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The map label for this gene is fadA [H]

Identifier: 41408158

GI number: 41408158

Start: 2268270

End: 2269445

Strand: Reverse

Name: fadA [H]

Synonym: MAP2060c

Alternate gene names: 41408158

Gene position: 2269445-2268270 (Counterclockwise)

Preceding gene: 41408161

Following gene: 41408156

Centisome position: 46.99

GC content: 69.47

Gene sequence:

>1176_bases
ATGGGTACACCCGTAATCGTCGGAGCCGTTCGAACGGCGATCGGCCGTTCCTTCAAGGGGACGCTCGTCAACACCCCGCC
CGAGACGCTGATCACCGCGGTGCTTCCCGAGGTGATACGTCGCTCCGGTGTCGACCCGGCCGCGATCGACGACATCATCT
TCGCCGAATCCCATTACGGCGGTGGCGATCTCGCGCGTTACGCGGCGGCGGCCACCGGCCTGGAGGACATTCCCGGCCAG
TCGGTGAACCGGCACTGCGCGGGCAGCCTCACCGCGATCGGCAACGCCGCGGCCCAGATCGGATCCGGCATGGAGCGGGT
GCTGATCGCCGGCGGCGTGCAGTCGTTGTCGATGACGCCGCTAGTCAACTGGCGCATCCCGGGCCCCGAGCTCAAGTTCG
AGGAACGCTGGATGCCGCCGACCCACGTCGAGGCGCCCGACGCGCCCACCCGGGACATGTCCATCACCGTCGGCTGGAAC
ACCGCCAAGACGGTCGGCATCACCCGCGAGGAAATGGACGCCTGGGCGGCCCGCTCGCACCAGCGCGCCATCGCGGCCAT
CGACGCCGGCAAGTTCGTCGACGAGATCCTGCCGCTCAAGATCACCCAGGTGGACGGTTCGGTCACCGAGTTCGCCATCG
ACGAGCATCCGCGCCGCGACACCACCGTCGAGAAGCTCGCCGGCCTGAAGGTGTTGCACCCCGAAATCGAGGGCTTCTCG
ATCACCGCCGGCAACAGCAGCGGCACCAACGACGCCGCCGCGGCGGTCGCGCTGGTCGACCGGGAGTACGCCGAAGCCGA
AAAGCTCAATGTGATGGGCACGGTGCGGGCGTGGGCCGCCGCGGGCGTGCCGCCGCGCGACTGTGGCCTGGGCGCGGTCA
AGGTGATCGGCAAGGTCCTGCAGCGGGCCGGGTTGTCGCCCGGCGACGTGGCGCTGTGGGAGATCAACGAGGCGTTCGCG
TCCGTGCCCATCGCGGCGTGCCGGGAATACGGTCTCGATGAGGAGAAGGTGAACTTCTCCGGTAGCGGCTGCAGCCTCGG
CCACCCCATCGCGGCCTCCGGCGCACGCATGGTGACCACGTTGACCTACGAATTGGCCCGCCGCGGTGGCGGTATCGGCG
TGGCGGCGATGTGCGCCGGTGGCGGCCAGGGCGGCGCGGTCGTCATCGAGGTCTAG

Upstream 100 bases:

>100_bases
AGACCGGCCCGCACCGAACTTAGACCAATACTATTGTCTATACAGTATTTGATACGATTCGCCGCGACTGACCGCTGCCA
GACCGTTCGAGGTTGAGAAC

Downstream 100 bases:

>100_bases
CCGGGCCTCAGTTGCAGAACGTGTAGCCGATGAACTGGGTGCCGCGGGTATCGCCGCTCGAGTAGTTCGCGAAATGCACC
GCGGGCATCCCGTGGTACTG

Product: hypothetical protein

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MGTPVIVGAVRTAIGRSFKGTLVNTPPETLITAVLPEVIRRSGVDPAAIDDIIFAESHYGGGDLARYAAAATGLEDIPGQ
SVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGPELKFEERWMPPTHVEAPDAPTRDMSITVGWN
TAKTVGITREEMDAWAARSHQRAIAAIDAGKFVDEILPLKITQVDGSVTEFAIDEHPRRDTTVEKLAGLKVLHPEIEGFS
ITAGNSSGTNDAAAAVALVDREYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVLQRAGLSPGDVALWEINEAFA
SVPIAACREYGLDEEKVNFSGSGCSLGHPIAASGARMVTTLTYELARRGGGIGVAAMCAGGGQGGAVVIEV

Sequences:

>Translated_391_residues
MGTPVIVGAVRTAIGRSFKGTLVNTPPETLITAVLPEVIRRSGVDPAAIDDIIFAESHYGGGDLARYAAAATGLEDIPGQ
SVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGPELKFEERWMPPTHVEAPDAPTRDMSITVGWN
TAKTVGITREEMDAWAARSHQRAIAAIDAGKFVDEILPLKITQVDGSVTEFAIDEHPRRDTTVEKLAGLKVLHPEIEGFS
ITAGNSSGTNDAAAAVALVDREYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVLQRAGLSPGDVALWEINEAFA
SVPIAACREYGLDEEKVNFSGSGCSLGHPIAASGARMVTTLTYELARRGGGIGVAAMCAGGGQGGAVVIEV
>Mature_390_residues
GTPVIVGAVRTAIGRSFKGTLVNTPPETLITAVLPEVIRRSGVDPAAIDDIIFAESHYGGGDLARYAAAATGLEDIPGQS
VNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTPLVNWRIPGPELKFEERWMPPTHVEAPDAPTRDMSITVGWNT
AKTVGITREEMDAWAARSHQRAIAAIDAGKFVDEILPLKITQVDGSVTEFAIDEHPRRDTTVEKLAGLKVLHPEIEGFSI
TAGNSSGTNDAAAAVALVDREYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVLQRAGLSPGDVALWEINEAFAS
VPIAACREYGLDEEKVNFSGSGCSLGHPIAASGARMVTTLTYELARRGGGIGVAAMCAGGGQGGAVVIEV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=35.7868020304569, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=37.7833753148615, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=33.7531486146096, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=34.5177664974619, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=29.3023255813954, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=49.438202247191, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787663, Length=418, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=36.8811881188119, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87082165, Length=397, Percent_Identity=37.5314861460957, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=34.9246231155779, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=32.0843091334895, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=34.5864661654135, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=31.328320802005, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=29.156010230179, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=28.3062645011601, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=34.5177664974619, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=33.7468982630273, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24655093, Length=399, Percent_Identity=36.8421052631579, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=32.1608040201005, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=31.9899244332494, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=29.0094339622642, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40651; Mature: 40519

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTPVIVGAVRTAIGRSFKGTLVNTPPETLITAVLPEVIRRSGVDPAAIDDIIFAESHYG
CCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCCC
GGDLARYAAAATGLEDIPGQSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTP
CHHHHHHHHHHCCHHHCCCCCCCHHHCCCHHHHHHHHHHHCCCHHEEEEECCCCCEECCE
LVNWRIPGPELKFEERWMPPTHVEAPDAPTRDMSITVGWNTAKTVGITREEMDAWAARSH
EEEEECCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHH
QRAIAAIDAGKFVDEILPLKITQVDGSVTEFAIDEHPRRDTTVEKLAGLKVLHPEIEGFS
CCEEEEEHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCCHHHHHCCCEEECCCCCCEE
ITAGNSSGTNDAAAAVALVDREYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCCCCCCHHHHHHHHHH
QRAGLSPGDVALWEINEAFASVPIAACREYGLDEEKVNFSGSGCSLGHPIAASGARMVTT
HHCCCCCCCEEEEEEHHHHHHCCHHHHHHCCCCHHHEECCCCCCCCCCCCCCCCCEEHHH
LTYELARRGGGIGVAAMCAGGGQGGAVVIEV
HHHHHHHCCCCCEEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
GTPVIVGAVRTAIGRSFKGTLVNTPPETLITAVLPEVIRRSGVDPAAIDDIIFAESHYG
CCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCCC
GGDLARYAAAATGLEDIPGQSVNRHCAGSLTAIGNAAAQIGSGMERVLIAGGVQSLSMTP
CHHHHHHHHHHCCHHHCCCCCCCHHHCCCHHHHHHHHHHHCCCHHEEEEECCCCCEECCE
LVNWRIPGPELKFEERWMPPTHVEAPDAPTRDMSITVGWNTAKTVGITREEMDAWAARSH
EEEEECCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHH
QRAIAAIDAGKFVDEILPLKITQVDGSVTEFAIDEHPRRDTTVEKLAGLKVLHPEIEGFS
CCEEEEEHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCCHHHHHCCCEEECCCCCCEE
ITAGNSSGTNDAAAAVALVDREYAEAEKLNVMGTVRAWAAAGVPPRDCGLGAVKVIGKVL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCCCCCCHHHHHHHHHH
QRAGLSPGDVALWEINEAFASVPIAACREYGLDEEKVNFSGSGCSLGHPIAASGARMVTT
HHCCCCCCCEEEEEEHHHHHHCCHHHHHHCCCCHHHEECCCCCCCCCCCCCCCCCEEHHH
LTYELARRGGGIGVAAMCAGGGQGGAVVIEV
HHHHHHHCCCCCEEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]