| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is purK
Identifier: 41409492
GI number: 41409492
Start: 3770074
End: 3771354
Strand: Reverse
Name: purK
Synonym: MAP3394c
Alternate gene names: 41409492
Gene position: 3771354-3770074 (Counterclockwise)
Preceding gene: 41409494
Following gene: 41409491
Centisome position: 78.09
GC content: 74.63
Gene sequence:
>1281_bases ATGGCCGTGCCGAGTACCCGCCCGCCGGGCGCCGCCTCCGCGAAAGCGGCGCCCCGAGCCGTTCCCCGCGCCGTTCCCGT CGTCGCCATGGTCGGCGGCGGCCAGCTCGCCCGGATGACCCACCAGGCCGCGATCGCGCTGGGCCAGTCGCTGCGGGTGC TGGCCACCGCCGCCGACGAGTCGGCCGCGCTGGTCGCGTCCGACGTGGTGATCGGCTCGCACACCGACCTCGAGGACCTG CGCCGGCTGGCCGCGGGCGCCGACGTGTTGACCTTCGACCACGAGCACGTGCCGGGCGAACTGCTGGACAAGCTGGTCGC CGAGGGCGTCAACGTGGCGCCGCCGCCGCAGGCCCTGGTGCACGCGCAGGACAAGCTGGTGATGCGGCGGCGGCTGGAAT CCCTGGGTGTGCCGGTGCCGCGGTACGCCGAGATCAACAGTCTCGACGAGCTCGACGCCTTCGCCCGGCGGGTCGGCGGC CCGGTGGTGGTCAAGGCGGTCCGCGGCGGCTACGACGGGCGCGGCGTGCGGATGGCCCGCGACCCGGTGCACGCCCGGGA GATCGCGGCCGCCTTCCTGGCCGACGGCGTGCCGGTGCTGGCCGAGGAACAGGTGAGCCTGCGCCGGGAGCTGTCCGCGC TGGTGGCCCGGTCGCCGTTCGGGCAGGGCGCGGCGTGGCCGGTGGTCGAGACGGTGCAACGCGACGGCATCTGCGTGCAG GTGATCGCGCCCGCACCCGGCCTGGGCGAGGACCTGGCCGCCGACGCGCAACGGCTGGCGCTGCGGCTGGCCGGCGAGCT CGGCGTGGTCGGCGTGCTGGCCGTGGAACTGTTCGAAACCACCGACGGCGCGCTGCTGGTCAACGAGCTGGCGATGCGTC CGCACAACTCCGGGCACTGGACCATGGACGGGTCGCGGACCGGCCAATTCGAGCAGCACCTGCGCGCGGTGCTGGACTAT CCGCTCGGCGACACCGACGCGCTGGCGCCGGTCACCGTGATGGCCAACGTGCTGGGCGCCCGGGAGCGGCCGCGGATGAG CGTCGACGAGCGGCTGCACCACCTGTTCGCGCGCATGCCCGACGCCCGGGTGCACCTGTACGGCAAGGCGGAACGCCCCG GCCGCAAGGTCGGTCACATCAACTTCCTCGGCGACTTCCCCGCCGCCGACACGGCCGGGCTGGCCGCGCTGCGGCGGCGC GCCGAGCTGGCGGCGCACTGGCTGTCCCACGGGCAGTGGACGGACGGATGGGACCCACACGAACAGGAGCGGCATCAATG A
Upstream 100 bases:
>100_bases ACAAAATCGACGCAAAATCGTACATAACAATTCTGTGTCAGCCCCGCTCAACACGGCGGCCGCCGGCATTTAGCACCCGG TTGTTCGCCGTGACACCATG
Downstream 100 bases:
>100_bases GCGTGACCGAAGCTCCTCGCGTCGCGGTGATCATGGGCAGCGACAGCGACTGGTCGGTGATGGCCGACGCCGCGGCCGCG CTGGCCGAGTTCGACGTGCC
Product: phosphoribosylaminoimidazole carboxylase ATPase subunit
Products: NA
Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]
Number of amino acids: Translated: 426; Mature: 425
Protein sequence:
>426_residues MAVPSTRPPGAASAKAAPRAVPRAVPVVAMVGGGQLARMTHQAAIALGQSLRVLATAADESAALVASDVVIGSHTDLEDL RRLAAGADVLTFDHEHVPGELLDKLVAEGVNVAPPPQALVHAQDKLVMRRRLESLGVPVPRYAEINSLDELDAFARRVGG PVVVKAVRGGYDGRGVRMARDPVHAREIAAAFLADGVPVLAEEQVSLRRELSALVARSPFGQGAAWPVVETVQRDGICVQ VIAPAPGLGEDLAADAQRLALRLAGELGVVGVLAVELFETTDGALLVNELAMRPHNSGHWTMDGSRTGQFEQHLRAVLDY PLGDTDALAPVTVMANVLGARERPRMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGDFPAADTAGLAALRRR AELAAHWLSHGQWTDGWDPHEQERHQ
Sequences:
>Translated_426_residues MAVPSTRPPGAASAKAAPRAVPRAVPVVAMVGGGQLARMTHQAAIALGQSLRVLATAADESAALVASDVVIGSHTDLEDL RRLAAGADVLTFDHEHVPGELLDKLVAEGVNVAPPPQALVHAQDKLVMRRRLESLGVPVPRYAEINSLDELDAFARRVGG PVVVKAVRGGYDGRGVRMARDPVHAREIAAAFLADGVPVLAEEQVSLRRELSALVARSPFGQGAAWPVVETVQRDGICVQ VIAPAPGLGEDLAADAQRLALRLAGELGVVGVLAVELFETTDGALLVNELAMRPHNSGHWTMDGSRTGQFEQHLRAVLDY PLGDTDALAPVTVMANVLGARERPRMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGDFPAADTAGLAALRRR AELAAHWLSHGQWTDGWDPHEQERHQ >Mature_425_residues AVPSTRPPGAASAKAAPRAVPRAVPVVAMVGGGQLARMTHQAAIALGQSLRVLATAADESAALVASDVVIGSHTDLEDLR RLAAGADVLTFDHEHVPGELLDKLVAEGVNVAPPPQALVHAQDKLVMRRRLESLGVPVPRYAEINSLDELDAFARRVGGP VVVKAVRGGYDGRGVRMARDPVHAREIAAAFLADGVPVLAEEQVSLRRELSALVARSPFGQGAAWPVVETVQRDGICVQV IAPAPGLGEDLAADAQRLALRLAGELGVVGVLAVELFETTDGALLVNELAMRPHNSGHWTMDGSRTGQFEQHLRAVLDYP LGDTDALAPVTVMANVLGARERPRMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGDFPAADTAGLAALRRRA ELAAHWLSHGQWTDGWDPHEQERHQ
Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]
COG id: COG0026
COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-grasp domain [H]
Homologues:
Organism=Escherichia coli, GI1786733, Length=370, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=3e-31, Organism=Saccharomyces cerevisiae, GI6324702, Length=372, Percent_Identity=34.4086021505376, Blast_Score=187, Evalue=3e-48,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005875 - InterPro: IPR011761 - InterPro: IPR003135 - InterPro: IPR013815 - InterPro: IPR013816 - InterPro: IPR013817 - InterPro: IPR016185 - InterPro: IPR011054 [H]
Pfam domain/function: PF02222 ATP-grasp [H]
EC number: =6.3.4.18 [H]
Molecular weight: Translated: 45520; Mature: 45388
Theoretical pI: Translated: 6.66; Mature: 6.66
Prosite motif: PS50975 ATP_GRASP ; PS00041 HTH_ARAC_FAMILY_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAVPSTRPPGAASAKAAPRAVPRAVPVVAMVGGGQLARMTHQAAIALGQSLRVLATAADE CCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCC SAALVASDVVIGSHTDLEDLRRLAAGADVLTFDHEHVPGELLDKLVAEGVNVAPPPQALV CHHEEECCEEECCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHH HAQDKLVMRRRLESLGVPVPRYAEINSLDELDAFARRVGGPVVVKAVRGGYDGRGVRMAR HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECC DPVHAREIAAAFLADGVPVLAEEQVSLRRELSALVARSPFGQGAAWPVVETVQRDGICVQ CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEE VIAPAPGLGEDLAADAQRLALRLAGELGVVGVLAVELFETTDGALLVNELAMRPHNSGHW EECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCE TMDGSRTGQFEQHLRAVLDYPLGDTDALAPVTVMANVLGARERPRMSVDERLHHLFARMP EECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC DARVHLYGKAERPGRKVGHINFLGDFPAADTAGLAALRRRAELAAHWLSHGQWTDGWDPH CCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC EQERHQ HHHCCC >Mature Secondary Structure AVPSTRPPGAASAKAAPRAVPRAVPVVAMVGGGQLARMTHQAAIALGQSLRVLATAADE CCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCC SAALVASDVVIGSHTDLEDLRRLAAGADVLTFDHEHVPGELLDKLVAEGVNVAPPPQALV CHHEEECCEEECCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHH HAQDKLVMRRRLESLGVPVPRYAEINSLDELDAFARRVGGPVVVKAVRGGYDGRGVRMAR HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECC DPVHAREIAAAFLADGVPVLAEEQVSLRRELSALVARSPFGQGAAWPVVETVQRDGICVQ CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEE VIAPAPGLGEDLAADAQRLALRLAGELGVVGVLAVELFETTDGALLVNELAMRPHNSGHW EECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCE TMDGSRTGQFEQHLRAVLDYPLGDTDALAPVTVMANVLGARERPRMSVDERLHHLFARMP EECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC DARVHLYGKAERPGRKVGHINFLGDFPAADTAGLAALRRRAELAAHWLSHGQWTDGWDPH CCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC EQERHQ HHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]