Click here to switch to the map view.

The map label for this gene is dhmA

Identifier: 41408155

GI number: 41408155

Start: 2265835

End: 2266740

Strand: Direct

Name: dhmA

Synonym: MAP2057

Alternate gene names: 41408155

Gene position: 2265835-2266740 (Clockwise)

Preceding gene: 41408153

Following gene: 41408157

Centisome position: 46.91

GC content: 68.65

Gene sequence:

>906_bases
ATGCATGTGCTGCGAACCCCGGACTCCCGATTCGAAAACCTGGAGGACTACCCGTTCGTGGCGCACTATCTCGACGTCAC
CGCGCGCGACACCCGGCCGCTTCGCATGCACTACCTGGACGAGGGGCCGATCGACGGGCCACCGATCGTGCTGCTGCACG
GCGAGCCCACCTGGAGCTACCTGTACCGCACCATGATCACGCCGCTGACCGACGCCGGAAACCGGGTGCTGGCACCCGAC
TTGATCGGCTTCGGCCGGTCGGACAAGCCCAGCCGGATCGAGGACTACTCCTACCAGCGGCACGTGGACTGGGTGGTCTC
CTGGTTCGAACACCTCAACCTCAGCGACGTCACGCTGTTCGTGCAGGACTGGGGATCATTGATCGGGCTGCGCATCGCCG
CCGAGCAGCCCGACCGGGTGGGACGGCTGGTGGTGGCCAACGGCTTTCTTCCCACCGCGCAGCGACGCACCCCGCCCGCC
TTCTACGCGTGGCGAGCCTTCGCGCGCTACTCCCCCGTGCTGCCCGCCGGCCGCATCGTCAGCGTCGGGACCGTCCGCCG
GGTTTCGTCCAAGGTGCGTGCCGGCTACGACGCGCCCTTCCCCGACAAGACGTATCAGGCCGGGGCGCGGGCATTTCCGC
AGCTGGTGCCCACCTCGCCGGCCGATCCCGCGATTCCGGCCAACCGCAAGGCGTGGGAAGCCCTCGGCCGCTGGGAAAAA
CCGTTCCTGGCCATCTTCGGCGCCCGCGACCCCATCCTCGGCCACGCGGACAGCCCGCTGATCAAGCACATTCCGGGCGC
CGCGGGCCAACCGCACGCCCGCATCAACGCCAGTCACTTCATCCAGGAGGACCGCGGACCCGAACTGGCCGAACGCATCC
TGTCCTGGCAGCAGGCGCTGCTCTGA

Upstream 100 bases:

>100_bases
TAGTGGCCGCAACGGTGTAGCTCAACGAATCTGCTACTAGACGAATGCCCGTCGGCGAGAGAGGCTAGCAGAGGTGCCGG
TTCACGACGAGGAGCTGAAT

Downstream 100 bases:

>100_bases
GTGCAGAGTCGCGGCCATTGCCCAGGCCCGCGTCCTAGCGCGAAAGACCAAGCGCGCCAGCGACTCTCGAGGACCGTCAG
CGGGTGACCGCGAGGACGGC

Product: haloalkane dehalogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPD
LIGFGRSDKPSRIEDYSYQRHVDWVVSWFEHLNLSDVTLFVQDWGSLIGLRIAAEQPDRVGRLVVANGFLPTAQRRTPPA
FYAWRAFARYSPVLPAGRIVSVGTVRRVSSKVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEK
PFLAIFGARDPILGHADSPLIKHIPGAAGQPHARINASHFIQEDRGPELAERILSWQQALL

Sequences:

>Translated_301_residues
MHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPD
LIGFGRSDKPSRIEDYSYQRHVDWVVSWFEHLNLSDVTLFVQDWGSLIGLRIAAEQPDRVGRLVVANGFLPTAQRRTPPA
FYAWRAFARYSPVLPAGRIVSVGTVRRVSSKVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEK
PFLAIFGARDPILGHADSPLIKHIPGAAGQPHARINASHFIQEDRGPELAERILSWQQALL
>Mature_301_residues
MHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPD
LIGFGRSDKPSRIEDYSYQRHVDWVVSWFEHLNLSDVTLFVQDWGSLIGLRIAAEQPDRVGRLVVANGFLPTAQRRTPPA
FYAWRAFARYSPVLPAGRIVSVGTVRRVSSKVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEK
PFLAIFGARDPILGHADSPLIKHIPGAAGQPHARINASHFIQEDRGPELAERILSWQQALL

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, which includes mono- and di- chlorinated

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI27597073, Length=126, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562298, Length=277, Percent_Identity=27.0758122743682, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17554012, Length=116, Percent_Identity=28.448275862069, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324392, Length=129, Percent_Identity=29.4573643410853, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHMA_MYCAV (Q93K00)

Other databases:

- EMBL:   AJ314789
- ProteinModelPortal:   Q93K00
- SMR:   Q93K00
- BRENDA:   3.8.1.5
- HAMAP:   MF_01230
- InterPro:   IPR000073
- InterPro:   IPR000639
- PRINTS:   PR00111
- PRINTS:   PR00412

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =3.8.1.5

Molecular weight: Translated: 33842; Mature: 33842

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: ACT_SITE 123-123 ACT_SITE 250-250 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSY
CCCCCCCCHHHCCCCCCCCEEHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHH
LYRTMITPLTDAGNRVLAPDLIGFGRSDKPSRIEDYSYQRHVDWVVSWFEHLNLSDVTLF
HHHHHHHHHCCCCCEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
VQDWGSLIGLRIAAEQPDRVGRLVVANGFLPTAQRRTPPAFYAWRAFARYSPVLPAGRIV
HHHHHHHHEEEEECCCCCHHCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEE
SVGTVRRVSSKVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEK
EHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCC
PFLAIFGARDPILGHADSPLIKHIPGAAGQPHARINASHFIQEDRGPELAERILSWQQAL
CEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure
MHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSY
CCCCCCCCHHHCCCCCCCCEEHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHH
LYRTMITPLTDAGNRVLAPDLIGFGRSDKPSRIEDYSYQRHVDWVVSWFEHLNLSDVTLF
HHHHHHHHHCCCCCEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
VQDWGSLIGLRIAAEQPDRVGRLVVANGFLPTAQRRTPPAFYAWRAFARYSPVLPAGRIV
HHHHHHHHEEEEECCCCCHHCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEE
SVGTVRRVSSKVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEK
EHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCC
PFLAIFGARDPILGHADSPLIKHIPGAAGQPHARINASHFIQEDRGPELAERILSWQQAL
CEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12147465