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The map label for this gene is atpA

Identifier: 41408551

GI number: 41408551

Start: 2758373

End: 2760037

Strand: Reverse

Name: atpA

Synonym: MAP2453c

Alternate gene names: 41408551

Gene position: 2760037-2758373 (Counterclockwise)

Preceding gene: 41408552

Following gene: 41408550

Centisome position: 57.15

GC content: 66.01

Gene sequence:

>1665_bases
ATGGCCGAGTTGACAATCTCCGCTGATGACATTCAGAGCGCCATCGAGGAGTACGTAGGCTCTTTCACCTCCGACACCTC
CCGCGAAGAGGTCGGTACCGTCGTCGACGCCGGTGACGGCATCGCCCACGTCGAAGGCCTGCCGTCCGTGATGACCCAGG
AGCTGCTCGAGTTCCCCGGCGGCGTGCTCGGCGTCGCGCTCAACCTGGACGAGCACAGCGTCGGCGCGGTGATCCTGGGT
GACTTCGAGAAGATCGAGGAAGGCCAGCAGGTCAAGCGTACCGGCGAGGTGCTCTCGGTTCCGGTGGGCGACGCCTTCCT
GGGCCGTGTGGTCAATCCGCTGGGCCAGCCGATCGACGGCCAGGGCGACATCGAGACCGACATTCGGCGGGCACTGGAGA
TCCAGGCGCCCTCGGTGGTGCAGCGGCAGAGCGTGAAAGAGCCGCTGCAGACCGGCATCAAGGCCATCGACGCGATGACC
CCGATCGGCCGTGGCCAGCGCCAGCTGATCATCGGCGACCGCAAGACGGGCAAGACCGCGGTCTGCGTGGACACCATCCT
CAACCAGCGGCAGAACTGGGAGAGCGGTGACGAGAAGAAGCAGGTGCGCTGCGTCTACGTGGCCATCGGCCAGAAGGGCA
CCACGATCGCGTCGGTCCGGCGCGCCCTGGAAGAGGGCGGGGCGATGGACTACACCACCATCGTCGCGGCGCCGGCCTCC
GACTCCGCCGGGTTCAAATGGCTTGCGCCCTATACCGGTTCGGCGATCGCCCAGCACTGGATGTACGACGGCAAGCACGT
GCTGATCGTCTTCGACGACCTGAGCAAGCAGGCCGAGGCCTACCGCGCGATCTCGCTGCTGCTGCGCCGCCCGCCGGGCC
GCGAGGCCTACCCGGGTGACGTGTTCTATTTGCACTCACGGCTTTTGGAGCGCTGCGCCAAGCTTTCCGACGAACTCGGT
GGCGGCTCGATGACCGGTCTGCCGATCATCGAGACCAAGGCCAACGACATCTCGGCCTACATCCCCACCAACGTCATCTC
GATCACCGACGGGCAGTGCTTCCTGGAGTCCGACCTGTTCAACCAGGGTGTGCGGCCGGCCATCAACGTCGGCGTCTCGG
TGTCCCGGGTGGGTGGCGCCGCGCAGATCAAGGCGATGAAGGAGGTGGCGGGCAGCCTGCGGCTGGACCTGTCGCAATTC
CGTGAGCTGGAAGCCTTCGCCGCGTTCGCCTCCGACCTGGACGCGACGTCGAAGGCCCAGCTGGACCGCGGCGCGCGGCT
GGTGGAGCTGCTCAAGCAACCGCAGTACCAGCCGATGCCCGTTGAGGAGCAAGTGGTTTCGATCTTCCTCGGCACCGGCG
GTCACCTCGACTCGGTGCCGGTGGAGGACGTCCGGCGGTTCGAAACCGAACTGCTGGACCACATGCGGGCCTCCGAGGAC
AAGATCCTCGCCGGGATCCGCGACACCCAGAAGCTCTCCGACGAGGCCGCCGAGGAGCTGGAGAAGGTGATCAACAACTT
CAAGAAGGGCTTCGCCGCCACCGGCGGCGCCTCGGTGGTGCCCGACGAGCACGTCGAGGCGCTCGACGAGGAGGAGCTGG
AAAAGGAATCGGTGAAGGTGAAGAAGCCGGCGCCGGAAAAGAAGGCAAAGAAAGAGCAGAAGTAG

Upstream 100 bases:

>100_bases
CTGGCCGCCGCAGAGGCCCAGTTGCCCGACTGACCGCAGCACCAACCACTGACCATCCCGACACACGCGATACCAAGATC
AAGTAGGAAGACGAAAAGCC

Downstream 100 bases:

>100_bases
CAACCGATGGCTGCCACACTTCGTGAACTACGCGGACGGATCCGCTCGGCCGGGTCGATCAAGAAGATCACCAAGGCCCA
GGAGCTGATCGCGACGTCGC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MAELTISADDIQSAIEEYVGSFTSDTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPGGVLGVALNLDEHSVGAVILG
DFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDGQGDIETDIRRALEIQAPSVVQRQSVKEPLQTGIKAIDAMT
PIGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDEKKQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAAPAS
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELG
GGSMTGLPIIETKANDISAYIPTNVISITDGQCFLESDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQF
RELEAFAAFASDLDATSKAQLDRGARLVELLKQPQYQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASED
KILAGIRDTQKLSDEAAEELEKVINNFKKGFAATGGASVVPDEHVEALDEEELEKESVKVKKPAPEKKAKKEQK

Sequences:

>Translated_554_residues
MAELTISADDIQSAIEEYVGSFTSDTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPGGVLGVALNLDEHSVGAVILG
DFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDGQGDIETDIRRALEIQAPSVVQRQSVKEPLQTGIKAIDAMT
PIGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDEKKQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAAPAS
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELG
GGSMTGLPIIETKANDISAYIPTNVISITDGQCFLESDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQF
RELEAFAAFASDLDATSKAQLDRGARLVELLKQPQYQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASED
KILAGIRDTQKLSDEAAEELEKVINNFKKGFAATGGASVVPDEHVEALDEEELEKESVKVKKPAPEKKAKKEQK
>Mature_553_residues
AELTISADDIQSAIEEYVGSFTSDTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPGGVLGVALNLDEHSVGAVILGD
FEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDGQGDIETDIRRALEIQAPSVVQRQSVKEPLQTGIKAIDAMTP
IGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDEKKQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAAPASD
SAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELGG
GSMTGLPIIETKANDISAYIPTNVISITDGQCFLESDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQFR
ELEAFAAFASDLDATSKAQLDRGARLVELLKQPQYQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASEDK
ILAGIRDTQKLSDEAAEELEKVINNFKKGFAATGGASVVPDEHVEALDEEELEKESVKVKKPAPEKKAKKEQK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=504, Percent_Identity=53.968253968254, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI4757810, Length=504, Percent_Identity=53.968253968254, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI19913428, Length=296, Percent_Identity=30.4054054054054, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI19913426, Length=293, Percent_Identity=29.3515358361775, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI32189394, Length=487, Percent_Identity=24.6406570841889, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1790172, Length=516, Percent_Identity=49.8062015503876, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1790170, Length=410, Percent_Identity=24.8780487804878, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788251, Length=322, Percent_Identity=27.3291925465839, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=505, Percent_Identity=55.8415841584158, Blast_Score=597, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71988080, Length=505, Percent_Identity=55.8415841584158, Blast_Score=595, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71988074, Length=505, Percent_Identity=52.0792079207921, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17510931, Length=330, Percent_Identity=30, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=291, Percent_Identity=29.8969072164948, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=484, Percent_Identity=24.1735537190083, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=62, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=503, Percent_Identity=54.6719681908549, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322581, Length=439, Percent_Identity=25.7403189066059, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319603, Length=297, Percent_Identity=28.956228956229, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24658560, Length=502, Percent_Identity=54.9800796812749, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI281361666, Length=302, Percent_Identity=29.4701986754967, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646341, Length=302, Percent_Identity=29.4701986754967, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136796, Length=302, Percent_Identity=29.4701986754967, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638766, Length=487, Percent_Identity=25.8726899383984, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28574560, Length=411, Percent_Identity=25.7907542579075, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_MYCA1 (A0QCX6)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_880764.1
- ProteinModelPortal:   A0QCX6
- SMR:   A0QCX6
- STRING:   A0QCX6
- EnsemblBacteria:   EBMYCT00000012434
- GeneID:   4529239
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_1525
- TIGR:   MAV_1525
- eggNOG:   COG0056
- GeneTree:   EBGT00050000014996
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   A0QCX6
- ProtClustDB:   PRK09281
- BioCyc:   MAVI243243:MAV_1525-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 59994; Mature: 59862

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTISADDIQSAIEEYVGSFTSDTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPG
CCEEEECHHHHHHHHHHHHHCCCCCCCHHHHCCEEECCCCCHHHCCCHHHHHHHHHHCCC
GVLGVALNLDEHSVGAVILGDFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDG
CEEEEEEECCCCCCCEEEECCHHHHHCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCC
QGDIETDIRRALEIQAPSVVQRQSVKEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTA
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHH
VCVDTILNQRQNWESGDEKKQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAAPAS
HHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCC
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGD
CCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCH
VFYLHSRLLERCAKLSDELGGGSMTGLPIIETKANDISAYIPTNVISITDGQCFLESDLF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCEEEECCCCEEEHHHHH
NQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQFRELEAFAAFASDLDATSKAQ
HCCCCCHHHCCEEHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHH
LDRGARLVELLKQPQYQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASED
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
KILAGIRDTQKLSDEAAEELEKVINNFKKGFAATGGASVVPDEHVEALDEEELEKESVKV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHCCEE
KKPAPEKKAKKEQK
CCCCCHHHHHCCCC
>Mature Secondary Structure 
AELTISADDIQSAIEEYVGSFTSDTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPG
CEEEECHHHHHHHHHHHHHCCCCCCCHHHHCCEEECCCCCHHHCCCHHHHHHHHHHCCC
GVLGVALNLDEHSVGAVILGDFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDG
CEEEEEEECCCCCCCEEEECCHHHHHCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCC
QGDIETDIRRALEIQAPSVVQRQSVKEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTA
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHH
VCVDTILNQRQNWESGDEKKQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAAPAS
HHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCC
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGD
CCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCH
VFYLHSRLLERCAKLSDELGGGSMTGLPIIETKANDISAYIPTNVISITDGQCFLESDLF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCEEEECCCCEEEHHHHH
NQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQFRELEAFAAFASDLDATSKAQ
HCCCCCHHHCCEEHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHH
LDRGARLVELLKQPQYQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASED
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
KILAGIRDTQKLSDEAAEELEKVINNFKKGFAATGGASVVPDEHVEALDEEELEKESVKV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHCCEE
KKPAPEKKAKKEQK
CCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA