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The map label for this gene is mutT2

Identifier: 41408719

GI number: 41408719

Start: 2958640

End: 2959032

Strand: Reverse

Name: mutT2

Synonym: MAP2621c

Alternate gene names: 41408719

Gene position: 2959032-2958640 (Counterclockwise)

Preceding gene: 41408722

Following gene: 41408718

Centisome position: 61.27

GC content: 76.34

Gene sequence:

>393_bases
ATGCCGACCCAGATCGTGGTCGCCGGGGCCCTCATCCGCGGCTCGCGCCTGTTGGTGGCCCAGCGCGCCCGCCCGCCGGA
GTTGGCCGGGCGCTGGGAACTGCCCGGCGGCAAGGTCGCGCCCGGCGAGACCGAGCGCGACGCGCTGGCCCGCGAGTTGG
CCGAGGAGCTGGATCTGCGGGCCGGCGACATCGCGGTGGGCGACCGGCTCGGCGGGGACATCGCGGTCGACGGTGGGATG
ACGCTGCGCGCCTACCGGGTGCGGTTGCTGCGCGGCCGACCGGACGCCCGCGACCATCGGGCCCTGCGCTGGATCACCGC
GGCGCAGCTGCACGACCTCGACTGGGTGCCGGCCGATCGCGGCTGGCTGGGCGACCTGGCGCGGGTCCTTTAA

Upstream 100 bases:

>100_bases
TCCGCGAAACCGTAAGAGAGTTGTTGTGCGGCAAGGGAATTGGGTGCGCTGCGCGGGTAAGGCGGGCGGCGTGCGCGCCG
ACGGTATACCGTCACTGGCC

Downstream 100 bases:

>100_bases
CCAAGTCCACAGACTTCCGGCAGCTGACGCACAGCCGTGTTGCAGGTCGTCGCAGTGAACTGAATAGAACAATATGACTT
GTAATAACGACGCCACACGA

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MPTQIVVAGALIRGSRLLVAQRARPPELAGRWELPGGKVAPGETERDALARELAEELDLRAGDIAVGDRLGGDIAVDGGM
TLRAYRVRLLRGRPDARDHRALRWITAAQLHDLDWVPADRGWLGDLARVL

Sequences:

>Translated_130_residues
MPTQIVVAGALIRGSRLLVAQRARPPELAGRWELPGGKVAPGETERDALARELAEELDLRAGDIAVGDRLGGDIAVDGGM
TLRAYRVRLLRGRPDARDHRALRWITAAQLHDLDWVPADRGWLGDLARVL
>Mature_129_residues
PTQIVVAGALIRGSRLLVAQRARPPELAGRWELPGGKVAPGETERDALARELAEELDLRAGDIAVGDRLGGDIAVDGGMT
LRAYRVRLLRGRPDARDHRALRWITAAQLHDLDWVPADRGWLGDLARVL

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=116, Percent_Identity=37.0689655172414, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 14214; Mature: 14082

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTQIVVAGALIRGSRLLVAQRARPPELAGRWELPGGKVAPGETERDALARELAEELDLR
CCCEEEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
AGDIAVGDRLGGDIAVDGGMTLRAYRVRLLRGRPDARDHRALRWITAAQLHDLDWVPADR
CCCEEECCCCCCCEEECCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GWLGDLARVL
CHHHHHHHHC
>Mature Secondary Structure 
PTQIVVAGALIRGSRLLVAQRARPPELAGRWELPGGKVAPGETERDALARELAEELDLR
CCEEEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
AGDIAVGDRLGGDIAVDGGMTLRAYRVRLLRGRPDARDHRALRWITAAQLHDLDWVPADR
CCCEEECCCCCCCEEECCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GWLGDLARVL
CHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]