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The map label for this gene is cysA [H]

Identifier: 41409151

GI number: 41409151

Start: 3395611

End: 3396723

Strand: Reverse

Name: cysA [H]

Synonym: MAP3053c

Alternate gene names: 41409151

Gene position: 3396723-3395611 (Counterclockwise)

Preceding gene: 41409152

Following gene: 41409150

Centisome position: 70.33

GC content: 72.33

Gene sequence:

>1113_bases
ATGAGCGGCAACTACGGTGACTCCACCCGTAGCCTCAAAGCTGTTGATCCTCAAGCTGTTTCGGGCCAACCGGTGGCGCC
GCAGCCGGTGCTGGCCGCCACCTATCACCTGTCCGGCGACGAAACCGCGGGCGTGGACAGCTATGGCCGCAACTCAAATC
CCACCTGGCGGCAACTGGAGTCGGCGCTCGCCGAGCTCGAGGGTGCCGGCGGCGCGCTGGTGTTCGGTTCCGGCATGGCG
GCCATCAGCGCCGTGCTGCGCGCGCTCGCCCCGCCCGGGTCGACCGTGGTGGTGCCGGCCGACGGCTATTACCAAGTGCG
CCGCCACGCCGCCGAAGACCTGGCGCCCGCGGGTGTGACGGTCATCGAGGCGTCGAGTGCGCAGATCTATGACGCCGCCG
CGACCGCCGACGTGGTGCTGGCCGAGACGCCGACCAATCCGGCGCTGGACGTGGTCGGTCTGCACCGGCTGGCCATCGTC
TGTCACGGTCGGGGAGCGCGGCTGGTGGTCGACAACACCGCGGCCACGCCGTTGGGTCAGCAGCCGCTGTCGCTGGGCGC
CGACGCGGTGGTGGCCAGCGCCACCAAGGCGTTGTCCGGTCACAGCGACCTGCTGGCCGGCTACGTCGCCACCAGCCGGC
CCGAGTTGCTGGCCGCGGTGGAACGCCAACGGCTGCTCGCCGGGGCGATCCTGGGCGGGTTCGAGGCGTGGCTTCTGTTG
CGCAGCTTGGGAACCGCCGGACTGCGCTTCGAGCGCCAGTGCCAGAACGCGCGGGCGGTGGCGACGCTGCTGGCCCGCCA
CCCGGCGGTGCGTGCGGTGCGCTATCCCGGGCTGGCCGAGCACCCGGGGCACGCGGTGGCCAGGGCCCAGATGCGCCGGT
TCGGTGGCCTGGTCGCCGTCGAACTGGCCGACGCCGCCGCGGTGCGCGCTCTCCTCGACGGCAGCGAGCTGCTGATCGCC
TCCACCAGCTTCGGCGGTTTGCACACCTCGGTGGACCGCCGGGCCCGCTGGGGAGACGCGGTCCCCGACGGGTTCGCGCG
CATCTCGTTGGGCATCGAGGACACCGACGACCTGCTCGCCGACATCGAGCGGGCCCTGCTGACCCTGCGCTGA

Upstream 100 bases:

>100_bases
TACGACAAGGCGGTCGAGCTCGGCGTGCCCATCCTGGACGAGGACGGCTTCCGCAAGCTGCTGGCCGAGGGCCCGCCCGA
AACCCCGGCGGACTGAGCCG

Downstream 100 bases:

>100_bases
CGGACCTTTGCAGCCGTGGCCATCCGGCGAGGTTCGCGGCGCCGAAATTCGTCGGCACCGGCCGAGCACATCTATGGTGG
GCGCTATGACCCAGACGGCC

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: Gamma-cystathionase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLSGDETAGVDSYGRNSNPTWRQLESALAELEGAGGALVFGSGMA
AISAVLRALAPPGSTVVVPADGYYQVRRHAAEDLAPAGVTVIEASSAQIYDAAATADVVLAETPTNPALDVVGLHRLAIV
CHGRGARLVVDNTAATPLGQQPLSLGADAVVASATKALSGHSDLLAGYVATSRPELLAAVERQRLLAGAILGGFEAWLLL
RSLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEHPGHAVARAQMRRFGGLVAVELADAAAVRALLDGSELLIA
STSFGGLHTSVDRRARWGDAVPDGFARISLGIEDTDDLLADIERALLTLR

Sequences:

>Translated_370_residues
MSGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLSGDETAGVDSYGRNSNPTWRQLESALAELEGAGGALVFGSGMA
AISAVLRALAPPGSTVVVPADGYYQVRRHAAEDLAPAGVTVIEASSAQIYDAAATADVVLAETPTNPALDVVGLHRLAIV
CHGRGARLVVDNTAATPLGQQPLSLGADAVVASATKALSGHSDLLAGYVATSRPELLAAVERQRLLAGAILGGFEAWLLL
RSLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEHPGHAVARAQMRRFGGLVAVELADAAAVRALLDGSELLIA
STSFGGLHTSVDRRARWGDAVPDGFARISLGIEDTDDLLADIERALLTLR
>Mature_369_residues
SGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLSGDETAGVDSYGRNSNPTWRQLESALAELEGAGGALVFGSGMAA
ISAVLRALAPPGSTVVVPADGYYQVRRHAAEDLAPAGVTVIEASSAQIYDAAATADVVLAETPTNPALDVVGLHRLAIVC
HGRGARLVVDNTAATPLGQQPLSLGADAVVASATKALSGHSDLLAGYVATSRPELLAAVERQRLLAGAILGGFEAWLLLR
SLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEHPGHAVARAQMRRFGGLVAVELADAAAVRALLDGSELLIAS
TSFGGLHTSVDRRARWGDAVPDGFARISLGIEDTDDLLADIERALLTLR

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=353, Percent_Identity=30.8781869688385, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI299473759, Length=351, Percent_Identity=28.4900284900285, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI25453487, Length=350, Percent_Identity=26, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1790375, Length=359, Percent_Identity=35.3760445682451, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789383, Length=355, Percent_Identity=27.0422535211268, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=30.9973045822102, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=360, Percent_Identity=32.7777777777778, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560056, Length=359, Percent_Identity=31.4763231197772, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319307, Length=382, Percent_Identity=34.2931937172775, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321904, Length=328, Percent_Identity=28.0487804878049, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321254, Length=382, Percent_Identity=27.2251308900524, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323333, Length=387, Percent_Identity=26.8733850129199, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321170, Length=295, Percent_Identity=28.135593220339, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19922554, Length=337, Percent_Identity=31.1572700296736, Blast_Score=158, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1 [H]

Molecular weight: Translated: 38274; Mature: 38143

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLSGDETAGVDSYGRNSNPTWRQLE
CCCCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
SALAELEGAGGALVFGSGMAAISAVLRALAPPGSTVVVPADGYYQVRRHAAEDLAPAGVT
HHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
VIEASSAQIYDAAATADVVLAETPTNPALDVVGLHRLAIVCHGRGARLVVDNTAATPLGQ
EEECCCCEEEEHHCCCEEEEEECCCCCCHHHHHHEEEEEEEECCCCEEEEECCCCCCCCC
QPLSLGADAVVASATKALSGHSDLLAGYVATSRPELLAAVERQRLLAGAILGGFEAWLLL
CCHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEHPGHAVARAQMRRFGGLVAV
HHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCHHHHHHHHHHHCCEEEE
ELADAAAVRALLDGSELLIASTSFGGLHTSVDRRARWGDAVPDGFARISLGIEDTDDLLA
EHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCHHHHHH
DIERALLTLR
HHHHHHHCCC
>Mature Secondary Structure 
SGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLSGDETAGVDSYGRNSNPTWRQLE
CCCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
SALAELEGAGGALVFGSGMAAISAVLRALAPPGSTVVVPADGYYQVRRHAAEDLAPAGVT
HHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
VIEASSAQIYDAAATADVVLAETPTNPALDVVGLHRLAIVCHGRGARLVVDNTAATPLGQ
EEECCCCEEEEHHCCCEEEEEECCCCCCHHHHHHEEEEEEEECCCCEEEEECCCCCCCCC
QPLSLGADAVVASATKALSGHSDLLAGYVATSRPELLAAVERQRLLAGAILGGFEAWLLL
CCHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEHPGHAVARAQMRRFGGLVAV
HHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCHHHHHHHHHHHCCEEEE
ELADAAAVRALLDGSELLIASTSFGGLHTSVDRRARWGDAVPDGFARISLGIEDTDDLLA
EHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCHHHHHH
DIERALLTLR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953; 8550407 [H]