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The map label for this gene is pks2 [H]

Identifier: 41408702

GI number: 41408702

Start: 2933453

End: 2935744

Strand: Reverse

Name: pks2 [H]

Synonym: MAP2604c

Alternate gene names: 41408702

Gene position: 2935744-2933453 (Counterclockwise)

Preceding gene: 41408703

Following gene: 41408701

Centisome position: 60.78

GC content: 71.25

Gene sequence:

>2292_bases
TTGCCTGCCGCAACTGCCACACCCGTTGCCGTCATCGGAATGGCCTGCCGGCTTCCCGGCGGGATCGATTCCCCGCAACG
CCTCTGGGAGGCATTGCTGCGCGGTGACGACCTGGTCGGCGAGATTCCGGCCGACCGGTGGGACGCGGACCTCTACTACG
ACCCCGAGCCCGGCGTGCCCGGCCGTTCGGTCACCCGGTGGGGGGCGTTCCTCGACGATGTCGGGGGCTTCGACTGCGAC
TTCTTCGGGATGACCGAGCGCGAGGCCACCGCGGTCGACCCGCAGCACCGGCTGCTGCTGGAAACGTCGTGGGACGCCAT
CGAACACGCGGGCCTGGACCCCGCGTCGCTGGCCGGATCGCAGACCGGCGTGTTCGTCGGGCTGACGCACGGCGACTACG
AACTGCTGTCCGCCGACTGCGGCGCGGCCGAGGGCCCGTACGGATTCACCGGCACCTCCAACAGCTTCGCCTCCGGGCGG
GTCGCCTACACGCTGGGCCTGCACGGGCCGGCGGTCACGGTGGACACGGCGTGCTCGTCCGGGTTGATGGCCGTGCACCA
GGCCTGCGGCAGCCTGGGCGGCGGCGAAAGCGACCTCACCCTGGCCGGTGGGGTGGTGGTGACCCTGGAACCACGCAAGT
CGGTGTCGGGTTCGCTGCAGGGCATGTTGTCCCCGACCGGCCGCTGCCACGCCTTCGACGTGAACGCCGACGGCTTCGTC
TCCGGTGAGGGATGCGTGATGCTGTTGCTCAAGCGGCTCGACGACGCCCGGCGCGACGGCGACCGCATCCTGGCGGTGCT
GCGGGGCACCGCCGCCAACCAGGACGGCCGCACCGTCAACATCGCCGCGCCCTCGGAAACGGCTCAGGTCGCCGTCTACC
GGAAGGCGTTGCAGGCGGCGGACATCGACGCCACCACGGTCGGCCTCGTCGAGGCGCACGGCACCGGCACCCCGGTCGGC
GATCCGATCGAATACTCCAGCCTGGCCGCGGTGTACGGAACCGACGGGCCGTGTGTGCTGGGGTCGGTCAAGACCAACTT
CGGCCACTTGCAGTCGGCGTCCGGGCCGCTGGGGATGATGAAGGCGATCCTCGCGCTGCAGCACGGCGTGGTGCCACGGA
ATCTGCACTTCACCCGGTTGCCCGACGAGATGGCCCGGATCAACACGGAACTTTTTGTGCCGCAGGAGAATACGCAGTGG
CCCAGCAACGGCCATCATCCGAGACGCGCCGCGGTGTCGTCGTACGGCATGTCCGGCACCAACGTGCACGCCATCCTGGA
GGAGGCCCCTGCCCCGGAGGCGGCGGGTTCGGCGGCGCCCGAAGCCGTTGGGCCACTGCTGTTTCCGTTGTCGTCCACCT
CCGCCGAGCAGCTGCGGGTCACCGCCGCCCGGCTCGCGGCGTGGCTCGACGAGCAGGCCGGCGACGCGCTTGCCGGCCCA
ACGGGCTGGGGCCTAAGGGATCTGGGCTACACGCTGACGCGCCGCCGTGCGCACCGCCCGGTGCGCACGGTGGTGTCGGC
CAGCGGTTTCGCCGAATTGCGCACCGAACTGCGCGCGGTCGCCGACGGCGACATCCCGTATCAGCCCGCCGTGGGACAAG
GCGACCGCGGGCCGGTCTGGGTGTTCTCCGGGCAGGGCTCGCAATGGTCGCAGATGGGCGCCGAACTGCTGGACAAGGAG
CCGGTGTTCGCCGCGACGATCGCCGCCGTCGAGCCGTTGATCGCCGCCGAATCGGGGTTCTCGGTCACCCGGGCGCTGTC
GGCCCCGCCGGCCGTGACCGGCATCGACAAAGTCCAGCCGACGATCTTCGCGATGCAGGTCGCCCTGGCCGAGACGATGA
AGTCCTACGGGGTGCGTCCCGGCGCGGTGATCGGGCATTCGCTCGGCGAGTGCGCGGCCGCGGTGGTCGCCGGCGGGCTC
TCGCTGGGCGACGGCGTGAAGGTCATCTGCCGCCGCTCCCGGCTGATGGCGCGGATCGCCGGCCGCGGCGCCATGGCATC
GGTGGAACTGCCCGGCCAGCAAGTGCTTTCGGAACTGTCCATCCGCGGCATCTCCGGCGTGGCCCTCTCGGTGGTCGCCT
CACCAACCTCGACCGTCGTCGGCGGGGGCGCCGAGGCGATCCGCGAGCTGGTCGCGGCCTGGCAGCAGCAGGACGTGATG
GCGCGCGAGGTCGCGGTGGACGTCGCCTCGCACTCGCCGCAGGTGGAGTCGATCCTCGACGAGCTGGTGGAGGTGCTCGC
CGAGCTGGAGCCGACGGCACCCGAGGTGCCGTACTACTCGGCGACCCTGTGA

Upstream 100 bases:

>100_bases
TTGACATCTGCACAATAACTGCTGTACGTACTTCCTCCGGCACGCGCGAAGAGACGGTGCGCGCCGGCCAGGGGAGTGGG
CGAGAACAGGGGACTGCACA

Downstream 100 bases:

>100_bases
AATCCGCGCGAGCGACCGTCGTTCGGCGGCGACTACTGGGCCGAAAACCTGCGCCACACCGTGCGATTCGCGGCGGCCGT
GCAGGCCGCGCTCAAGGACG

Product: hypothetical protein

Products: [acyl carrier protein]; acetoacetyl-ACP; CO2; [acyl carrier protein]; beta-ketoacyl-ACP [C]

Alternate protein names: Polyketide synthase pks2 [H]

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MPAATATPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDADLYYDPEPGVPGRSVTRWGAFLDDVGGFDCD
FFGMTEREATAVDPQHRLLLETSWDAIEHAGLDPASLAGSQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGR
VAYTLGLHGPAVTVDTACSSGLMAVHQACGSLGGGESDLTLAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDVNADGFV
SGEGCVMLLLKRLDDARRDGDRILAVLRGTAANQDGRTVNIAAPSETAQVAVYRKALQAADIDATTVGLVEAHGTGTPVG
DPIEYSSLAAVYGTDGPCVLGSVKTNFGHLQSASGPLGMMKAILALQHGVVPRNLHFTRLPDEMARINTELFVPQENTQW
PSNGHHPRRAAVSSYGMSGTNVHAILEEAPAPEAAGSAAPEAVGPLLFPLSSTSAEQLRVTAARLAAWLDEQAGDALAGP
TGWGLRDLGYTLTRRRAHRPVRTVVSASGFAELRTELRAVADGDIPYQPAVGQGDRGPVWVFSGQGSQWSQMGAELLDKE
PVFAATIAAVEPLIAAESGFSVTRALSAPPAVTGIDKVQPTIFAMQVALAETMKSYGVRPGAVIGHSLGECAAAVVAGGL
SLGDGVKVICRRSRLMARIAGRGAMASVELPGQQVLSELSIRGISGVALSVVASPTSTVVGGGAEAIRELVAAWQQQDVM
AREVAVDVASHSPQVESILDELVEVLAELEPTAPEVPYYSATL

Sequences:

>Translated_763_residues
MPAATATPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDADLYYDPEPGVPGRSVTRWGAFLDDVGGFDCD
FFGMTEREATAVDPQHRLLLETSWDAIEHAGLDPASLAGSQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGR
VAYTLGLHGPAVTVDTACSSGLMAVHQACGSLGGGESDLTLAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDVNADGFV
SGEGCVMLLLKRLDDARRDGDRILAVLRGTAANQDGRTVNIAAPSETAQVAVYRKALQAADIDATTVGLVEAHGTGTPVG
DPIEYSSLAAVYGTDGPCVLGSVKTNFGHLQSASGPLGMMKAILALQHGVVPRNLHFTRLPDEMARINTELFVPQENTQW
PSNGHHPRRAAVSSYGMSGTNVHAILEEAPAPEAAGSAAPEAVGPLLFPLSSTSAEQLRVTAARLAAWLDEQAGDALAGP
TGWGLRDLGYTLTRRRAHRPVRTVVSASGFAELRTELRAVADGDIPYQPAVGQGDRGPVWVFSGQGSQWSQMGAELLDKE
PVFAATIAAVEPLIAAESGFSVTRALSAPPAVTGIDKVQPTIFAMQVALAETMKSYGVRPGAVIGHSLGECAAAVVAGGL
SLGDGVKVICRRSRLMARIAGRGAMASVELPGQQVLSELSIRGISGVALSVVASPTSTVVGGGAEAIRELVAAWQQQDVM
AREVAVDVASHSPQVESILDELVEVLAELEPTAPEVPYYSATL
>Mature_762_residues
PAATATPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDADLYYDPEPGVPGRSVTRWGAFLDDVGGFDCDF
FGMTEREATAVDPQHRLLLETSWDAIEHAGLDPASLAGSQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGRV
AYTLGLHGPAVTVDTACSSGLMAVHQACGSLGGGESDLTLAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDVNADGFVS
GEGCVMLLLKRLDDARRDGDRILAVLRGTAANQDGRTVNIAAPSETAQVAVYRKALQAADIDATTVGLVEAHGTGTPVGD
PIEYSSLAAVYGTDGPCVLGSVKTNFGHLQSASGPLGMMKAILALQHGVVPRNLHFTRLPDEMARINTELFVPQENTQWP
SNGHHPRRAAVSSYGMSGTNVHAILEEAPAPEAAGSAAPEAVGPLLFPLSSTSAEQLRVTAARLAAWLDEQAGDALAGPT
GWGLRDLGYTLTRRRAHRPVRTVVSASGFAELRTELRAVADGDIPYQPAVGQGDRGPVWVFSGQGSQWSQMGAELLDKEP
VFAATIAAVEPLIAAESGFSVTRALSAPPAVTGIDKVQPTIFAMQVALAETMKSYGVRPGAVIGHSLGECAAAVVAGGLS
LGDGVKVICRRSRLMARIAGRGAMASVELPGQQVLSELSIRGISGVALSVVASPTSTVVGGGAEAIRELVAAWQQQDVMA
REVAVDVASHSPQVESILDELVEVLAELEPTAPEVPYYSATL

Specific function: Catalyzes the synthesis of methyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of cell wall lipids [H]

COG id: COG3321

COG function: function code Q; Polyketide synthase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=782, Percent_Identity=31.5856777493606, Blast_Score=272, Evalue=1e-72,
Organism=Homo sapiens, GI8923559, Length=272, Percent_Identity=26.8382352941176, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI310129082, Length=105, Percent_Identity=37.1428571428571, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI310109937, Length=105, Percent_Identity=37.1428571428571, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI239744023, Length=105, Percent_Identity=37.1428571428571, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1787337, Length=291, Percent_Identity=29.8969072164948, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788663, Length=342, Percent_Identity=26.9005847953216, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI212642053, Length=758, Percent_Identity=29.4195250659631, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17550940, Length=425, Percent_Identity=32.4705882352941, Blast_Score=219, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI71983541, Length=295, Percent_Identity=29.8305084745763, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71983535, Length=274, Percent_Identity=29.9270072992701, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=354, Percent_Identity=25.9887005649718, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221330659, Length=766, Percent_Identity=31.4621409921671, Blast_Score=292, Evalue=7e-79,
Organism=Drosophila melanogaster, GI19920632, Length=766, Percent_Identity=31.4621409921671, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24581345, Length=777, Percent_Identity=28.4427284427284, Blast_Score=256, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24644341, Length=435, Percent_Identity=27.816091954023, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: 2.3.1.41 [C]

Molecular weight: Translated: 79257; Mature: 79126

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAATATPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDADLYYDPEPGVP
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCEEECCCCCCC
GRSVTRWGAFLDDVGGFDCDFFGMTEREATAVDPQHRLLLETSWDAIEHAGLDPASLAGS
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCHHHHCCC
QTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGRVAYTLGLHGPAVTVDTACSS
CCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECHHCC
GLMAVHQACGSLGGGESDLTLAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDVNADGFV
CHHHHHHHHHCCCCCCCCEEEECCEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCCEE
SGEGCVMLLLKRLDDARRDGDRILAVLRGTAANQDGRTVNIAAPSETAQVAVYRKALQAA
CCCHHHHHHHHHHHHHHCCHHHEEEEHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHC
DIDATTVGLVEAHGTGTPVGDPIEYSSLAAVYGTDGPCVLGSVKTNFGHLQSASGPLGMM
CCCCEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHH
KAILALQHGVVPRNLHFTRLPDEMARINTELFVPQENTQWPSNGHHPRRAAVSSYGMSGT
HHHHHHHHCCCCCCCEEEECCHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCC
NVHAILEEAPAPEAAGSAAPEAVGPLLFPLSSTSAEQLRVTAARLAAWLDEQAGDALAGP
CHHHHHHCCCCCCCCCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
TGWGLRDLGYTLTRRRAHRPVRTVVSASGFAELRTELRAVADGDIPYQPAVGQGDRGPVW
CCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
VFSGQGSQWSQMGAELLDKEPVFAATIAAVEPLIAAESGFSVTRALSAPPAVTGIDKVQP
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHCCH
TIFAMQVALAETMKSYGVRPGAVIGHSLGECAAAVVAGGLSLGDGVKVICRRSRLMARIA
HHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GRGAMASVELPGQQVLSELSIRGISGVALSVVASPTSTVVGGGAEAIRELVAAWQQQDVM
CCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHH
AREVAVDVASHSPQVESILDELVEVLAELEPTAPEVPYYSATL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAATATPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDADLYYDPEPGVP
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCEEECCCCCCC
GRSVTRWGAFLDDVGGFDCDFFGMTEREATAVDPQHRLLLETSWDAIEHAGLDPASLAGS
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCHHHHCCC
QTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGRVAYTLGLHGPAVTVDTACSS
CCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECHHCC
GLMAVHQACGSLGGGESDLTLAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDVNADGFV
CHHHHHHHHHCCCCCCCCEEEECCEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCCEE
SGEGCVMLLLKRLDDARRDGDRILAVLRGTAANQDGRTVNIAAPSETAQVAVYRKALQAA
CCCHHHHHHHHHHHHHHCCHHHEEEEHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHC
DIDATTVGLVEAHGTGTPVGDPIEYSSLAAVYGTDGPCVLGSVKTNFGHLQSASGPLGMM
CCCCEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHH
KAILALQHGVVPRNLHFTRLPDEMARINTELFVPQENTQWPSNGHHPRRAAVSSYGMSGT
HHHHHHHHCCCCCCCEEEECCHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCC
NVHAILEEAPAPEAAGSAAPEAVGPLLFPLSSTSAEQLRVTAARLAAWLDEQAGDALAGP
CHHHHHHCCCCCCCCCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
TGWGLRDLGYTLTRRRAHRPVRTVVSASGFAELRTELRAVADGDIPYQPAVGQGDRGPVW
CCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
VFSGQGSQWSQMGAELLDKEPVFAATIAAVEPLIAAESGFSVTRALSAPPAVTGIDKVQP
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHCCH
TIFAMQVALAETMKSYGVRPGAVIGHSLGECAAAVVAGGLSLGDGVKVICRRSRLMARIA
HHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GRGAMASVELPGQQVLSELSIRGISGVALSVVASPTSTVVGGGAEAIRELVAAWQQQDVM
CCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHH
AREVAVDVASHSPQVESILDELVEVLAELEPTAPEVPYYSATL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} [C]

Substrates: acetyl-ACP; malonyl-ACP; acyl-ACP [C]

Specific reaction: acetyl-ACP + malonyl-ACP = [acyl carrier protein] + acetoacetyl-ACP + CO2 acyl-ACP + malonyl-ACP = [acyl carrier protein] + beta-ketoacyl-ACP + CO2 [C]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]