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The map label for this gene is uppS [H]

Identifier: 41408239

GI number: 41408239

Start: 2370545

End: 2371435

Strand: Reverse

Name: uppS [H]

Synonym: MAP2141c

Alternate gene names: 41408239

Gene position: 2371435-2370545 (Counterclockwise)

Preceding gene: 41408240

Following gene: 41408238

Centisome position: 49.1

GC content: 66.67

Gene sequence:

>891_bases
GTGGTTAGAGCCGAGCGCGCCCCGACGTCGACCGGCTTTCCGCAGCTGCCCCCGGCGCCCGACGACTACCCGGTGTTCCC
GGACAAGTCGACGTGGCCGGTGGTCTTCCCCGAGTTGCCGCCGTCGCCCGGCGGCGGGCCGAGCCGGCCGCCGCAGCACA
TCTCCAAGGCGGCCGCGCCGCGCATCCCCGCGGACCGACTGCCCAACCACGTGGCCATCGTGATGGACGGCAACGGCCGC
TGGGCCACCGAACGGGGCATGTCACGCACCGACGGCCACAAGGCCGGCGAGGCGGTGGTCATCGACATCGTCTGCGGCGC
AATCGAAATCGGCATCAAGTGGCTCAGCCTGTACGCCTTTTCCACCGAGAACTGGAAGCGGTCCCCCGAAGAGGTCCGGT
TTTTGATGGGCTTCAACCGCGACGTGGTGCGGATGCGACGGGTGAACCTGAACACGATAGGGGTCAAGATCCGCTGGGTG
GGTTCGCGGCCCCGGCTGTGGCGCAGCGTGATCAACGAATTGGCGATCGCCGAGGAGATGACCAAGCGCAACGACGTCAT
CACCGTCAACTACTGCGTCAACTACGGGGGCAGGGCCGAAATTGCCGAGGCCACAAAGGAAATCGCCCGGCTGGCCGCCG
CCGGCCGGTTGAACCCCGAGCGCATCACCGAGTCCACCGTGGCGCATCACCTGCAACGGCCCGACATCCCCGATGTGGAC
CTGTTCTTGCGGACCTCGGGGGAGCAGCGGTCCAGCAACTTCATGTTGTGGCAGGCCGCCTACGCCGAATACATCTTCCA
GGACAAGTTGTGGCCCGACTACGACCGCCGCGATCTGTGGGCCGCCTGCCAGGAATACGCTTCCCGCAACCGCAGATTCG
GGAGCGCATAA

Upstream 100 bases:

>100_bases
GAGCGCCAGCTCAAGACGTTGCCGCTCGTCGAGCGGACCTATCACATCGACCGCACCATCGCCGACCAGCGCGCCACGCT
GATCGGGCAGGATATGGACT

Downstream 100 bases:

>100_bases
TGTCCTCGCTGCAAGAGCGTCTGGCATCGGTGCTGCGCGAGGTGCTGCCGTCGCAGGAGGAGTCCGACGGCGCGCTGACC
GTCCACCACGAGGGCACCAT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MVRAERAPTSTGFPQLPPAPDDYPVFPDKSTWPVVFPELPPSPGGGPSRPPQHISKAAAPRIPADRLPNHVAIVMDGNGR
WATERGMSRTDGHKAGEAVVIDIVCGAIEIGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRMRRVNLNTIGVKIRWV
GSRPRLWRSVINELAIAEEMTKRNDVITVNYCVNYGGRAEIAEATKEIARLAAAGRLNPERITESTVAHHLQRPDIPDVD
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACQEYASRNRRFGSA

Sequences:

>Translated_296_residues
MVRAERAPTSTGFPQLPPAPDDYPVFPDKSTWPVVFPELPPSPGGGPSRPPQHISKAAAPRIPADRLPNHVAIVMDGNGR
WATERGMSRTDGHKAGEAVVIDIVCGAIEIGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRMRRVNLNTIGVKIRWV
GSRPRLWRSVINELAIAEEMTKRNDVITVNYCVNYGGRAEIAEATKEIARLAAAGRLNPERITESTVAHHLQRPDIPDVD
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACQEYASRNRRFGSA
>Mature_296_residues
MVRAERAPTSTGFPQLPPAPDDYPVFPDKSTWPVVFPELPPSPGGGPSRPPQHISKAAAPRIPADRLPNHVAIVMDGNGR
WATERGMSRTDGHKAGEAVVIDIVCGAIEIGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRMRRVNLNTIGVKIRWV
GSRPRLWRSVINELAIAEEMTKRNDVITVNYCVNYGGRAEIAEATKEIARLAAAGRLNPERITESTVAHHLQRPDIPDVD
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACQEYASRNRRFGSA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=232, Percent_Identity=34.4827586206897, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI45580742, Length=232, Percent_Identity=34.4827586206897, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=41.7391304347826, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=33.6283185840708, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=37.0892018779343, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=34.9282296650718, Blast_Score=117, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 33439; Mature: 33439

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRAERAPTSTGFPQLPPAPDDYPVFPDKSTWPVVFPELPPSPGGGPSRPPQHISKAAAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHCC
RIPADRLPNHVAIVMDGNGRWATERGMSRTDGHKAGEAVVIDIVCGAIEIGIKWLSLYAF
CCCHHHCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHEEEHEEEE
STENWKRSPEEVRFLMGFNRDVVRMRRVNLNTIGVKIRWVGSRPRLWRSVINELAIAEEM
CCCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHH
TKRNDVITVNYCVNYGGRAEIAEATKEIARLAAAGRLNPERITESTVAHHLQRPDIPDVD
HHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCE
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACQEYASRNRRFGSA
EEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVRAERAPTSTGFPQLPPAPDDYPVFPDKSTWPVVFPELPPSPGGGPSRPPQHISKAAAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHCC
RIPADRLPNHVAIVMDGNGRWATERGMSRTDGHKAGEAVVIDIVCGAIEIGIKWLSLYAF
CCCHHHCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHEEEHEEEE
STENWKRSPEEVRFLMGFNRDVVRMRRVNLNTIGVKIRWVGSRPRLWRSVINELAIAEEM
CCCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHH
TKRNDVITVNYCVNYGGRAEIAEATKEIARLAAAGRLNPERITESTVAHHLQRPDIPDVD
HHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCE
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACQEYASRNRRFGSA
EEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]