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The map label for this gene is hisN [H]

Identifier: 41409285

GI number: 41409285

Start: 3537268

End: 3538047

Strand: Direct

Name: hisN [H]

Synonym: MAP3187

Alternate gene names: 41409285

Gene position: 3537268-3538047 (Clockwise)

Preceding gene: 41409283

Following gene: 41409286

Centisome position: 73.24

GC content: 71.54

Gene sequence:

>780_bases
GTGAGCAACGACGATCTGGCGCTGGCGTTGCTGCTGGCCGACCGGGCGGATGCGGTGACCTCGGCCCGGTTCGGCGCGCT
GGACCTGCGCATCGACACCAAACCGGACCTGACGCCGGTCACCGACGCCGATCGCGCCGCCGAGGCCGAGCTGCGCGCGG
TGCTGGCGCGGCAGCGCCCGAACGACAGCATCGTCGGCGAAGAGTTCGGCGGAGACACCGTCTTCACCGGGCGGCAATGG
ATCATCGACCCGATCGACGGCACCAAGAACTTCGTCCGCGGGGTGCCGGTGTGGGCCACCCTGATCGCGTTGCTGCACGA
CGGCGTTCCCGTCGTCGGCGCGGTGAGCGCCCCGGCGCTGGCCCGCCGGTGGTGGGCCGCGCACGGCCGGGGAGCGTTCG
TCGCGGTCAACGGGGCCGCCGCCCGTCGGCTATCGGTTTCCTCTGTGGCACAACTGGATTCGGCCAGTCTTTCGTTCTCC
AGCCTGTCCGGGTGGGCGCAGCTGGGCCTGCGGGATCGATTCCTGGCGCTGACGGATGCGGTGTGGCGGGTGCGCGCCTT
CGGCGACTTCCTGTCCTACTGCCTGGTGGCCGAAGGGGCCGTCGACATCGCCGCCGAACCGGAGGTGTCGGTGTGGGACC
TGGCCGCCCTCGACATCCTCGTGCGCGAGGCCGGCGGGACGCTGACCGGGTTGGACGGCACCCCAGGGCCGCATCGCGGC
AGCGCGGTGGCCAGCAATGGACTGCTACAGCGACAGGTGCTCGAGCGCCTCGCACTGTGA

Upstream 100 bases:

>100_bases
CACCAGCAGTCCGAATTCCCACACCCGGCCATGGTAGGACTGCTCACATGAATCGCACCGGCGGCGATGCGTCGCCCGGC
GAACCAAGGGAGCGGCGCGG

Downstream 100 bases:

>100_bases
ATTAGTTAACAAGTGTTCTCCATGATCTTACTCCGGAGTAAGATCGGCTCTATCCGCACTGCCCATCAACCTGAGGCTGC
TGAAAATGACCGATTCCGGT

Product: hypothetical protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSNDDLALALLLADRADAVTSARFGALDLRIDTKPDLTPVTDADRAAEAELRAVLARQRPNDSIVGEEFGGDTVFTGRQW
IIDPIDGTKNFVRGVPVWATLIALLHDGVPVVGAVSAPALARRWWAAHGRGAFVAVNGAAARRLSVSSVAQLDSASLSFS
SLSGWAQLGLRDRFLALTDAVWRVRAFGDFLSYCLVAEGAVDIAAEPEVSVWDLAALDILVREAGGTLTGLDGTPGPHRG
SAVASNGLLQRQVLERLAL

Sequences:

>Translated_259_residues
MSNDDLALALLLADRADAVTSARFGALDLRIDTKPDLTPVTDADRAAEAELRAVLARQRPNDSIVGEEFGGDTVFTGRQW
IIDPIDGTKNFVRGVPVWATLIALLHDGVPVVGAVSAPALARRWWAAHGRGAFVAVNGAAARRLSVSSVAQLDSASLSFS
SLSGWAQLGLRDRFLALTDAVWRVRAFGDFLSYCLVAEGAVDIAAEPEVSVWDLAALDILVREAGGTLTGLDGTPGPHRG
SAVASNGLLQRQVLERLAL
>Mature_258_residues
SNDDLALALLLADRADAVTSARFGALDLRIDTKPDLTPVTDADRAAEAELRAVLARQRPNDSIVGEEFGGDTVFTGRQWI
IDPIDGTKNFVRGVPVWATLIALLHDGVPVVGAVSAPALARRWWAAHGRGAFVAVNGAAARRLSVSSVAQLDSASLSFSS
LSGWAQLGLRDRFLALTDAVWRVRAFGDFLSYCLVAEGAVDIAAEPEVSVWDLAALDILVREAGGTLTGLDGTPGPHRGS
AVASNGLLQRQVLERLAL

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=269, Percent_Identity=29.368029739777, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI221625487, Length=272, Percent_Identity=29.0441176470588, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7657236, Length=221, Percent_Identity=31.2217194570136, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788882, Length=232, Percent_Identity=30.6034482758621, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790659, Length=202, Percent_Identity=28.2178217821782, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=243, Percent_Identity=31.6872427983539, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=240, Percent_Identity=30.8333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320493, Length=201, Percent_Identity=29.8507462686567, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357329, Length=202, Percent_Identity=32.6732673267327, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24664918, Length=207, Percent_Identity=31.8840579710145, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664922, Length=244, Percent_Identity=29.0983606557377, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357957, Length=204, Percent_Identity=30.3921568627451, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664926, Length=204, Percent_Identity=30.3921568627451, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357303, Length=205, Percent_Identity=30.2439024390244, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27374; Mature: 27243

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDDLALALLLADRADAVTSARFGALDLRIDTKPDLTPVTDADRAAEAELRAVLARQRP
CCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NDSIVGEEFGGDTVFTGRQWIIDPIDGTKNFVRGVPVWATLIALLHDGVPVVGAVSAPAL
CCCCCCCCCCCCEEEECCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEECCCCHHH
ARRWWAAHGRGAFVAVNGAAARRLSVSSVAQLDSASLSFSSLSGWAQLGLRDRFLALTDA
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHH
VWRVRAFGDFLSYCLVAEGAVDIAAEPEVSVWDLAALDILVREAGGTLTGLDGTPGPHRG
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
SAVASNGLLQRQVLERLAL
CHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNDDLALALLLADRADAVTSARFGALDLRIDTKPDLTPVTDADRAAEAELRAVLARQRP
CCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NDSIVGEEFGGDTVFTGRQWIIDPIDGTKNFVRGVPVWATLIALLHDGVPVVGAVSAPAL
CCCCCCCCCCCCEEEECCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEECCCCHHH
ARRWWAAHGRGAFVAVNGAAARRLSVSSVAQLDSASLSFSSLSGWAQLGLRDRFLALTDA
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHH
VWRVRAFGDFLSYCLVAEGAVDIAAEPEVSVWDLAALDILVREAGGTLTGLDGTPGPHRG
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
SAVASNGLLQRQVLERLAL
CHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]