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The map label for this gene is fadA6_3

Identifier: 41408744

GI number: 41408744

Start: 2979308

End: 2980456

Strand: Reverse

Name: fadA6_3

Synonym: MAP2646c

Alternate gene names: 41408744

Gene position: 2980456-2979308 (Counterclockwise)

Preceding gene: 41408745

Following gene: 41408743

Centisome position: 61.71

GC content: 67.8

Gene sequence:

>1149_bases
ATGGCTGAAGCCGTCATCGTCGAGGCAGTGCGCTCACCGATCGGCAAGCGCAACGGCGGGTTGTCGGGGGTGCATCCGGC
CGAGCTTTCCGCGCAGGTGCTCAACGGCCTGGTCGACAAGGCCGGCGTCGACCCGGGCATCGTCGACGACGTCATCTGGG
GCTGCGTCATGCAGGCCGGCGAACAGGCCCTCGACATCGGCCGCACCGCGCTGCTGACCGCCGGCTGGCCCGAGACCGTG
CCGGGCGTGACCGTCGACCGGCAGTGCGGGTCGAGCCAGCAATCCATCCACTTCGCGGCGGCGGGCGTGATCGCCGGGCA
CTACGACGTCGTCGTCGCCGGCGGCGTCGAGTCGATGTCGCGCACCCCGATGGGCGCGTCGCTGGCCAACGGCGGGCGGC
CCTACCCCCAGGCCTTCCTGGACCGCTACCAGGGCCAGATCCCGAACCAGGGTATCGGTGCGGAGATGATCGCCGAGAAG
TGGGGCTTCGACCGCACCGCGCTCGACGAATTCTCCCTGGCGTCGCACGAAAAGGCCGCGGCCGCACAGGATTCCGGCGC
ATTCGACGACCAGATCGTGGGCATCAAGGACCAGGACGGCAATGTCGTCTTGAAGGACGAGGGCATCCGGCGCGGCACCC
CGATGGAGAAGATGGCCTCGCTGAAGCCGGCGTTCAAGGAGGACGGCGTGATTCACGCCGGCAACTCCTCGCAGATCTCC
GACGGTTCGGCGGCCATCCTCTTCATGTCCGCGGAGAAGGCAAAGGAGTTGGGGCTCAAGCCAATCGCGAAGGTGCACAC
CGCGACGCTGGCCGGGGCCGACCCGGTGATCATGCTGACCGCGCCCATCCCGGCGACGCAGAAGGTGCTCAAGAAGTCCG
GCCTGTCCATCGACGACATCGGCGTCTACGAGGTCAACGAGGCCTTCGCTCCGGTCCCGATGGCGTGGCTCAAGGACATC
GGCGCCGACGAGAAGAAGCTCAACCCCAACGGCGGGGCGATCGCGTTGGGCCACCCGCTCGGCGGCTCGGGTGCCCGGAT
CATGACCACGCTGCTGTATCACATGCGGGACAAGGGAATTCGTTACGGCCTGCAGACCATGTGCGAGGGCGGCGGGCAGG
CCAACGCCACCATCGTGGAACTGTTGTGA

Upstream 100 bases:

>100_bases
GGCGCCGAGCGACCCCGCCCTCCGACCTGCCAACCCCTTGGTTGACAATCGAGGCAAGACTCACTCTTCTCGAAGTCCAC
GTGTCAAAGGAGACAAGACC

Downstream 100 bases:

>100_bases
CCGACGCGCCGGGGGCCCTGGCCGAACGCCGGGGCAACGTGATGGTGATAACCATCAACCGGCCGGAAGCCCGCAACGCG
ATCAACGCCGCGGTCAGCAT

Product: FadA6_3

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAEAVIVEAVRSPIGKRNGGLSGVHPAELSAQVLNGLVDKAGVDPGIVDDVIWGCVMQAGEQALDIGRTALLTAGWPETV
PGVTVDRQCGSSQQSIHFAAAGVIAGHYDVVVAGGVESMSRTPMGASLANGGRPYPQAFLDRYQGQIPNQGIGAEMIAEK
WGFDRTALDEFSLASHEKAAAAQDSGAFDDQIVGIKDQDGNVVLKDEGIRRGTPMEKMASLKPAFKEDGVIHAGNSSQIS
DGSAAILFMSAEKAKELGLKPIAKVHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDIGVYEVNEAFAPVPMAWLKDI
GADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGIRYGLQTMCEGGGQANATIVELL

Sequences:

>Translated_382_residues
MAEAVIVEAVRSPIGKRNGGLSGVHPAELSAQVLNGLVDKAGVDPGIVDDVIWGCVMQAGEQALDIGRTALLTAGWPETV
PGVTVDRQCGSSQQSIHFAAAGVIAGHYDVVVAGGVESMSRTPMGASLANGGRPYPQAFLDRYQGQIPNQGIGAEMIAEK
WGFDRTALDEFSLASHEKAAAAQDSGAFDDQIVGIKDQDGNVVLKDEGIRRGTPMEKMASLKPAFKEDGVIHAGNSSQIS
DGSAAILFMSAEKAKELGLKPIAKVHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDIGVYEVNEAFAPVPMAWLKDI
GADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGIRYGLQTMCEGGGQANATIVELL
>Mature_381_residues
AEAVIVEAVRSPIGKRNGGLSGVHPAELSAQVLNGLVDKAGVDPGIVDDVIWGCVMQAGEQALDIGRTALLTAGWPETVP
GVTVDRQCGSSQQSIHFAAAGVIAGHYDVVVAGGVESMSRTPMGASLANGGRPYPQAFLDRYQGQIPNQGIGAEMIAEKW
GFDRTALDEFSLASHEKAAAAQDSGAFDDQIVGIKDQDGNVVLKDEGIRRGTPMEKMASLKPAFKEDGVIHAGNSSQISD
GSAAILFMSAEKAKELGLKPIAKVHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDIGVYEVNEAFAPVPMAWLKDIG
ADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGIRYGLQTMCEGGGQANATIVELL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=39.5939086294416, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=35.9173126614987, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=36.9230769230769, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=36.4321608040201, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=33.0188679245283, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.5629820051414, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI48994986, Length=391, Percent_Identity=44.7570332480818, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=40.3508771929825, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=40.8629441624365, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=37.4045801526718, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=27.7641277641278, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=37.6923076923077, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=33.248730964467, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=32.3076923076923, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=28.4037558685446, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=28.1329923273657, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=387, Percent_Identity=35.4005167958656, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=35.1620947630923, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=38.7755102040816, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=35.929648241206, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=35.4755784061697, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17137578, Length=420, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39800; Mature: 39669

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAVIVEAVRSPIGKRNGGLSGVHPAELSAQVLNGLVDKAGVDPGIVDDVIWGCVMQAG
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
EQALDIGRTALLTAGWPETVPGVTVDRQCGSSQQSIHFAAAGVIAGHYDVVVAGGVESMS
HHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCCCEEEEHHHHEECCEEEEEECCHHHHH
RTPMGASLANGGRPYPQAFLDRYQGQIPNQGIGAEMIAEKWGFDRTALDEFSLASHEKAA
CCCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHH
AAQDSGAFDDQIVGIKDQDGNVVLKDEGIRRGTPMEKMASLKPAFKEDGVIHAGNSSQIS
HCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHHHCCCCHHCCCEEECCCCCCCC
DGSAAILFMSAEKAKELGLKPIAKVHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDI
CCCEEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCC
GVYEVNEAFAPVPMAWLKDIGADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGI
CEEECCCCCCCCCHHHHHHCCCCCCEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
RYGLQTMCEGGGQANATIVELL
HHHHHHHHCCCCCCCCEEEEEC
>Mature Secondary Structure 
AEAVIVEAVRSPIGKRNGGLSGVHPAELSAQVLNGLVDKAGVDPGIVDDVIWGCVMQAG
CHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
EQALDIGRTALLTAGWPETVPGVTVDRQCGSSQQSIHFAAAGVIAGHYDVVVAGGVESMS
HHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCCCEEEEHHHHEECCEEEEEECCHHHHH
RTPMGASLANGGRPYPQAFLDRYQGQIPNQGIGAEMIAEKWGFDRTALDEFSLASHEKAA
CCCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHH
AAQDSGAFDDQIVGIKDQDGNVVLKDEGIRRGTPMEKMASLKPAFKEDGVIHAGNSSQIS
HCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHHHCCCCHHCCCEEECCCCCCCC
DGSAAILFMSAEKAKELGLKPIAKVHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDI
CCCEEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCC
GVYEVNEAFAPVPMAWLKDIGADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGI
CEEECCCCCCCCCHHHHHHCCCCCCEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
RYGLQTMCEGGGQANATIVELL
HHHHHHHHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA