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The map label for this gene is lysA_2

Identifier: 41408567

GI number: 41408567

Start: 2773625

End: 2775043

Strand: Reverse

Name: lysA_2

Synonym: MAP2469c

Alternate gene names: 41408567

Gene position: 2775043-2773625 (Counterclockwise)

Preceding gene: 41408568

Following gene: 41408566

Centisome position: 57.46

GC content: 68.71

Gene sequence:

>1419_bases
GTGAACGTCCACCCCGCCGGTCCTCGGCATGCCGAAGAGACCCGCCACCCCGAAAGCCCGCCGCGCCCGCAGTCTCCCGA
GGAGCTGTTGCTGCTCGCGCCGAATGTGTGGCCTCGCAACGCAACTCGCAACGAGGCCGGCGTCGCGACCATCGCCGGGG
TCGCGGTGACCGAGCTGGCCCGCGAGTACGGCACCCCGCTGTTCGTCGTCGACGAGGACGACTTTCGGTCCCGCTGCCGC
GAGATCGCGTCGGCCTTCGGCGGCGGCAACAACGTGCACTATGCCGCCAAGGCCTTCCTGTGCAGCGAGGTGGCCCGCTG
GATCGACGAGGAAGGCCTGTCACTCGACGTGTGCACCGGCGGGGAACTGGCCGTCGCCCTGCACGCCGACTTCCCTCCGG
AGCGAATCACCTTCCACGGCAACAACAAATCTGTCGCGGAGCTGACGGCCGCGGTCAAAGCCGGTGTGGGGCATGTCGTT
TTGGACTCGATGACCGAGATCGAGCGGCTGGACGCCATCGCGGCCGACGCGGGCATCGTCCAGGACGTCTTCGTGCGTCT
CACCGTCGGTGTGGAGGCCCACACCCACGAGTTCATCTCCACCGCGCACGAGGACCAGAAGTTCGGGCTGTCCGTGGCCA
GCGGTGCGGCGCTGGCCGCCGTCGGCCGGGTTTTCGACACCGAACACCTGCGGCTGGTCGGCCTGCACAGCCACATCGGT
TCGCAGATCTTCGACGTCGCCGGCTTCGAACTCGCCGCGCGCCGCGTCATCGGCTTGCTGCACGACGCGGTCGAGCAGTT
CGGCGTCGAGAAAACAGCGCAGATAGCCACCGTGGATCTCGGTGGGGGACTTGGCATTTCGTACCTAGCCGCGGACGATC
CGCCGCCGATGGGTGAGCTGGCGGGCAAGCTGAGCGCGATCGTGCAGCACGAGTCCGCGGCGGTGGGGCTGCCGACACCG
CGGCTGGTGGTCGAGCCGGGACGGGCCATCGCTGGCCCCGGCACGATCACCCTCTACGAGGTGGGCACCGTCAAGGACGT
CGACGTGAGCGCCACCGCGCACCGGCGCTACGTGAGCGTGGACGGCGGCATGAGCGACAACATCCGCACCGCGCTGTATG
ACGCCCAGTACGACGCCCGGCTGGTCTCCCGGGTCAGCGATGCACCCGCCGAGTTGGCCCGGGTCGTCGGAAAGCATTGC
GAGAGCGGCGATATCGTGGTTCGAGACACCTGGGTCCCCGGCGATCTGAGGCCCGGCGACCTGATCGGGGTGGCCGCCAC
CGGCGCCTACTGTTATTCGCTGTCGAGTCGGTACAACATGGTCTGCCGCCCGGCCGTCGTCGCGGTGCGTGACGGCCGCG
CGCGTCTGGTGCTGCGCCGCGAGACGGTCGACGATCTACTGAGTCTGGAAGTGAGGTGA

Upstream 100 bases:

>100_bases
CCACCGATCTGCACACCGCCCGGCTGGCGCTGTGCCAGGCGACCCGGCAGGTGATCGCCAACGGGCTGGCGATACTGGGC
GTGACCGCTCCGGAGCGAAT

Downstream 100 bases:

>100_bases
GCTGTGCCCCGTGACGAAAAGCCGGTCGGTGTAGCGGTACTCGGGTTGGGCAACGTCGGCAGCGAAGTCGTCCGCATCAT
CGAGGACAGCGCCGGTGACC

Product: LysA_2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVATIAGVAVTELAREYGTPLFVVDEDDFRSRCR
EIASAFGGGNNVHYAAKAFLCSEVARWIDEEGLSLDVCTGGELAVALHADFPPERITFHGNNKSVAELTAAVKAGVGHVV
LDSMTEIERLDAIAADAGIVQDVFVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAALAAVGRVFDTEHLRLVGLHSHIG
SQIFDVAGFELAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPMGELAGKLSAIVQHESAAVGLPTP
RLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYDAQYDARLVSRVSDAPAELARVVGKHC
ESGDIVVRDTWVPGDLRPGDLIGVAATGAYCYSLSSRYNMVCRPAVVAVRDGRARLVLRRETVDDLLSLEVR

Sequences:

>Translated_472_residues
MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVATIAGVAVTELAREYGTPLFVVDEDDFRSRCR
EIASAFGGGNNVHYAAKAFLCSEVARWIDEEGLSLDVCTGGELAVALHADFPPERITFHGNNKSVAELTAAVKAGVGHVV
LDSMTEIERLDAIAADAGIVQDVFVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAALAAVGRVFDTEHLRLVGLHSHIG
SQIFDVAGFELAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPMGELAGKLSAIVQHESAAVGLPTP
RLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYDAQYDARLVSRVSDAPAELARVVGKHC
ESGDIVVRDTWVPGDLRPGDLIGVAATGAYCYSLSSRYNMVCRPAVVAVRDGRARLVLRRETVDDLLSLEVR
>Mature_472_residues
MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVATIAGVAVTELAREYGTPLFVVDEDDFRSRCR
EIASAFGGGNNVHYAAKAFLCSEVARWIDEEGLSLDVCTGGELAVALHADFPPERITFHGNNKSVAELTAAVKAGVGHVV
LDSMTEIERLDAIAADAGIVQDVFVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAALAAVGRVFDTEHLRLVGLHSHIG
SQIFDVAGFELAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPMGELAGKLSAIVQHESAAVGLPTP
RLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYDAQYDARLVSRVSDAPAELARVVGKHC
ESGDIVVRDTWVPGDLRPGDLIGVAATGAYCYSLSSRYNMVCRPAVVAVRDGRARLVLRRETVDDLLSLEVR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=28.3372365339578, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50283; Mature: 50283

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVATIAGVAVTELA
CCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
REYGTPLFVVDEDDFRSRCREIASAFGGGNNVHYAAKAFLCSEVARWIDEEGLSLDVCTG
HHHCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
GELAVALHADFPPERITFHGNNKSVAELTAAVKAGVGHVVLDSMTEIERLDAIAADAGIV
CCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHH
QDVFVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAALAAVGRVFDTEHLRLVGLHSHIG
HHHHEEEEECCCHHHHHHHHHHCCCHHCCCCHHCCHHHHHHHHHHCCCCEEEEEEHHHHH
SQIFDVAGFELAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPMGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHH
AGKLSAIVQHESAAVGLPTPRLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSV
HHHHHHHHHHCCCEECCCCCCEEECCCCEECCCCEEEEEEECCEEECCCCCCCCEEEEEE
DGGMSDNIRTALYDAQYDARLVSRVSDAPAELARVVGKHCESGDIVVRDTWVPGDLRPGD
CCCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
LIGVAATGAYCYSLSSRYNMVCRPAVVAVRDGRARLVLRRETVDDLLSLEVR
EEEEEECCCEEEECCCCCCEEECCEEEEEECCCEEEEEEHHHHHHHHHCCCC
>Mature Secondary Structure
MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVATIAGVAVTELA
CCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
REYGTPLFVVDEDDFRSRCREIASAFGGGNNVHYAAKAFLCSEVARWIDEEGLSLDVCTG
HHHCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
GELAVALHADFPPERITFHGNNKSVAELTAAVKAGVGHVVLDSMTEIERLDAIAADAGIV
CCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHH
QDVFVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAALAAVGRVFDTEHLRLVGLHSHIG
HHHHEEEEECCCHHHHHHHHHHCCCHHCCCCHHCCHHHHHHHHHHCCCCEEEEEEHHHHH
SQIFDVAGFELAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPMGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHH
AGKLSAIVQHESAAVGLPTPRLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSV
HHHHHHHHHHCCCEECCCCCCEEECCCCEECCCCEEEEEEECCEEECCCCCCCCEEEEEE
DGGMSDNIRTALYDAQYDARLVSRVSDAPAELARVVGKHCESGDIVVRDTWVPGDLRPGD
CCCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
LIGVAATGAYCYSLSSRYNMVCRPAVVAVRDGRARLVLRRETVDDLLSLEVR
EEEEEECCCEEEECCCCCCEEECCEEEEEECCCEEEEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]