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The map label for this gene is purE

Identifier: 41409491

GI number: 41409491

Start: 3769556

End: 3770077

Strand: Reverse

Name: purE

Synonym: MAP3393c

Alternate gene names: 41409491

Gene position: 3770077-3769556 (Counterclockwise)

Preceding gene: 41409492

Following gene: 41409490

Centisome position: 78.06

GC content: 73.75

Gene sequence:

>522_bases
ATGAGCGTGACCGAAGCTCCTCGCGTCGCGGTGATCATGGGCAGCGACAGCGACTGGTCGGTGATGGCCGACGCCGCGGC
CGCGCTGGCCGAGTTCGACGTGCCCGCCGAGGTGCGGGTGGTCTCGGCGCACCGCACGCCGGGGGTGATGTTCGACTACG
CGCGCGACGCCGCCGGGCGGGGCATCGAGGTGATCATCGCCGGCGCCGGAGGCGCCGCCCACCTGCCCGGCATGGTCGCC
TCGGCGACGCCGCTGCCGGTGATCGGGGTCCCGGTGCCGCTGGGCCGGCTGGACGGGCTGGACTCGCTGCTGTCGATCGT
GCAGATGCCCGCGGGGGTGCCGGTGGCCACCGTCTCCATCGGCGGCGCCCGCAACGCCGGCCTGCTGGCGGTGCGCATCC
TCGGCGCCTCCGACCCGGGGCTGCGGGCCCGCATCGTCGAGTTCCAGACCCAGCTGGCCGACAGCGTGCGGGCCAAGGAT
GAGGCGCTGCAAAGGCTGCACGGTAAAGTTACCGGTCAGTAG

Upstream 100 bases:

>100_bases
GGCTGGCCGCGCTGCGGCGGCGCGCCGAGCTGGCGGCGCACTGGCTGTCCCACGGGCAGTGGACGGACGGATGGGACCCA
CACGAACAGGAGCGGCATCA

Downstream 100 bases:

>100_bases
CACTAGGAGGCGTTAGAGATGGCTGGATGGGCCGGAAACCCCGACTTCGATCTGTTCCAACTGCCCGAGGAGCACCAGGA
GCTGCGTGCCGCGATCCGGG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSVTEAPRVAVIMGSDSDWSVMADAAAALAEFDVPAEVRVVSAHRTPGVMFDYARDAAGRGIEVIIAGAGGAAHLPGMVA
SATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGASDPGLRARIVEFQTQLADSVRAKD
EALQRLHGKVTGQ

Sequences:

>Translated_173_residues
MSVTEAPRVAVIMGSDSDWSVMADAAAALAEFDVPAEVRVVSAHRTPGVMFDYARDAAGRGIEVIIAGAGGAAHLPGMVA
SATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGASDPGLRARIVEFQTQLADSVRAKD
EALQRLHGKVTGQ
>Mature_172_residues
SVTEAPRVAVIMGSDSDWSVMADAAAALAEFDVPAEVRVVSAHRTPGVMFDYARDAAGRGIEVIIAGAGGAAHLPGMVAS
ATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGASDPGLRARIVEFQTQLADSVRAKDE
ALQRLHGKVTGQ

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=119, Percent_Identity=57.1428571428571, Blast_Score=130, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=59.4936708860759, Blast_Score=173, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17609; Mature: 17477

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTEAPRVAVIMGSDSDWSVMADAAAALAEFDVPAEVRVVSAHRTPGVMFDYARDAAGR
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCHHCCCC
GIEVIIAGAGGAAHLPGMVASATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSI
CEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEE
GGARNAGLLAVRILGASDPGLRARIVEFQTQLADSVRAKDEALQRLHGKVTGQ
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVTEAPRVAVIMGSDSDWSVMADAAAALAEFDVPAEVRVVSAHRTPGVMFDYARDAAGR
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCHHCCCC
GIEVIIAGAGGAAHLPGMVASATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSI
CEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEE
GGARNAGLLAVRILGASDPGLRARIVEFQTQLADSVRAKDEALQRLHGKVTGQ
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]