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The map label for this gene is deoD

Identifier: 41409527

GI number: 41409527

Start: 3808372

End: 3809187

Strand: Direct

Name: deoD

Synonym: MAP3429

Alternate gene names: 41409527

Gene position: 3808372-3809187 (Clockwise)

Preceding gene: 41409523

Following gene: 41409528

Centisome position: 78.85

GC content: 75.25

Gene sequence:

>816_bases
GTGGCCGAAACCCCGTCCAACCCAGGCGAGCTCGCGCGCCAGGCGGCCGCGGTCATCGGCGAACGGACCGGCGTCGCCGA
ACACGACGTGGCCATCGTCCTGGGGTCGGGATGGTCGCCGGCGGTCGCCGCGCTGGGCACCCCGACGGCGGTGCTGCCGC
AGGCCGAACTGCCCGGCTTCCGCCCGCCCACCGCGGTCGGGCACACCGGCGAGCTGGTGTCGATGCGCATCGGCGAGCAC
CGGGTGCTGGTGTTGGTCGGCCGCATCCACGCCTACGAGGGCCACGACCTGTGCCACGTCGTGCACCCGGTCCGGGCGGC
CTGCGCGGCCGGGGTGCGCGCGGTGGTGCTCACCAACGCGGCCGGCGGCCTGCGCCCGGACCTTGCCGTCGGCGAACCGG
TGCTGATCAGCGACCACCTCAACCTGACCGGGCGGTCCCCGCTGGTCGGCCCGCAGTTCGTCGACCTCACCGACGCCTAC
TCGCCGCGGCTGCGCGAGCTGGCCCGCCAAGCCGATCCCACGCTGGCCGAGGGCGTCTACGCCGGCCTTCCCGGCCCGCA
CTACGAGACCCCGGCCGAGATCCGGATGCTGCGCACGCTGGGCGCCGACCTGGTCGGCATGTCGACGGTGCACGAAACCA
TCGCCGCCCGGGCGGCCGGCGCCGAGGTGCTGGGGGTGTCGCTGGTGACCAACCTGGCCGCCGGCATCAGCGGCGAGCCG
CTGAGCCACACCGAGGTGCTGGCCGCCGGCGCCGCCTCGGCCACCCGGATGGGCGCGCTGCTGGCCCTGATCCTTTGCCA
ACTCCCCCGGTTCTAG

Upstream 100 bases:

>100_bases
ACCGGCCACCCACGCAGATTCATACGCCAGATCCTGGCACACCCCCCCGACACCCGCTCCCGGGCCGGCGTTCGCCGTCG
CCGGGCTAGGCTCGATCGCT

Downstream 100 bases:

>100_bases
GACCGTGACGCCCGAGGAATGGATCGCGCACGATCCCGACCCCCGCACGGCCGCCGAGCTCGCCGCATGCGGCGCCGCAG
AACTCGCCGCCCGCTTCGCC

Product: purine nucleoside phosphorylase

Products: NA

Alternate protein names: PNP; Inosine phosphorylase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MAETPSNPGELARQAAAVIGERTGVAEHDVAIVLGSGWSPAVAALGTPTAVLPQAELPGFRPPTAVGHTGELVSMRIGEH
RVLVLVGRIHAYEGHDLCHVVHPVRAACAAGVRAVVLTNAAGGLRPDLAVGEPVLISDHLNLTGRSPLVGPQFVDLTDAY
SPRLRELARQADPTLAEGVYAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGISGEP
LSHTEVLAAGAASATRMGALLALILCQLPRF

Sequences:

>Translated_271_residues
MAETPSNPGELARQAAAVIGERTGVAEHDVAIVLGSGWSPAVAALGTPTAVLPQAELPGFRPPTAVGHTGELVSMRIGEH
RVLVLVGRIHAYEGHDLCHVVHPVRAACAAGVRAVVLTNAAGGLRPDLAVGEPVLISDHLNLTGRSPLVGPQFVDLTDAY
SPRLRELARQADPTLAEGVYAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGISGEP
LSHTEVLAAGAASATRMGALLALILCQLPRF
>Mature_270_residues
AETPSNPGELARQAAAVIGERTGVAEHDVAIVLGSGWSPAVAALGTPTAVLPQAELPGFRPPTAVGHTGELVSMRIGEHR
VLVLVGRIHAYEGHDLCHVVHPVRAACAAGVRAVVLTNAAGGLRPDLAVGEPVLISDHLNLTGRSPLVGPQFVDLTDAYS
PRLRELARQADPTLAEGVYAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGISGEPL
SHTEVLAAGAASATRMGALLALILCQLPRF

Specific function: Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=258, Percent_Identity=39.922480620155, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1788746, Length=247, Percent_Identity=37.246963562753, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17541190, Length=273, Percent_Identity=39.9267399267399, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323238, Length=270, Percent_Identity=35.1851851851852, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24656090, Length=282, Percent_Identity=34.0425531914894, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45552887, Length=277, Percent_Identity=33.9350180505415, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24656093, Length=277, Percent_Identity=33.9350180505415, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45552885, Length=277, Percent_Identity=33.9350180505415, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24762376, Length=224, Percent_Identity=30.8035714285714, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR011269
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.1 [H]

Molecular weight: Translated: 27855; Mature: 27724

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETPSNPGELARQAAAVIGERTGVAEHDVAIVLGSGWSPAVAALGTPTAVLPQAELPGF
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCC
RPPTAVGHTGELVSMRIGEHRVLVLVGRIHAYEGHDLCHVVHPVRAACAAGVRAVVLTNA
CCCCCCCCCCCEEEEEECCCEEEEEEEEHEECCCCCHHHHHHHHHHHHHHCCEEEEEECC
AGGLRPDLAVGEPVLISDHLNLTGRSPLVGPQFVDLTDAYSPRLRELARQADPTLAEGVY
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEECHHCCCCHHHHHHHHHCCCHHHHHHH
AGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGISGEP
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
LSHTEVLAAGAASATRMGALLALILCQLPRF
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AETPSNPGELARQAAAVIGERTGVAEHDVAIVLGSGWSPAVAALGTPTAVLPQAELPGF
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCC
RPPTAVGHTGELVSMRIGEHRVLVLVGRIHAYEGHDLCHVVHPVRAACAAGVRAVVLTNA
CCCCCCCCCCCEEEEEECCCEEEEEEEEHEECCCCCHHHHHHHHHHHHHHCCEEEEEECC
AGGLRPDLAVGEPVLISDHLNLTGRSPLVGPQFVDLTDAYSPRLRELARQADPTLAEGVY
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEECHHCCCCHHHHHHHHHCCCHHHHHHH
AGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGISGEP
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
LSHTEVLAAGAASATRMGALLALILCQLPRF
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]