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The map label for this gene is accD5

Identifier: 41409497

GI number: 41409497

Start: 3775092

End: 3776732

Strand: Direct

Name: accD5

Synonym: MAP3399

Alternate gene names: 41409497

Gene position: 3775092-3776732 (Clockwise)

Preceding gene: 41409493

Following gene: 41409498

Centisome position: 78.16

GC content: 68.01

Gene sequence:

>1641_bases
ATGACGAGCGTTACCGACCACACCGCCGAACCCGCCGCGGAACACTCCATCGACATCCACACCACCGCGGGCAAGCTGGC
CGAGCTGCACAAGCGCCGCGAGGAGTCGCTGCACCCGGTGGGTGAAGAGGCCGTCGAGAAGGTGCACGCCAAGGGCAAGC
TGACCGCCCGCGAGCGGATCCTGGCCCTGCTCGACGAGGACTCGTTCGTGGAGCTGGACGCGCTGGCCCGGCACCGCAGC
AAGAACTTCGGCCTGGAGAACAACCGCCCGCTCGGCGACGGCGTGATCACCGGCTACGGCACCATCGACGGCCGCGACGT
GTGCATCTTCAGCCAGGACGCCACCGTGTTCGGCGGCAGTCTGGGCGAGGTGTACGGCGAGAAGATCGTCAAGGTGCAGG
AGCTGGCCATCAAGACGGGCCGCCCACTGATCGGCATCAACGACGGCGCCGGCGCCCGCATCCAGGAGGGCGTCGTCTCG
CTGGGCCTCTACAGCCGCATCTTCCGCAACAACATCCTGGCCTCGGGCGTCATCCCGCAGATCTCGCTGATCATGGGCGC
GGCCGCCGGCGGGCACGTCTACTCCCCCGCCCTGACCGACTTCGTCGTCATGGTCGACCAGACCAGCCAGATGTTCATCA
CCGGGCCCGACGTCATCAAGACCGTCACCGGTGAGGACGTCACCATGGAGGAGCTGGGCGGCGCACACACCCACATGGCC
AAGTCGGGCACCCTGCACTACGTGGCCTCGGGCGAGCAGGACGCCTTCGACTGGGTCCGCGACCTGCTCAGCTACCTGCC
GCCCAACAACGCCACCGACCCGCCCCGCTACGCCGAGCCGCACCCGGCGGGGGCCATCGAGGACAACCTCACCGACGAGG
ACCTCGAGCTGGACACGCTGATCCCGGACTCGCCCAACCAGCCCTACGACATGCACGAGGTGATCACCCGGATCCTCGAC
GACGACGAGTTCCTGGAAATCCAGGGCGGTTACGCGCAGAACATCGTCGTCGGGTTCGGCCGCATCGACGGCCGGCCGGT
CGGGATCGTGGCCAACCAGCCCACCCAGTTCGCCGGCTGCCTGGACATCAACGCCTCGGAGAAGGCGGCGCGGTTCGTGC
GGACCTGCGACTGCTTCAACATCCCGATCATCATGCTGGTCGACGTCCCGGGCTTTCTGCCGGGCACCGGCCAGGAGTAC
AACGGCATCATCCGGCGCGGCGCCAAGCTGCTGTACGCCTACGGCGAGGCCACCGTCCCCAAGATCACCGTGATCACCCG
CAAGGCCTACGGCGGCGCCTACTGCGTGATGGGCTCCAAGGACATGGGCTGCGACGTCAACATCGCCTGGCCGTCGGCGC
AGATCGCGGTGATGGGCGCCTCGGGTGCGGTCGGGTTCGTCTACCGCAAGCAGCTGGCCGAGGCCGCGAAGAAGGGCGAG
GACGTCGACGCGCTGCGGCTGCAGCTGCAGCAGGAGTACGAGGACACCCTGGTCAACCCGTACGTCGCCGCCGAGCGCGG
CTACGTCGACGCGGTGATCCCGCCGTCGCACACCCGCGGCTACATCGCCACCGCGCTGCGGCTGCTGGAACGCAAGATCG
CCCATCTGCCCCCCAAGAAGCACGGGAACATTCCGCTATGA

Upstream 100 bases:

>100_bases
CGCCGGCACCGGATCCCGCCACCAGCACGTCGCACTCCGCGGTCCACTGCACCGTGCCCATAGTCAGCGCAGCCTATCCG
CGCCGCTAAGCTCGTCTCCC

Downstream 100 bases:

>100_bases
GTTCCGCCACGAGTGACGAAAACGGTTCGGCCGCAACAGAAGCCGCGCCGCACGAGCCGCACATCCAGATCCTCAAGGGT
GAACCCACCGTCGAGGAGGT

Product: AccD5

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTSVTDHTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEKVHAKGKLTARERILALLDEDSFVELDALARHRS
KNFGLENNRPLGDGVITGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVS
LGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMA
KSGTLHYVASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLELDTLIPDSPNQPYDMHEVITRILD
DDEFLEIQGGYAQNIVVGFGRIDGRPVGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGTGQEY
NGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGE
DVDALRLQLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKKHGNIPL

Sequences:

>Translated_546_residues
MTSVTDHTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEKVHAKGKLTARERILALLDEDSFVELDALARHRS
KNFGLENNRPLGDGVITGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVS
LGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMA
KSGTLHYVASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLELDTLIPDSPNQPYDMHEVITRILD
DDEFLEIQGGYAQNIVVGFGRIDGRPVGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGTGQEY
NGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGE
DVDALRLQLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKKHGNIPL
>Mature_545_residues
TSVTDHTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEKVHAKGKLTARERILALLDEDSFVELDALARHRSK
NFGLENNRPLGDGVITGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSL
GLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAK
SGTLHYVASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLELDTLIPDSPNQPYDMHEVITRILDD
DEFLEIQGGYAQNIVVGFGRIDGRPVGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGTGQEYN
GIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGED
VDALRLQLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=521, Percent_Identity=53.742802303263, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI295821216, Length=541, Percent_Identity=51.7560073937153, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI11545863, Length=502, Percent_Identity=33.4661354581673, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1788655, Length=200, Percent_Identity=28, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=519, Percent_Identity=52.7938342967245, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25147359, Length=519, Percent_Identity=52.7938342967245, Blast_Score=534, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17552936, Length=554, Percent_Identity=31.5884476534296, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI71997163, Length=379, Percent_Identity=24.5382585751979, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586065, Length=537, Percent_Identity=31.8435754189944, Blast_Score=240, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 59082; Mature: 58951

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVTDHTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEKVHAKGKLTARERI
CCCCCCCCCCCCHHCCEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
LALLDEDSFVELDALARHRSKNFGLENNRPLGDGVITGYGTIDGRDVCIFSQDATVFGGS
HHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECCC
LGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGVIPQ
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHCCCHHH
ISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMA
HHHHHCCCCCCCEECCHHHEEEEEEECCCEEEEECCHHHEECCCCCEEHHHHCCCHHHHC
KSGTLHYVASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLELDTL
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
IPDSPNQPYDMHEVITRILDDDEFLEIQGGYAQNIVVGFGRIDGRPVGIVANQPTQFAGC
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCEECEEEEEEECCCCEEEEEEECCCCCEEEE
LDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGTGQEYNGIIRRGAKLLYAYGEATVP
EECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCCCC
KITVITRKAYGGAYCVMGSKDMGCDVNIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGE
EEEEEEEECCCCEEEEECCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
DVDALRLQLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKK
CHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
HGNIPL
CCCCCC
>Mature Secondary Structure 
TSVTDHTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEKVHAKGKLTARERI
CCCCCCCCCCCHHCCEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
LALLDEDSFVELDALARHRSKNFGLENNRPLGDGVITGYGTIDGRDVCIFSQDATVFGGS
HHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECCC
LGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGVIPQ
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHCCCHHH
ISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMA
HHHHHCCCCCCCEECCHHHEEEEEEECCCEEEEECCHHHEECCCCCEEHHHHCCCHHHHC
KSGTLHYVASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLELDTL
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
IPDSPNQPYDMHEVITRILDDDEFLEIQGGYAQNIVVGFGRIDGRPVGIVANQPTQFAGC
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCEECEEEEEEECCCCEEEEEEECCCCCEEEE
LDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGTGQEYNGIIRRGAKLLYAYGEATVP
EECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCCCC
KITVITRKAYGGAYCVMGSKDMGCDVNIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGE
EEEEEEEECCCCEEEEECCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
DVDALRLQLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKK
CHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
HGNIPL
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]