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The map label for this gene is thrA

Identifier: 41408566

GI number: 41408566

Start: 2772296

End: 2773621

Strand: Reverse

Name: thrA

Synonym: MAP2468c

Alternate gene names: 41408566

Gene position: 2773621-2772296 (Counterclockwise)

Preceding gene: 41408567

Following gene: 41408565

Centisome position: 57.43

GC content: 69.68

Gene sequence:

>1326_bases
GTGCCCCGTGACGAAAAGCCGGTCGGTGTAGCGGTACTCGGGTTGGGCAACGTCGGCAGCGAAGTCGTCCGCATCATCGA
GGACAGCGCCGGTGACCTGGCGGCCCGCATCGGTGCGCCCCTGGTGCTTCGGGGCGTCGGGGTGCGCCGCGTCGCCGACG
ACCGCGGTGTTCCGGTCGAGCTGCTCACCGACGACATCGAAGGACTCGCCGCGCGCGACGACGTCGACATCGTCGTGGAG
TTGATGGGGCCGGTGGAACCGTCCCGCAAGGCCATCCTGTGCGCGCTCGAGCATGGCAAGTCGGTCGTCACGGCCAACAA
GGCGCTGCTGTCCACCTCCACCGGCGAATTGGCACAGGCCGCCGAAAGCGCGCACGTGGACCTGCATTTCGAGGCCGCCG
TGGCCGGCGCCATCCCGGTGATCCGGCCGCTGACCCAGTCGTTGGCGGGTGACACGGTGCTGCGGGTCGCCGGCATCGTC
AACGGCACCACCAACTACATCTTGTCCGCGATGGACAGCACCGGCGCCGACTACGACACCGCGCTGGCCGAAGCCAGCGA
CCTGGGCTACGCCGAGGCCGACCCCACCGCCGACGTCGAGGGGTACGACGCCGCGGCCAAGGCCGCGATTCTCGCGTCGA
TCGCGTTCCACACCCGGGTGACCGCCGACGACGTCTACCGGGAGGGCATCACCAAGATCACCCCGGCCGACTTCGCCTCC
GCCCGCGCCCTGGGCTGCACCATCAAACTGTTGTCCATCTGCGAACGCATCACCGGCGACGATGGCCAGGAACGGGTTTC
GGCGCGCGTCTACCCGGCGCTGGTGCCGCTGTCCCATCCGCTGGCCACGGTCAACGGCGCCTTCAACGCGGTGGTGGTCG
AGGCCAGGGCCTCCGGCCGGCTGATGTTCTACGGCCAGGGCGCCGGTGGAGCGCCGACGGCGTCCGCGGTGGCCGGTGAC
CTGGTGATGGCCGCGCGAAACCGGGTGCTGGGCAGCCGCGGCCCGCGGGAGTCCAAGTACGCCCAACTCCCGGTCGCGCC
AATGGGTTTCATCTCCACCCGCTACTACGTGAGCATGAACGTGGCCGACAAGCCGGGTGTGTTGTCGTCGGTGGCGGCTG
AATTCGCCAAGCGCGAGGTGAGCATCGCCGAGGTCCGTCAGGAGGGCGTCGCCGACGAGGGCGGCCGCCGGGTGGGCGCC
CGCATCGTCGTGGTCACCCACACCGCCACCGATGCCGCGCTTTCCGAAACCGTGCATGCGCTCGCCGATTTGGACGTCGT
GCAGAGCGTGACGAGCGTGCTGCGACTGGAAGGGACCAGCCTATGA

Upstream 100 bases:

>100_bases
CTGCCGCCCGGCCGTCGTCGCGGTGCGTGACGGCCGCGCGCGTCTGGTGCTGCGCCGCGAGACGGTCGACGATCTACTGA
GTCTGGAAGTGAGGTGAGCT

Downstream 100 bases:

>100_bases
GCGCCCAGCGCACCGCCGTCCATCAGCCCTGGCCCGGCCTCATCGAGGCCTACCGAGACCGGCTGCCGGTGGGCGACGAC
TGGACCCCGGTGACCCTGCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPRDEKPVGVAVLGLGNVGSEVVRIIEDSAGDLAARIGAPLVLRGVGVRRVADDRGVPVELLTDDIEGLAARDDVDIVVE
LMGPVEPSRKAILCALEHGKSVVTANKALLSTSTGELAQAAESAHVDLHFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIV
NGTTNYILSAMDSTGADYDTALAEASDLGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKITPADFAS
ARALGCTIKLLSICERITGDDGQERVSARVYPALVPLSHPLATVNGAFNAVVVEARASGRLMFYGQGAGGAPTASAVAGD
LVMAARNRVLGSRGPRESKYAQLPVAPMGFISTRYYVSMNVADKPGVLSSVAAEFAKREVSIAEVRQEGVADEGGRRVGA
RIVVVTHTATDAALSETVHALADLDVVQSVTSVLRLEGTSL

Sequences:

>Translated_441_residues
MPRDEKPVGVAVLGLGNVGSEVVRIIEDSAGDLAARIGAPLVLRGVGVRRVADDRGVPVELLTDDIEGLAARDDVDIVVE
LMGPVEPSRKAILCALEHGKSVVTANKALLSTSTGELAQAAESAHVDLHFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIV
NGTTNYILSAMDSTGADYDTALAEASDLGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKITPADFAS
ARALGCTIKLLSICERITGDDGQERVSARVYPALVPLSHPLATVNGAFNAVVVEARASGRLMFYGQGAGGAPTASAVAGD
LVMAARNRVLGSRGPRESKYAQLPVAPMGFISTRYYVSMNVADKPGVLSSVAAEFAKREVSIAEVRQEGVADEGGRRVGA
RIVVVTHTATDAALSETVHALADLDVVQSVTSVLRLEGTSL
>Mature_440_residues
PRDEKPVGVAVLGLGNVGSEVVRIIEDSAGDLAARIGAPLVLRGVGVRRVADDRGVPVELLTDDIEGLAARDDVDIVVEL
MGPVEPSRKAILCALEHGKSVVTANKALLSTSTGELAQAAESAHVDLHFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVN
GTTNYILSAMDSTGADYDTALAEASDLGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKITPADFASA
RALGCTIKLLSICERITGDDGQERVSARVYPALVPLSHPLATVNGAFNAVVVEARASGRLMFYGQGAGGAPTASAVAGDL
VMAARNRVLGSRGPRESKYAQLPVAPMGFISTRYYVSMNVADKPGVLSSVAAEFAKREVSIAEVRQEGVADEGGRRVGAR
IVVVTHTATDAALSETVHALADLDVVQSVTSVLRLEGTSL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=25.7617728531856, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=29.3172690763052, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45644; Mature: 45513

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRDEKPVGVAVLGLGNVGSEVVRIIEDSAGDLAARIGAPLVLRGVGVRRVADDRGVPVE
CCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHCCCEEEECCCCEEECCCCCCCCE
LLTDDIEGLAARDDVDIVVELMGPVEPSRKAILCALEHGKSVVTANKALLSTSTGELAQA
EECCCHHCCCCCCCHHHHHEECCCCCCCCCEEEEEECCCCEEEEECHHHEECCCHHHHHH
AESAHVDLHFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDT
HHHCEEEEEEHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
ALAEASDLGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKITPADFAS
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHH
ARALGCTIKLLSICERITGDDGQERVSARVYPALVPLSHPLATVNGAFNAVVVEARASGR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCCHHHHCCCCEEEEEEECCCCE
LMFYGQGAGGAPTASAVAGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFISTRYYVSMN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHEEEEEEEEE
VADKPGVLSSVAAEFAKREVSIAEVRQEGVADEGGRRVGARIVVVTHTATDAALSETVHA
CCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEECEEEEEEEECCCHHHHHHHHHH
LADLDVVQSVTSVLRLEGTSL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PRDEKPVGVAVLGLGNVGSEVVRIIEDSAGDLAARIGAPLVLRGVGVRRVADDRGVPVE
CCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHCCCEEEECCCCEEECCCCCCCCE
LLTDDIEGLAARDDVDIVVELMGPVEPSRKAILCALEHGKSVVTANKALLSTSTGELAQA
EECCCHHCCCCCCCHHHHHEECCCCCCCCCEEEEEECCCCEEEEECHHHEECCCHHHHHH
AESAHVDLHFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDT
HHHCEEEEEEHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
ALAEASDLGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKITPADFAS
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHH
ARALGCTIKLLSICERITGDDGQERVSARVYPALVPLSHPLATVNGAFNAVVVEARASGR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCCHHHHCCCCEEEEEEECCCCE
LMFYGQGAGGAPTASAVAGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFISTRYYVSMN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHEEEEEEEEE
VADKPGVLSSVAAEFAKREVSIAEVRQEGVADEGGRRVGARIVVVTHTATDAALSETVHA
CCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEECEEEEEEEECCCHHHHHHHHHH
LADLDVVQSVTSVLRLEGTSL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]