| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is kduD [C]
Identifier: 41409428
GI number: 41409428
Start: 3699095
End: 3699898
Strand: Direct
Name: kduD [C]
Synonym: MAP3330
Alternate gene names: 41409428
Gene position: 3699095-3699898 (Clockwise)
Preceding gene: 41409423
Following gene: 41409429
Centisome position: 76.59
GC content: 70.15
Gene sequence:
>804_bases TTGCGGCGGGTTGCGGCGGTGAAGGGGATTTCCATGGGTCTTCGCGGTCTGGCGGACAAGGTCGCTGTCGTGGTCGGCGG GGCCACCGGCATCGGTGCGGCGACGGCCGCCCGGCTGGCCGGGGAAGGCTGCCGCGTGGTCATCGGCGACGTGGCCGTCG ACGCCGCGCGGCAGACGGCCGACCGCATCGCCGCCGCCGGCGGCACGGCGACCCAGGTGGCCTTCGACCTCGCCGACCCG GCGTCGGTTGCCACCCTGATCGACTGTGCCGCAACGACTTACGGCGGCGTGGACCTGCTGTTCAACGTGGGCGCCGACAT GAGCACCATCCGGGCCGACACCGACGTGGTCGATATCGACTTCGACGTCTGGGACCGGGTGATGACGGTCAGCCTGCGCG GTTATGTGGCCGCCATGAAATATGCAATCCCGCGCATGCTGGACCGCGGCGGAGGGGCCATCGTCAACATGTCATCGGCC GCGGCGTTTCAGGGTGAGCCCGCCCGGCCGGCCTATGCCACCGCGAAAGCCGGCATCGGCGCTCTCACGCGCCACGTCGC GTCGCGGTGGGGCAAGGACAACATCCGGTGCAACGCGGTCGCGCCCGGGTTCACCGCCACCGAGACCATCCGGTCGGTGC CGCAATGGCCGGAGCTGGAAGCCGCCGCGCTCAAGCGAATTCGTGGGCCGCGCGTCGGCGACCCGGCCGACGTCGCCACG TTGGTCGCGTTTCTGCTCTCCGCCGAGGGTGATTGGATCAACGGTCAGGTCATCAACATCGACGGCGGCACCGTCCTTCG GTGA
Upstream 100 bases:
>100_bases CGGCCGCCAGGTCGCCGGCTCCGGGTCGCTCCCGGTGAATCCCAGCCATGACTGGCGATCCTCTACAGTTCTAGAGGTAA AGTCAATATGTTGCGGCGGG
Downstream 100 bases:
>100_bases CTCATGGCATCCGACTCCCGATCCCGCAGGCGTGACGGCGACGAACGCCGCCGCCAGCTGTGTGACGCCGCGATCCGGGT GCTCGCCGAGCACGGCTCGC
Product: hypothetical protein
Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]
Alternate protein names: NA
Number of amino acids: Translated: 267; Mature: 267
Protein sequence:
>267_residues MRRVAAVKGISMGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAARQTADRIAAAGGTATQVAFDLADP ASVATLIDCAATTYGGVDLLFNVGADMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIVNMSSA AAFQGEPARPAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGFTATETIRSVPQWPELEAAALKRIRGPRVGDPADVAT LVAFLLSAEGDWINGQVINIDGGTVLR
Sequences:
>Translated_267_residues MRRVAAVKGISMGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAARQTADRIAAAGGTATQVAFDLADP ASVATLIDCAATTYGGVDLLFNVGADMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIVNMSSA AAFQGEPARPAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGFTATETIRSVPQWPELEAAALKRIRGPRVGDPADVAT LVAFLLSAEGDWINGQVINIDGGTVLR >Mature_267_residues MRRVAAVKGISMGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAARQTADRIAAAGGTATQVAFDLADP ASVATLIDCAATTYGGVDLLFNVGADMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIVNMSSA AAFQGEPARPAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGFTATETIRSVPQWPELEAAALKRIRGPRVGDPADVAT LVAFLLSAEGDWINGQVINIDGGTVLR
Specific function: Unknown
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=30.6772908366534, Blast_Score=121, Evalue=6e-28, Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=31.0077519379845, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=29.3436293436293, Blast_Score=104, Evalue=7e-23, Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=29.5275590551181, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=26.6129032258064, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=29.8804780876494, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=30.3846153846154, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=27.6422764227642, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI66933014, Length=230, Percent_Identity=30, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI83715985, Length=261, Percent_Identity=29.8850574712644, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI4503301, Length=248, Percent_Identity=28.2258064516129, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=28.6458333333333, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI31542939, Length=255, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=27.0161290322581, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI4504505, Length=237, Percent_Identity=28.6919831223629, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=32.5396825396825, Blast_Score=128, Evalue=3e-31, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=31.3008130081301, Blast_Score=111, Evalue=4e-26, Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=33.4630350194552, Blast_Score=111, Evalue=5e-26, Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=26.8939393939394, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=27.1255060728745, Blast_Score=99, Evalue=3e-22, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=24.5059288537549, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=28.6852589641434, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=30.6451612903226, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=27.7566539923954, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=27.1653543307087, Blast_Score=64, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=30.5019305019305, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=30.1204819277108, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=30.8270676691729, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=29.2, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=29.6, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=30.3846153846154, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=28.8461538461538, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=29.0196078431373, Blast_Score=91, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=30.2681992337165, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=30.3703703703704, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17561272, Length=271, Percent_Identity=31.3653136531365, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538182, Length=264, Percent_Identity=28.7878787878788, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=29.5454545454545, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=29.6153846153846, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=30.0380228136882, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=28.1954887218045, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=31.4393939393939, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=28.7878787878788, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=29.2134831460674, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=24.904214559387, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=25.0996015936255, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=27.7566539923954, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17568967, Length=221, Percent_Identity=31.6742081447964, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=29.7397769516729, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=26.8939393939394, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.2357414448669, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=26.953125, Blast_Score=68, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=28.4974093264249, Blast_Score=67, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=249, Percent_Identity=25.7028112449799, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=31.0756972111554, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=31.6205533596838, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=29.5719844357977, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=29.8804780876494, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=27.1653543307087, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=27.843137254902, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=29.3436293436293, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=29.2079207920792, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI221331218, Length=262, Percent_Identity=29.0076335877863, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24665243, Length=263, Percent_Identity=28.8973384030418, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=31.7948717948718, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI221331216, Length=263, Percent_Identity=28.8973384030418, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24665247, Length=264, Percent_Identity=28.7878787878788, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=27.2, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.125 [C]
Molecular weight: Translated: 27469; Mature: 27469
Theoretical pI: Translated: 7.19; Mature: 7.19
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRRVAAVKGISMGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAARQTA CCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHH DRIAAAGGTATQVAFDLADPASVATLIDCAATTYGGVDLLFNVGADMSTIRADTDVVDID HHHHHCCCCHHEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHEECCCCEEEEE FDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIVNMSSAAAFQGEPARPAYATAKAGIG HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH ALTRHVASRWGKDNIRCNAVAPGFTATETIRSVPQWPELEAAALKRIRGPRVGDPADVAT HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHH LVAFLLSAEGDWINGQVINIDGGTVLR HHHHHHHCCCCEECCEEEEECCCEECC >Mature Secondary Structure MRRVAAVKGISMGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAARQTA CCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHH DRIAAAGGTATQVAFDLADPASVATLIDCAATTYGGVDLLFNVGADMSTIRADTDVVDID HHHHHCCCCHHEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHEECCCCEEEEE FDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIVNMSSAAAFQGEPARPAYATAKAGIG HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH ALTRHVASRWGKDNIRCNAVAPGFTATETIRSVPQWPELEAAALKRIRGPRVGDPADVAT HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHH LVAFLLSAEGDWINGQVINIDGGTVLR HHHHHHHCCCCEECCEEEEECCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+ [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 15.4 {2-deoxygluconate}} [C]
Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]
Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9655913; 12597275 [H]