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The map label for this gene is thrS

Identifier: 41408814

GI number: 41408814

Start: 3051092

End: 3053146

Strand: Reverse

Name: thrS

Synonym: MAP2716c

Alternate gene names: 41408814

Gene position: 3053146-3051092 (Counterclockwise)

Preceding gene: 41408816

Following gene: 41408813

Centisome position: 63.21

GC content: 68.76

Gene sequence:

>2055_bases
ATGACCGTCCCCGCAACCGATTCCTGTCCAGCCCCGATCCGGGTGCCGGCCGGGACCACCGCCGCCGCCGCGGTGCGCGA
CGCGGGGCTGCCGGGCCGGGGAGCGCCCGACGCCGTCGTGGTGGTGCGCGACGCCTCGGGCACGCTGCGCGACCTGAGCT
GGGTGCCCGACACCGACGCCGAGGTCGTCCCCGTCGCCGCCAACACCGACGAGGGCCGCAGCGTCATCCGGCACTCGGCG
GCACACGTGCTGGCCCAGGCCGTGCAGGAGTTGTTCCCGCAGGCCAAGCTGGGCATCGGCCCGCCCATCACCGACGGCTT
CTACTACGACTTCGACGTGCCCGAGCCGTTCACGCCGGAGGATCTGGACAAGCTGGAAAAGCGGATGCGCCAGATCGTCA
AGGAGGGCCAGCTGTTCTCCCGGCGGGTGTACGAGTCCAAGGAGCAGGCGCGCGCCGAGCTGGCCGGCGAGCCCTACAAG
CTGGAGCTGGTCGACGACAAGTCCGGTGACCCCGACATCATGGAGGTCGGCGGCGACGAGCTCACCGCCTACGACAACCT
CAATCCCCGTACCCGGGAACGGGTTTGGGGTGATTTGTGCCGCGGGCCGCACATCCCGACCACCCGCCACATCCCGGCCT
TCAAGCTGACCCGCAGCTCGGCGGCCTACTGGCGGGGCGATCAGAACAACGCCAGCCTGCAACGCATCTACGGCACCGCG
TGGGAGTCGCAGGAGGCGCTGGACGACCACCTGCGGCTGATCGAGGAAGCCCAGCGGCGCGACCACCGCAAGCTGGGCAG
CGAGCTGGACCTGTTCAGCTTCCCCGACGAAATCGGTTCGGGCTTGGCGGTTTTCCACCCCAGGGGCGGGGTGGTGCGCC
GGGAGCTGGAGGAGTATTCGCGGCGCAAGCACATCGAGGCCGGCTACGAGTTCGTCAACACCCCGCACATCACCAAGGCG
CAGCTGTTCCACACCTCCGGGCACCTGGACTGGTACGCCGACGGGATGTTCCCGCCCATGCACCTCGACGCCGAATACGA
CGACGACGGGACGGTGCGCAAGCCCGGGCAGGACTACTACCTCAAGCCGATGAACTGCCCGATGCACACGCTGATCTACC
GGTCCCGCGGCCGGTCCTACCGCGAATTGCCGTTGCGGCTCTTCGAATTCGGCACCGTGTACCGCTACGAGAAGTCCGGC
GTGGTGCACGGGCTGACCCGGGCGCGCGGGTTCACCATGGACGACTCGCACATCTTCTGCACCCGCGAGCAGCTGCACGG
CGAGCTGGCGTCGCTGCTGCGGTTCGTGCTCGAGCTGCTGGGCGACTACGGGTTGACCGACTTCTACCTGGAGCTGTCCA
CCAAGGACCCGGACAAGTTCGTCGGCTCCGACGAAGTGTGGGAGCAGGCCACCACTTCGCTGGCCGACGTGGCCGCCGAG
TCCGGCCTGGAGCTGGTGCCCGATCCGGGCGGGGCGGCGTTCTACGGCCCGAAGATCTCGGTGCAGGCCCGCGACGCGCT
GGGCCGCAGCTGGCAGATGTCGACGATTCAGGTGGACTTCAACTTCCCGGAACGATTCGAGCTGGAATACACCGCGTCCG
ACGGCACCCGGCAGCGGCCGGTGATGATCCACCGCGCGCTGTTCGGGTCGATCGAGCGGTTCTTCGGCATCCTGACCGAG
CACTACGCGGGCGCGTTCCCGGCCTGGCTGGCGCCGGTGCAGGCGGTGGGCATCCCGGTCGCCGACGAGCACGTGCCGTA
CCTGGAAAGCGTTGCCGCACAGCTGAAGTCGTACGGGGTGCGGGTGGAGGTGGACGCCAGCGACGACCGGATGGCCAAGA
AGATCGTGCACCACACCGCGCAGAAGGTGCCGTTCATGCTGCTGGCCGGCGACCGGGACGTGGCCGCGGGGGCGGTCAGC
TTCCGGTTCGGCGACCGCACCCAGATCAACGGCGTGCCCCGCGACAGCGCGGTCGACGCGATCGTCAAGTGGATCGCCGA
CCGCGAGAATTCCGTCCCCAGCGCCGAACTCGTGAAAGTGTCCAGTGGTGAGTGA

Upstream 100 bases:

>100_bases
ATTGTGCCGGACCGGACGGTGGCTACTCGACGGCCCTGCTCGCCGTTCGGCCGCCCCGATAGCATGGTCGTCGACCCTGC
GAGCCTTGGAGACCGCCACA

Downstream 100 bases:

>100_bases
TCCCGAACAGGCCGAGCAGGACGCCGAGCGCACCATCCTGGACCGCGGTGTCGGCGAGCAGGACCACCTGCAGCGGTTGT
GGACGCCGTACCGGATGACC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MTVPATDSCPAPIRVPAGTTAAAAVRDAGLPGRGAPDAVVVVRDASGTLRDLSWVPDTDAEVVPVAANTDEGRSVIRHSA
AHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPEDLDKLEKRMRQIVKEGQLFSRRVYESKEQARAELAGEPYK
LELVDDKSGDPDIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTRHIPAFKLTRSSAAYWRGDQNNASLQRIYGTA
WESQEALDDHLRLIEEAQRRDHRKLGSELDLFSFPDEIGSGLAVFHPRGGVVRRELEEYSRRKHIEAGYEFVNTPHITKA
QLFHTSGHLDWYADGMFPPMHLDAEYDDDGTVRKPGQDYYLKPMNCPMHTLIYRSRGRSYRELPLRLFEFGTVYRYEKSG
VVHGLTRARGFTMDDSHIFCTREQLHGELASLLRFVLELLGDYGLTDFYLELSTKDPDKFVGSDEVWEQATTSLADVAAE
SGLELVPDPGGAAFYGPKISVQARDALGRSWQMSTIQVDFNFPERFELEYTASDGTRQRPVMIHRALFGSIERFFGILTE
HYAGAFPAWLAPVQAVGIPVADEHVPYLESVAAQLKSYGVRVEVDASDDRMAKKIVHHTAQKVPFMLLAGDRDVAAGAVS
FRFGDRTQINGVPRDSAVDAIVKWIADRENSVPSAELVKVSSGE

Sequences:

>Translated_684_residues
MTVPATDSCPAPIRVPAGTTAAAAVRDAGLPGRGAPDAVVVVRDASGTLRDLSWVPDTDAEVVPVAANTDEGRSVIRHSA
AHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPEDLDKLEKRMRQIVKEGQLFSRRVYESKEQARAELAGEPYK
LELVDDKSGDPDIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTRHIPAFKLTRSSAAYWRGDQNNASLQRIYGTA
WESQEALDDHLRLIEEAQRRDHRKLGSELDLFSFPDEIGSGLAVFHPRGGVVRRELEEYSRRKHIEAGYEFVNTPHITKA
QLFHTSGHLDWYADGMFPPMHLDAEYDDDGTVRKPGQDYYLKPMNCPMHTLIYRSRGRSYRELPLRLFEFGTVYRYEKSG
VVHGLTRARGFTMDDSHIFCTREQLHGELASLLRFVLELLGDYGLTDFYLELSTKDPDKFVGSDEVWEQATTSLADVAAE
SGLELVPDPGGAAFYGPKISVQARDALGRSWQMSTIQVDFNFPERFELEYTASDGTRQRPVMIHRALFGSIERFFGILTE
HYAGAFPAWLAPVQAVGIPVADEHVPYLESVAAQLKSYGVRVEVDASDDRMAKKIVHHTAQKVPFMLLAGDRDVAAGAVS
FRFGDRTQINGVPRDSAVDAIVKWIADRENSVPSAELVKVSSGE
>Mature_683_residues
TVPATDSCPAPIRVPAGTTAAAAVRDAGLPGRGAPDAVVVVRDASGTLRDLSWVPDTDAEVVPVAANTDEGRSVIRHSAA
HVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPEDLDKLEKRMRQIVKEGQLFSRRVYESKEQARAELAGEPYKL
ELVDDKSGDPDIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTRHIPAFKLTRSSAAYWRGDQNNASLQRIYGTAW
ESQEALDDHLRLIEEAQRRDHRKLGSELDLFSFPDEIGSGLAVFHPRGGVVRRELEEYSRRKHIEAGYEFVNTPHITKAQ
LFHTSGHLDWYADGMFPPMHLDAEYDDDGTVRKPGQDYYLKPMNCPMHTLIYRSRGRSYRELPLRLFEFGTVYRYEKSGV
VHGLTRARGFTMDDSHIFCTREQLHGELASLLRFVLELLGDYGLTDFYLELSTKDPDKFVGSDEVWEQATTSLADVAAES
GLELVPDPGGAAFYGPKISVQARDALGRSWQMSTIQVDFNFPERFELEYTASDGTRQRPVMIHRALFGSIERFFGILTEH
YAGAFPAWLAPVQAVGIPVADEHVPYLESVAAQLKSYGVRVEVDASDDRMAKKIVHHTAQKVPFMLLAGDRDVAAGAVSF
RFGDRTQINGVPRDSAVDAIVKWIADRENSVPSAELVKVSSGE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=648, Percent_Identity=34.7222222222222, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI38570111, Length=625, Percent_Identity=34.72, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI20070344, Length=645, Percent_Identity=35.1937984496124, Blast_Score=338, Evalue=1e-92,
Organism=Escherichia coli, GI1788013, Length=614, Percent_Identity=40.7166123778502, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71984192, Length=687, Percent_Identity=34.2066957787482, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71984184, Length=687, Percent_Identity=34.4978165938865, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322112, Length=609, Percent_Identity=37.7668308702791, Blast_Score=399, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=35, Blast_Score=247, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24583842, Length=616, Percent_Identity=37.5, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI28574141, Length=616, Percent_Identity=37.5, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24583839, Length=609, Percent_Identity=37.6026272577997, Blast_Score=400, Evalue=1e-111,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 76238; Mature: 76107

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPATDSCPAPIRVPAGTTAAAAVRDAGLPGRGAPDAVVVVRDASGTLRDLSWVPDTDA
CCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCC
EVVPVAANTDEGRSVIRHSAAHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPE
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCCCCCHH
DLDKLEKRMRQIVKEGQLFSRRVYESKEQARAELAGEPYKLELVDDKSGDPDIMEVGGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEECCCCC
LTAYDNLNPRTRERVWGDLCRGPHIPTTRHIPAFKLTRSSAAYWRGDQNNASLQRIYGTA
EEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCCCCHHHHHHCCC
WESQEALDDHLRLIEEAQRRDHRKLGSELDLFSFPDEIGSGLAVFHPRGGVVRRELEEYS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCCCCHHHHHHHHHH
RRKHIEAGYEFVNTPHITKAQLFHTSGHLDWYADGMFPPMHLDAEYDDDGTVRKPGQDYY
HHHHHHHCHHHCCCCCCCCEEEEECCCCCEEEECCCCCCEECCCCCCCCCCCCCCCCCCE
LKPMNCPMHTLIYRSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTMDDSHIFC
EECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCCCCEEEE
TREQLHGELASLLRFVLELLGDYGLTDFYLELSTKDPDKFVGSDEVWEQATTSLADVAAE
EHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHH
SGLELVPDPGGAAFYGPKISVQARDALGRSWQMSTIQVDFNFPERFELEYTASDGTRQRP
CCCEECCCCCCCEEECCEEEEEEHHHCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCH
VMIHRALFGSIERFFGILTEHYAGAFPAWLAPVQAVGIPVADEHVPYLESVAAQLKSYGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
RVEVDASDDRMAKKIVHHTAQKVPFMLLAGDRDVAAGAVSFRFGDRTQINGVPRDSAVDA
EEEECCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
IVKWIADRENSVPSAELVKVSSGE
HHHHHHHCCCCCCCCCEEEECCCC
>Mature Secondary Structure 
TVPATDSCPAPIRVPAGTTAAAAVRDAGLPGRGAPDAVVVVRDASGTLRDLSWVPDTDA
CCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCC
EVVPVAANTDEGRSVIRHSAAHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPE
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCCCCCHH
DLDKLEKRMRQIVKEGQLFSRRVYESKEQARAELAGEPYKLELVDDKSGDPDIMEVGGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEECCCCC
LTAYDNLNPRTRERVWGDLCRGPHIPTTRHIPAFKLTRSSAAYWRGDQNNASLQRIYGTA
EEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCCCCHHHHHHCCC
WESQEALDDHLRLIEEAQRRDHRKLGSELDLFSFPDEIGSGLAVFHPRGGVVRRELEEYS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCCCCHHHHHHHHHH
RRKHIEAGYEFVNTPHITKAQLFHTSGHLDWYADGMFPPMHLDAEYDDDGTVRKPGQDYY
HHHHHHHCHHHCCCCCCCCEEEEECCCCCEEEECCCCCCEECCCCCCCCCCCCCCCCCCE
LKPMNCPMHTLIYRSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTMDDSHIFC
EECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCCCCEEEE
TREQLHGELASLLRFVLELLGDYGLTDFYLELSTKDPDKFVGSDEVWEQATTSLADVAAE
EHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHH
SGLELVPDPGGAAFYGPKISVQARDALGRSWQMSTIQVDFNFPERFELEYTASDGTRQRP
CCCEECCCCCCCEEECCEEEEEEHHHCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCH
VMIHRALFGSIERFFGILTEHYAGAFPAWLAPVQAVGIPVADEHVPYLESVAAQLKSYGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
RVEVDASDDRMAKKIVHHTAQKVPFMLLAGDRDVAAGAVSFRFGDRTQINGVPRDSAVDA
EEEECCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
IVKWIADRENSVPSAELVKVSSGE
HHHHHHHCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA