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The map label for this gene is lipK

Identifier: 41408295

GI number: 41408295

Start: 2442083

End: 2443087

Strand: Direct

Name: lipK

Synonym: MAP2197

Alternate gene names: 41408295

Gene position: 2442083-2443087 (Clockwise)

Preceding gene: 41408294

Following gene: 41408296

Centisome position: 50.56

GC content: 68.36

Gene sequence:

>1005_bases
ATGACGGGCGGTGTTCCGGCTCGCGGGTCATTGCGGTCCCGCGGCGCGGCAGCGGTAAGTACGTACACCCTTCGGCCGAT
CACCAGCGTGATCCCGCCCGAGCGGGCATGGGGACTGTGGCTTTCGCGCCAGATCGTCGCCCGGATCATGGGAACGTTCG
GCCCCTCGCTGTCCGGCACCCGCGTCCAATCGGTGGACACCAGGCTGCCCGACGGCCGCCGCGTCAAGGGTGAATGGGTC
TTCGGCCCGCGCACCCCGACGAGCGAGCACTCGCGCCCGTCCAGCATCGCCGAAGCGATCTACTACATACACGGCAGCGG
CTACGCGGTGTGTTCGCCAAAGACGCACCGCCGCTTGACATCCTGGCTGTCGTCGCTGACCGGCCTGCCGGTGTTCTGCG
TGGACTACCGACTGGCCCCGCGTCATCGCTTCCCCACCGCTGCCGACGACGTGCGCGCCGGCTGGGACTGGCTGATCAAC
ACCTGCGGTGTGTTGCCCGAACAGATGGTGATCGCCGGTGACTCGGCCGGCGGTCACCTGTCCGTCGACCTACTGCTGCA
ACCGGGGGTCGAACACCCCGCCGCCATGGTGTTGTTCTCCCCCCTCTATGACCTGACGTTCGAGCTGGCCAAGGCGCGAG
AACGGATTCGCCCCGATCCGACCACCCGGGCGGCCAACGCGATCCGGCTGGTGGGCCTCTACCACAGCGGCGTCGACCTC
ACCCATGAGCGGCTGACGCTCGACGTCGCCCGCGGTCCCGCGCTTCCGCCCACATTGATCCAGGCCGGCGGAGCCGAAAT
GCTGCAAGCGGACGCCCACCAACTCGCCGCCGACATCCGCACCGCCGGCGGCAGATGCGAACTACAGATCTGGCCGCACC
AGGTGCACGTCTTTCAGGCGTTGCCGCGCATGACGCCCGAAGCCGCCAAGGCCATGGCCTATGTCGCGCGGTTCATCACC
CACGCCCTGCAGGATGCCCGTGCCCTCACCCAGGAGATGCACTGA

Upstream 100 bases:

>100_bases
GACTCCCAACACTGCATTCGCTCCCACCAAGCACCACGCGTACGGCGCAGACCAAAAGCTGCCATTGACCAATGTCACCA
TTTAGTGTTGACTGCATTGC

Downstream 100 bases:

>100_bases
CATGTTGGACCGGCTGCTGCACCGATCGAAGACCAGCCGCGGCGCCCTGGCGGTGGTGACCGGCGCGGGAAGCGGCATCG
GTGCGGCCTTCGCCCTCGAA

Product: LipK

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTGGVPARGSLRSRGAAAVSTYTLRPITSVIPPERAWGLWLSRQIVARIMGTFGPSLSGTRVQSVDTRLPDGRRVKGEWV
FGPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLTSWLSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLIN
TCGVLPEQMVIAGDSAGGHLSVDLLLQPGVEHPAAMVLFSPLYDLTFELAKARERIRPDPTTRAANAIRLVGLYHSGVDL
THERLTLDVARGPALPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQALPRMTPEAAKAMAYVARFIT
HALQDARALTQEMH

Sequences:

>Translated_334_residues
MTGGVPARGSLRSRGAAAVSTYTLRPITSVIPPERAWGLWLSRQIVARIMGTFGPSLSGTRVQSVDTRLPDGRRVKGEWV
FGPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLTSWLSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLIN
TCGVLPEQMVIAGDSAGGHLSVDLLLQPGVEHPAAMVLFSPLYDLTFELAKARERIRPDPTTRAANAIRLVGLYHSGVDL
THERLTLDVARGPALPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQALPRMTPEAAKAMAYVARFIT
HALQDARALTQEMH
>Mature_333_residues
TGGVPARGSLRSRGAAAVSTYTLRPITSVIPPERAWGLWLSRQIVARIMGTFGPSLSGTRVQSVDTRLPDGRRVKGEWVF
GPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLTSWLSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLINT
CGVLPEQMVIAGDSAGGHLSVDLLLQPGVEHPAAMVLFSPLYDLTFELAKARERIRPDPTTRAANAIRLVGLYHSGVDLT
HERLTLDVARGPALPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQALPRMTPEAAKAMAYVARFITH
ALQDARALTQEMH

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted (Potential). Note=External to the cytoplasmic membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Caenorhabditis elegans, GI115533410, Length=142, Percent_Identity=31.6901408450704, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533412, Length=142, Percent_Identity=31.6901408450704, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 36466; Mature: 36335

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGVPARGSLRSRGAAAVSTYTLRPITSVIPPERAWGLWLSRQIVARIMGTFGPSLSGT
CCCCCCCCCCHHHCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
RVQSVDTRLPDGRRVKGEWVFGPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLT
EEEHHHCCCCCCCEECCEEEECCCCCCCCCCCHHHHHHHEEEEECCCEEEECCHHHHHHH
SWLSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLINTCGVLPEQMVIAGDSAGGHL
HHHHHHCCCCEEEEECEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEE
SVDLLLQPGVEHPAAMVLFSPLYDLTFELAKARERIRPDPTTRAANAIRLVGLYHSGVDL
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEEEEECCCCC
THERLTLDVARGPALPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQA
CHHHEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
LPRMTPEAAKAMAYVARFITHALQDARALTQEMH
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGGVPARGSLRSRGAAAVSTYTLRPITSVIPPERAWGLWLSRQIVARIMGTFGPSLSGT
CCCCCCCCCHHHCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
RVQSVDTRLPDGRRVKGEWVFGPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLT
EEEHHHCCCCCCCEECCEEEECCCCCCCCCCCHHHHHHHEEEEECCCEEEECCHHHHHHH
SWLSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLINTCGVLPEQMVIAGDSAGGHL
HHHHHHCCCCEEEEECEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEE
SVDLLLQPGVEHPAAMVLFSPLYDLTFELAKARERIRPDPTTRAANAIRLVGLYHSGVDL
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEEEEECCCCC
THERLTLDVARGPALPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQA
CHHHEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
LPRMTPEAAKAMAYVARFITHALQDARALTQEMH
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2545531 [H]