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The map label for this gene is csd [H]

Identifier: 41407288

GI number: 41407288

Start: 1250585

End: 1251832

Strand: Direct

Name: csd [H]

Synonym: MAP1190

Alternate gene names: 41407288

Gene position: 1250585-1251832 (Clockwise)

Preceding gene: 41407287

Following gene: 41407289

Centisome position: 25.89

GC content: 70.27

Gene sequence:

>1248_bases
ATGACGGCGACACAACTGGATGTGGCCGCGATCCGCGCCGATTTCCCCATTCTGAAACGGATCATGCGCAGCGGAAACCA
GTTGGCGTACCTGGATTCCGGTGCGACGTCGCAACGCCCACTGCAGGTGCTCGACGCCGAGCGGGAATTCCTGCTGACCT
CCAACGGCGCCGTGCACCGCGGCGCGCACCAGCTGATGGAGGAGTCCACCGACGCCTACGAGCAGGGCCGCGCCGACATC
GCGGCGTTCGTCGGCGCCGACCCGGACGAGCTGGTGTTCACCAAGAACGCCACCGAGGCGCTCAACCTGGTGTCGTACGT
GGTGGGGGACAACCGTTTCGAGGGGGCCGTCGGCCCCGGCGACGTGATCGTCACCACCGAGCTGGAGCATCACGCCAACC
TGGTGCCGTGGCAGGAGTTGGCCCGGCGCACCGGCGCCAGCCTGCGCTGGTACGGCGTCACCGACGACGGGCGGATCGAC
CTGGACTCGTTGCAGCTCGACGAGCGGGTCAAAGTGGTTGCCTTCAGCCATCATTCGAACGTGACCGGCGCGGTGGCGCC
GGTGGCCGAGCTGGTGGGGCGGGCCCGCGCGGTGGGCGCGCTGACGGTGCTGGACGCCTGTCAGTCGGTGCCGCACCAGC
CGGTGGACTTCCACGCGCTCGACGTCGACTTCGCCGCGTTCTCCGGGCACAAGATGTTGGGCCCCAACGGGATCGGCGTG
CTCTACGGGCGCCGCGAGGTGTTGTCGCAGCTGCCGCCGTTCCTCACCGGTGGCTCGATGATCGAGACCGTGACCATGGA
GTCCTCCAGCTACGCGCAGGTGCCGCAGCGGTTCGAGGCCGGCACCCCGATGACCTCCCAGGTGGTCGGGTTGGCCGCGG
CCGCCCGCTATCTCGGCGCCTTCGGCATGGACGCGGTGCAGGCCCACGAGGAGCGGCTGGTCGCCGCGGCCATCGAGGGC
CTGTCCGGTATCGACGCGGTCCGCATCGTCGGGCCGACGTCGACCGAAAACCGTGGCTCGCCGGTGTCTTTCGTCGTCGA
CGGGGTGCACGCGCACGACGTCGGGCAGGTGCTCGACGACGAGGGCGTGGCGGTGCGGGTGGGCCACCACTGCGCGCTGC
CGCTGCACCGCCGGTTCGGATTGGCGGCCACCGCCCGGGCGTCCTTCGCGGTGTACAACACCGCCGAGGAGGTCGACCGC
CTGGTGGCGGGTGTGCGCCGCGCCCTGGACTTCTTCGGCGGAGTGTGA

Upstream 100 bases:

>100_bases
GCGGCCGGATCGCCGAATCCGGTGGCTCGGAGCTGGCCGACGAACTCGAGCAGAACGGCTACGTGCGCTTCACCCAAGCG
GCGGCAGCGGGGGCGTAAGC

Downstream 100 bases:

>100_bases
GCCGTGCGTCTGGAACAGATGTATCAGGACGTGATCCTCGATCACTACAAGCACCCGCAGCATCGCGGGTTGCGGGAACC
GTTCGGCGCCGAGGTGTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTATQLDVAAIRADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADI
AAFVGADPDELVFTKNATEALNLVSYVVGDNRFEGAVGPGDVIVTTELEHHANLVPWQELARRTGASLRWYGVTDDGRID
LDSLQLDERVKVVAFSHHSNVTGAVAPVAELVGRARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGV
LYGRREVLSQLPPFLTGGSMIETVTMESSSYAQVPQRFEAGTPMTSQVVGLAAAARYLGAFGMDAVQAHEERLVAAAIEG
LSGIDAVRIVGPTSTENRGSPVSFVVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRRFGLAATARASFAVYNTAEEVDR
LVAGVRRALDFFGGV

Sequences:

>Translated_415_residues
MTATQLDVAAIRADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADI
AAFVGADPDELVFTKNATEALNLVSYVVGDNRFEGAVGPGDVIVTTELEHHANLVPWQELARRTGASLRWYGVTDDGRID
LDSLQLDERVKVVAFSHHSNVTGAVAPVAELVGRARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGV
LYGRREVLSQLPPFLTGGSMIETVTMESSSYAQVPQRFEAGTPMTSQVVGLAAAARYLGAFGMDAVQAHEERLVAAAIEG
LSGIDAVRIVGPTSTENRGSPVSFVVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRRFGLAATARASFAVYNTAEEVDR
LVAGVRRALDFFGGV
>Mature_414_residues
TATQLDVAAIRADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADIA
AFVGADPDELVFTKNATEALNLVSYVVGDNRFEGAVGPGDVIVTTELEHHANLVPWQELARRTGASLRWYGVTDDGRIDL
DSLQLDERVKVVAFSHHSNVTGAVAPVAELVGRARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGVL
YGRREVLSQLPPFLTGGSMIETVTMESSSYAQVPQRFEAGTPMTSQVVGLAAAARYLGAFGMDAVQAHEERLVAAAIEGL
SGIDAVRIVGPTSTENRGSPVSFVVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRRFGLAATARASFAVYNTAEEVDRL
VAGVRRALDFFGGV

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=302, Percent_Identity=29.1390728476821, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156713448, Length=327, Percent_Identity=25.9938837920489, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787970, Length=412, Percent_Identity=43.6893203883495, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1789175, Length=410, Percent_Identity=35.8536585365854, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=28.5353535353535, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=299, Percent_Identity=27.0903010033445, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=376, Percent_Identity=24.7340425531915, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319831, Length=405, Percent_Identity=28.3950617283951, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20129463, Length=231, Percent_Identity=33.7662337662338, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44268; Mature: 44137

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATQLDVAAIRADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHR
CCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCCCEEEECCCCHHH
GAHQLMEESTDAYEQGRADIAAFVGADPDELVFTKNATEALNLVSYVVGDNRFEGAVGPG
HHHHHHHHHHHHHHCCCHHEEHCCCCCCHHEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
DVIVTTELEHHANLVPWQELARRTGASLRWYGVTDDGRIDLDSLQLDERVKVVAFSHHSN
CEEEEEEHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCEEHHHCCCCCCEEEEEEECCCC
VTGAVAPVAELVGRARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCEEECCCCCEE
LYGRREVLSQLPPFLTGGSMIETVTMESSSYAQVPQRFEAGTPMTSQVVGLAAAARYLGA
EECCHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FGMDAVQAHEERLVAAAIEGLSGIDAVRIVGPTSTENRGSPVSFVVDGVHAHDVGQVLDD
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHCC
EGVAVRVGHHCALPLHRRFGLAATARASFAVYNTAEEVDRLVAGVRRALDFFGGV
CCCEEEECCEECCCHHHHCCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TATQLDVAAIRADFPILKRIMRSGNQLAYLDSGATSQRPLQVLDAEREFLLTSNGAVHR
CCCHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCCCEEEECCCCHHH
GAHQLMEESTDAYEQGRADIAAFVGADPDELVFTKNATEALNLVSYVVGDNRFEGAVGPG
HHHHHHHHHHHHHHCCCHHEEHCCCCCCHHEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
DVIVTTELEHHANLVPWQELARRTGASLRWYGVTDDGRIDLDSLQLDERVKVVAFSHHSN
CEEEEEEHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCEEHHHCCCCCCEEEEEEECCCC
VTGAVAPVAELVGRARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCEEECCCCCEE
LYGRREVLSQLPPFLTGGSMIETVTMESSSYAQVPQRFEAGTPMTSQVVGLAAAARYLGA
EECCHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FGMDAVQAHEERLVAAAIEGLSGIDAVRIVGPTSTENRGSPVSFVVDGVHAHDVGQVLDD
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHCC
EGVAVRVGHHCALPLHRRFGLAATARASFAVYNTAEEVDRLVAGVRRALDFFGGV
CCCEEEECCEECCCHHHHCCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]