Click here to switch to the map view.

The map label for this gene is ald

Identifier: 41408986

GI number: 41408986

Start: 3217225

End: 3218346

Strand: Direct

Name: ald

Synonym: MAP2888

Alternate gene names: 41408986

Gene position: 3217225-3218346 (Clockwise)

Preceding gene: 41408981

Following gene: 41408992

Centisome position: 66.61

GC content: 69.52

Gene sequence:

>1122_bases
ATGCGAGTCGGCGTACCGACCGAGACCAAGACCAACGAATTTCGCGTGGCCCTCACCCCCGCCGGCGTCGCCGAGTTGAC
CCGCCGCGGCCACGAGGTGCTGGTGCAAAGCGGCGCCGGCGAGGGGTCGTCGATCCCCGACTCCGAGTTCAAGGCGGCCG
GCGCCCAACTGGCCGACACCGCCGAACAGGTCTGGGCCGACGCGGAGCTGCTGCTCAAGGTGAAGGAACCGGTGCCGGCC
GAGTATGACCTGTTGCGGCGCAACCAGATTCTGTTCACCTTTCTGCATCTGGCCGCCTCGCGTGCCTGCACCGAGGCGCT
GTTGACCTCCGGCACGACGTCGATCGCCTACGAGACGGTGCAAACCGCGGACGGCACCCTGCCGTTGCTGGCCCCGATGA
GCGAGGTGGCCGGCCGGCTGTCCGCTCAGGTGGGCGCCTACCACCTGATGCGCACCCACGGCGGACGCGGCGTGCTGATG
GGCGGGGTGCCGGGGGTCAAGCCCGCCGACGTCGTGGTGGTCGGGGCGGGCACGGCCGGCTACAACGCGGCCCGGGTCGC
CGGCGGGATGGGAGCCATGGTCACGGTTCTCGACGTCAACATCAACAAGCTTCGGCTGCTCGACGCCGAGTTCGGCGGTC
AGGTCCGCACCCGGTATTCGTCGGCCTACGACCTGGAGGGCACCGTCAAGCGCGCCGACCTGGTCATCGGCGCGGTGCTG
CTGCCCGGCGCCAAGGCCCCCAACCTGATCTCGAATTCGCTTGTCGCGCAGATGAAGTCGGGCGCGGTGCTGGTGGACAT
CTCCATCGACCAGGGCGGCTGCTTCGAGGACTCCCGGCCGACCACGCACGACGACCCGACCTTCGCCGTGCACGACACGG
TGTTCTACTGCGTGGCGAACATGCCCAGCGCGGTGCCCAAGACGTCGACGGTGGCGCTGACCAACGCCACCATGCCCTAC
GTGCTGGCCCTGGCCGACCGCGGCTGGCGTGCGGCGTGCCGCTCGAATCATGCTCTGGCCAAAGGGCTTTCGACACATGA
CGGTGCGCTGCTGTCGCAGCAGGTGGCCGCCGACCTCGGTCTGCCGTGCACCGACCCGGCCGGCGTGCTGCAGCAGGACT
AA

Upstream 100 bases:

>100_bases
ATCCACCCGCTCTGTCCAGCGGGTATCCGTTTTCGGTCCGATTGCGGGCCCTCCGAAGTTTCTCCACACTTGAAAGGGAA
TCCGCGGACAAGGGGCGATC

Downstream 100 bases:

>100_bases
CCGGTGGCGGCCAGGCCGGCGACGATATCGGCCGCGGGGCCGGCGCTGGCGTGCTTGAACGCCGCCCCCGCCCACAGCGG
TATCCCGTTGGGGTCCTCGA

Product: hypothetical protein

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRVGVPTETKTNEFRVALTPAGVAELTRRGHEVLVQSGAGEGSSIPDSEFKAAGAQLADTAEQVWADAELLLKVKEPVPA
EYDLLRRNQILFTFLHLAASRACTEALLTSGTTSIAYETVQTADGTLPLLAPMSEVAGRLSAQVGAYHLMRTHGGRGVLM
GGVPGVKPADVVVVGAGTAGYNAARVAGGMGAMVTVLDVNINKLRLLDAEFGGQVRTRYSSAYDLEGTVKRADLVIGAVL
LPGAKAPNLISNSLVAQMKSGAVLVDISIDQGGCFEDSRPTTHDDPTFAVHDTVFYCVANMPSAVPKTSTVALTNATMPY
VLALADRGWRAACRSNHALAKGLSTHDGALLSQQVAADLGLPCTDPAGVLQQD

Sequences:

>Translated_373_residues
MRVGVPTETKTNEFRVALTPAGVAELTRRGHEVLVQSGAGEGSSIPDSEFKAAGAQLADTAEQVWADAELLLKVKEPVPA
EYDLLRRNQILFTFLHLAASRACTEALLTSGTTSIAYETVQTADGTLPLLAPMSEVAGRLSAQVGAYHLMRTHGGRGVLM
GGVPGVKPADVVVVGAGTAGYNAARVAGGMGAMVTVLDVNINKLRLLDAEFGGQVRTRYSSAYDLEGTVKRADLVIGAVL
LPGAKAPNLISNSLVAQMKSGAVLVDISIDQGGCFEDSRPTTHDDPTFAVHDTVFYCVANMPSAVPKTSTVALTNATMPY
VLALADRGWRAACRSNHALAKGLSTHDGALLSQQVAADLGLPCTDPAGVLQQD
>Mature_373_residues
MRVGVPTETKTNEFRVALTPAGVAELTRRGHEVLVQSGAGEGSSIPDSEFKAAGAQLADTAEQVWADAELLLKVKEPVPA
EYDLLRRNQILFTFLHLAASRACTEALLTSGTTSIAYETVQTADGTLPLLAPMSEVAGRLSAQVGAYHLMRTHGGRGVLM
GGVPGVKPADVVVVGAGTAGYNAARVAGGMGAMVTVLDVNINKLRLLDAEFGGQVRTRYSSAYDLEGTVKRADLVIGAVL
LPGAKAPNLISNSLVAQMKSGAVLVDISIDQGGCFEDSRPTTHDDPTFAVHDTVFYCVANMPSAVPKTSTVALTNATMPY
VLALADRGWRAACRSNHALAKGLSTHDGALLSQQVAADLGLPCTDPAGVLQQD

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=308, Percent_Identity=33.1168831168831, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI122939153, Length=308, Percent_Identity=33.1168831168831, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1787887, Length=302, Percent_Identity=32.4503311258278, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17550456, Length=354, Percent_Identity=28.8135593220339, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38905; Mature: 38905

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00836 ALADH_PNT_1 ; PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVPTETKTNEFRVALTPAGVAELTRRGHEVLVQSGAGEGSSIPDSEFKAAGAQLADT
CCCCCCCCCCCCCEEEEECCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHH
AEQVWADAELLLKVKEPVPAEYDLLRRNQILFTFLHLAASRACTEALLTSGTTSIAYETV
HHHHHCCCHHEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
QTADGTLPLLAPMSEVAGRLSAQVGAYHLMRTHGGRGVLMGGVPGVKPADVVVVGAGTAG
HCCCCCEEHHCCHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCC
YNAARVAGGMGAMVTVLDVNINKLRLLDAEFGGQVRTRYSSAYDLEGTVKRADLVIGAVL
CCHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHEEEHEE
LPGAKAPNLISNSLVAQMKSGAVLVDISIDQGGCFEDSRPTTHDDPTFAVHDTVFYCVAN
CCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHHC
MPSAVPKTSTVALTNATMPYVLALADRGWRAACRSNHALAKGLSTHDGALLSQQVAADLG
CCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHCC
LPCTDPAGVLQQD
CCCCCCCCCCCCC
>Mature Secondary Structure
MRVGVPTETKTNEFRVALTPAGVAELTRRGHEVLVQSGAGEGSSIPDSEFKAAGAQLADT
CCCCCCCCCCCCCEEEEECCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHH
AEQVWADAELLLKVKEPVPAEYDLLRRNQILFTFLHLAASRACTEALLTSGTTSIAYETV
HHHHHCCCHHEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
QTADGTLPLLAPMSEVAGRLSAQVGAYHLMRTHGGRGVLMGGVPGVKPADVVVVGAGTAG
HCCCCCEEHHCCHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCC
YNAARVAGGMGAMVTVLDVNINKLRLLDAEFGGQVRTRYSSAYDLEGTVKRADLVIGAVL
CCHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHEEEHEE
LPGAKAPNLISNSLVAQMKSGAVLVDISIDQGGCFEDSRPTTHDDPTFAVHDTVFYCVAN
CCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHHC
MPSAVPKTSTVALTNATMPYVLALADRGWRAACRSNHALAKGLSTHDGALLSQQVAADLG
CCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHCC
LPCTDPAGVLQQD
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]