BacMap

Definition	Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession	NC_002944
Length	4,829,781

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The map label for this gene is fabG [H]

Identifier: 41407805

GI number: 41407805

Start: 1865261

End: 1865971

Strand: Direct

Name: fabG [H]

Synonym: MAP1707

Alternate gene names: 41407805

Gene position: 1865261-1865971 (Clockwise)

Preceding gene: 41407804

Following gene: 41407806

Centisome position: 38.62

GC content: 68.21

Gene sequence:

>711_bases
ATGCCGTCGCGACGGGTTTTGATCACCGGGGCATCGAGGGGTATCGGCCGCGCGGTGGCCGATCGGCTGGCCGAGGGTGG
CCACGAACCGATCGGCCTTGCCCGGAGCGCCCCCAAGGATTTTCCGGGGGAGTTCTACGAGGTCGACTTGGCCGACCCGT
ACGCAACCGCGGCGACGCTGGACAAGATCGTCGGGCACGCTGCCGTACACGCCGTGGTCAACAACGTGGGTTTCGCCCGG
TTCGGCCGACTCGGCTCGATCGAGCTGGACCACCTGTTCGACACCTACAACCTGAATGTGCGCGCCGCCGTTCAGGTCGT
GCAGGCGGCCCTGCCCGGCATGCTCGACGCGGAATGGGGCCGCATCGTCAATGTGACCAGCTTGACCACGCTCGGCACGC
CCGAGCGGACCCCGTACGCTGCGGCCAAGGCGGCGCTCGAGGCGTGCACCCGCATCTGGGCGGGCGAGCTCGCCTCGGCC
GGCATCACGGTGAACGCCGTGGCACCGGGACCCACCGAAACCGACATGTACCGCGAACGCAGCCCGGTCGGATCGGCACG
CGAAGCCCGCTTCCTGCAAAGCATTCCGCTGCATCGGGTCGCCAGGCCGCGCGAGATCGCCCACGCGATTTGTTTTCTCC
TCGACGAGGACGCCGGCTACATCACCGGTCAAATCCTGCGCGTCGACGGGGGCGGAAGTATCGCCGCGTAA

Upstream 100 bases:

>100_bases
TTTTTGTGGGATATACGGCTCAGCAGTCATGGGAGAGCACGGCCCGCCGGCCCCAGACTGGCTCCAGGCGCACCGCCATC
ACGATTCCAAGGAGCAGTCC

Downstream 100 bases:

>100_bases
TGCCAAGGCGGCCAACACAGTACAGCTCAACCGAGGAGACATATCATGACCACCACGTCGTCCATCGAAACCATCGCCGA
CATCGCCATACCCGACACCG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MPSRRVLITGASRGIGRAVADRLAEGGHEPIGLARSAPKDFPGEFYEVDLADPYATAATLDKIVGHAAVHAVVNNVGFAR
FGRLGSIELDHLFDTYNLNVRAAVQVVQAALPGMLDAEWGRIVNVTSLTTLGTPERTPYAAAKAALEACTRIWAGELASA
GITVNAVAPGPTETDMYRERSPVGSAREARFLQSIPLHRVARPREIAHAICFLLDEDAGYITGQILRVDGGGSIAA

Sequences:

>Translated_236_residues
MPSRRVLITGASRGIGRAVADRLAEGGHEPIGLARSAPKDFPGEFYEVDLADPYATAATLDKIVGHAAVHAVVNNVGFAR
FGRLGSIELDHLFDTYNLNVRAAVQVVQAALPGMLDAEWGRIVNVTSLTTLGTPERTPYAAAKAALEACTRIWAGELASA
GITVNAVAPGPTETDMYRERSPVGSAREARFLQSIPLHRVARPREIAHAICFLLDEDAGYITGQILRVDGGGSIAA
>Mature_235_residues
PSRRVLITGASRGIGRAVADRLAEGGHEPIGLARSAPKDFPGEFYEVDLADPYATAATLDKIVGHAAVHAVVNNVGFARF
GRLGSIELDHLFDTYNLNVRAAVQVVQAALPGMLDAEWGRIVNVTSLTTLGTPERTPYAAAKAALEACTRIWAGELASAG
ITVNAVAPGPTETDMYRERSPVGSAREARFLQSIPLHRVARPREIAHAICFLLDEDAGYITGQILRVDGGGSIAA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=234, Percent_Identity=33.7606837606838, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI7705925, Length=240, Percent_Identity=31.6666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=29.7619047619048, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI66933014, Length=171, Percent_Identity=32.1637426900585, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=29.1497975708502, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI19923817, Length=249, Percent_Identity=26.9076305220884, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI226371731, Length=196, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI7657478, Length=192, Percent_Identity=31.25, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI10190704, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=235, Percent_Identity=37.8723404255319, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786812, Length=244, Percent_Identity=32.3770491803279, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=29.3650793650794, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=32.6693227091633, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=28.3400809716599, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=32.258064516129, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=28.125, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786701, Length=182, Percent_Identity=32.967032967033, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=28.9156626506024, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI2367365, Length=239, Percent_Identity=28.0334728033473, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=27.5590551181102, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=34.8547717842324, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=31.5789473684211, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=30.1470588235294, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=29.0322580645161, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=31.5384615384615, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17560220, Length=256, Percent_Identity=31.25, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=257, Percent_Identity=31.9066147859922, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=256, Percent_Identity=31.640625, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.1526717557252, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=30.7116104868914, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=30.0411522633745, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=31.7829457364341, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=29.811320754717, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=256, Percent_Identity=31.25, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=30.4029304029304, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=30.3030303030303, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=32.2222222222222, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=28.0769230769231, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=30.188679245283, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=30.0380228136882, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=264, Percent_Identity=28.4090909090909, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=25.6, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=257, Percent_Identity=28.4046692607004, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=262, Percent_Identity=27.0992366412214, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=206, Percent_Identity=28.6407766990291, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193207185, Length=147, Percent_Identity=34.6938775510204, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=32.520325203252, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=32.2448979591837, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=31.1203319502075, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=30.8943089430894, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=30.9803921568627, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=30.0813008130081, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644337, Length=222, Percent_Identity=32.8828828828829, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=29.8449612403101, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25010; Mature: 24878

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRRVLITGASRGIGRAVADRLAEGGHEPIGLARSAPKDFPGEFYEVDLADPYATAATL
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
DKIVGHAAVHAVVNNVGFARFGRLGSIELDHLFDTYNLNVRAAVQVVQAALPGMLDAEWG
HHHHHHHHHHHHHHHCCHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
RIVNVTSLTTLGTPERTPYAAAKAALEACTRIWAGELASAGITVNAVAPGPTETDMYRER
CEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHC
SPVGSAREARFLQSIPLHRVARPREIAHAICFLLDEDAGYITGQILRVDGGGSIAA
CCCCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
PSRRVLITGASRGIGRAVADRLAEGGHEPIGLARSAPKDFPGEFYEVDLADPYATAATL
CCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
DKIVGHAAVHAVVNNVGFARFGRLGSIELDHLFDTYNLNVRAAVQVVQAALPGMLDAEWG
HHHHHHHHHHHHHHHCCHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
RIVNVTSLTTLGTPERTPYAAAKAALEACTRIWAGELASAGITVNAVAPGPTETDMYRER
CEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHC
SPVGSAREARFLQSIPLHRVARPREIAHAICFLLDEDAGYITGQILRVDGGGSIAA
CCCCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10464226; 10984043 [H]