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The map label for this gene is fumC

Identifier: 41408791

GI number: 41408791

Start: 3028057

End: 3029469

Strand: Direct

Name: fumC

Synonym: MAP2693

Alternate gene names: 41408791

Gene position: 3028057-3029469 (Clockwise)

Preceding gene: 41408790

Following gene: 41408792

Centisome position: 62.7

GC content: 68.51

Gene sequence:

>1413_bases
ATGGCCACTGACGACGGCGACACCGACTACCGCATCGAGCGCGACACCATGGGCGAGGTCCGGGTACCCGCAAAAGCGTT
GTGGCGCGCGCAAACCCAGCGCGCGGTCGAGAACTTCCCGATCTCGGGCCGGGGCCTGGAACGCACCCAGATCCGCGCCC
TGGGCCTGCTGAAGGGCGCCTGCGCGCAGGTCAACAAGGATCTGGGGCTGCTGGCGCCGGAGAAGGCCGACGCGATCATC
GCCGCGGCCGCCGAGATCGCCGACGGTCGCCACGACGACCAGTTTCCCATCGACGTCTTCCAGACCGGCTCGGGCACCAG
CTCGAACATGAACACCAACGAGGTGATCGCGTCCATCGCGGCCGCCAACGGGGTGACCGTGCATCCTAACGACGACGTCA
ACATGTCGCAGTCGTCGAACGACACCTTCCCCACCGCAACCCACATCGCGGCCACGGAAGCCGCAGTGCGCCATCTGATT
CCGGCGCTGCAGGTGCTGCACGACGCCCTGGCGAGCAAGGCCCGCGAGTGGCACACCGTGGTCAAGTCGGGCCGCACCCA
CCTGATGGACGCCGTGCCGGTGACACTCGGCCAGGAGTTCAGCGGCTACGCCCGCCAGATCGAGGCCGGCATCGAACGGG
TGCGGGCCACGCTGCCCCGGCTGGGTGAGCTGGCGATCGGCGGGACCGCGGTGGGCACCGGCCTCAACGCTCCCGACGGC
TTCGGCGCCAAGGTGGTCGAGACGCTGATCGCCTCCACCGGATTGAGCGAATTGCGCACGGCGACAAACTCGTTCGAGGC
CCAGGCGGCGCGCGACGGGCTGGTCGAGGCCTCCGGCGCGCTGCGCACCATCGCGGTGTCGCTGACCAAGATCGCCAACG
ACATCCGCTGGATGGGCTCGGGGCCGCTGACCGGCCTGGCCGAGATCGCCCTTCCCGATCTGCAGCCGGGCAGCTCGATC
ATGCCGGGCAAGGTTAATCCGGTTATCCCCGAAGCGGTTACGCAGGTCGCCGCGCAGGTGATCGGCAACGACGCGGCGGT
GGCCGTCGGCGGCTTGTCGGGCGCCTTCGAGCTCAACGTGTACATCCCGATGATGGCCCGCAACATCCTGGAGTCGTTCA
AGCTGCTGACCAACGTGTCGAGGCTGTTCGCCGAGCGCTGCATCAGCGGGCTGAGCGCCAACGTGGAGCACCTGCGCGAG
CTCGCCGAATCCTCACCGTCCATCGTGACGCCGCTGAACTCGGCGATCGGCTACGAGGAGGCGGCGGCGGTGGCCAAGCA
GGCGCTCAAGGAGCGCAAGACGATTCGGCAGACCGTCATCGACCGCGGGCTGATCGGCGACAAGCTGTCGCTCGAGGAGC
TCGACCGCCGGCTCGACGTGCTGGCCATGGCCAAGGTCAAGCCGCAGGACTGA

Upstream 100 bases:

>100_bases
GTCGAAGCTCAACGAGTACTCCGCCATCGACTTCACCGGCGACAGCTCTGCCGCCTATCCCCTGCCCTGAGAACCGACCC
GAGAACGAGGAAGCCACTGT

Downstream 100 bases:

>100_bases
GCCGACCGTTCGGTGACGGCGGTTGATGACAGTAAGGATGGTTTTTCGATGACGGCTCCTCCCGGCGGTATCTACGGCCC
GGGGTCCTACGGAAGCAATC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MATDDGDTDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAPEKADAII
AAAAEIADGRHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAANGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLI
PALQVLHDALASKAREWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDG
FGAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIALPDLQPGSSI
MPGKVNPVIPEAVTQVAAQVIGNDAAVAVGGLSGAFELNVYIPMMARNILESFKLLTNVSRLFAERCISGLSANVEHLRE
LAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD

Sequences:

>Translated_470_residues
MATDDGDTDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAPEKADAII
AAAAEIADGRHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAANGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLI
PALQVLHDALASKAREWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDG
FGAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIALPDLQPGSSI
MPGKVNPVIPEAVTQVAAQVIGNDAAVAVGGLSGAFELNVYIPMMARNILESFKLLTNVSRLFAERCISGLSANVEHLRE
LAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD
>Mature_469_residues
ATDDGDTDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAPEKADAIIA
AAAEIADGRHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAANGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLIP
ALQVLHDALASKAREWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDGF
GAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIALPDLQPGSSIM
PGKVNPVIPEAVTQVAAQVIGNDAAVAVGGLSGAFELNVYIPMMARNILESFKLLTNVSRLFAERCISGLSANVEHLREL
AESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=470, Percent_Identity=51.7021276595745, Blast_Score=442, Evalue=1e-124,
Organism=Escherichia coli, GI1787896, Length=428, Percent_Identity=51.1682242990654, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI87082375, Length=445, Percent_Identity=40.8988764044944, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17553882, Length=448, Percent_Identity=51.7857142857143, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI32565146, Length=314, Percent_Identity=53.1847133757962, Blast_Score=323, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324993, Length=451, Percent_Identity=50.3325942350333, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24640179, Length=450, Percent_Identity=49.7777777777778, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24640177, Length=450, Percent_Identity=49.7777777777778, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI78710009, Length=451, Percent_Identity=49.8891352549889, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24662684, Length=447, Percent_Identity=48.0984340044743, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24583245, Length=447, Percent_Identity=42.0581655480984, Blast_Score=344, Evalue=9e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49697; Mature: 49566

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDDGDTDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGA
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
CAQVNKDLGLLAPEKADAIIAAAAEIADGRHDDQFPIDVFQTGSGTSSNMNTNEVIASIA
HHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
AANGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLIPALQVLHDALASKAREWHTV
HCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDG
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCC
FGAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGS
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCC
GPLTGLAEIALPDLQPGSSIMPGKVNPVIPEAVTQVAAQVIGNDAAVAVGGLSGAFELNV
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
YIPMMARNILESFKLLTNVSRLFAERCISGLSANVEHLRELAESSPSIVTPLNSAIGYEE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCHHHHCCHHH
AAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ATDDGDTDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGA
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
CAQVNKDLGLLAPEKADAIIAAAAEIADGRHDDQFPIDVFQTGSGTSSNMNTNEVIASIA
HHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
AANGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLIPALQVLHDALASKAREWHTV
HCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDG
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCC
FGAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGS
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCC
GPLTGLAEIALPDLQPGSSIMPGKVNPVIPEAVTQVAAQVIGNDAAVAVGGLSGAFELNV
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
YIPMMARNILESFKLLTNVSRLFAERCISGLSANVEHLRELAESSPSIVTPLNSAIGYEE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCHHHHCCHHH
AAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]