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The map label for this gene is mbtE

Identifier: 41408271

GI number: 41408271

Start: 2407531

End: 2412810

Strand: Reverse

Name: mbtE

Synonym: MAP2173c

Alternate gene names: 41408271

Gene position: 2412810-2407531 (Counterclockwise)

Preceding gene: 41408272

Following gene: 41408270

Centisome position: 49.96

GC content: 69.39

Gene sequence:

>5280_bases
GTGACAGAAACCACCGGCGCCGGCACCCGCCTCGACGACGAGCGGCTGGAGTTGTTGCGCCGCAAGCTTGCTGAGCGCGG
CCTGTCCCGGTCGACCGGCACGGCCAGGCACGACGAGCCACGCATGTCCGTCGGTCAGCACCGGATGTGGTTCGTGCAGT
CGGTCGATCCCGACAGCGCGCTGCTCAACATCTGCGTTTCCTATCGCCTCACCGGCGGCGTCGACACCGGGCGGCTGCAC
CGCGCGGTCGACGCCGTTGCGGCCCGACACCCGGTCCTGCACACCACGTATGACACCACCGATGAGGGGGACCCGCGGCC
GGTGCTCCGCGCGGACCTGCGGCCCGAGTGGGCCGAACACGACCTGTCCGGGCTGACCGAGCAGGCCCGCCGGTTGCGGC
TGGATGTGTTGGCCCAGCGGGACTTTCGCCGGCCGTTCGACCTGAGCAAGGATTCGCCGCTGCGCGTCACGGCGGCCCGC
CTGGCCGACGAAGAGCTGATGCTGTTGATCACCGCCCACCACATCGCCTGGGACGATGGCTCGTGGGCGCCGTTTTTCGC
CGACCTGACCCGGGCGTACGCCGCCCCGGGCGACTTCGATACCACGCCGGTGGTGCCTGACCTATCGGCGGATCCGACCG
CGATCCGCCGGGAAGACCTGGACTATTGGCGTCCGCTGATGGCCGATCTGCCGGAGCCGCTCGAGCTGCCCGGACCCAAC
GGTTCGGTGGTGCCCAGCACCTGGCGCGCGCAGCGTGCCTTCGCCGAATTGCCGGCGGAGATCGTCGACCGGGCGGCCGC
GCTGGCCCGCGAGACGGGCGCCACCCCGTACATGGTGTTGATGGCCGCGTTCGCCGCGCTGGTGCACCGCTACACCGGGT
CGACGGACTTCCTCGTCGCCGCCCCGGTGCTCAACCGCGGCGCGGCGACCGAGAACGTCATCGGCTACTACGGCAACACC
GTGGTGATCCGGCTGCGACCGCAGTCGCATCAGAGCTTTCGCGAGCTGCTGGCCCAAACCCGCGACGGCGCGGTGGGCGC
CTTCGCTCACTCCCGCGCCGACCTGGATTGGCTGGTGCGCGAATCGAATCCGGATCGCCGGCACGGCGCCGACCGGATGA
CCCGGGTCAGCTTCGGGCAGCGCGAGCCCGACGGCGCCAGCTTCTGCCCGCCCGGCGTGCGTTGTGAACGCGGCGATTTA
CGAGGGCATTTCAACCAGCTGCCGCTGAGCCTGATGATCGAGCTGAACCGCACACCGGACGGTTCCGGTGGCGGTTTGGT
GGAGGCCGAGTATCTGGTCGAGGTGCTCGATCAGCAGTTGGTGGAGCAGATGCTGCGTCACTACCGCACCCTGCTGGACA
GCCTGCTGTCCGACCCGGACGCGACGCTGTCGGCATGTGCGCTGATGAGCGACGCGGACGCCGAGTGGCTGCGCGCGGTG
TCGACCGGTGAACAATTCATCACCCCGGCCGCCACGTTGTCCGAGTTGGTCAGCCACCGGGCGGCGCGCACCCCCGACGC
CGTTGCCGTCGTCTACGAGGGCCACACCTACACCTACCGGGACATCGAGGAAGAGTCGAACCGGGTGGCGCACTGGCTCA
TCGAGCGGGGCGTCGGCACCGAGGACCGGGTCGCGGTGCTGCTGGACAAGTCACCCGAACTGGTCATCACCGCGCTCGGC
GTGCTCAAGGCGGGCGGGGTGTACCTGCCGGTGGACCCCACCTATCCGCAGGACCGGCTGAACTTCATCCTCGGCGACGC
CGACGCCAAACTCGTGCTGCGCGAACCGGTTACCGACCTGGCCGACTATCCGGCCACCGCGCCCACCGAGTTGCTCCGGC
CGCTGACCCCGCAGAACACCGCCTACCTCATCTACACCTCGGGTTCCACCGGGCTGCCCAAGGGCGTTCCGGTGCCGCAC
GCGCCCATCGCCGAGTACTTCGTCTGGTTCGGCGACGAGTACCGCATCGACGAGACGGACCGGCTGTTGCAGGTCGCATC
GCCCAGCTTCGACGTGTCCATCGGAGAGATCTTCGGCACCCTGATCATGGGTGCGCGCCTGGTGATTCCGCGGCCCGACG
GGCTGCGTGACATCGGCTACCTCACCGAACTGCTGGCCCGGGAGGGCATCACGTCGATGCACTTCGTGCCGTCGCTGCTG
GGGCTGTTCCTGTCGCTGCCCGGGGTCAGCCAGTGGCGCACCCTGCGTCGGGTACCCATCGGCGGCGAGGCGCTGCCCGG
CGAGATCGCCGACAAGTTCCACGCCACCTTCGACGCGTCGCTGTACAACTTCTACGGGCCGACCGAGACGGTGGTCAACT
GCACCAGCTACCCGGTGGAAGGCGCACAGGGGACCCGGGTGGTGCCCATCGGGCGGCCCAAGATCAACACCCGGGTGTAT
CTGCTCGACAACGCCCTGCAGCCTGTTCCGCCCGGTGTGATCGGCGAAATCTACATCGCCGGAACACATGTCGCGCACGG
ATACCACCGCCGGCCGCAGCTGACCGCCGAGCGTTTCGTCGCCGACCCGTTCTCCCGGGGCGGGCGCATGTACCGCTCCG
GCGACCTGGCCCGGCGCAACGCGAACGGCGACATCGAGTTCGTCGGCCGCGCCGACGAACAGGTGAAGATCCGCGGCTTC
CGCATCGAGCTGGGCGAGATCGCCGCCGCCATCTCGGTCGACCCCAGCGTGGGGCAAGCGGTCGTGCTGGCCATGGACCT
GCCCCAGTTGGGCAAGAGCCTGGTGGGATACGTGACACCGGCCCAGGGTGCCGGCACGGAAACCGTTGACGTCGAACGCA
TCCGGGCCCGGGTGGCGGCCGCGCTGCCGGACTACATGACGCCGGCCGCCTACGTGGTGCTCGACGAGATCCCGATCACC
GCGCACCAGAAGATCGACCGCGCCGCGCTGCCGCAGCCGCAGATCGGCGCGGGCACCGAGTACCGCGATCCCGCGACTCC
CACCGAACACCGTATCGCCCAACTGTTTTCCGGACTGCTCGGTCACGAACGGGTGGGCGTCGACGACTCGTTCTTCGATC
TGGGTGGCCACTCGCTGGTCGCCACCAAACTGGTCACCGCGATCCGCGCCGAATGCGGGGTCGAGATCGGGATCCGCGAC
GTGTTCGAGCTCGCGACGGTGGGCCTGTTGGCGGAGCGGGTCGATCAGCTCAGTTCGGGTGAACTGACCGGAACGCGGCC
CAAACTGATCGCGACCGCCCACGACGAGCCCCTGCCGCTTTCGGCGTCCCAGCTGCGCAGCTGGTTCGCCTACCGGATGG
ATGGGCCCAGTCCGGTCAACAACATTCCCTTCGCGGCGAGGCTGACCGGCCCGTGGGACATCGACGCGCTGATCGCGGCC
GTCGGCGACGTCGTCGCCCGGCACGAGATCCTGCGCACCCGCTACGTCGAACTCGACGGCGTGCCCTACCAGGTGGTGGG
CCCGCCCGGCGTCGAGATCCCGGTGCGCCGCGAGGACGGCCCCGACGACCCCTGGCTGCAGCAGCAGCTCGACGCCGAGC
GGCGGCACTGCTTCGAGCTGGACGGTGAATTGCCGATCCGGGTCGCGGTGCTGCGCGTCGCGAACGCGGCCGAGCATGTG
CTGTCCCTGGTCGTGCACCACATCGCATCCGACCATTGGTCGGCGGGTGTGCTGTTCGCCGACGTGATGACCGCCTACCG
CGCGCGGCGCGGTGGGGAAGCGCCGTCCTGGGCTCCGCTGCGCGTGCAGTACGCCGACTACGCGGCCTGGCAGCGCACGT
TTCTCGGTGACGCCGGCGGCCAGGAGTCCGCGGTTGCCGGTGCGCAGCGCGAGTACTGGACCCGGCAGCTGGCCGGGTTG
CCGGAGGACACCGGACTGCGTCCGGACTTCCCGCGCCAGCCGGTGCCCAGCGGGGACGGCGAATCCGTCGACTTCCACAT
CGACGCGGCCACCAGGGTCAAGCTCGCCGAGGTGTGCCGCGAATTGGGCATCACCGAGTTCATGCTGCTGCAAACGGCGG
TCGCCGTCGTGCTGCACAAGGCCGGTGGCGGCGTGGACATTCCGCTGGGCACCCCGGTAGCCGGTCGCACCGAAGCCGAA
TTGGACCAGCTGATCGGCTTTTTCGTCAACATCCTGGTGCTGCGCAACGACCTGGACGGCAACCCGACGTTGCGCGAACT
GCTCAAGCGGGCCCGGGAAACCGCGCTGGCCGCCTATGCGCACCAGGACCTGCCGTTCGACCGGGTGGTCGACAGCGTCA
GCCCGGTGCGGTCACTGTCGCGCAATCCGCTGTTCCAGGTCGTCGTGCACGTCCGCGATCACCTGTCCGCCACCCGGGTC
ATCGAGACCGCACCCGTCGGAGGCGACGGCCAGGACACCGTGTGCACGTCGCTGGATCCCGTCTTCGACATGGCGCACGC
CGATCTAAGCGTGAACTTCTTCGGCACCGACGGCGCCAGCGACATCGGCTACAACTGCCATCTGATCTTCCGCACCGACC
TGTATCGCAGGACCACCATCGAGCGGCTGGCCGGATGGCTGGTCCGGGCCGTCACCGCGTTCGCCGACGACCTCGACCAG
ACGTTGCGGGACGTCGCGCTGATCGACGCCGGCGAACAACAGCGCATCCTGCGACAGTGGAGCCGCGGCGCGCAGCCGCC
ACGGGACCGGCCGCGCACCATACCGGAACTGCTGCAACCCACCCGGTCGCTGGGGGCCGACCGGATCGCGGTGCGCTGCG
GCGCCGAGCACATCGACTACCCTGCGCTGCACCGCCGTTCGGACAACCTGGCCGCGCTGCTCGTCGATAGGGGGGTAGGA
CCGGGCACGCTGGTCGGGCTGTCCACCCGGCGCGGCATCGAGCTGGTGGTGGCGCTGGTGGCCATCATGAAGGCCGGTGC
CGGTTACTTCCCCGTCGATCCCGGATATCCTTCGGCGCGTAAGCAATTCATGCTCGACGACGTGCGGCCACCGGTCGTGG
TCGCGACGGTCGAAGCGGTGGACACCATGCCGGCGCTGCCCGGGGTCGAGCTGCTCTCGCTGGACGATCCGCAGGTGCGC
GCGCTGGTGGACCGCGACCGCCCCACCCCGATGATCCGATGTATCTGGTGTTCACCTCGGGCTCCACCGGCAAGCCGAAA
GGTGCTGTGGGAACGCATCGCTCGATGGCGGCCCGGCTGGATTGGCAGCTGCGGCACTACCCGCCGCGCACCGACGACGT
TCGATTGGCGCAGGCCTCCATCACCTTCCTGGAAGGCGGCATGGAGATGCTGGCCGGGCTGGCGGCGGGCGCGACGATGA

Upstream 100 bases:

>100_bases
ACCGGCGGCCCCGTGGTCCCACCAACCGTCCAGCGCACCGGCGCCGTCAGCGGTGCGCATCCCTCAACGCTCGCGATGCT
AGAAAGGTTGGACTCCTAGC

Downstream 100 bases:

>100_bases
TCCTGGCCGACGACGCCGAACACCGCGACCCCGAGGCGCTCGGGGAGTTGATGCACCGGCATTCGGTCGCCCAGGTGACC
GCGGTGCCCAGCCTGGTCTC

Product: MbtE

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 1759; Mature: 1758

Protein sequence:

>1759_residues
MTETTGAGTRLDDERLELLRRKLAERGLSRSTGTARHDEPRMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLH
RAVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAAR
LADEELMLLITAHHIAWDDGSWAPFFADLTRAYAAPGDFDTTPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPN
GSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAATENVIGYYGNT
VVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGASFCPPGVRCERGDL
RGHFNQLPLSLMIELNRTPDGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAV
STGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESNRVAHWLIERGVGTEDRVAVLLDKSPELVITALG
VLKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDLADYPATAPTELLRPLTPQNTAYLIYTSGSTGLPKGVPVPH
APIAEYFVWFGDEYRIDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLL
GLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVY
LLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGF
RIELGEIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPIT
AHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRD
VFELATVGLLAERVDQLSSGELTGTRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAA
VGDVVARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDGELPIRVAVLRVANAAEHV
LSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGL
PEDTGLRPDFPRQPVPSGDGESVDFHIDAATRVKLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAE
LDQLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRDHLSATRV
IETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGASDIGYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQ
TLRDVALIDAGEQQRILRQWSRGAQPPRDRPRTIPELLQPTRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVG
PGTLVGLSTRRGIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAVDTMPALPGVELLSLDDPQVR
ALVDRDRPTPMIRCIWCSPRAPPASRKVLWERIARWRPGWIGSCGTTRRAPTTFDWRRPPSPSWKAAWRCWPGWRRARR

Sequences:

>Translated_1759_residues
MTETTGAGTRLDDERLELLRRKLAERGLSRSTGTARHDEPRMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLH
RAVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAAR
LADEELMLLITAHHIAWDDGSWAPFFADLTRAYAAPGDFDTTPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPN
GSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAATENVIGYYGNT
VVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGASFCPPGVRCERGDL
RGHFNQLPLSLMIELNRTPDGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAV
STGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESNRVAHWLIERGVGTEDRVAVLLDKSPELVITALG
VLKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDLADYPATAPTELLRPLTPQNTAYLIYTSGSTGLPKGVPVPH
APIAEYFVWFGDEYRIDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLL
GLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVY
LLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGF
RIELGEIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPIT
AHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRD
VFELATVGLLAERVDQLSSGELTGTRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAA
VGDVVARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDGELPIRVAVLRVANAAEHV
LSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGL
PEDTGLRPDFPRQPVPSGDGESVDFHIDAATRVKLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAE
LDQLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRDHLSATRV
IETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGASDIGYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQ
TLRDVALIDAGEQQRILRQWSRGAQPPRDRPRTIPELLQPTRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVG
PGTLVGLSTRRGIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAVDTMPALPGVELLSLDDPQVR
ALVDRDRPTPMIRCIWCSPRAPPASRKVLWERIARWRPGWIGSCGTTRRAPTTFDWRRPPSPSWKAAWRCWPGWRRARR
>Mature_1758_residues
TETTGAGTRLDDERLELLRRKLAERGLSRSTGTARHDEPRMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLHR
AVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAARL
ADEELMLLITAHHIAWDDGSWAPFFADLTRAYAAPGDFDTTPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPNG
SVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAATENVIGYYGNTV
VIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGASFCPPGVRCERGDLR
GHFNQLPLSLMIELNRTPDGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAVS
TGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESNRVAHWLIERGVGTEDRVAVLLDKSPELVITALGV
LKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDLADYPATAPTELLRPLTPQNTAYLIYTSGSTGLPKGVPVPHA
PIAEYFVWFGDEYRIDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLLG
LFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVYL
LDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFR
IELGEIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPITA
HQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDV
FELATVGLLAERVDQLSSGELTGTRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAV
GDVVARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDGELPIRVAVLRVANAAEHVL
SLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGLP
EDTGLRPDFPRQPVPSGDGESVDFHIDAATRVKLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAEL
DQLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRDHLSATRVI
ETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGASDIGYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQT
LRDVALIDAGEQQRILRQWSRGAQPPRDRPRTIPELLQPTRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVGP
GTLVGLSTRRGIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAVDTMPALPGVELLSLDDPQVRA
LVDRDRPTPMIRCIWCSPRAPPASRKVLWERIARWRPGWIGSCGTTRRAPTTFDWRRPPSPSWKAAWRCWPGWRRARR

Specific function: Specifically adenylates threonine and glycine, and loads them onto their corresponding peptidyl carrier domains [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=505, Percent_Identity=22.3762376237624, Blast_Score=99, Evalue=4e-20,
Organism=Homo sapiens, GI28416953, Length=574, Percent_Identity=23.3449477351916, Blast_Score=93, Evalue=2e-18,
Organism=Homo sapiens, GI45580730, Length=437, Percent_Identity=25.1716247139588, Blast_Score=91, Evalue=8e-18,
Organism=Homo sapiens, GI157311624, Length=511, Percent_Identity=22.5048923679061, Blast_Score=86, Evalue=5e-16,
Organism=Homo sapiens, GI157311622, Length=511, Percent_Identity=22.5048923679061, Blast_Score=86, Evalue=5e-16,
Organism=Homo sapiens, GI156151445, Length=358, Percent_Identity=24.5810055865922, Blast_Score=77, Evalue=2e-13,
Organism=Homo sapiens, GI122937307, Length=498, Percent_Identity=21.8875502008032, Blast_Score=76, Evalue=3e-13,
Organism=Homo sapiens, GI42544132, Length=508, Percent_Identity=21.8503937007874, Blast_Score=75, Evalue=4e-13,
Organism=Escherichia coli, GI1786801, Length=670, Percent_Identity=36.865671641791, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI145693145, Length=535, Percent_Identity=26.9158878504673, Blast_Score=120, Evalue=6e-28,
Organism=Escherichia coli, GI1788107, Length=545, Percent_Identity=24.2201834862385, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1786810, Length=528, Percent_Identity=22.3484848484848, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1790505, Length=555, Percent_Identity=22.5225225225225, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1789201, Length=315, Percent_Identity=27.3015873015873, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17556356, Length=514, Percent_Identity=26.4591439688716, Blast_Score=128, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=549, Percent_Identity=22.4043715846995, Blast_Score=109, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560308, Length=383, Percent_Identity=23.7597911227154, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994694, Length=536, Percent_Identity=20.1492537313433, Blast_Score=74, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994690, Length=539, Percent_Identity=20.4081632653061, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994703, Length=550, Percent_Identity=20.1818181818182, Blast_Score=72, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=910, Percent_Identity=24.6153846153846, Blast_Score=245, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6319699, Length=551, Percent_Identity=22.5045372050817, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648676, Length=652, Percent_Identity=32.361963190184, Blast_Score=241, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24581924, Length=458, Percent_Identity=23.3624454148472, Blast_Score=78, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 193401; Mature: 193269

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTGAGTRLDDERLELLRRKLAERGLSRSTGTARHDEPRMSVGQHRMWFVQSVDPDSA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHH
LLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEH
HHHHHHHHEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHH
DLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAARLADEELMLLITAHHIAWDDG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCCEEEEEEEEEEEECCC
SWAPFFADLTRAYAAPGDFDTTPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPN
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVA
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
APVLNRGAATENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVR
CCHHCCCCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEE
ESNPDRRHGADRMTRVSFGQREPDGASFCPPGVRCERGDLRGHFNQLPLSLMIELNRTPD
CCCCCHHHCHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCHHHCCCEEEEEEECCCCC
GSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAV
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHH
STGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESNRVAHWLIERGVGT
HCCHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCC
EDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDL
CCCEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCCHHHHEEEECCCCCEEEECCCHHHH
ADYPATAPTELLRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAEYFVWFGDEYRIDETD
HCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECHHH
RLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLL
HHHHHCCCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
GLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVE
HHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCHHHHEECCCCCCC
GAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFV
CCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEEHHHCCCCCCCCHHHHHHH
ADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELGEIAAAISVDPSVGQA
CCHHHHCCCEEECCCHHHCCCCCCEEEEECCCCEEEEEEEEEEHHHHHEEEECCCCCCCE
VVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPIT
EEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCH
AHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLV
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHH
ATKLVTAIRAECGVEIGIRDVFELATVGLLAERVDQLSSGELTGTRPKLIATAHDEPLPL
HHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
SASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILRTRYVELDG
CHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
VPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDGELPIRVAVLRVANAAEHV
CCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
LSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRTFLGDAGG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCC
QESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGESVDFHIDAATRVKLAEVCR
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHH
ELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQLIGFFVNILVLRNDLDG
HCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
NPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRDHLSATRV
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHE
IETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGASDIGYNCHLIFRTDLYRRTTI
EEECCCCCCCCCCHHHCCCHHHHHHHCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHH
ERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSRGAQPPRDRPRTIPELLQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVGPGTLVGLSTRRGIELVVALV
HHHCCCCEEEEEECCCCCCCCHHHCCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHH
AIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAVDTMPALPGVELLSLDDPQVR
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCEEEECCCHHHH
ALVDRDRPTPMIRCIWCSPRAPPASRKVLWERIARWRPGWIGSCGTTRRAPTTFDWRRPP
HHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
SPSWKAAWRCWPGWRRARR
CCCCCHHEEECCCHHHCCC
>Mature Secondary Structure 
TETTGAGTRLDDERLELLRRKLAERGLSRSTGTARHDEPRMSVGQHRMWFVQSVDPDSA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHH
LLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHTTYDTTDEGDPRPVLRADLRPEWAEH
HHHHHHHHEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHH
DLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAARLADEELMLLITAHHIAWDDG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCCEEEEEEEEEEEECCC
SWAPFFADLTRAYAAPGDFDTTPVVPDLSADPTAIRREDLDYWRPLMADLPEPLELPGPN
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVA
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
APVLNRGAATENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVR
CCHHCCCCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEE
ESNPDRRHGADRMTRVSFGQREPDGASFCPPGVRCERGDLRGHFNQLPLSLMIELNRTPD
CCCCCHHHCHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCHHHCCCEEEEEEECCCCC
GSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRAV
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHH
STGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESNRVAHWLIERGVGT
HCCHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCC
EDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDADAKLVLREPVTDL
CCCEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCCHHHHEEEECCCCCEEEECCCHHHH
ADYPATAPTELLRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAEYFVWFGDEYRIDETD
HCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECHHH
RLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSMHFVPSLL
HHHHHCCCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
GLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFYGPTETVVNCTSYPVE
HHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCHHHHEECCCCCCC
GAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFV
CCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEEHHHCCCCCCCCHHHHHHH
ADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELGEIAAAISVDPSVGQA
CCHHHHCCCEEECCCHHHCCCCCCEEEEECCCCEEEEEEEEEEHHHHHEEEECCCCCCCE
VVLAMDLPQLGKSLVGYVTPAQGAGTETVDVERIRARVAAALPDYMTPAAYVVLDEIPIT
EEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCH
AHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLV
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHH
ATKLVTAIRAECGVEIGIRDVFELATVGLLAERVDQLSSGELTGTRPKLIATAHDEPLPL
HHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
SASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILRTRYVELDG
CHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
VPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDGELPIRVAVLRVANAAEHV
CCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
LSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRTFLGDAGG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCC
QESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGESVDFHIDAATRVKLAEVCR
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHH
ELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQLIGFFVNILVLRNDLDG
HCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
NPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRDHLSATRV
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHE
IETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGASDIGYNCHLIFRTDLYRRTTI
EEECCCCCCCCCCHHHCCCHHHHHHHCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHH
ERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSRGAQPPRDRPRTIPELLQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVGPGTLVGLSTRRGIELVVALV
HHHCCCCEEEEEECCCCCCCCHHHCCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHH
AIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAVDTMPALPGVELLSLDDPQVR
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCEEEECCCHHHH
ALVDRDRPTPMIRCIWCSPRAPPASRKVLWERIARWRPGWIGSCGTTRRAPTTFDWRRPP
HHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
SPSWKAAWRCWPGWRRARR
CCCCCHHEEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11112781; 9384377; 10568751; 8550523 [H]