSLYQAGDLKLDELVTRHYRLDEINEAFADLREGRNIRGVIDFASR

Sequences:

>Translated_386_residues
MKCRAAVIRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFTGDVVPTPEVVAASGQPAPDWFPLLGGHEGAGV
VAEVGPNVTSVRPGDHVALSFIPACGSCRFCVNGQSYICDIGASLFQREMPTDGTCRRHLGAENLLAYGQLGTFAEYAVL
SERSVIKIDEAIPFHAASLVSCGVSTGWGSATVSAGTEPGDTVVVIGAGGVGMNALQGARAVGAKYVVAVDPVAAKRDSA
KIFGATHTAASARDAIPLVREITAGLMADRVVVCPGVVHVDLIPLALALLRKGGVCVLTGITPFTEPPVPLVLQEMTLSA
KQLRGALYGGMNPRTSVPMLLSLYQAGDLKLDELVTRHYRLDEINEAFADLREGRNIRGVIDFASR
>Mature_386_residues
MKCRAAVIRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFTGDVVPTPEVVAASGQPAPDWFPLLGGHEGAGV
VAEVGPNVTSVRPGDHVALSFIPACGSCRFCVNGQSYICDIGASLFQREMPTDGTCRRHLGAENLLAYGQLGTFAEYAVL
SERSVIKIDEAIPFHAASLVSCGVSTGWGSATVSAGTEPGDTVVVIGAGGVGMNALQGARAVGAKYVVAVDPVAAKRDSA
KIFGATHTAASARDAIPLVREITAGLMADRVVVCPGVVHVDLIPLALALLRKGGVCVLTGITPFTEPPVPLVLQEMTLSA
KQLRGALYGGMNPRTSVPMLLSLYQAGDLKLDELVTRHYRLDEINEAFADLREGRNIRGVIDFASR

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=391, Percent_Identity=35.2941176470588, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI34577061, Length=391, Percent_Identity=35.0383631713555, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI156523966, Length=385, Percent_Identity=32.4675324675325, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI4501939, Length=379, Percent_Identity=32.4538258575198, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI71743840, Length=389, Percent_Identity=32.3907455012853, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI262073058, Length=389, Percent_Identity=32.3907455012853, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4501929, Length=388, Percent_Identity=34.020618556701, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI71565154, Length=390, Percent_Identity=34.1025641025641, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI71565152, Length=395, Percent_Identity=29.3670886075949, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI156627571, Length=376, Percent_Identity=25.531914893617, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786552, Length=393, Percent_Identity=35.3689567430025, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1788073, Length=391, Percent_Identity=25.5754475703325, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081918, Length=362, Percent_Identity=29.0055248618785, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787863, Length=365, Percent_Identity=25.2054794520548, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082125, Length=374, Percent_Identity=25.4010695187166, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786825, Length=213, Percent_Identity=30.5164319248826, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=375, Percent_Identity=25.0666666666667, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=23.9010989010989, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786518, Length=390, Percent_Identity=27.4358974358974, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=391, Percent_Identity=32.7365728900256, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71997431, Length=393, Percent_Identity=32.5699745547074, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17565904, Length=363, Percent_Identity=32.7823691460055, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71988145, Length=385, Percent_Identity=27.5324675324675, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17562584, Length=390, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=381, Percent_Identity=27.5590551181102, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=394, Percent_Identity=26.1421319796954, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=390, Percent_Identity=33.5897435897436, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6319258, Length=319, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=238, Percent_Identity=30.672268907563, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=292, Percent_Identity=26.7123287671233, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=231, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=247, Percent_Identity=27.5303643724696, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=218, Percent_Identity=27.9816513761468, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=350, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=350, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=374, Percent_Identity=24.0641711229947, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737895, Length=394, Percent_Identity=32.2335025380711, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17737897, Length=378, Percent_Identity=28.042328042328, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137530, Length=377, Percent_Identity=26.2599469496021, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40528; Mature: 40528

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCRAAVIRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFTGDVVPTPEVVAA
CCCHHHHHHCCCCCCEEEEEEECCCCCCHHEEEEEHHHHCCCCCCEEECCCCCCCCEEEC
SGQPAPDWFPLLGGHEGAGVVAEVGPNVTSVRPGDHVALSFIPACGSCRFCVNGQSYICD
CCCCCCCCCCCCCCCCCCCEEEECCCCCCEECCCCEEEEEEECCCCCEEEEECCCCEEEH
IGASLFQREMPTDGTCRRHLGAENLLAYGQLGTFAEYAVLSERSVIKIDEAIPFHAASLV
HHHHHHHHCCCCCCHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHH
SCGVSTGWGSATVSAGTEPGDTVVVIGAGGVGMNALQGARAVGAKYVVAVDPVAAKRDSA
HCCCCCCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHCCCCCC
KIFGATHTAASARDAIPLVREITAGLMADRVVVCPGVVHVDLIPLALALLRKGGVCVLTG
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEC
ITPFTEPPVPLVLQEMTLSAKQLRGALYGGMNPRTSVPMLLSLYQAGDLKLDELVTRHYR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHC
LDEINEAFADLREGRNIRGVIDFASR
HHHHHHHHHHHHHCCCEEEEEEECCC
>Mature Secondary Structure
MKCRAAVIRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFTGDVVPTPEVVAA
CCCHHHHHHCCCCCCEEEEEEECCCCCCHHEEEEEHHHHCCCCCCEEECCCCCCCCEEEC
SGQPAPDWFPLLGGHEGAGVVAEVGPNVTSVRPGDHVALSFIPACGSCRFCVNGQSYICD
CCCCCCCCCCCCCCCCCCCEEEECCCCCCEECCCCEEEEEEECCCCCEEEEECCCCEEEH
IGASLFQREMPTDGTCRRHLGAENLLAYGQLGTFAEYAVLSERSVIKIDEAIPFHAASLV
HHHHHHHHCCCCCCHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHH
SCGVSTGWGSATVSAGTEPGDTVVVIGAGGVGMNALQGARAVGAKYVVAVDPVAAKRDSA
HCCCCCCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHCCCCCC
KIFGATHTAASARDAIPLVREITAGLMADRVVVCPGVVHVDLIPLALALLRKGGVCVLTG
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEC
ITPFTEPPVPLVLQEMTLSAKQLRGALYGGMNPRTSVPMLLSLYQAGDLKLDELVTRHYR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHC
LDEINEAFADLREGRNIRGVIDFASR
HHHHHHHHHHHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]