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The map label for this gene is aroA

Identifier: 41409432

GI number: 41409432

Start: 3703282

End: 3704589

Strand: Direct

Name: aroA

Synonym: MAP3334

Alternate gene names: 41409432

Gene position: 3703282-3704589 (Clockwise)

Preceding gene: 41409430

Following gene: 41409433

Centisome position: 76.68

GC content: 73.93

Gene sequence:

>1308_bases
GTGACTACGTGGACGGCCCCCCTCGCACCGCAACCGGTGCACGCGACCGTGACCGTTCCGGGTTCGAAGTCGCAGACCAA
CCGGGCCCTGGTGCTGGCGGCGCTGGCCGCCGCCCAGGGCCGGGGCACCCCGACCCTCAGCGGGGCGCTGCGCAGCCGCG
ACACCGACCTGATGATCGGCGCGCTGCGCACCCTGGGCCTGCGCGTCGACGGGACAGGCCCGGAACTGACCGTCAGCGGC
CACATCGCGCCCGGACCACACGCCCGAGTCGACTGCGGGCTGGCCGGAACGGTGCTGCGGTTCGTTCCGCCCCTGGCGGC
GCTGGCCGACGCGGTGGTGGAGTTCGACGGCGACGAGCAGGCCCGGGCCCGGCCGATCGCGCCGCTGCTGGACGCGCTGC
GCGGGCTCGGCGTGCGGATCGAAGGCACCGCCCTGCCGTTCCGGGTGCACGGCAGCGGCGCGCTCGCCGGGGGCACGGTG
GCCATCGACGCGTCGGCCTCCTCGCAGTTCGTCTCCGGGCTGTTGCTCTGCGCGGCCTCCTTCACCGAGGGCCTGACCGT
GCAACACACCGGCGCGGCGCTGCCGTCGGCCCCGCACATCGCGATGACGGTGGCGATGCTGCGCCAGGCCGGCGTCGACG
TCGACGACTCGGTCCCCAACCGCTGGCAGGTACGGCCGGGGCCGGTCGCGGCCCGGCACTGGGAGGTGGAACCGGACCTG
ACCAACGCCGTTCCGTTCCTGGCGGCGGCCGTGGTCAGCGGCGGCACCGTGCGCATCACCGGCTGGCCGGCCGACAGCGT
GCAACCCGCCGACAATATCCTGAGCGTGTTGGGCAAGCTGAATGCCGTTGTCTCCCAGACTGATTCGTCTCTGGAGGTGC
GCGGCTCCGGGAGCTATGACGGTTTCGACGTCGACCTGCGCGCGGTCGGCGAGCTGACACCGTCGGTGGCCGCCCTGGCG
GCGCTGGCCACGCCGGGATCGGTGTCGCGGCTGTCCGGCATCGCGCACCTGCGCGGCCACGAGACCGACCGGCTGGCCGC
GCTGAGCGCCGAGATCAACCGCCTCGGCGGCGACTGCACCGAAACACCCGACGGCCTGGTGATCACCGCGACGCCGCTGC
GCCCCGGGGTGTGGCACGCCTACGCCGACCACCGGATGGCGATGGCCGGTGCGATCGTCGGGCTGCGGGTGGCCGGGGTC
CGAGTCGACGACATCGGCGCCACCAGCAAGACGCTGCCGGACTTTCCGCGGCTGTGGGCCCGCATGCTGGACGCCAGCCT
GCCGGACGGGGAAGAGCACGGCATGTGA

Upstream 100 bases:

>100_bases
GCACATGACTCCCATGGTGGCAGAGCCACCGGGTGCAGGTCCGTGGCAGAGCCACGCAGTGCTATTGGGCCCGAAAACGG
TGACAGGCGATGATGGACCG

Downstream 100 bases:

>100_bases
GACCCGGCGACTACGACGAGTCCGACGTCAAGATCCGCTCCGGCCGCGGTTCGCGGCCGCGCACCAAGACCCGTCCCGAG
CACGCCGACGCGCGGGCCGC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTTWTAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGRGTPTLSGALRSRDTDLMIGALRTLGLRVDGTGPELTVSG
HIAPGPHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQARARPIAPLLDALRGLGVRIEGTALPFRVHGSGALAGGTV
AIDASASSQFVSGLLLCAASFTEGLTVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWEVEPDL
TNAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLGKLNAVVSQTDSSLEVRGSGSYDGFDVDLRAVGELTPSVAALA
ALATPGSVSRLSGIAHLRGHETDRLAALSAEINRLGGDCTETPDGLVITATPLRPGVWHAYADHRMAMAGAIVGLRVAGV
RVDDIGATSKTLPDFPRLWARMLDASLPDGEEHGM

Sequences:

>Translated_435_residues
MTTWTAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGRGTPTLSGALRSRDTDLMIGALRTLGLRVDGTGPELTVSG
HIAPGPHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQARARPIAPLLDALRGLGVRIEGTALPFRVHGSGALAGGTV
AIDASASSQFVSGLLLCAASFTEGLTVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWEVEPDL
TNAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLGKLNAVVSQTDSSLEVRGSGSYDGFDVDLRAVGELTPSVAALA
ALATPGSVSRLSGIAHLRGHETDRLAALSAEINRLGGDCTETPDGLVITATPLRPGVWHAYADHRMAMAGAIVGLRVAGV
RVDDIGATSKTLPDFPRLWARMLDASLPDGEEHGM
>Mature_434_residues
TTWTAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGRGTPTLSGALRSRDTDLMIGALRTLGLRVDGTGPELTVSGH
IAPGPHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQARARPIAPLLDALRGLGVRIEGTALPFRVHGSGALAGGTVA
IDASASSQFVSGLLLCAASFTEGLTVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWEVEPDLT
NAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLGKLNAVVSQTDSSLEVRGSGSYDGFDVDLRAVGELTPSVAALAA
LATPGSVSRLSGIAHLRGHETDRLAALSAEINRLGGDCTETPDGLVITATPLRPGVWHAYADHRMAMAGAIVGLRVAGVR
VDDIGATSKTLPDFPRLWARMLDASLPDGEEHGM

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=441, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320332, Length=471, Percent_Identity=30.3609341825902, Blast_Score=150, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_MYCPA (Q73UN2)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962268.1
- HSSP:   P22487
- ProteinModelPortal:   Q73UN2
- SMR:   Q73UN2
- EnsemblBacteria:   EBMYCT00000038143
- GeneID:   2718142
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3334
- NMPDR:   fig|262316.1.peg.3334
- GeneTree:   EBGT00050000016231
- HOGENOM:   HBG646626
- OMA:   HRMATAG
- ProtClustDB:   PRK02427
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 44721; Mature: 44590

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTWTAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGRGTPTLSGALRSRDTDLMIG
CCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHH
ALRTLGLRVDGTGPELTVSGHIAPGPHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQ
HHHHHCEEECCCCCEEEEECCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHHHCCCCCCH
ARARPIAPLLDALRGLGVRIEGTALPFRVHGSGALAGGTVAIDASASSQFVSGLLLCAAS
HCCCCCHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
FTEGLTVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWEVEPDL
HHCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCEEEEECCCCH
TNAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLGKLNAVVSQTDSSLEVRGSGSYD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
GFDVDLRAVGELTPSVAALAALATPGSVSRLSGIAHLRGHETDRLAALSAEINRLGGDCT
CEEEEHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
ETPDGLVITATPLRPGVWHAYADHRMAMAGAIVGLRVAGVRVDDIGATSKTLPDFPRLWA
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCHHHHHHH
RMLDASLPDGEEHGM
HHHHCCCCCCHHCCC
>Mature Secondary Structure 
TTWTAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGRGTPTLSGALRSRDTDLMIG
CCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHH
ALRTLGLRVDGTGPELTVSGHIAPGPHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQ
HHHHHCEEECCCCCEEEEECCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHHHCCCCCCH
ARARPIAPLLDALRGLGVRIEGTALPFRVHGSGALAGGTVAIDASASSQFVSGLLLCAAS
HCCCCCHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
FTEGLTVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWEVEPDL
HHCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCEEEEECCCCH
TNAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLGKLNAVVSQTDSSLEVRGSGSYD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
GFDVDLRAVGELTPSVAALAALATPGSVSRLSGIAHLRGHETDRLAALSAEINRLGGDCT
CEEEEHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
ETPDGLVITATPLRPGVWHAYADHRMAMAGAIVGLRVAGVRVDDIGATSKTLPDFPRLWA
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCHHHHHHH
RMLDASLPDGEEHGM
HHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA