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The map label for this gene is fadA6_4

Identifier: 41409435

GI number: 41409435

Start: 3706136

End: 3707311

Strand: Direct

Name: fadA6_4

Synonym: MAP3337

Alternate gene names: 41409435

Gene position: 3706136-3707311 (Clockwise)

Preceding gene: 41409433

Following gene: 41409436

Centisome position: 76.74

GC content: 69.56

Gene sequence:

>1176_bases
ATGAACCGCGACGCCGTCATCGTCGGAGCCGTCCGCACCCCGATCGGCAAGGGCAAGGCCAGTGGTGCGCTGCACGACGT
GTTGCCCGCCGACCTGCTGGCCCACAGCCTGCGGGAGCTGGTGGCGCGCACCGGAGTCGATCCGGCGCAGATCGACGACG
TCATCGCCGGCGCCGTCACCCAGGTCGGCGACCAGGCGGTCAACATCGCGCGAAACGCGTTGCTGGGAGCGGGCTTCCCG
GAGTCGGTTCCCGGTGTCACCATCGACCGCCAGTGCGGCAGCAGCCAGCAGGCGATCAACTTCGCGGCCCAGGGCGTCAT
CGCCGGCGCCTATGACGTGGTGATCGCCGCCGGGGTGGAGTCGATGGGCCGCGTCCCGATGGGCTCCCAGGTGCTGCCCG
GCAGCAACCCGTTCGGCGAGGCGATGAACGCCCGGTATCCCGAAGGCCTGGTGCCGCAAGGGATCAGCGCCGAACTGATC
GCCGCGAAGTGGGGATTCTCGCGCACCCAGCTCGACGAGTTCTCCGCCGCCAGCCACGAGAAGGCCGCCCGCGCCACCAA
GGACGGGCTGTTCGACAACGAGCTCATCCCGATCGCCGGGCTGGCCACCGACGAGTTCATCCGGCCCGGGACCACGGTGC
AGACGCTGGCCGGACTACAGCCCGCGTTCTACAGCGAAGCCACCGAAGCCCGCTTCCCGCAGATCAATTGGGAGATCACG
GCCGGCAACTCCTCGCCGCTGTCCGACGGCAGCGCCGCGGTGCTGATCACCAGCAGCGAGACCGCCGCGCGGCTGGGTCT
GCGGCCGCTGGCCCGGATCCACACCACCGCCGTGGTCGGCTCCGAGCCGCTCTACATGCTGACCGGCGTGATTCCGGCCA
CCGAGAAGGTGCTGTCGAAGGCGGGCCTGACGCTGGCCGACATCGACCTGTTCGAGGTGAACGAGGCGTTCGCCCCCGTC
GTGCTGGCCTGGGCGCAGGACACCGGCGCGGATCTGGACAAGACCAACGTCAACGGCGGGGCGATCGCGATCGGACATCC
GTTGGGGGCCAGCGGCGCCCGCATCATCACCACTCTCGTCAACGCGCTGGAGCAACGCGGCGGAAGGTATGGCCTGCAGA
CGATGTGCGAGGGCGGCGGCATGGCCAACGCCACCATCATCGAGCGGTTGAGTTAG

Upstream 100 bases:

>100_bases
TGTCATACAAATCACCTCCTCGGCTGAGTTGCTTTAAGCATACCGAGGTGCGTATCTGAGTACAGTCGAATATATCCAGA
CCTGGACTCGAGGAGGAGCC

Downstream 100 bases:

>100_bases
GCCCGTGACCGAGACCCGGTACATCCCCTTTCACGGCGTGCGGGTGCACTACGACAGCGCCAAGAGCTACGACCAACTGC
GTGCCGCGCTGCTCGCCGAC

Product: FadA6_4

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNRDAVIVGAVRTPIGKGKASGALHDVLPADLLAHSLRELVARTGVDPAQIDDVIAGAVTQVGDQAVNIARNALLGAGFP
ESVPGVTIDRQCGSSQQAINFAAQGVIAGAYDVVIAAGVESMGRVPMGSQVLPGSNPFGEAMNARYPEGLVPQGISAELI
AAKWGFSRTQLDEFSAASHEKAARATKDGLFDNELIPIAGLATDEFIRPGTTVQTLAGLQPAFYSEATEARFPQINWEIT
AGNSSPLSDGSAAVLITSSETAARLGLRPLARIHTTAVVGSEPLYMLTGVIPATEKVLSKAGLTLADIDLFEVNEAFAPV
VLAWAQDTGADLDKTNVNGGAIAIGHPLGASGARIITTLVNALEQRGGRYGLQTMCEGGGMANATIIERLS

Sequences:

>Translated_391_residues
MNRDAVIVGAVRTPIGKGKASGALHDVLPADLLAHSLRELVARTGVDPAQIDDVIAGAVTQVGDQAVNIARNALLGAGFP
ESVPGVTIDRQCGSSQQAINFAAQGVIAGAYDVVIAAGVESMGRVPMGSQVLPGSNPFGEAMNARYPEGLVPQGISAELI
AAKWGFSRTQLDEFSAASHEKAARATKDGLFDNELIPIAGLATDEFIRPGTTVQTLAGLQPAFYSEATEARFPQINWEIT
AGNSSPLSDGSAAVLITSSETAARLGLRPLARIHTTAVVGSEPLYMLTGVIPATEKVLSKAGLTLADIDLFEVNEAFAPV
VLAWAQDTGADLDKTNVNGGAIAIGHPLGASGARIITTLVNALEQRGGRYGLQTMCEGGGMANATIIERLS
>Mature_391_residues
MNRDAVIVGAVRTPIGKGKASGALHDVLPADLLAHSLRELVARTGVDPAQIDDVIAGAVTQVGDQAVNIARNALLGAGFP
ESVPGVTIDRQCGSSQQAINFAAQGVIAGAYDVVIAAGVESMGRVPMGSQVLPGSNPFGEAMNARYPEGLVPQGISAELI
AAKWGFSRTQLDEFSAASHEKAARATKDGLFDNELIPIAGLATDEFIRPGTTVQTLAGLQPAFYSEATEARFPQINWEIT
AGNSSPLSDGSAAVLITSSETAARLGLRPLARIHTTAVVGSEPLYMLTGVIPATEKVLSKAGLTLADIDLFEVNEAFAPV
VLAWAQDTGADLDKTNVNGGAIAIGHPLGASGARIITTLVNALEQRGGRYGLQTMCEGGGMANATIIERLS

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=38.6533665835411, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=37.8109452736318, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI167614485, Length=404, Percent_Identity=36.3861386138614, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=36, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=32.9493087557604, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI194353979, Length=387, Percent_Identity=30.2325581395349, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=45.4773869346734, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=41.504854368932, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.6551724137931, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=37.6847290640394, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=32.2966507177034, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=404, Percent_Identity=35.1485148514851, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=406, Percent_Identity=33.9901477832512, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=31.9306930693069, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=31.7351598173516, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=408, Percent_Identity=30.1470588235294, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=38.0952380952381, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=33.8235294117647, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=38.7096774193548, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17648125, Length=403, Percent_Identity=34.2431761786601, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=32.7586206896552, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17137578, Length=436, Percent_Identity=31.8807339449541, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40357; Mature: 40357

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDAVIVGAVRTPIGKGKASGALHDVLPADLLAHSLRELVARTGVDPAQIDDVIAGAVT
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QVGDQAVNIARNALLGAGFPESVPGVTIDRQCGSSQQAINFAAQGVIAGAYDVVIAAGVE
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHH
SMGRVPMGSQVLPGSNPFGEAMNARYPEGLVPQGISAELIAAKWGFSRTQLDEFSAASHE
HHCCCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
KAARATKDGLFDNELIPIAGLATDEFIRPGTTVQTLAGLQPAFYSEATEARFPQINWEIT
HHHHHHHCCCCCCCCEEEECCCHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEE
AGNSSPLSDGSAAVLITSSETAARLGLRPLARIHTTAVVGSEPLYMLTGVIPATEKVLSK
CCCCCCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHEECCCCCEEEECCCHHHHHHHHH
AGLTLADIDLFEVNEAFAPVVLAWAQDTGADLDKTNVNGGAIAIGHPLGASGARIITTLV
CCCEEEECCHHHCCHHHCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHH
NALEQRGGRYGLQTMCEGGGMANATIIERLS
HHHHHCCCCCCHHHHHCCCCCCCHHHHHHCC
>Mature Secondary Structure
MNRDAVIVGAVRTPIGKGKASGALHDVLPADLLAHSLRELVARTGVDPAQIDDVIAGAVT
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QVGDQAVNIARNALLGAGFPESVPGVTIDRQCGSSQQAINFAAQGVIAGAYDVVIAAGVE
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHH
SMGRVPMGSQVLPGSNPFGEAMNARYPEGLVPQGISAELIAAKWGFSRTQLDEFSAASHE
HHCCCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
KAARATKDGLFDNELIPIAGLATDEFIRPGTTVQTLAGLQPAFYSEATEARFPQINWEIT
HHHHHHHCCCCCCCCEEEECCCHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEE
AGNSSPLSDGSAAVLITSSETAARLGLRPLARIHTTAVVGSEPLYMLTGVIPATEKVLSK
CCCCCCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHEECCCCCEEEECCCHHHHHHHHH
AGLTLADIDLFEVNEAFAPVVLAWAQDTGADLDKTNVNGGAIAIGHPLGASGARIITTLV
CCCEEEECCHHHCCHHHCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHH
NALEQRGGRYGLQTMCEGGGMANATIIERLS
HHHHHCCCCCCHHHHHCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA