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The map label for this gene is cysN

Identifier: 41408582

GI number: 41408582

Start: 2787416

End: 2789266

Strand: Reverse

Name: cysN

Synonym: MAP2484c

Alternate gene names: 41408582

Gene position: 2789266-2787416 (Counterclockwise)

Preceding gene: 41408583

Following gene: 41408581

Centisome position: 57.75

GC content: 66.88

Gene sequence:

>1851_bases
ATGGCCGCCCCAACCACGCTATTGCGTTTGGCCACTGCGGGATCCGTCGACGACGGTAAGTCCACGCTGATCGGCCGGCT
GCTCTACGACTCCAAGGCCGTGATGGAAGACCAGTGGGCGGCGGTGGAGCAGACCTCGAAGGACCGCGGCCACGACTACA
CCGACCTGGCGCTGGTCACCGACGGCTTGCGGGCCGAACGCGAGCAGGGCATCACCATCGACGTCGCCTACCGCTACTTC
GCCACGCCCAAGCGGAAATTCATCATCGCCGACACGCCCGGCCACATCCAGTACACCCGCAACATGGTGACCGGCGCGTC
GACCGCGCAGCTGGTGATCGTGCTGGTCGATGCGCGGCACGGCCTGCTGGAGCAGTCCCGCCGGCACGCCTTCCTGGCCT
CGCTGCTGGGCATCCAGCACATCGTGCTCGCGGTCAACAAGATGGACCTGATCGGTTGGGACAGAGAGAAATTCGAGTCC
ATCCGAGACGAATTCCACGCCTTCGCCGCGCGCCTGGACGTGCACGACGTGGCCACCATCCCGATTTCGGCCCTGCACGG
CGACAACGTGGTGACCAAGTCGGATCAGACACCCTGGTACGAGGGGCCGGCGCTGCTGTCGCACCTCGAAGAGGTGTACA
TCGCCGGTGACCGCAACCTGGTCGACGTGCGGTTCCCGGTGCAGTACGTGATCCGTCCGCACACCCACGAGCATCAGGAC
CACCGCAGCTACGCCGGTACCGTCGCCAGCGGCGTGATGCGTCCCGGCGACGAGGTCGTGGTGCTGCCGGTCGGCAAGCG
CACCCGGATCACCGCGATCGAGGGCCCGAACGGCCCAGTGCAAGAAGCGTTCCCACCGATGGCGGTGTCGCTGACCCTGG
CCGACGAGATCGACATCTCGCGCGGGGATCTGATCGCGCGCACCCACAACCAGCCCAGGATCGCCCAGGATTTCGACGCG
ACGTTGTGCTGGATGGCCGACAACACGACGCTGGAACCGGGCCGCGACTACGTCATCAAGCACACCACCCGCACCACGCA
CGCGAGGGTGACCGGGCTCGACTACCGGCTCGACGTCAACACGCTGCATCGGGACAAGACCGCGACGGCGCTGAAACTCA
ATGAGCTGGGCCGTATTTCGCTGCGCACCCAGGTGCCCCTGCTGCTCGACGAGTACACCCGCAACCCCAGCACCGGCTCG
TTCATCCTGATCGACCCGCACACCAACGGCACGGTGGCCGCGGGCATGGTGCTGCGCGACGCCTCGGCCCAGGCCGCGAG
CCCGAACACGGTGCGGCACAAGTCATCAGCGATCGCCGCGGCGCGGCCCCGCGGCAAGACGGTGTGGTTCACCGGTCTGT
CCGGTTCCGGCAAGTCGTCGGTGGCCATGCTGGTCGAGCAGAAGCTGCTCGAAAAGGGTGCGCAGGCTTATGTTCTCGAC
GGCGACAACCTTCGGCACGGGCTCAACGCGGACCTTGGTTTCTCCATGGCCGACCGGGCGGAGAACCTGCGCCGGCTCGC
GCACGTGGCGGCGCTGCTGGCCGATTGCGGCAACGTCGTGCTGGTTCCGGCGATCAGCCCACTGGCCGAGCAACGCGAAT
TGGCGCGCAAAGTGCACGCCGACGCCGGCTTCGACTTCATCGAGGTGTTCTGCGACACCCCGATCGAGGAATGCGAAAAG
CGTGACCCCAAGGGTCTGTACGCCAAGGCGCGGGCCGGCGAGATCACCCAGTTCACCGGCATCGACAGCCCATATCAGCC
GCCGGCGAACCCCGACCTGCGGCTCATCCCGGACGGCACCGTCGAGGAGCAGGCGCAGCGGGTGATCGACCTGCTCGAAT
CACGCGGGTAG

Upstream 100 bases:

>100_bases
AGACCGCGGTGTCCCGGCTCACCGAGCGCGGGGCGACCCGGGCGGACGACCGGATCTCGGAGGCCGGCATGGAAGACCGC
AAGCGGCAGGGGTACTTCTG

Downstream 100 bases:

>100_bases
CCCGCCGGGTCAGCCAGGCTGCATCGAAATCGCCGCTCCGGGTGGCACAATCCTGAGGGTGCGGATGTCAGCGAAGGCGG
AGTACGCCGTGCGGGCGATG

Product: bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein

Products: NA

Alternate protein names: Sulfate adenylyltransferase subunit 1; ATP-sulfurylase large subunit; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MAAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYF
ATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFES
IRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQD
HRSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDISRGDLIARTHNQPRIAQDFDA
TLCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVNTLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGS
FILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLD
GDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFDFIEVFCDTPIEECEK
RDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLIPDGTVEEQAQRVIDLLESRG

Sequences:

>Translated_616_residues
MAAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYF
ATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFES
IRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQD
HRSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDISRGDLIARTHNQPRIAQDFDA
TLCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVNTLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGS
FILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLD
GDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFDFIEVFCDTPIEECEK
RDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLIPDGTVEEQAQRVIDLLESRG
>Mature_615_residues
AAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFA
TPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFESI
RDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQDH
RSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDISRGDLIARTHNQPRIAQDFDAT
LCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVNTLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGSF
ILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLDG
DNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFDFIEVFCDTPIEECEKR
DPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLIPDGTVEEQAQRVIDLLESRG

Specific function: APS kinase catalyzes the synthesis of activated sulfate [H]

COG id: COG2895

COG function: function code P; GTPases - Sulfate adenylate transferase subunit 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI46094058, Length=187, Percent_Identity=50.8021390374332, Blast_Score=186, Evalue=7e-47,
Organism=Homo sapiens, GI34447231, Length=212, Percent_Identity=45.7547169811321, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI62912492, Length=212, Percent_Identity=45.7547169811321, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI194097354, Length=423, Percent_Identity=27.4231678486998, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI194018520, Length=423, Percent_Identity=27.4231678486998, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI194018522, Length=423, Percent_Identity=27.4231678486998, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI223555963, Length=426, Percent_Identity=29.1079812206573, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI5729864, Length=426, Percent_Identity=29.1079812206573, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI46094014, Length=423, Percent_Identity=26.4775413711584, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI4503475, Length=444, Percent_Identity=26.8018018018018, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4503471, Length=469, Percent_Identity=26.4392324093817, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI34147630, Length=285, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789108, Length=427, Percent_Identity=50.1170960187354, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1789107, Length=169, Percent_Identity=52.6627218934911, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI1790412, Length=143, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789737, Length=143, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17542422, Length=193, Percent_Identity=50.259067357513, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566629, Length=428, Percent_Identity=26.4018691588785, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552884, Length=442, Percent_Identity=28.2805429864253, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17569207, Length=442, Percent_Identity=28.2805429864253, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI115532067, Length=264, Percent_Identity=29.1666666666667, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115532065, Length=264, Percent_Identity=29.1666666666667, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32566303, Length=435, Percent_Identity=26.4367816091954, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32566301, Length=149, Percent_Identity=35.5704697986577, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25141371, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=170, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322852, Length=171, Percent_Identity=52.6315789473684, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325337, Length=444, Percent_Identity=27.027027027027, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319594, Length=444, Percent_Identity=27.027027027027, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322937, Length=419, Percent_Identity=27.9236276849642, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320377, Length=433, Percent_Identity=28.6374133949192, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324761, Length=159, Percent_Identity=36.4779874213836, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667032, Length=174, Percent_Identity=53.448275862069, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24667028, Length=174, Percent_Identity=53.448275862069, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24667036, Length=174, Percent_Identity=53.448275862069, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI116007838, Length=174, Percent_Identity=53.448275862069, Blast_Score=189, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24667044, Length=174, Percent_Identity=53.448275862069, Blast_Score=189, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24667040, Length=174, Percent_Identity=53.448275862069, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI45553807, Length=437, Percent_Identity=28.1464530892449, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45553816, Length=437, Percent_Identity=28.1464530892449, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24651721, Length=437, Percent_Identity=28.1464530892449, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17864154, Length=437, Percent_Identity=28.1464530892449, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24652838, Length=447, Percent_Identity=27.2930648769575, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17137572, Length=447, Percent_Identity=27.2930648769575, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17137380, Length=424, Percent_Identity=26.1792452830189, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45550900, Length=431, Percent_Identity=28.3062645011601, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281363316, Length=203, Percent_Identity=30.5418719211823, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864358, Length=203, Percent_Identity=30.5418719211823, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921738, Length=156, Percent_Identity=32.6923076923077, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR000795
- InterPro:   IPR011779
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF01583 APS_kinase; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 67655; Mature: 67524

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVT
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
DGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARH
CCHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCEEEEHHEECCCCCEEEEEEEEECCC
GLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFESIRDEFHAFAARLDVHDVATI
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEC
PISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQD
EEEEECCCCEEECCCCCCCCCCHHHHHHHHHEEEECCCCEEEEECCEEEEECCCCCCCHH
HRSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDIS
HHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCCCHHHCCCCEEEEEEEECCCCCC
RGDLIARTHNQPRIAQDFDATLCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVN
CCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEECEEEEEECH
TLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRD
HHCCCCCCEEEEECCCCEEEEEECCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEEC
ASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLD
CCCCCCCCCCHHHCCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEC
GDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHC
DAGFDFIEVFCDTPIEECEKRDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLIPDGT
CCCCHHHHHHHCCCHHHHHCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCEEECCCCC
VEEQAQRVIDLLESRG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVT
CCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
DGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARH
CCHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCEEEEHHEECCCCCEEEEEEEEECCC
GLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFESIRDEFHAFAARLDVHDVATI
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEC
PISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQD
EEEEECCCCEEECCCCCCCCCCHHHHHHHHHEEEECCCCEEEEECCEEEEECCCCCCCHH
HRSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDIS
HHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCCCHHHCCCCEEEEEEEECCCCCC
RGDLIARTHNQPRIAQDFDATLCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVN
CCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEECEEEEEECH
TLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRD
HHCCCCCCEEEEECCCCEEEEEECCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEEC
ASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLD
CCCCCCCCCCHHHCCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEC
GDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHC
DAGFDFIEVFCDTPIEECEKRDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLIPDGT
CCCCHHHHHHHCCCHHHHHCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCEEECCCCC
VEEQAQRVIDLLESRG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]