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The map label for this gene is trxB

Identifier: 41407294

GI number: 41407294

Start: 1256354

End: 1256707

Strand: Direct

Name: trxB

Synonym: MAP1196

Alternate gene names: 41407294

Gene position: 1256354-1256707 (Clockwise)

Preceding gene: 41407290

Following gene: 41407295

Centisome position: 26.01

GC content: 64.69

Gene sequence:

>354_bases
GTGACAACAGTCGATCTCACCGCCGAGAAATTCAACGAAACCATCGAGGGCAACGACATCGTGCTCGTCGACTTCTGGGC
GTCCTGGTGCGGCCCCTGCCGCCAGTTCGGGCCCACTTTCCAGGCTTCGTCGGAGAAACACCCCGACATCGTGCACGCCA
AGGTCGACACCGAGGCCGAACAGCAGCTGGCCGCGGCCGCCCAGATCCGGTCCATTCCCACGCTGATGGCCTTCAAGAAG
GGCAAACTGCTGTTCAACCAGCCCGGCGCGCTGCCGCCCGCCGCTCTGGAAGACCTGGTGCAGCAGGTCCGCGCGTTCGA
CGTGGACGCGGCCATCGCCGAGCAAGGCGAATAA

Upstream 100 bases:

>100_bases
GCTCAGTCTGTCGGACGCGAGAAAACGTACGCAACCGTAACCAGGCCGGCGCCGCTCAGGTCCGGGAACATCGGGTGGCC
GCCGCGCGTTGGGAGCAAAT

Downstream 100 bases:

>100_bases
CCCGACGCGCTACCGTGCACGGGTGAGTTTGGTACTGGTAGACCACCCGCGGCCCGGCGTCGCGCTGATCACCCTCAATC
GCCCCGAGCGGATGAACTCC

Product: hypothetical protein

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MTTVDLTAEKFNETIEGNDIVLVDFWASWCGPCRQFGPTFQASSEKHPDIVHAKVDTEAEQQLAAAAQIRSIPTLMAFKK
GKLLFNQPGALPPAALEDLVQQVRAFDVDAAIAEQGE

Sequences:

>Translated_117_residues
MTTVDLTAEKFNETIEGNDIVLVDFWASWCGPCRQFGPTFQASSEKHPDIVHAKVDTEAEQQLAAAAQIRSIPTLMAFKK
GKLLFNQPGALPPAALEDLVQQVRAFDVDAAIAEQGE
>Mature_116_residues
TTVDLTAEKFNETIEGNDIVLVDFWASWCGPCRQFGPTFQASSEKHPDIVHAKVDTEAEQQLAAAAQIRSIPTLMAFKKG
KLLFNQPGALPPAALEDLVQQVRAFDVDAAIAEQGE

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI50592994, Length=74, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI4758304, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788936, Length=101, Percent_Identity=37.6237623762376, Blast_Score=85, Evalue=1e-18,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=32.3232323232323, Blast_Score=65, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=41.9753086419753, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=81, Percent_Identity=34.5679012345679, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=81, Percent_Identity=34.5679012345679, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=81, Percent_Identity=34.5679012345679, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=89, Percent_Identity=37.0786516853933, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=101, Percent_Identity=31.6831683168317, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=36.1702127659575, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=104, Percent_Identity=31.7307692307692, Blast_Score=69, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=87, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 12756; Mature: 12625

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVDLTAEKFNETIEGNDIVLVDFWASWCGPCRQFGPTFQASSEKHPDIVHAKVDTEAE
CCCCCCCHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHH
QQLAAAAQIRSIPTLMAFKKGKLLFNQPGALPPAALEDLVQQVRAFDVDAAIAEQGE
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure 
TTVDLTAEKFNETIEGNDIVLVDFWASWCGPCRQFGPTFQASSEKHPDIVHAKVDTEAE
CCCCCCHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHH
QQLAAAAQIRSIPTLMAFKKGKLLFNQPGALPPAALEDLVQQVRAFDVDAAIAEQGE
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]