Click here to switch to the map view.

The map label for this gene is add

Identifier: 41409536

GI number: 41409536

Start: 3817888

End: 3818988

Strand: Reverse

Name: add

Synonym: MAP3438c

Alternate gene names: 41409536

Gene position: 3818988-3817888 (Counterclockwise)

Preceding gene: 41409537

Following gene: 41409535

Centisome position: 79.07

GC content: 67.21

Gene sequence:

>1101_bases
ATGACCGCACCATTGGAGCTCGAGCAGATCCGCAAGGCGCCCAAGGCTCTGCTGCACGATCACCTCGACGGCGGGCTGCG
CCCGTCGACCGTGCTGGACATCGCCGGACAGACCGGCTACGACGGGCTGCCCGCCACCGACGTCGAGGAGCTGGCGACCT
GGTTTCGCACCCGCTCGCACAGCGGCTCGCTGGAGCGCTACCTGGAGCCGTTCTCGCACACCGTGGCGGTGATGCAGACC
CCCGAGGCGCTGCACCGGGTGGCGTACGAATGCGTGGAGGACCTGGCCGAGGACTCGGTGGTCTACGCCGAGATCCGGTT
CGCTCCCGAGCTGCACATCAACCGCGGCATGTCCTTCGACGAGATCGTCGACGCCGTGCTGGCCGGGTTCGCCGACGGCG
AGAAGGCTTGTGCGGCAGCGGGCCGGCCGATCGTGGTGCGACTGTTGGTGACTGCCATGCGGCACGCGGCGGTGTCCCGG
GAGATCGCCGAGCTGGCGATCCGGTGGCGGGACAAGGGAGTGGTCGGTTTCGACATCGCCGGCGCCGAGGCCGGCAACCC
GCCGACCCGGCACCTGGAGGCGTTCGACTACATGCGAGATCACAACGCGCGCTTCACCATTCACGCCGGGGAGGCGTTCG
GCCTGCCGTCCATCCACGAGGCCATCGCGTTCTGCGGCGCCGACCGGCTCGGCCACGGGGTGCGGATCGTCGACGACATC
GACGTGCTGGCCGACGGCCCCGACAAGGGCAAGGTACGGTTGGGCAGACTGGCGAACATCTTGCGGGACAAGCGAATTCC
GTTGGAACTGTGCCCCAGCTCCAACGTGCAGACCGGGGCCGTCAAAAGCATCGCCGACCATCCGTTCGACCTGCTGGCCC
GCACCCGGTTCCGGGTGACCGTCAACACCGACAACCGGCTGATGAGCGACACCTACATGAGCCGCGAGATGCACCGGCTG
GTCCAGGCTTTCGGCTACGGATGGAGCGATCTGGAAAGGTTCACCATCAACGCGATGAAGTCCGCCTTCATCCCGTTCGA
CGAGCGGCTGGCCATTATCGACGAGGTGATCAAACCCCGGTACGCGGTGCTGATCGGCTGA

Upstream 100 bases:

>100_bases
CGGAACGCTTCGGCGCCGCGCTGGCCGAGCTGGACGGCGGCTGGAGCGTCGGCGACGGCGCGCCGGCGCCGCGACCGCTG
ATCATCGATCGGATCGTCAC

Downstream 100 bases:

>100_bases
GCGGCCGTGCGCGGTCTTCGGCTGCTCCGCTAACCGTCACCGTGGGGTGGTACGTCTCCGTGATCATGCTGTCTCCTCAA
TCGCTCGCATTCGGACCGCT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTAPLELEQIRKAPKALLHDHLDGGLRPSTVLDIAGQTGYDGLPATDVEELATWFRTRSHSGSLERYLEPFSHTVAVMQT
PEALHRVAYECVEDLAEDSVVYAEIRFAPELHINRGMSFDEIVDAVLAGFADGEKACAAAGRPIVVRLLVTAMRHAAVSR
EIAELAIRWRDKGVVGFDIAGAEAGNPPTRHLEAFDYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVLADGPDKGKVRLGRLANILRDKRIPLELCPSSNVQTGAVKSIADHPFDLLARTRFRVTVNTDNRLMSDTYMSREMHRL
VQAFGYGWSDLERFTINAMKSAFIPFDERLAIIDEVIKPRYAVLIG

Sequences:

>Translated_366_residues
MTAPLELEQIRKAPKALLHDHLDGGLRPSTVLDIAGQTGYDGLPATDVEELATWFRTRSHSGSLERYLEPFSHTVAVMQT
PEALHRVAYECVEDLAEDSVVYAEIRFAPELHINRGMSFDEIVDAVLAGFADGEKACAAAGRPIVVRLLVTAMRHAAVSR
EIAELAIRWRDKGVVGFDIAGAEAGNPPTRHLEAFDYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVLADGPDKGKVRLGRLANILRDKRIPLELCPSSNVQTGAVKSIADHPFDLLARTRFRVTVNTDNRLMSDTYMSREMHRL
VQAFGYGWSDLERFTINAMKSAFIPFDERLAIIDEVIKPRYAVLIG
>Mature_365_residues
TAPLELEQIRKAPKALLHDHLDGGLRPSTVLDIAGQTGYDGLPATDVEELATWFRTRSHSGSLERYLEPFSHTVAVMQTP
EALHRVAYECVEDLAEDSVVYAEIRFAPELHINRGMSFDEIVDAVLAGFADGEKACAAAGRPIVVRLLVTAMRHAAVSRE
IAELAIRWRDKGVVGFDIAGAEAGNPPTRHLEAFDYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDID
VLADGPDKGKVRLGRLANILRDKRIPLELCPSSNVQTGAVKSIADHPFDLLARTRFRVTVNTDNRLMSDTYMSREMHRLV
QAFGYGWSDLERFTINAMKSAFIPFDERLAIIDEVIKPRYAVLIG

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=362, Percent_Identity=29.0055248618785, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1787910, Length=344, Percent_Identity=29.0697674418605, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17538512, Length=359, Percent_Identity=30.08356545961, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32565969, Length=351, Percent_Identity=30.4843304843305, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324188, Length=369, Percent_Identity=23.3062330623306, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645260, Length=362, Percent_Identity=25.414364640884, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_MYCA1 (A0QKJ4)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_883432.1
- ProteinModelPortal:   A0QKJ4
- SMR:   A0QKJ4
- STRING:   A0QKJ4
- EnsemblBacteria:   EBMYCT00000009254
- GeneID:   4528762
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_4294
- TIGR:   MAV_4294
- eggNOG:   COG1816
- GeneTree:   EBGT00050000016615
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- PhylomeDB:   A0QKJ4
- ProtClustDB:   PRK09358
- BioCyc:   MAVI243243:MAV_4294-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 40535; Mature: 40404

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 211-211 BINDING 21-21 BINDING 23-23 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLELEQIRKAPKALLHDHLDGGLRPSTVLDIAGQTGYDGLPATDVEELATWFRTRSH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCC
SGSLERYLEPFSHTVAVMQTPEALHRVAYECVEDLAEDSVVYAEIRFAPELHINRGMSFD
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHCCCCCHH
EIVDAVLAGFADGEKACAAAGRPIVVRLLVTAMRHAAVSREIAELAIRWRDKGVVGFDIA
HHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GAEAGNPPTRHLEAFDYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCCCEEEEECH
DVLADGPDKGKVRLGRLANILRDKRIPLELCPSSNVQTGAVKSIADHPFDLLARTRFRVT
HHHCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCCHHHHHCCEEEEE
VNTDNRLMSDTYMSREMHRLVQAFGYGWSDLERFTINAMKSAFIPFDERLAIIDEVIKPR
ECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
YAVLIG
EEEEEC
>Mature Secondary Structure 
TAPLELEQIRKAPKALLHDHLDGGLRPSTVLDIAGQTGYDGLPATDVEELATWFRTRSH
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCC
SGSLERYLEPFSHTVAVMQTPEALHRVAYECVEDLAEDSVVYAEIRFAPELHINRGMSFD
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHCCCCCHH
EIVDAVLAGFADGEKACAAAGRPIVVRLLVTAMRHAAVSREIAELAIRWRDKGVVGFDIA
HHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GAEAGNPPTRHLEAFDYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCCCEEEEECH
DVLADGPDKGKVRLGRLANILRDKRIPLELCPSSNVQTGAVKSIADHPFDLLARTRFRVT
HHHCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCCHHHHHCCEEEEE
VNTDNRLMSDTYMSREMHRLVQAFGYGWSDLERFTINAMKSAFIPFDERLAIIDEVIKPR
ECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
YAVLIG
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA