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The map label for this gene is ilvG [H]

Identifier: 41407631

GI number: 41407631

Start: 1683585

End: 1684592

Strand: Direct

Name: ilvG [H]

Synonym: MAP1533

Alternate gene names: 41407631

Gene position: 1683585-1684592 (Clockwise)

Preceding gene: 41407630

Following gene: 41407632

Centisome position: 34.86

GC content: 72.82

Gene sequence:

>1008_bases
GTGATCATGGCGGGCACCAACGTCTGGTGGGGGCATGGGGAAGCGGCTCTGCTGCGGCTGGCCGAGGAACTGGCCATCCC
GGTGCTGATGAACGGGATGGCGCGCGGGGCGGTGCCCGCCGACCATCCGCTGGCCTTCTCCCGCGTTCGCGGAAAAGCGT
TGGGGGAGGCCGATGTTGCGCTGATCGTCGGCGTGCCCATGGATTTCCGGCTCGGTTTCGGCGCGGTGTTCGGGCCGCAC
ACCCGGCTGATCGTGGCCGACCGGGTGGCGCCCGAGCGCAAGCATCCCCGGCCCGTCGAGGCGCAGCTGTACGGCGACCT
GATGACGATCCTGGCCGCGTTGGCCACCGCGGGTGGGGGCGACCACCCGGACTGGATCGACGAACTGCGCACGGCCGAGA
CGGCGGCGCGCGCCGCCGAGCGGGCCGAGCTGGCCGACGACCGCGTCCCGCTGCATCCGATGCGGGTGTACGCGGAGCTG
GCGCCGATGCTGGACCGCGACGCCATCGTCGTCATCGACGCCGGCGACTTCGGCTCCTACGCCGGGCGGGTGATCGACAG
CTACCGGCCGGGCTGCTGGCTGGACAGCGGCCCCTTCGGCTGCCTGGGGTCGGGACCCGGCTACGCGCTGGCCGCCAAGC
TGGCCCGGCCGGAGCGCCAGGTGGTGCTGCTGCAGGGCGACGGCGCGTTCGGCTTCAGCGGCATGGAATGGGACACCCTG
GTCCGCCACCGGGTGCCGGTGGTCTCGGTGATCGGCAACAACGGGATCTGGGCGCTGGAAAAGCATCCAATGGAGCAGCT
GTACGGCTATTCGGTGGTGGCCGAGCTGCGCCCGGGCACCCGCTACGACGAGGTGGCGCGCGCGCTGGGCGGGCACGGCG
AGTTGGTCGCCGCGCCGGGCGAGCTGCGACCGGCGCTGGAACGCGCCTTCGCCAGCGGCCTGCCCGCCGTCGTCAACGTG
CTCACCGACCCCACGGTCGCCTACCCGCGGCGGTCGAACCTGGCCTGA

Upstream 100 bases:

>100_bases
ACGGCCGCCCCGGGGCGCTCATCGACCTGCCGCGCGAACCCGAACCCGACGGCGCCGCGCTGGGCCGGGCCGCCGGCCTG
CTGTCCGGCGCGAAGCGGCG

Downstream 100 bases:

>100_bases
CGGGCGTGTCGGGTGCGAACACGCGGGCTCGCCCCACCGGTACCGTTGACCTGTGCCTAAGACGAACCGAGCTCAACCCG
GCCGGCTGAGCAGCCGATTC

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MIMAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGPH
TRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGGDHPDWIDELRTAETAARAAERAELADDRVPLHPMRVYAEL
APMLDRDAIVVIDAGDFGSYAGRVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTL
VRHRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPGELRPALERAFASGLPAVVNV
LTDPTVAYPRRSNLA

Sequences:

>Translated_335_residues
MIMAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGPH
TRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGGDHPDWIDELRTAETAARAAERAELADDRVPLHPMRVYAEL
APMLDRDAIVVIDAGDFGSYAGRVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTL
VRHRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPGELRPALERAFASGLPAVVNV
LTDPTVAYPRRSNLA
>Mature_335_residues
MIMAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGPH
TRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGGDHPDWIDELRTAETAARAAERAELADDRVPLHPMRVYAEL
APMLDRDAIVVIDAGDFGSYAGRVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTL
VRHRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPGELRPALERAFASGLPAVVNV
LTDPTVAYPRRSNLA

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=340, Percent_Identity=34.4117647058824, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI93004078, Length=345, Percent_Identity=26.9565217391304, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1788716, Length=333, Percent_Identity=30.3303303303303, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790104, Length=325, Percent_Identity=24.6153846153846, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081685, Length=311, Percent_Identity=25.4019292604502, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787096, Length=338, Percent_Identity=24.5562130177515, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17542570, Length=330, Percent_Identity=35.4545454545455, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17531301, Length=336, Percent_Identity=32.4404761904762, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17531299, Length=336, Percent_Identity=32.4404761904762, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320816, Length=327, Percent_Identity=29.3577981651376, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922626, Length=352, Percent_Identity=26.9886363636364, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 35847; Mature: 35847

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVA
CEEECCCEEECCCHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCHHHHHHCCCCCCCCCEE
LIVGVPMDFRLGFGAVFGPHTRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGG
EEEECCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
DHPDWIDELRTAETAARAAERAELADDRVPLHPMRVYAELAPMLDRDAIVVIDAGDFGSY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHH
AGRVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTL
HHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHH
VRHRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPG
HHHCCCEEEEECCCCEEEECCCCHHHHHCCEEEEECCCCCCHHHHHHHHCCCCCEEECCH
ELRPALERAFASGLPAVVNVLTDPTVAYPRRSNLA
HHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MIMAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVA
CEEECCCEEECCCHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCHHHHHHCCCCCCCCCEE
LIVGVPMDFRLGFGAVFGPHTRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGG
EEEECCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
DHPDWIDELRTAETAARAAERAELADDRVPLHPMRVYAELAPMLDRDAIVVIDAGDFGSY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHH
AGRVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTL
HHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHH
VRHRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPG
HHHCCCEEEEECCCCEEEECCCCHHHHHCCEEEEECCCCCCHHHHHHHHCCCCCEEECCH
ELRPALERAFASGLPAVVNVLTDPTVAYPRRSNLA
HHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]