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The map label for this gene is pmmB

Identifier: 41409528

GI number: 41409528

Start: 3809192

End: 3810772

Strand: Direct

Name: pmmB

Synonym: MAP3430

Alternate gene names: 41409528

Gene position: 3809192-3810772 (Clockwise)

Preceding gene: 41409527

Following gene: 41409530

Centisome position: 78.87

GC content: 73.75

Gene sequence:

>1581_bases
GTGACGCCCGAGGAATGGATCGCGCACGATCCCGACCCCCGCACGGCCGCCGAGCTCGCCGCATGCGGCGCCGCAGAACT
CGCCGCCCGCTTCGCCCGGCCCTTGCGATTCGGCACGGCGGGACTGCGCGGCCCGGTCCGCGCCGGCCCCGACGCGATGA
ACGTCGCGGTGGTGTCGCGGGCCAGCTGGGCGCTGGCGCAGGTGCTCAAGCGCCGCGGCCCGGCCGGCGCGCGGGTGATC
GTGGGACGCGACGCCCGGCACGGCTCGGCGGTATTCGCCACGGTGGCCGCTGAAGTGCTTGCCGCCCAAGGGTTTTCGGT
ACTGCTGCTGCCCGGTCCGGCACCCACCCCGGTGGTCGCGTTCGCGGTGCGGCACACCGGCGCCGCCGCCGGGGTCCAGA
TCACCGCCTCGCACAACCCGCCGACCGACAACGGCTACAAGGTGTACGACGGCGGCGGCATCCAGATCGTCTCCCCCACC
GACCACCAGATCGAAGCCGCGATGGCCGACGCGCCACCGGCCGACGAGATCCGCCGAACACCCGTCCCACCGGCGCACAC
CGACCTCGTCCAGCGCTACATCGAGCGGGCGGCCGGGGTGCGGCGCGGCACCGGTTCGGTGCGGGTGGCGCTCACCGCTC
TGCACGGCGTGGGCGGGACGGTGGCCGTCGACGCTCTGCACCGCGCCGGTTTCGGCCGAATACACACCGTGGCAAGCCAA
TTCGCGCCCGACCCGGACTTTCCCACCGTCGTGTTCCCCAACCCCGAGGAGCCCGGCGCCACCGACGCGCTGCTGACCCT
GGCCGCCGATGTGGACGCCGACGTGGCGATCGCACTGGATCCTGACGCCGACCGCTGCGCCGTCGGCATACCCGACGCCT
CCGGCTGGCGGATGCTCTCCGGCGACGAAACCGGTTGGCTGCTCGGCGATTACCTGCTCTCCCAGCCGCAGCGGGCCGAC
CGACCCGTGGTGGCCAGCACGGTGGTGTCGTCGCGGATGTTGTCGGCCATCGCCGCGCGGCACGGCGCCGTGCACGTGGA
AACCCTCACCGGCTTCAAGTGGTTGGCACGCGCCGACGCCGAGGTGCCCGGCGGCACCCTGGTGTACGCCTATGAGGAGG
CGATCGGACACTGCGTGGACCCCGCCGCGGTGCGCGACAAGGACGGCATCAGCGCCGCCGTGCTGGTGTGCGACCTGGTG
GCCGGCCTGATCGCGCGGGGCGGTTCGGTGTCCGGCCGGCTCGACGAGCTGGCCCGCCGCCACGGCGTGCACGACGTCGC
CGCGGTGTCGCGCCGCGTCGGGACCGACGGGGCTGCCGAGCTGATGCGACGGCTGCGCACCAGCCCGCCGGAGACGCTGG
CCGGGTTCGGGGTGGCGCTCACCGACATCACCGACGCGCTGATCTTCACCGGCGGCGACGACGACACGTCGGTCAGGCTG
GTGGTGCGGCCTTCCGGGACCGAGCCGAAGGTGAAGTGCTACTTGGAGATTCGCTGCGCGCCGAGCGACGACCTGGCGTC
TTCGCGGCGGCGCGCCCGCGCCCTGCGGGAGCTTCTGGTCGCGACGGTGCGGAGCTGGTGA

Upstream 100 bases:

>100_bases
CTGAGCCACACCGAGGTGCTGGCCGCCGGCGCCGCCTCGGCCACCCGGATGGGCGCGCTGCTGGCCCTGATCCTTTGCCA
ACTCCCCCGGTTCTAGGACC

Downstream 100 bases:

>100_bases
ACAGGTTCGGCCCGAATTGGCGATCCCCGGCATCGCCGAGGCCGGGCACGATGTAGGCCGCCTTGTTGAGTCCCTTGTCT
ACCGCGGCAGTGAACACTCG

Product: PmmB

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTPEEWIAHDPDPRTAAELAACGAAELAARFARPLRFGTAGLRGPVRAGPDAMNVAVVSRASWALAQVLKRRGPAGARVI
VGRDARHGSAVFATVAAEVLAAQGFSVLLLPGPAPTPVVAFAVRHTGAAAGVQITASHNPPTDNGYKVYDGGGIQIVSPT
DHQIEAAMADAPPADEIRRTPVPPAHTDLVQRYIERAAGVRRGTGSVRVALTALHGVGGTVAVDALHRAGFGRIHTVASQ
FAPDPDFPTVVFPNPEEPGATDALLTLAADVDADVAIALDPDADRCAVGIPDASGWRMLSGDETGWLLGDYLLSQPQRAD
RPVVASTVVSSRMLSAIAARHGAVHVETLTGFKWLARADAEVPGGTLVYAYEEAIGHCVDPAAVRDKDGISAAVLVCDLV
AGLIARGGSVSGRLDELARRHGVHDVAAVSRRVGTDGAAELMRRLRTSPPETLAGFGVALTDITDALIFTGGDDDTSVRL
VVRPSGTEPKVKCYLEIRCAPSDDLASSRRRARALRELLVATVRSW

Sequences:

>Translated_526_residues
MTPEEWIAHDPDPRTAAELAACGAAELAARFARPLRFGTAGLRGPVRAGPDAMNVAVVSRASWALAQVLKRRGPAGARVI
VGRDARHGSAVFATVAAEVLAAQGFSVLLLPGPAPTPVVAFAVRHTGAAAGVQITASHNPPTDNGYKVYDGGGIQIVSPT
DHQIEAAMADAPPADEIRRTPVPPAHTDLVQRYIERAAGVRRGTGSVRVALTALHGVGGTVAVDALHRAGFGRIHTVASQ
FAPDPDFPTVVFPNPEEPGATDALLTLAADVDADVAIALDPDADRCAVGIPDASGWRMLSGDETGWLLGDYLLSQPQRAD
RPVVASTVVSSRMLSAIAARHGAVHVETLTGFKWLARADAEVPGGTLVYAYEEAIGHCVDPAAVRDKDGISAAVLVCDLV
AGLIARGGSVSGRLDELARRHGVHDVAAVSRRVGTDGAAELMRRLRTSPPETLAGFGVALTDITDALIFTGGDDDTSVRL
VVRPSGTEPKVKCYLEIRCAPSDDLASSRRRARALRELLVATVRSW
>Mature_525_residues
TPEEWIAHDPDPRTAAELAACGAAELAARFARPLRFGTAGLRGPVRAGPDAMNVAVVSRASWALAQVLKRRGPAGARVIV
GRDARHGSAVFATVAAEVLAAQGFSVLLLPGPAPTPVVAFAVRHTGAAAGVQITASHNPPTDNGYKVYDGGGIQIVSPTD
HQIEAAMADAPPADEIRRTPVPPAHTDLVQRYIERAAGVRRGTGSVRVALTALHGVGGTVAVDALHRAGFGRIHTVASQF
APDPDFPTVVFPNPEEPGATDALLTLAADVDADVAIALDPDADRCAVGIPDASGWRMLSGDETGWLLGDYLLSQPQRADR
PVVASTVVSSRMLSAIAARHGAVHVETLTGFKWLARADAEVPGGTLVYAYEEAIGHCVDPAAVRDKDGISAAVLVCDLVA
GLIARGGSVSGRLDELARRHGVHDVAAVSRRVGTDGAAELMRRLRTSPPETLAGFGVALTDITDALIFTGGDDDTSVRLV
VRPSGTEPKVKCYLEIRCAPSDDLASSRRRARALRELLVATVRSW

Specific function: This Enzyme Participates In Both The Breakdown And Synthesis Of Glucose. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=586, Percent_Identity=33.2764505119454, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI31377548, Length=592, Percent_Identity=30.9121621621622, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1789566, Length=286, Percent_Identity=29.020979020979, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788361, Length=245, Percent_Identity=28.1632653061224, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993870, Length=572, Percent_Identity=30.7692307692308, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71993878, Length=304, Percent_Identity=33.2236842105263, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323934, Length=580, Percent_Identity=31.8965517241379, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI20129809, Length=570, Percent_Identity=31.2280701754386, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24651977, Length=458, Percent_Identity=33.4061135371179, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24653722, Length=430, Percent_Identity=32.093023255814, Blast_Score=193, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 54946; Mature: 54815

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEEWIAHDPDPRTAAELAACGAAELAARFARPLRFGTAGLRGPVRAGPDAMNVAVVSR
CCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEHH
ASWALAQVLKRRGPAGARVIVGRDARHGSAVFATVAAEVLAAQGFSVLLLPGPAPTPVVA
HHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEE
FAVRHTGAAAGVQITASHNPPTDNGYKVYDGGGIQIVSPTDHQIEAAMADAPPADEIRRT
EEEHHCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCHHHHHHCCCCCHHHHCCC
PVPPAHTDLVQRYIERAAGVRRGTGSVRVALTALHGVGGTVAVDALHRAGFGRIHTVASQ
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHH
FAPDPDFPTVVFPNPEEPGATDALLTLAADVDADVAIALDPDADRCAVGIPDASGWRMLS
CCCCCCCCEEEECCCCCCCCCHHHEEEEECCCCCEEEEECCCCCCEEEECCCCCCCEEEC
GDETGWLLGDYLLSQPQRADRPVVASTVVSSRMLSAIAARHGAVHVETLTGFKWLARADA
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCHHHHHHCCC
EVPGGTLVYAYEEAIGHCVDPAAVRDKDGISAAVLVCDLVAGLIARGGSVSGRLDELARR
CCCCCEEEEEEHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HGVHDVAAVSRRVGTDGAAELMRRLRTSPPETLAGFGVALTDITDALIFTGGDDDTSVRL
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHCCEEEEECCCCCCEEEE
VVRPSGTEPKVKCYLEIRCAPSDDLASSRRRARALRELLVATVRSW
EEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEEWIAHDPDPRTAAELAACGAAELAARFARPLRFGTAGLRGPVRAGPDAMNVAVVSR
CCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEHH
ASWALAQVLKRRGPAGARVIVGRDARHGSAVFATVAAEVLAAQGFSVLLLPGPAPTPVVA
HHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEE
FAVRHTGAAAGVQITASHNPPTDNGYKVYDGGGIQIVSPTDHQIEAAMADAPPADEIRRT
EEEHHCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCHHHHHHCCCCCHHHHCCC
PVPPAHTDLVQRYIERAAGVRRGTGSVRVALTALHGVGGTVAVDALHRAGFGRIHTVASQ
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHH
FAPDPDFPTVVFPNPEEPGATDALLTLAADVDADVAIALDPDADRCAVGIPDASGWRMLS
CCCCCCCCEEEECCCCCCCCCHHHEEEEECCCCCEEEEECCCCCCEEEECCCCCCCEEEC
GDETGWLLGDYLLSQPQRADRPVVASTVVSSRMLSAIAARHGAVHVETLTGFKWLARADA
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCHHHHHHCCC
EVPGGTLVYAYEEAIGHCVDPAAVRDKDGISAAVLVCDLVAGLIARGGSVSGRLDELARR
CCCCCEEEEEEHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HGVHDVAAVSRRVGTDGAAELMRRLRTSPPETLAGFGVALTDITDALIFTGGDDDTSVRL
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHCCEEEEECCCCCCEEEE
VVRPSGTEPKVKCYLEIRCAPSDDLASSRRRARALRELLVATVRSW
EEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]