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The map label for this gene is accD1

Identifier: 41408412

GI number: 41408412

Start: 2594879

End: 2596558

Strand: Reverse

Name: accD1

Synonym: MAP2314c

Alternate gene names: 41408412

Gene position: 2596558-2594879 (Counterclockwise)

Preceding gene: 41408415

Following gene: 41408411

Centisome position: 53.76

GC content: 67.62

Gene sequence:

>1680_bases
ATGGTATTCTCGACCACCGAGTTAATCAGAATTAACTCAAAGCTCCGACCGCCCGACGGCAAGGAGGCTGCTGCGGCGAT
GGACAAGGTGATGGCCGCACCCGCGAAGGCTGACCCGGTATCGTTCGCCGACGAGCACCGCCGGCTGGTCGGCGAGTTGA
ATGCCAAGCTGGCCGCGGCCGCGCTAGGCGGCAACGAGCGCGCCCGCGAACGCCACGTCAGCCGCGGAAAGCTGCTGCCC
CGCGAACGGGTGGACCGCCTGCTCGACCCGGGTAGCCCGTTCCTGGAACTCTCGCCGCTGGCCGCCGACGGCATGTACGA
CGACGAATCCCCGGGAGCCGGAATCATCACCGGGATCGGCCGGGTGTCCGAGCGCGAGTGCGTGATCGTCGCCAACGACG
CGACGGTCAAGGGCGGCACCTATTACCCGATGACGGTCAAAAAACACCTGCGCGCCCAGGAGGTGGCGCTGCAGAACCGG
CTGCCGTGCATCTACCTGGTCGACTCCGGTGGCGCCTTCTTGCCGCGCCAAGACGAGGTTTTCCCCGACCGCGAGCATTT
CGGCCGCATCTTCTACAACCAGGCGACCATGAGCGCCAAGGGAATTCCGCAAGTGGCGGCGGTGCTGGGCTCCTGCACGG
CCGGCGGCGCCTACGTGCCGGCGATGAGCGACGAAGCCGTCATCGTGCGCGAGCAGGGCACGATTTTTCTGGGCGGCCCG
CCGCTGGTCAAGGCGGCGACCGGAGAGGTGGTGTCGGCCGAAGAGCTGGGCGGCGGCGACCTGCACTCGCGTATCTCCGG
GGTGACCGATCACCTCGCCGACGACGACGAGCACGCGCTGCGGATCGTCCGCTCGATCGCGGCCACCTTCGGCCCGCGCG
AGCCCAGCCCGTGGCAGGTGCGCACCCCGGTCCCGCCCAAGGCCGCGCAGAACGAGCTCTACGACGTGGTGCCGCCCGAC
CCGCGGGTGCCCTACGACGTGCACGAGGTGATCGTGCGGTTGGTCGACGGCGGCGAATTCAGCGAATTCAAGGCCAATTA
CGGCAAGACGCTGGTGACCGGGTTCGCCCACATCCACGGCCACCCGGTGGGCATCGTCGCCAACAACGGTGTGCTGTTCA
GCGAATCCGCTTTGAAGGGAGCACATTTCATCGAACTCTGCGACAAACGCAAGGTGCCGCTGCTGTTCCTGCAGAACATC
GCCGGGTTCATGGTGGGACGCGACTACGAGGCCGGCGGCATCGCCAAGCACGGCGCCAAGATGGTCACCGCCGTCGCCTG
CGCGCGGGTGCCCAAGCTGACCGTGGTGATCGGCGGATCCTATGGCGCGGGCAATTATTCGATGTGCGGGCGGGCCTACT
CGCCGCGCTTCCTGTGGCTGTGGCCCAACGCCCGGATCTCGGTGATGGGCGGCGAGCAGGCCGCCTCGGTGCTGGCCACC
GTGCGCGGTGAGCAGCTCACCGCGGCCGGCAAGCCCTGGTCGGCCGAGGAGGAAGAGGCGTTCAAGGCGCCTATCCGGGC
GCAGTACGAGGACCAGGGCAACCCCTACTATTCGACCGCCCGGCTGTGGGACGATGGGATCATCGACCCGGCCGACACCA
GAACCTTTGTCGGGCTTGCTCTTTCGGTGTGCGCGCAGGCTCCGTTGGAGCCCGTCGGCTACGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
GACCTCCGTCTGTGTCGATCCCGCCCAACCTAGCACGAGTTATTCGCAATTAACTCGTATCGTGCCGCGGTGCCCGCTCC
CTGGACCGGCAACGGCGACG

Downstream 100 bases:

>100_bases
GTGCAGTGTTCGAAACGGTATTGGTGGCCAACCGCGGCGAGATCGCGGTGCGGGTGATCCGCACCCTGCACCGGCTGGGC
ATCCGGTCGGTCGCCGTCTA

Product: AccD1

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MVFSTTELIRINSKLRPPDGKEAAAAMDKVMAAPAKADPVSFADEHRRLVGELNAKLAAAALGGNERARERHVSRGKLLP
RERVDRLLDPGSPFLELSPLAADGMYDDESPGAGIITGIGRVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNR
LPCIYLVDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGP
PLVKAATGEVVSAEELGGGDLHSRISGVTDHLADDDEHALRIVRSIAATFGPREPSPWQVRTPVPPKAAQNELYDVVPPD
PRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHIHGHPVGIVANNGVLFSESALKGAHFIELCDKRKVPLLFLQNI
AGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWLWPNARISVMGGEQAASVLAT
VRGEQLTAAGKPWSAEEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTFVGLALSVCAQAPLEPVGYGVFRM

Sequences:

>Translated_559_residues
MVFSTTELIRINSKLRPPDGKEAAAAMDKVMAAPAKADPVSFADEHRRLVGELNAKLAAAALGGNERARERHVSRGKLLP
RERVDRLLDPGSPFLELSPLAADGMYDDESPGAGIITGIGRVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNR
LPCIYLVDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGP
PLVKAATGEVVSAEELGGGDLHSRISGVTDHLADDDEHALRIVRSIAATFGPREPSPWQVRTPVPPKAAQNELYDVVPPD
PRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHIHGHPVGIVANNGVLFSESALKGAHFIELCDKRKVPLLFLQNI
AGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWLWPNARISVMGGEQAASVLAT
VRGEQLTAAGKPWSAEEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTFVGLALSVCAQAPLEPVGYGVFRM
>Mature_559_residues
MVFSTTELIRINSKLRPPDGKEAAAAMDKVMAAPAKADPVSFADEHRRLVGELNAKLAAAALGGNERARERHVSRGKLLP
RERVDRLLDPGSPFLELSPLAADGMYDDESPGAGIITGIGRVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNR
LPCIYLVDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGP
PLVKAATGEVVSAEELGGGDLHSRISGVTDHLADDDEHALRIVRSIAATFGPREPSPWQVRTPVPPKAAQNELYDVVPPD
PRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHIHGHPVGIVANNGVLFSESALKGAHFIELCDKRKVPLLFLQNI
AGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWLWPNARISVMGGEQAASVLAT
VRGEQLTAAGKPWSAEEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTFVGLALSVCAQAPLEPVGYGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=516, Percent_Identity=65.5038759689922, Blast_Score=689, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=547, Percent_Identity=32.3583180987203, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI295821216, Length=561, Percent_Identity=31.9073083778966, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI310133460, Length=126, Percent_Identity=65.8730158730159, Blast_Score=152, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17552936, Length=516, Percent_Identity=62.2093023255814, Blast_Score=668, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=33.0708661417323, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=33.0708661417323, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=63.2958801498127, Blast_Score=694, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 60040; Mature: 60040

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFSTTELIRINSKLRPPDGKEAAAAMDKVMAAPAKADPVSFADEHRRLVGELNAKLAAA
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEE
ALGGNERARERHVSRGKLLPRERVDRLLDPGSPFLELSPLAADGMYDDESPGAGIITGIG
ECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEECC
RVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYLVDSGGAFLPRQDEV
CCCCCCEEEEECCCEECCCEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
FPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGP
CCCHHHHCEEEEECHHCCCCCCHHHHHHHHCCCCCCEECCCCCCCEEEEEECCEEEECCC
PLVKAATGEVVSAEELGGGDLHSRISGVTDHLADDDEHALRIVRSIAATFGPREPSPWQV
CEEEECCCCEEEHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
RTPVPPKAAQNELYDVVPPDPRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHIHG
ECCCCCCHHCCCCEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCC
HPVGIVANNGVLFSESALKGAHFIELCDKRKVPLLFLQNIAGFMVGRDYEAGGIAKHGAK
CEEEEEECCCEEEECHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
MVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWLWPNARISVMGGEQAASVLAT
HHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHH
VRGEQLTAAGKPWSAEEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTFVGLA
HCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHH
LSVCAQAPLEPVGYGVFRM
HHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVFSTTELIRINSKLRPPDGKEAAAAMDKVMAAPAKADPVSFADEHRRLVGELNAKLAAA
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEE
ALGGNERARERHVSRGKLLPRERVDRLLDPGSPFLELSPLAADGMYDDESPGAGIITGIG
ECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEECC
RVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYLVDSGGAFLPRQDEV
CCCCCCEEEEECCCEECCCEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
FPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGP
CCCHHHHCEEEEECHHCCCCCCHHHHHHHHCCCCCCEECCCCCCCEEEEEECCEEEECCC
PLVKAATGEVVSAEELGGGDLHSRISGVTDHLADDDEHALRIVRSIAATFGPREPSPWQV
CEEEECCCCEEEHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
RTPVPPKAAQNELYDVVPPDPRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHIHG
ECCCCCCHHCCCCEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCC
HPVGIVANNGVLFSESALKGAHFIELCDKRKVPLLFLQNIAGFMVGRDYEAGGIAKHGAK
CEEEEEECCCEEEECHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
MVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWLWPNARISVMGGEQAASVLAT
HHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHH
VRGEQLTAAGKPWSAEEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTFVGLA
HCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHH
LSVCAQAPLEPVGYGVFRM
HHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]