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The map label for this gene is accA3

Identifier: 41409502

GI number: 41409502

Start: 3779191

End: 3781014

Strand: Direct

Name: accA3

Synonym: MAP3404

Alternate gene names: 41409502

Gene position: 3779191-3781014 (Clockwise)

Preceding gene: 41409501

Following gene: 41409503

Centisome position: 78.25

GC content: 71.44

Gene sequence:

>1824_bases
CTGCCGATATGCCAAACAGGAGGCGCAGTGGCCAGTCACGCCAGCTCGAGGATCTCCAAGGTGCTCGTCGCCAACCGCGG
CGAGATCGCTGTCCGGGTGATCCGCGCGGCCCGCGATGCGGGCCTGTCCAGCGTGGCGGTGTACGCCGAACCGGATGCCG
ACGCGCCGCACGTCCGGCTGGCCGACGAGGCGTTCGCTCTGGGTGGTCAGACGTCGGCCGAGTCCTACCTGGACTTCGGC
AAGCTGCTCGACGCGGCCGCCAAGTCCGGGGCCAACGCCATCCACCCCGGCTACGGCTTCCTGTCCGAGAACGCCGACTT
CGCCCAGGCCGTGATCGACGCCGGGCTGATCTGGATCGGCCCCAGCCCGCAGTCCATCCGCGACCTCGGTGACAAGGTCA
CCGCCCGCCACATCGCCGCCCGCGCGCAGGCGCCGCTGGTGCCCGGCACCCCCGACCCGGTCAAGGACGCCGACGAGGTG
GTGGCCTTCGCCAAGGAGTACGGCGTGCCGATCGCCATCAAGGCCGCGTTCGGCGGCGGCGGCAAGGGCATGAAGGTGGC
CCGCACCATCGAGGAGATCCCCGAGCTCTACGAGTCGGCGGTGCGCGAGGCCGTCGCGGCGTTCGGCCGCGGCGAGTGCT
TCGTCGAGCGCTACCTGGACAAGCCGCGCCACGTCGAGGCCCAGGTGATCGCCGACCAGCACGGCAACGTCGTCGTCGCC
GGCACCCGCGACTGCTCGCTGCAGCGCCGGTTCCAGAAGCTGGTCGAGGAGGCGCCGGCGCCGTTCCTGTCGGACGCGCA
GCGCAAGGAGATCCACGAGTCGGCCAAGCGGATCTGCAAGGAGGCCCACTACTACGGCGCCGGCACCGTCGAATACCTGG
TCGGCCAGGACGGCCTGATCTCCTTCCTGGAGGTCAACACCCGTCTGCAGGTCGAGCACCCGGTCACCGAGGAGACCGCC
GGCATCGACCTGGTGCTGCAGCAGTTCAAGATCGCCAACGGCGACAAGCTGGACATCACCGAGGACCCGGAGCCGCGCGG
GCACGCCATCGAGTTCCGGATCAACGGCGAGGACGCGGGACGCAACTTCCTGCCCGCGCCCGGCCCGGTCACCCGCTACG
ACATTCCCACCGGGCCCGGGGTGCGGCTGGACTCCGGCGTCGAGGCCGGCTCGGTGATCGGCGGGCAGTTCGACTCGATG
CTGTCCAAGCTGATCGTGTACGGCGCCGACCGGCAGCAGGCGCTGGCCCGCGCCCGCCGCGCCCTGGACGAGTTCCACGT
CGAGGGTCTGGCCACCGTCATCCCGTTCCACCGCGCCGTGGTGCGCGACCCGGCCTTCATCGGTGACGACAACGGGTTCG
CGGTGCACACCCGCTGGATCGAGACCGAGTGGAACAACACCGTCGAGCCGTTCACCGGCGGCGAGCCCCTGGACGACGAG
GACGCCCGCCCCCGCCAGAAGGCGGTGGTGGAGGTCGGCGGCCGCCGGCTCGAGGTGTCGCTGCCCGGGGATCTGGCCCT
GTCCAACGGGGGCTCGGCCGACCCGGCCGGCGTGATCCGCAAGAAGCCCAAGCCGCGCAAGCGGGGCGGGCACGGCGGCG
CGACGGCCTCCGGCGACGCGGTCACCGCACCCATGCAGGGCACCGTGGTCAAGGTCGCGGTCGAGGAGGGCCAGGAGGTC
TCCGCCGGCGACCTGGTGGTGGTGCTCGAGGCGATGAAGATGGAGAACCCGGTCACCGCGCACAAGGACGGCGTCATCAC
CGGCCTTGCGGTCGAGGCCGGCGCCGCCATCACCCAGGGCACGGTGCTCGCCGAGATCAAGTAG

Upstream 100 bases:

>100_bases
CTAAATCCGGACCGCCTGCATCGGCCCAACGGTGCGGCGCTTAGACTTCCGGAGAACTCGTAGTAAGAAATTCTCTTAGA
GAAGCCCCGCAGCAATACGT

Downstream 100 bases:

>100_bases
GGCTCCGGCGAGAGATTTCACCGACGGCGTTGTCGGGCCCGGGCGCCGGGAGTAGGGTTACCGGCAGGGTTGAGTTCACA
GCCGCCCGGGATGCGTCGGT

Product: AccA3

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MPICQTGGAVASHASSRISKVLVANRGEIAVRVIRAARDAGLSSVAVYAEPDADAPHVRLADEAFALGGQTSAESYLDFG
KLLDAAAKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEV
VAFAKEYGVPIAIKAAFGGGGKGMKVARTIEEIPELYESAVREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVA
GTRDCSLQRRFQKLVEEAPAPFLSDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETA
GIDLVLQQFKIANGDKLDITEDPEPRGHAIEFRINGEDAGRNFLPAPGPVTRYDIPTGPGVRLDSGVEAGSVIGGQFDSM
LSKLIVYGADRQQALARARRALDEFHVEGLATVIPFHRAVVRDPAFIGDDNGFAVHTRWIETEWNNTVEPFTGGEPLDDE
DARPRQKAVVEVGGRRLEVSLPGDLALSNGGSADPAGVIRKKPKPRKRGGHGGATASGDAVTAPMQGTVVKVAVEEGQEV
SAGDLVVVLEAMKMENPVTAHKDGVITGLAVEAGAAITQGTVLAEIK

Sequences:

>Translated_607_residues
MPICQTGGAVASHASSRISKVLVANRGEIAVRVIRAARDAGLSSVAVYAEPDADAPHVRLADEAFALGGQTSAESYLDFG
KLLDAAAKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEV
VAFAKEYGVPIAIKAAFGGGGKGMKVARTIEEIPELYESAVREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVA
GTRDCSLQRRFQKLVEEAPAPFLSDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETA
GIDLVLQQFKIANGDKLDITEDPEPRGHAIEFRINGEDAGRNFLPAPGPVTRYDIPTGPGVRLDSGVEAGSVIGGQFDSM
LSKLIVYGADRQQALARARRALDEFHVEGLATVIPFHRAVVRDPAFIGDDNGFAVHTRWIETEWNNTVEPFTGGEPLDDE
DARPRQKAVVEVGGRRLEVSLPGDLALSNGGSADPAGVIRKKPKPRKRGGHGGATASGDAVTAPMQGTVVKVAVEEGQEV
SAGDLVVVLEAMKMENPVTAHKDGVITGLAVEAGAAITQGTVLAEIK
>Mature_606_residues
PICQTGGAVASHASSRISKVLVANRGEIAVRVIRAARDAGLSSVAVYAEPDADAPHVRLADEAFALGGQTSAESYLDFGK
LLDAAAKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVV
AFAKEYGVPIAIKAAFGGGGKGMKVARTIEEIPELYESAVREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAG
TRDCSLQRRFQKLVEEAPAPFLSDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAG
IDLVLQQFKIANGDKLDITEDPEPRGHAIEFRINGEDAGRNFLPAPGPVTRYDIPTGPGVRLDSGVEAGSVIGGQFDSML
SKLIVYGADRQQALARARRALDEFHVEGLATVIPFHRAVVRDPAFIGDDNGFAVHTRWIETEWNNTVEPFTGGEPLDDED
ARPRQKAVVEVGGRRLEVSLPGDLALSNGGSADPAGVIRKKPKPRKRGGHGGATASGDAVTAPMQGTVVKVAVEEGQEVS
AGDLVVVLEAMKMENPVTAHKDGVITGLAVEAGAAITQGTVLAEIK

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=44.9438202247191, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=630, Percent_Identity=36.3492063492063, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049528, Length=436, Percent_Identity=45.6422018348624, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI106049295, Length=436, Percent_Identity=45.6422018348624, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI106049292, Length=436, Percent_Identity=45.6422018348624, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI189095269, Length=434, Percent_Identity=43.3179723502304, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI65506442, Length=434, Percent_Identity=43.3179723502304, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI38679960, Length=472, Percent_Identity=31.3559322033898, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679974, Length=472, Percent_Identity=31.3559322033898, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679971, Length=472, Percent_Identity=31.3559322033898, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679977, Length=472, Percent_Identity=31.3559322033898, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679967, Length=472, Percent_Identity=31.3559322033898, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=30.0395256916996, Blast_Score=213, Evalue=5e-55,
Organism=Escherichia coli, GI1789654, Length=431, Percent_Identity=46.1716937354988, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17562816, Length=436, Percent_Identity=46.7889908256881, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567343, Length=433, Percent_Identity=43.1870669745958, Blast_Score=354, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI71987519, Length=431, Percent_Identity=44.5475638051044, Blast_Score=350, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=458, Percent_Identity=29.0393013100437, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=28.3495145631068, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=28.3495145631068, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319695, Length=437, Percent_Identity=45.766590389016, Blast_Score=356, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=437, Percent_Identity=45.9954233409611, Blast_Score=350, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=41.3551401869159, Blast_Score=328, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=443, Percent_Identity=30.2483069977427, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=30.0766283524904, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI281363050, Length=436, Percent_Identity=46.7889908256881, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=436, Percent_Identity=46.7889908256881, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=436, Percent_Identity=46.7889908256881, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=436, Percent_Identity=46.7889908256881, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=436, Percent_Identity=46.7889908256881, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=436, Percent_Identity=46.7889908256881, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=436, Percent_Identity=46.7889908256881, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=436, Percent_Identity=46.7889908256881, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=436, Percent_Identity=46.7889908256881, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=436, Percent_Identity=46.7889908256881, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651757, Length=457, Percent_Identity=43.1072210065646, Blast_Score=359, Evalue=3e-99,
Organism=Drosophila melanogaster, GI24651759, Length=418, Percent_Identity=41.866028708134, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=29.8, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=29.8, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=29.8, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=29.8, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 64338; Mature: 64207

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPICQTGGAVASHASSRISKVLVANRGEIAVRVIRAARDAGLSSVAVYAEPDADAPHVRL
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEE
ADEAFALGGQTSAESYLDFGKLLDAAAKSGANAIHPGYGFLSENADFAQAVIDAGLIWIG
CHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEC
PSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEYGVPIAIKAAFGGG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCC
GKGMKVARTIEEIPELYESAVREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEE
GTRDCSLQRRFQKLVEEAPAPFLSDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLI
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCE
SFLEVNTRLQVEHPVTEETAGIDLVLQQFKIANGDKLDITEDPEPRGHAIEFRINGEDAG
EEEEECCEEEECCCCCCHHCCHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCC
RNFLPAPGPVTRYDIPTGPGVRLDSGVEAGSVIGGQFDSMLSKLIVYGADRQQALARARR
CCCCCCCCCCEEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
ALDEFHVEGLATVIPFHRAVVRDPAFIGDDNGFAVHTRWIETEWNNTVEPFTGGEPLDDE
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCC
DARPRQKAVVEVGGRRLEVSLPGDLALSNGGSADPAGVIRKKPKPRKRGGHGGATASGDA
CCCHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCE
VTAPMQGTVVKVAVEEGQEVSAGDLVVVLEAMKMENPVTAHKDGVITGLAVEAGAAITQG
EECCCCCCEEEEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEECCCCCEECC
TVLAEIK
EEEEEEC
>Mature Secondary Structure 
PICQTGGAVASHASSRISKVLVANRGEIAVRVIRAARDAGLSSVAVYAEPDADAPHVRL
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEE
ADEAFALGGQTSAESYLDFGKLLDAAAKSGANAIHPGYGFLSENADFAQAVIDAGLIWIG
CHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEC
PSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEYGVPIAIKAAFGGG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCC
GKGMKVARTIEEIPELYESAVREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEE
GTRDCSLQRRFQKLVEEAPAPFLSDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLI
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCE
SFLEVNTRLQVEHPVTEETAGIDLVLQQFKIANGDKLDITEDPEPRGHAIEFRINGEDAG
EEEEECCEEEECCCCCCHHCCHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCC
RNFLPAPGPVTRYDIPTGPGVRLDSGVEAGSVIGGQFDSMLSKLIVYGADRQQALARARR
CCCCCCCCCCEEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
ALDEFHVEGLATVIPFHRAVVRDPAFIGDDNGFAVHTRWIETEWNNTVEPFTGGEPLDDE
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCC
DARPRQKAVVEVGGRRLEVSLPGDLALSNGGSADPAGVIRKKPKPRKRGGHGGATASGDA
CCCHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCE
VTAPMQGTVVKVAVEEGQEVSAGDLVVVLEAMKMENPVTAHKDGVITGLAVEAGAAITQG
EECCCCCCEEEEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEECCCCCEECC
TVLAEIK
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]