Click here to switch to the map view.

The map label for this gene is thyA

Identifier: 41408967

GI number: 41408967

Start: 3196231

End: 3197031

Strand: Reverse

Name: thyA

Synonym: MAP2869c

Alternate gene names: 41408967

Gene position: 3197031-3196231 (Counterclockwise)

Preceding gene: 41408969

Following gene: 41408966

Centisome position: 66.19

GC content: 65.54

Gene sequence:

>801_bases
GTGCCCATCCCGACGCCCTACGAGGACCTTCTGCGTCTGGTGCTCGATCGGGGAACGGCCAAATCCGACCGAACCGGCAC
CGGGACGCGCAGCCTGTTCGGCCAGCAGCTGCGCTATGACCTGTCGGCCGGCTTCCCGCTGATCACCACCAAGAAGGTGC
ATCTGAAATCGGTGGTCTATGAGTTGCTGTGGTTCTTGCGCGGCGACTCCAACGTCGACTGGCTGCACCGGCACGGCGTC
ACCATTTGGGACGAATGGGCAAGCGACACAGGCGATCTCGGACCGATCTACGGCGTGCAGTGGCGGTCCTGGCCGACGCC
GTCGGGTGAGCACATCGACCAGATCAGCGCCGCGCTGGATCTGTTGCGCACCGACCCCGACTCGCGGCGCATCATCGTGT
CGGCGTGGAACGTCGGCGAGATCCCGCGGATGGCGCTGCCGCCGTGTCACGCGTTCTTCCAGTTCTACGTGGCCGACGGG
CGGCTGAGCTGCCAGCTCTACCAGCGCAGCGCCGACCTGTTTCTGGGCGTGCCGTTCAACATCGCCAGCTACGCCCTGCT
CACCCACATGATGGCCGCCCAGGCCGGGCTGTCGGTCGGCGAATTCGTGTGGACCGGTGGCGACTGCCACATCTACGACA
ACCACGTCGAGCAGGTCCGGCTGCAGCTGAGCCGCGAGCCCCGGCCCTACCCGGAACTCATTCTGGCGCATAGGGATTCG
ATCTTCGACTACACCTACGACGACGTCGTGGTGCACAACTACGATCCGCACCCGGCCATCAAGGCCCCCGTCGCGGTATG
A

Upstream 100 bases:

>100_bases
ACAGGCGCACCGGGCAGGTGCCGTCGGCGGTGCTGATGCTGTCGGTGATCTTCGGCATGGCACCCGTTCTACTCCTGGCC
GTCCGACGTAAGATCGCCGC

Downstream 100 bases:

>100_bases
CCCGTGCCGAGGTGGGCCTGGTGTGGGCCCAGTCGACGTCTGGCGTCATCGGCCGCGGCGGTGACATCCCGTGGAGCGTG
CCCGAAGACCTCACCCGGTT

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGV
TIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADG
RLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDS
IFDYTYDDVVVHNYDPHPAIKAPVAV

Sequences:

>Translated_266_residues
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGV
TIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADG
RLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDS
IFDYTYDDVVVHNYDPHPAIKAPVAV
>Mature_265_residues
PIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVT
IWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGR
LSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDSI
FDYTYDDVVVHNYDPHPAIKAPVAV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507751, Length=274, Percent_Identity=50.7299270072993, Blast_Score=275, Evalue=3e-74,
Organism=Escherichia coli, GI1789191, Length=261, Percent_Identity=67.4329501915709, Blast_Score=396, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71993377, Length=283, Percent_Identity=45.2296819787986, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6324648, Length=279, Percent_Identity=37.9928315412186, Blast_Score=186, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137556, Length=283, Percent_Identity=48.7632508833922, Blast_Score=271, Evalue=3e-73,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 30149; Mature: 30017

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00091 THYMIDYLATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVY
CCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHH
ELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALD
HHHHHHCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFN
HHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCEEEECCHH
IASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDS
HHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHCCC
IFDYTYDDVVVHNYDPHPAIKAPVAV
CCCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
PIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVY
CCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHH
ELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALD
HHHHHHCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFN
HHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCEEEECCHH
IASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDS
HHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHCCC
IFDYTYDDVVVHNYDPHPAIKAPVAV
CCCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA