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The map label for this gene is deoA

Identifier: 41409537

GI number: 41409537

Start: 3818985

End: 3820268

Strand: Reverse

Name: deoA

Synonym: MAP3439c

Alternate gene names: 41409537

Gene position: 3820268-3818985 (Counterclockwise)

Preceding gene: 41409538

Following gene: 41409536

Centisome position: 79.1

GC content: 73.91

Gene sequence:

>1284_bases
ATGCGGCCCGGGTTCGACGCGCCCACGGTGATTAGGACCAAGCGCGACGGCGGCCGGCTGTCCGACGCCGCCATCGACTG
GGTGATCGACGCCTACACCGGCGGCCTGGTGGCCGAGGAACAGATGGCGGCCCTGTTGATGGCCATCCTGCTGCGCGGCA
TGGACGGCGGCGAGACCGCCGCCTGGACGTCGGCGATGCTGGCCTCCGGCGACCGGCTGGACTTCTCCGACCTGGGTGTG
CCGACGGTGGACAAGCACTCCACCGGCGGGGTGGGCGACAAGATCACCCTGCCGCTGGTGCCGGTCGTCGCCGCCTGCGG
GGCGGCGGTGCCGCAGGCCTCGGGCCGTGGGCTCGGCCACACCGGCGGCACCCTGGACAAGCTGGACGCGATCGCCGGGT
TCAGCGCGCAGCTGCCCAGCCGGCGGGTGCGTGAGCAGCTGCGCGAGGTCGGGGCGGCCATCTTCGCCGCCGGTGACCTG
GCCCCGGCCGACGCCAAGCTGTACGCGCTGCGCGACATCACCGCCACCGTGGAATCGCTGCCGCTGATCGCCAGCTCGGT
GATGAGCAAGAAGCTGGCCGAGGGGGCCGGCGCGCTGGTGCTCGACGTGAAGGTCGGCTCGGGGGCGTTGGTGAAGACCG
AGGAGCAGTGCCGCGACCTGGCGCACACCATGGTCGGGCTGGGCGCCGCGCACGGGGTGCCCACCCGCGCGCTGCTCACC
GACATGAACCGCCCGCTGGGCGCGACCGTCGGCAACGCGTTGGAGGTGGCCGAGGCGCTCGAGGTGCTGGCCGGGGGCGG
GCCGGCCGATGTCGTCGAGCTGACGCTGCGGCTGGCCGCCGAGATGCTCGCGCTGGCCGGGGTCGGCGACCGGGACCCCG
CCGACACCCTGCGCGACGGCACCGCGATGGACCGGTTCCGCCGTCTCGTCGCCGCTCAGGGCGGCGATTTGTCGGTACCG
TTGCCGATCGGTAGGCACTCCGAGACCGTGACCGCTCCCCGGGGCGGCACAATGGGCGATATCGACGCGATGGCAGTGGG
GCTGGCGGCTTGGCGGCTCGGCGCGGGAAGATCCCGTCCGGGCGAACGGGTGCAAGCCGGCGCCGGCCTCCGGATTCACC
GCCATCCCGGCGAGCCGGTCGCCGCCGGGGAGCCGCTGTTCACCCTCTACACCGACACGCCGGAACGCTTCGGCGCCGCG
CTGGCCGAGCTGGACGGCGGCTGGAGCGTCGGCGACGGCGCGCCGGCGCCGCGACCGCTGATCATCGATCGGATCGTCAC
ATGA

Upstream 100 bases:

>100_bases
GCCCGGAGCTGCTGATCGACCATCCGGGCGGGCCGCGCCGGCTCGGCGAGCTGCTGCCGGACGCGTTCGGCCCCGACCAG
CTGGCCGCCGGGCGGGACTG

Downstream 100 bases:

>100_bases
CCGCACCATTGGAGCTCGAGCAGATCCGCAAGGCGCCCAAGGCTCTGCTGCACGATCACCTCGACGGCGGGCTGCGCCCG
TCGACCGTGCTGGACATCGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRPGFDAPTVIRTKRDGGRLSDAAIDWVIDAYTGGLVAEEQMAALLMAILLRGMDGGETAAWTSAMLASGDRLDFSDLGV
PTVDKHSTGGVGDKITLPLVPVVAACGAAVPQASGRGLGHTGGTLDKLDAIAGFSAQLPSRRVREQLREVGAAIFAAGDL
APADAKLYALRDITATVESLPLIASSVMSKKLAEGAGALVLDVKVGSGALVKTEEQCRDLAHTMVGLGAAHGVPTRALLT
DMNRPLGATVGNALEVAEALEVLAGGGPADVVELTLRLAAEMLALAGVGDRDPADTLRDGTAMDRFRRLVAAQGGDLSVP
LPIGRHSETVTAPRGGTMGDIDAMAVGLAAWRLGAGRSRPGERVQAGAGLRIHRHPGEPVAAGEPLFTLYTDTPERFGAA
LAELDGGWSVGDGAPAPRPLIIDRIVT

Sequences:

>Translated_427_residues
MRPGFDAPTVIRTKRDGGRLSDAAIDWVIDAYTGGLVAEEQMAALLMAILLRGMDGGETAAWTSAMLASGDRLDFSDLGV
PTVDKHSTGGVGDKITLPLVPVVAACGAAVPQASGRGLGHTGGTLDKLDAIAGFSAQLPSRRVREQLREVGAAIFAAGDL
APADAKLYALRDITATVESLPLIASSVMSKKLAEGAGALVLDVKVGSGALVKTEEQCRDLAHTMVGLGAAHGVPTRALLT
DMNRPLGATVGNALEVAEALEVLAGGGPADVVELTLRLAAEMLALAGVGDRDPADTLRDGTAMDRFRRLVAAQGGDLSVP
LPIGRHSETVTAPRGGTMGDIDAMAVGLAAWRLGAGRSRPGERVQAGAGLRIHRHPGEPVAAGEPLFTLYTDTPERFGAA
LAELDGGWSVGDGAPAPRPLIIDRIVT
>Mature_427_residues
MRPGFDAPTVIRTKRDGGRLSDAAIDWVIDAYTGGLVAEEQMAALLMAILLRGMDGGETAAWTSAMLASGDRLDFSDLGV
PTVDKHSTGGVGDKITLPLVPVVAACGAAVPQASGRGLGHTGGTLDKLDAIAGFSAQLPSRRVREQLREVGAAIFAAGDL
APADAKLYALRDITATVESLPLIASSVMSKKLAEGAGALVLDVKVGSGALVKTEEQCRDLAHTMVGLGAAHGVPTRALLT
DMNRPLGATVGNALEVAEALEVLAGGGPADVVELTLRLAAEMLALAGVGDRDPADTLRDGTAMDRFRRLVAAQGGDLSVP
LPIGRHSETVTAPRGGTMGDIDAMAVGLAAWRLGAGRSRPGERVQAGAGLRIHRHPGEPVAAGEPLFTLYTDTPERFGAA
LAELDGGWSVGDGAPAPRPLIIDRIVT

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=437, Percent_Identity=43.7070938215103, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI4503445, Length=437, Percent_Identity=43.7070938215103, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI166158922, Length=437, Percent_Identity=43.7070938215103, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1790842, Length=439, Percent_Identity=41.2300683371298, Blast_Score=277, Evalue=7e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 43790; Mature: 43790

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGFDAPTVIRTKRDGGRLSDAAIDWVIDAYTGGLVAEEQMAALLMAILLRGMDGGETA
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHH
AWTSAMLASGDRLDFSDLGVPTVDKHSTGGVGDKITLPLVPVVAACGAAVPQASGRGLGH
HHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
TGGTLDKLDAIAGFSAQLPSRRVREQLREVGAAIFAAGDLAPADAKLYALRDITATVESL
CCCCHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHH
PLIASSVMSKKLAEGAGALVLDVKVGSGALVKTEEQCRDLAHTMVGLGAAHGVPTRALLT
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHH
DMNRPLGATVGNALEVAEALEVLAGGGPADVVELTLRLAAEMLALAGVGDRDPADTLRDG
HCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
TAMDRFRRLVAAQGGDLSVPLPIGRHSETVTAPRGGTMGDIDAMAVGLAAWRLGAGRSRP
HHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GERVQAGAGLRIHRHPGEPVAAGEPLFTLYTDTPERFGAALAELDGGWSVGDGAPAPRPL
CCHHHCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
IIDRIVT
HHHHHCC
>Mature Secondary Structure
MRPGFDAPTVIRTKRDGGRLSDAAIDWVIDAYTGGLVAEEQMAALLMAILLRGMDGGETA
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHH
AWTSAMLASGDRLDFSDLGVPTVDKHSTGGVGDKITLPLVPVVAACGAAVPQASGRGLGH
HHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
TGGTLDKLDAIAGFSAQLPSRRVREQLREVGAAIFAAGDLAPADAKLYALRDITATVESL
CCCCHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHH
PLIASSVMSKKLAEGAGALVLDVKVGSGALVKTEEQCRDLAHTMVGLGAAHGVPTRALLT
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHH
DMNRPLGATVGNALEVAEALEVLAGGGPADVVELTLRLAAEMLALAGVGDRDPADTLRDG
HCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
TAMDRFRRLVAAQGGDLSVPLPIGRHSETVTAPRGGTMGDIDAMAVGLAAWRLGAGRSRP
HHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GERVQAGAGLRIHRHPGEPVAAGEPLFTLYTDTPERFGAALAELDGGWSVGDGAPAPRPL
CCHHHCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
IIDRIVT
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]